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Effect of turmeric on the viability, ovarian folliculogenesis, fecundity, ovarian hormones and response to luteinizing hormone of rabbits

Published online by Cambridge University Press:  26 October 2017

A. V. Sirotkin ,
A. Kadasi ,
A. Stochmalova ,
A. Balazi ,
M. Földesiová ,
P. Makovicky ,
P. Makovicky ,
P. Chrenek  and
A. H. Harrath
A. V. Sirotkin*
Affiliation:
Department of Zoology and Anthropology, Constantine the Philosopher University, Tr. A. Hlinku 1, 949 74 Nitra, Slovak Republic Institute for Farm Animal Genetics and Reproduction, Research Institute for Animal Production Nitra, Hlohovecká 2, 951 41 Lužianky, Slovak Republic
A. Kadasi
Affiliation:
Department of Animal Physiology, Faculty of Biotechnology and Food Science, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, Slovak Republic
A. Stochmalova
Affiliation:
Department of Zoology and Anthropology, Constantine the Philosopher University, Tr. A. Hlinku 1, 949 74 Nitra, Slovak Republic
A. Balazi
Affiliation:
Institute for Farm Animal Genetics and Reproduction, Research Institute for Animal Production Nitra, Hlohovecká 2, 951 41 Lužianky, Slovak Republic
M. Földesiová
Affiliation:
Institute for Farm Animal Genetics and Reproduction, Research Institute for Animal Production Nitra, Hlohovecká 2, 951 41 Lužianky, Slovak Republic
P. Makovicky
Affiliation:
Department of Transgenic Models of Diseases, Czech Centre for Phenogenomics, Division BIOCEV, Institute of Molecular Genetics, ASCR, v.v.i., Prumyslova 595, 252 50 Vestec, Czech Republic
P. Makovicky
Affiliation:
Department of Biology, Faculty of Education, Selye Janos University, Bratislavska 3322, Komárno, Slovak Republic
P. Chrenek
Affiliation:
Institute for Farm Animal Genetics and Reproduction, Research Institute for Animal Production Nitra, Hlohovecká 2, 951 41 Lužianky, Slovak Republic Department of Animal Physiology, Faculty of Biotechnology and Food Science, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, Slovak Republic
A. H. Harrath
Affiliation:
Zoology Department, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia
*
†E-mail: asirotkin@ukf.sk
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Abstract

The present study investigated whether dietary turmeric (Curcuma longa L.) can improve rabbit reproduction, ovarian function, growth, or viability. Female New Zealand White rabbits were either fed a standard diet (n=15) or a diet enriched with 5 g (group E1) or 20 g (group E2) turmeric powder per 100 kg feed mixture (n=16 or 15, respectively). After 295 days, weight gain, conception and kindling rates, pup and mother viability, ovarian macro- and micro-morphometric indices, release of leptin in response to the addition LH, and the release of progesterone, testosterone and leptin by isolated ovarian fragments were analyzed. Dietary turmeric failed to affect ovarian length and weight but did increase the number of primary follicles (E2: 32.5% greater than control group), as well as the diameter of primary (E1: +19.4%, E2: +21.1%), secondary (E2: +41.4%), and tertiary (E1: +97.1%, E2: +205.1%) follicles. Turmeric also increased the number of liveborn (E1: +21.0%) and weaned (E1: +25.0%) pups and decreased the number of stillborn pups (E2: −87.5%) but did not affect weight gain, conception, or kindling rate. Furthermore, dietary turmeric decreased doe mortality during the first reproductive cycle (13.3% in control; 0% in E1; and 6.7% in E2) but not during the second cycle. In vitro, the ovaries of the turmeric-treated rabbits released more progesterone (E1: +85.7%, E2: +90.0%) and less testosterone (E2: −87.0%) and leptin (E2: −29.0%) than the ovaries of control rabbits. Moreover, LH decreased the leptin output of control rabbits but increased that of experimental rabbits. Therefore, it is likely that dietary turmeric improves pup viability and that it could promote rabbit fecundity by either (1) promoting the production of primary ovarian follicles or (2) stimulating the growth of follicles at all stages of folliculogenesis.

Keywords

turmeric (Curcuma longa)/curcuminovaryhormoneviabilityfecundity
Type
Research Article
Information
animal , Volume 12 , Issue 6 , June 2018 , pp. 1242 - 1249
Copyright
© The Animal Consortium 2017 

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References

Aktas, C, Kanter, M and Kocak, Z 2012. Antiapoptotic and proliferative activity of curcumin on ovarian follicles in mice exposed to whole body ionizing radiation. Toxicology and Industrial Health 28, 852–863.CrossRefGoogle ScholarPubMed
Bachmeier, BE, Mirisola, V, Romeo, F, Generoso, L, Esposito, A, Dell’eva, R, Blengio, F, Killian, PH, Albini, A and Pfeffer, U 2010. Reference profile correlation reveals estrogen-like transcriptional activity of curcumin. Cellular Physiology and Biochemistry 26, 471–482.Google Scholar
Bondì, ML, Emma, MR, Botto, C, Augello, G, Azzolina, A, Di Gaudio, F, Craparo, EF, Cavallaro, G, Bachvarov, D and Cervello, M 2017. Biocompatible lipid nanoparticles as carriers to improve curcumin efficacy in ovarian cancer treatment. Journal of Agricultural and Food Chemistry 22, 1342–1352.Google Scholar
Fan, X, Zhang, C, Liu, DB, Yan, J and Liang, HP 2013. The clinical applications of curcumin: current state and the future. Current Pharmaceutical Design 19, 2011–2031.Google Scholar
Inano, H, Onoda, M, Inafuku, N, Kubota, M, Kamada, Y, Osawa, T, Kobayashi, H and Wakabayashi, K 1999. Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with gamma-rays. Carcinogenesis 20, 1011–1018.Google Scholar
Inano, H, Onoda, M, Inafuku, N, Kubota, M, Kamada, Y, Osawa, T, Kobayashi, H and Wakabayashi, K 2000. Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats. Carcinogenesis 21, 1835–1841.CrossRefGoogle ScholarPubMed
Kunnumakkara, AB, Bordoloi, D, Padmavathi, G, Monisha, J, Roy, NK, Prasad, S and Aggarwal, BB 2016. Curcumin, the golden nutraceutical: multitargeting for multiplechronic diseases. British Journal of Pharmacology 174, 1325–1348.Google Scholar
Lestari, ML and Indrayanto, G 2014. Curcumin. Profiles of Drug Substances, Excipients and Related Methodology 39, 113–204.CrossRefGoogle ScholarPubMed
Murphy, CJ, Tang, H, Van Kirk, EA, Shen, Y and Murdoch, WJ 2012. Reproductive effects of a pegylated curcumin. Reproductive Toxicology 34, 120–124.Google Scholar
Sak, ME, Soydinc, HE, Sak, S, Evsen, MS, Alabalik, U, Akdemir, F and Gul, T 2013. The protective effect of curcumin on ischemia-reperfusion injury in rat ovary. International Journal of Surgery 11, 967–970.Google Scholar
Sirotkin, AV 2011. The role and application of leptin in control of female reproductive functions. In Leptin: hormonal functions, dysfunctions and clinical uses (ed. RM Hemling and AT Belkin), pp. 123–140. Nova Science Publishers Inc., Hauppauge, NY, USA.Google Scholar
Sirotkin, AV 2014. Regulators of ovarian functions. Nova Science Publishers Inc., Hauppauge, NY, USA.Google Scholar
Sirotkin, AV and Harrath, AH 2014. Phytoestrogens and their effects. European Journal of Pharmacology 741, 230–236.Google Scholar
Sirotkin, AV, Chrenek, P, Kolesarová, A, Parillo, F, Zerani, M and Boiti, C 2014. Novel regulators of rabbit reproductive functions. Animal Reproduction Science 148, 188–196.CrossRefGoogle ScholarPubMed
Stanić, Z 2017. Curcumin, a compound from natural sources, a true scientific challenge – a review. Plant Foods for Human Nutrition 72, 1–12.Google Scholar
Terlikowska, KM, Witkowska, AM, Zujko, ME, Dobrzycka, B and Terlikowski, SJ 2014. Potential application of curcumin and its analogues in the treatment strategy of patients with primary epithelial ovarian cancer. International Journal of Molecular Sciences 15, 21703–21722.Google Scholar
Tiwari-Pandey, R and Ram Sairam, M 2009. Modulation of ovarian structure and abdominal obesity in curcumin- and flutamide-treated aging FSH-R haploinsufficient mice. Reproductive Sciences 16, 539–550.CrossRefGoogle ScholarPubMed
Valentine, SP, Le Nedelec, MJ, Menzies, AR, Scandlyn, MJ, Goodin, MG and Rosengren, RJ 2006. Curcumin modulates drug metabolizing enzymes in the female Swiss Webster mouse. Life Sciences 78, 2391–2398.Google Scholar
Voznesens’ka, TI, Bryzhina, TM, Sukhina, VS, Makohon, NV and Aleksieieva, IM 2010. Effect of NF-kappa B activation inhibitor curcumin on the oogenesis and follicular cell death in immune ovarian failure in mice. Fiziolohichnyi Zhurnal 56, 96–101.Google Scholar