In 2013, Hardy et al. offered a broad behavioural contextfor the hypothesis that the ingestion of non-nutritional plants (yarrow andcamomile) by Neanderthals was for the purpose of self-medication. Chemicaltraces of these plants had been detected in samples of dental calculus fromNeanderthals at the site of El Sidrón, Spain, along with traces of bitumenand wood smoke, as well as starch granules that showed evidence of roasting(Hardy et al.2012). Subsequently, the presenceof traces of resin and a piece of non-edible conifer wood were alsoidentified from these samples (Radini et al.2016). Although not rejecting ourinterpretation for the presence of these two non-edible plants as evidenceof medicinal plant use, two recent articles offer alternative scenarios forwhy and how those plants may have reached the mouth and, eventually, thedental calculus of the individual concerned. Buck and Stringer (2014) suggest that the plants werenot deliberately ingested, and that the traces of yarrow and camomile werein fact embedded in the chyme, or stomach contents, of herbivore prey. Krief et al. (2015)propose two hypotheses: first, they suggest that the plants could have beenused to flavour meat; second, while not ruling out the possibility that theycould be medicinal, they argue on a technical point that the plants were notself-administered but were provided by a caregiver. Here, we examine thesesuggestions and consider their probability and feasibility as alternativesto our original proposal of self-medication.