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Effects of curcumin on performance, antioxidation, intestinal barrier and mitochondrial function in ducks fed corn contaminated with ochratoxin A

Published online by Cambridge University Press:  12 April 2018

D. Ruan ,
W. C. Wang ,
C. X. Lin ,
A. M. Fouad ,
W. Chen ,
W. G. Xia ,
S. Wang ,
X. Luo ,
W. H. Zhang  and
S. J. Yan
...Show all authors
D. Ruan
Affiliation:
College of Animal Science, South China Agricultural University, Guangzhou 510642, China Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China
W. C. Wang
Affiliation:
College of Animal Science, South China Agricultural University, Guangzhou 510642, China
C. X. Lin
Affiliation:
Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China
A. M. Fouad
Affiliation:
Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China Department of Animal Production, Faculty of Agriculture, Cairo University, Giza 12613, Egypt
W. Chen
Affiliation:
Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China
W. G. Xia
Affiliation:
Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China
S. Wang
Affiliation:
Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China
X. Luo
Affiliation:
Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China
W. H. Zhang
Affiliation:
Agro-biological Gene Research Center, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China
S. J. Yan
Affiliation:
Agro-biological Gene Research Center, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China
C. T. Zheng
Affiliation:
Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China
L. Yang*
Affiliation:
College of Animal Science, South China Agricultural University, Guangzhou 510642, China
*
†E-mail: ylin898@126.com
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Abstract

Curcumin has been attributed with antioxidant, anti-inflammatory, antibacterial activities, and has shown highly protective effects against enteropathogenic bacteria and mycotoxins. Ochratoxin A (OTA) is one of the major intestinal pathogenic mycotoxins. The possible effect of curcumin on the alleviation of enterotoxicity induced by OTA is unknown. The effects of dietary curcumin supplementation on OTA-induced oxidative stress, intestinal barrier and mitochondrial dysfunctions were examined in young ducks. A total of 540 mixed-sex 1-day-old White Pekin ducklings with initial BW (43.4±0.1 g) were randomly assigned into controls (fed only the basal diet), a group fed an OTA-contaminated diet (2 mg/kg feed), and a group fed the same OTA-contaminated feed plus 400 mg/kg of curcumin. Each treatment consisted of six replicates, each containing 30 ducklings and treatment lasted for 21 days. There was a significant decrease in average daily gain (ADG) and increased feed : gain caused by OTA (P<0.05); curcumin co-treatment prevented the decrease in BW and ADG compared with the OTA group (P<0.05). Histopathological and ultrastructural examination showed clear signs of enterotoxicity caused by OTA, but these changes were largely prevented by curcumin supplementation. Curcumin decreased the concentrations of interleukin-1β, tumor necrosis factor-α and malondialdehyde, and increased the activity of glutathione peroxidase induced by OTA in the jejunal mucosa of ducks (P<0.05). Additionally, curcumin increased jejunal mucosa occludin and tight junction protein 1 mRNA and protein levels, and decreased those of ρ-associated protein kinase 1 (P<0.05). Notably, curcumin inhibited the increased expression of apoptosis-related genes, and downregulated mitochondrial transcription factors A, B1 and B2 caused by OTA without any effects on RNA polymerase mitochondrial (P<0.05). These results indicated that curcumin could protect ducks from OTA-induced impairment of intestinal barrier function and mitochondrial integrity.

Keywords

curcuminochratoxin Aenterotoxicityintestinal functionducks
Type
Research Article
Information
animal , Volume 13 , Issue 1 , January 2019 , pp. 42 - 52
Copyright
© The Animal Consortium 2018 

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Footnotes

a

Present address: Institute of Animal Science, Guangdong Academy of Agricultural Sciences, No.1 Dafeng First Street, Wushan Road, Tianhe District, Guangzhou 510640, China.

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