Before placing his son at Cambridge Mr. Clerk Maxwell had, as was usual with him, consulted various persons, including Professor James Forbes and Professor Kelland of Edinburgh, Professors Thomson and Blackburn of Glasgow, and Charles Mackenzie, afterwards Bishop of Natal, then a Lecturer of Caius College, Cambridge. Forbes strongly advised Trinity, and offered an introduction to Whewell; but after various reasons urged for Trinity, Caius, and Peter house, the decision was in favour of Peterhouse.

Maxwell's first impression of college life, like that of some other clever freshmen, was not one of unalloyed satisfaction. He was transplanted from the rural solitudes of Galloway into the midst of a society which was of curious interest to him, but did not make him feel immediately at home. He found himself amongst the freshmen spelling out Euclid again, and again “monotonously parsing” a Greek play. He had brought with him his scraps of gelatine, gutta percha, and unannealed glass, his bits of magnetised steel, and other objects, which were apt to appear to the uninitiated as “matter in the wrong place.” And this in the home of science! Nor were his experiments facilitated by the casual “dropping-in” of the average undergraduate.

His boyish spirits and his social temper, together with the novelty of the scene, and a deep-rooted presentiment of the possibilities of Cambridge, no doubt made even his first term a happy one.

After his recovery from the attack of erysipelas at Glenlair in 1865, Maxwell's health appears to have been fairly good until the spring of 1877. He then began to be troubled with dyspeptic symptoms, especially with a painful choking sensation after taking meat. He consulted no one for about two years. But one day in 1877, on coming into the Laboratory after his luncheon, he dissolved a crystal of carbonate of soda in a small beaker of water, and drank it off. A little while after this he said he had found how to manage so as to avoid pain. The trouble proved obstinate, however, and at last, on the 21st of April 1879, he mentioned it when writing to Dr. Paget about Mrs. Maxwell.

By this time his friends at Cambridge had begun to observe a change in his appearance, and some failure of the old superabundant energy. They missed the elasticity of step, and the well-known sparkle in his eye. During the Easter Term of 1879 he attended the Laboratory daily, but only stayed a very short time. At the end of the term he remarked that he had been unable to do much more than to give his lectures. And before leaving Cambridge for the vacation, he was more than once very seriously unwell.

In June he returned, as usual, to Glenlair. His letters continued to be marked by humorous cheerfulness, and, as was always the case, contained information about everything and everybody except himself.