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Short communication: Manipulation of neonatal leptin profile via exogenous glucocorticoids in beef calves

Published online by Cambridge University Press:  25 January 2019

L. K. Lewis ,
R. E. Ricks  and
N. M. Long Open the ORCID record for N. M. Long [Opens in a new window]
L. K. Lewis
Affiliation:
Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA
R. E. Ricks
Affiliation:
Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA
N. M. Long*
Affiliation:
Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA
*
†E-mail: nlong2@clemson.edu
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Abstract

The link between circulating glucocorticoids and leptin in beef calves has not been explored but has been noted in several studies. The aim of this study is to determine the effects of exogenous glucocorticoids given at birth and 1 day of age on serum leptin concentrations in beef calves. Ruminant animals secrete leptin, which is thought to be important for the programming of the hypothalamic appetite centers. Angus crossbred cows (n = 31) bred via natural service were utilized for this experiment. At parturition (day 0), calf BW was recorded and each calf was infused intravenously with either a hydrocortisol sodium succinate solution (HC, 8 males and 8 females) at a dosage of 3.5 μg/kg of BW or a similar volume of saline solution (CONT, 7 males and 8 females). Each calf was given a second infusion of its respective treatment 24 h postpartum at 1.5 μg/kg of BW for HC treatment. Calf treatment was blocked by sex, dam body condition score (BCS), and dam age. Blood samples were taken via jugular venipuncture before infusion, daily from days 0 to 5, then every other day up to day 17. Serum leptin and cortisol concentrations were analyzed via radioimmunoassay. Dam age, dam BCS, calf BW, and serum leptin and cortisol concentrations were analyzed using MIXED procedure of SAS. Dam age was not different (P = 0.81) among HC and CONT calves (4.9±0.5 and 4.7±0.5, respectively). Dam BCS was not different between treatments (5.7±0.2 and 5.6±0.2 HC and CONT, respectively; P = 0.66). There was no difference in calf birth BW between treatments (P = 0.87) and averaged 38.3±1.4 kg. Cortisol concentrations were not different between both treatments (P = 0.23) from birth to day 4 of age. Calves that received the HC treatment showed significantly reduced (P = 0.03) leptin concentrations on days 1 to 13. Calf BW from 60 to 150 days of age was not different between CONT and HC treated calves (P = 0.65). These data indicate that exogenous glucocorticoids can be used to suppress neonatal leptin levels in calves. This could lead to changes in voluntary feed intake of treated calves.

Keywords

bos taurusnewborn calfcortisolpostnataldam age
Type
Short Communication
Information
animal , Volume 13 , Issue 9 , September 2019 , pp. 1982 - 1985
Copyright
© The Animal Consortium 2019 

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