This chapter analyzes magic and attitudes toward magic in early modern Spain. The time period for review is primarily the sixteenth century. The chapter summarizes basic Spanish terminology such as hechicería, bruja, and sortilegio. There are two elements to this discussion. First, the chapter examines the cases of famous witch crazes in the Basque region of Spain in 1525 and 1609–11 in Zugarramurdi. There is a lot of popular imagery concerning witch crazes, seen for example in Goya’s painting of the Aquelarre, or the witches’ sabbath. In reality, Catholic courts and the Inquisition were skeptical of the existence of witches. The chapter analyzes some specific anti-sorcery writings such as treatises by Martín de Arlés and Martín de Castañega. It also looks at inquisitor manuals such as those by Alfonso de Castro, Nicolau Eimeric, and Diego de Simancas. Furthermore, this chapter examines the role of royal law in Siete Partidas in establishing jurisdiction over witchcraft. The chapter also includes some observations about uniquely Spanish types of magic and folk healing, such as the belief in the evil eye, herbal remedies, and Saint John’s Night.