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The hunting of the hippocampal function

Published online by Cambridge University Press:  04 February 2010

Wim E. Crusio
Génétique, Neurogénéique et Comportement, URA 1294 CNRS, UFR Biomédicale, Université Paris V René Descartes, 75270 Paris Cedex 06, France,


Eichenbaum et al.'s (1994a) theory suffers from a lack of ecological validation. It is not at all clear why the hypothesized faculties would have evolved and what their adaptive value would be. I argue that hippocampal function can only be understood if the animal is seen in its natural context.

Continuing Commentary
Copyright © Cambridge University Press 1996

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Aggleton, J. P. (1994) Commentary on Eichenbaum et al.'s “Two functional components of the hippocampal memory system.” Behavioral and Brain Sciences 17: 472–73. [DGM]Google Scholar
Baars, B. J. (1988) A cognitive theory of conciousness. Cambridge University Press. [MM]Google Scholar
Bentin, S. (1994) Attention and memory. In: Attention and performance: 15. Conscious and nonconscious information processing, ed. Umiltà, C. & Moscovitch, M.. MIT/Bradford Press. [MM]Google Scholar
Bingman, V. P. (1994) Remembering spatial cognition as a hippocampal functional component. Behavioral and Brain Sciences 17:473–74. [WEC]Google Scholar
Bunsey, M. & Eichenbaum, H. (1995) Selective damage to the hippocampal region blocks long-term retention of a natural and nonspatial stimulusstimulus association. Hippocampus 5:546–56. [HE]CrossRefGoogle ScholarPubMed
Bunsey, M. & Eichenbaum, H. (1996) Conservation of hippocampal memory function in rats and humans. Nature 37:255–57. [HE]CrossRefGoogle Scholar
Carroll, L. (18651872/1992) Through the looking-glass, unabridged ed. Wordsworth Editions. [WEC]Google Scholar
Clayton, N. S. & Krebs, J. R. (1995) Memory in food-storing birds: From behaviour to brain. Current Opinion in Neurobiology 5:149–54. [WEC]CrossRefGoogle Scholar
Cohen, N. J. & Eichenbaum, H. (1993) Memory, amnesia, and the hippocampal system. MIT Press. [HE]Google Scholar
Colombo, M. & Cross, C. G. (1994) Responses of inferior temporal cortex and hippocampal neurons during delayed matching to sample in monkeys (Macaca fascicularis). Behavioral Neuroscience 108:443–55. [MC]CrossRefGoogle Scholar
Cowey, A. & Stoerig, P. (1992) A structural model of autobiographical memory. In: The neuropsychology of consciousness, ed. Milner, A. D. & Rugg, M. D.. Academic Press. [MM]Google Scholar
Cowey, A. & Stoerig, P. (1994) Blindsight in monkeys. Nature 373:247–49. [MM]CrossRefGoogle Scholar
Crusio, W. E., Genthner-Grimm, G. & Schwegler, H. (1986) A quantitativegenetic quantitativegenetic analysis of hippocampal variation in the mouse. Journal of Neurogcnetics 3:203–14. [WEC]CrossRefGoogle ScholarPubMed
Crusio, W. E., Schwegler, H. & Brust, I. (1993) Covariations between hippocampal mossy fibres and working and reference memory in spatial and non-spatial radial maze tasks in mice. European Journal of Neuroscience 5:1413–20. [WEC]CrossRefGoogle ScholarPubMed
Eichenbaum, H. (1996) Is the rodent hippocampus just for ‘place’? Current Opinion in Neurobiology 6:187–75. [HE]CrossRefGoogle Scholar
Eichenbaum, H. & Bunsey, M. (1995) On the binding of associations in memory: Clues from studies on the role of the hippocampal region in paired associate learning. Current Directions in Psychological Science 4:1923. [HE]CrossRefGoogle Scholar
Eichenbaum, H., Otto, T. & Cohen, N. J. (1994a) Two functional components of the hippocampal memory system. Behavioral and Brain Sciences 17:449–72. [MC, WEC, MM, DCM]CrossRefGoogle Scholar
Eichenbaum, H., Otto, T. & Cohen, N. J. (1994r) The hippocampal memory system and its functional components: Further explication and clarification [authors response to commentary]. Behavioral and Brain Science 17:500–17. [MC, WEC, DGM]CrossRefGoogle Scholar
Furedy, J. J. & Riley, D. M. (1987) Human Pavlovian autonomic: conditioning and the cognitive paradigm. In: Cognitive processes and Pavlovian conditioning in humans, ed. Davey, G.Wiley [FT]Google Scholar
Fuster, J. M. & Jervey, J. P. (1981) Inferotemporal neurons distinguish and retain behaviorally relevant features of visual stimuli. Science 212:952–55. [MC]CrossRefGoogle ScholarPubMed
Fuster, J. M. & Jervey, J. P. (1982) Neuronal firing in the inferotemporal cortex of the monkey in a visual memory task. Journal of Nettroscience 2:361–75. [MC]Google Scholar
Galef, B. G. (1990) An adaptionist perspective on social learning, social feeding, and social foraging in Norway rats. In: Contemporary issues in comparative psychology, ed. Dewsbury, D. A.. Sinauer. [HE]Google Scholar
Gallistel, C. R. (1980) The organization of action: A netv stjstfiesis. Erlbaum. [FT]Google Scholar
Gallup, G. G. Jr, (1985) Do minds exist in species other than our own? Neuroscience and Biobehavioral Reviews 9:631–41. [MM]CrossRefGoogle Scholar
Goldman-Rakic, P. S. (1988) Topography of cognition: Parallel distributed networks in primate association cortex. Annual Reviews of Neuroscience 11:137–56. [HE]CrossRefGoogle ScholarPubMed
Gray, J. A. (1982) Multiple book review of The neurobiology of anxiety: An enquiry into the functions of the septo-hippocampal system. Behavioral and Brain Sciences 5:469534. [FT]CrossRefGoogle Scholar
Hampson, R. E. & Deadwyler, S. A. (1994) Hippocampal representations of DMS/DNMS in the rat. Behavioral and Brain Sciences 17:480–82. [MC]Google Scholar
Hirsh, R. (1974) The hippocampus and contextual retrieval of information from memory: A theory. Behavioural Biology 12:421–44. [FT]CrossRefGoogle ScholarPubMed
Jarrard, L. E. (1993) Review: On the role sof the hippocampus in learning and memory in the nit. Behavioral ami Neural Biology 60:926. [HE]CrossRefGoogle Scholar
Jung, M. W., Wiener, S. I. & McNaughton, B. L. (1994) Comparison of spatial firing characteristics of units in dorsal and ventral hippocampus of the rat. Journal of Neuroscience 14:7347–56. [MC]CrossRefGoogle ScholarPubMed
Lipp, H. P., Schwegler, H., Crusio, W. E., Wolfer, D., Leisinger-Trigona, M.-C., Heiinrich, B. & Driscoll, P. (1989) Using genetically-defined rodent strains for the identification of hippocampal traits relevant for two-way avoidance learning: A non-invasive approach. Experientia 45:845–59. [WEC]CrossRefGoogle ScholarPubMed
McDonald, R. J. & White, N. M. (1995) Information acquired by the hippocampus interferes with acquisition of the amygdala-based conditonedcue preference in the rat. Hippocampus 5:189–97. [HE]CrossRefGoogle ScholarPubMed
McNaughton, N. (1994) The hippocampus: Relational processor or antiprocessor? Behavioral and Brain Sciences 17:487–88. [FT]Google Scholar
Meunier, M., Bachevalier, J., Mishkin, M. & Murray, E. A. (1993) Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys. Journal of Neuroscience 13:5418–32. [DGM]CrossRefGoogle ScholarPubMed
Morris, M., Camid, P., Rawlins, J. N. P. & O'Keefe, J. (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297:681–83. [DCM]CrossRefGoogle ScholarPubMed
Moscovitch, M. (1989) Confabulation and the frontal system: Strategic vs. associative retrieval in neuropsychological theories of memory. In: Varieties of memory and consciousness: Essays in honor of Endel Tulving, ed. Roediger, H. L. III & Crail, F. I. M.. Erlbaum. [MM]Google Scholar
Moscovitch, M. (1992a) Memory and working-with-inemory: A component process model based on modules and central systems. Journal of Cognitive Neuroscience 4:257–67. [MM]CrossRefGoogle ScholarPubMed
Moscovitch, M. (1992b) A neuropsychological model of memory and consciousness. In: The neuropsychology of memory, 2d ed., ed. Squire, L. R. & Butters, N.. Guilford Press. [MM]Google Scholar
Moscovitch, M. (1994a) Models of conscousness and memory. In: The cognitive neurosdences, ed. Gazzaniga, M. S.. MIT/Bradford Press. [MM]Google Scholar
Moscovitch, M. (1994b) Memory and working-with-memory: Evaluation of a component process model and comparisons with other models. In: Menumj systems 1994, ed. Schacter, D. & Tulving, E.. MIT/Bradford Press. [MM]Google Scholar
Moscovitch, M. (1995) Recovered conciousness: A hypothesis concerning modularity and episodic memory. Journal ofClincal and Experimental Neuropsychology 17:276–90. [MM]CrossRefGoogle Scholar
Moscovitch, M., Goshen-Gottstein, Y. & Vriezen, E. (1994) Memory without conscious recollection: A tutorial review from a neuropsychological perspective. In: Attention and performance: 15. Conscious and nonconscious information processing, ed.Umiltà, C. & Moscovitch, . MIT/Bradford Press. [MM]Google Scholar
Moscovitch, M. & Umiltà, C. (1990) Modularity and neuropsychology: Implications for the organization of attention and memdory in normal and hrain-damaged people. In: Modular processes in dementia, ed. Schwartz, M. E.. MIT Bradford Press. [MM]Google Scholar
Moscovitch, M. & Umiltà, C. (1991) Conscious and nonconscious aspects of memory: A neuropsychological framework of modules and central systems. In: Perspectives on cognitive neuroscience, ed. Lister, R. G. & Weingartner, H. J.. Oxford University Press. [MM]Google Scholar
Moscovitch, M., Vriezen, E. & Goshen-Gottstein, Y. (1993) Implicit tests of memory in patients with focal lesions and degenerative brain disorders. In: Handbook of neuropsychology, vol. 8, ed. Spinnler, H. & Boiler, F.. Elsevier. [MM]Google Scholar
Moser, E., Moser, M. B. & Andersen, P. (1993) Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. Journal of Neuroscience 13:3916–25. [MC]CrossRefGoogle ScholarPubMed
Mumby, D. C. & Pinel, J. P. J. (1994) Rhinal cortex lesions and object recognition in rats. Behavioral Neuroscience 108:1118. [DGM]CrossRefGoogle ScholarPubMed
Mumby, D. C., Wood, E. R. & Pinel, J. P. J. (1992) Object recognition memory in rats is only mildly impaired by lesions of the hippocampus and amygdala. Psychobiology 20:1827. [DGM]Google Scholar
Nachson, I. (1995) On the modularity of face recognition: The riddle of domain specificity. Journal of Clinical and Experimental Neuropsychology 17:256–75. [MM]CrossRefGoogle ScholarPubMed
Nadel, L. (1991) The hippocampus and space revisited. Hippocampus 1:221–29. [WEC]CrossRefGoogle ScholarPubMed
Nadel, L. (1994) Hippocampus, space, and relations. Behavioral and Brain Sciences 17:490–91. [WEC]Google Scholar
O'Boyle, V. J., Murray, E. A. & Mishkin, M. (1993) Effects of excitotoxic amygdalo-hippocampal lesions on visual recognition in rhesus monkeys. Society for Neuroscience Abstracts 19:438. [DGM]Google Scholar
O'Keefe, J. (1985) Is consciousness the gateway to the hippocampal cognitive map? A speculative essay on the neural basis of mind. In: Brain and mind, ed. Oakley, . Methuen. [MM]Google Scholar
O'Keefe, J. & Nadel, L. (1978) The hippocampus as a cognitive map. Clarendon. [MM]Google Scholar
O'Keefe, J. (1979) Précis of O'Keefe and Nadel's The hippocampus as a cognitive map. Behavioral and Brain Sciences 2:487533. [WEC, FT]CrossRefGoogle Scholar
Olton, D. S., Becker, J. T. & Handelmann, G. E. (1979) Hippocampus, space and memory. Behavioral and Brain Sciences 2:313–65. [WEC, FT]CrossRefGoogle Scholar
Ono, T., Ramura, R. & Nakamura, K. (1991) The hippocampus and space: Are there “place neurons” in the monkey hippocampus? Hippocampus 1:253–57. [HE]CrossRefGoogle ScholarPubMed
Phillips, R. & LeDoux, J. E. (1995) Lesions of the fornix but not the entorhinal or perirhinal cortex interfere with contextual conditioning. Journal of Neuroscience 15:5308–15. [HE]CrossRefGoogle Scholar
Rawlins, J. N. P. (1985) Associations across time: The hippocampus as a temporary memory store. Behavioral and Brain Sciences 8:479–96. [FT]CrossRefGoogle Scholar
Riches, I. P., Wilson, F. A. W. & Brown, M. W. (1991) The effects of visual stimulation and memory on neurons of the hippocampal formation and the neighboring parahippocampal gynis and inferior temporal cortex of the primate. Journal of Neuroscience 11:1763–79. [MC]CrossRefGoogle ScholarPubMed
Roediger, H. L. III & McDermott, K. B. (1993) Implicit memory in normal human subjects. In: Handbook of neuropsychology, ed. Boller, F. & Grafman, J.. Elsevier. [MM]Google Scholar
Rolls, E. T. (1991) Functions of the primate hippocampus in spatial and nonspatial memory. Hippocampus 1:258–61. [HE]CrossRefGoogle ScholarPubMed
Rothblat, L. A. & Kramer, L. F. (1991) Object recognition memory in the rat: The role of the hippocampus. Behavioral Brain Research 42:2532. [DGM]CrossRefGoogle ScholarPubMed
Rozin, P. (1976) The evaluation of intelligence and access to the cognitive unconscious. In: Progress in psychobiology and physiological psychology, ed. Sprague, J. & Epstein, A.. Academic Press. [MM]Google Scholar
Salzmann, E., Vidyasagar, T. R. & Creuzfeldt, O. D. (1993) Functional comparison of neuronal properties in the primate posterior hippocampus and parahippocampus (area TF/TH) during different behavioral paradigms involving memory and selective attention. Behavioral Brain Research 53:133–49. [MC]CrossRefGoogle Scholar
Schacter, D. (1989) Priming and multiple memory systems. In: Varieties of memories and consciousness: Essays in honor of Endel Tulving, ed. Roediger, H. L. III & Craik, F. I. M.. Erlbaum. [MM]Google Scholar
Schacter, D. L., McAndrews, M. P. & Moscovitch, M. (1988) Access to conciousness: Dissociations between implicit and explicit knowledge in neuropsycholgocial systems. In: Thimght without language, ed. Weiskrantz, L.. Oxford University Press. [MM]Google Scholar
Schoenbaum, G. & Eichenbaum, H. (1994) Information coding in the rodent prefrontal cortex: I. Single neuron activity in the orbitofrontal cortex compared with that in the periform cortex. Journal of Neurophysiology 74:733–50. [HE]CrossRefGoogle Scholar
Shettleworth, S. J. (1993) Varieties of learning and memory in animals. Journal of Experimental Psychology: Animal Behavior Processes 19:514. [WEC]Google ScholarPubMed
Squire, (1994) Commentary on Eichenbaum et al.'s “Two functional components of the hippocampal memory system.” Behavioral and Brain Sciences 17. [DGM]Google Scholar
Stuss, D. (1991) Self, awareness, and the frontal lobe: A neuropsychological perspective. In: The self: Interdisciplinary approaches, ed. Strauss, J. & Goethals, G. R.. Springer-Verlag. [MM]CrossRefGoogle Scholar
Sutherland, R. J., Whishaw, I. Q. & Kolb, B. (1983) A behavioral analysis of spatial localization following electrolytic, kainate- or colchicine-induced damage to the hippocampal formation in the rat. Behavioral Brain Research 7:133–53. [DGM]CrossRefGoogle ScholarPubMed
Suzuki, W. A. & Amaral, D. G. (1994a) Perirhinal and parahippocampal cortices of the macaque monkey: Cortical afferents. Journal of Comparative Neurology 350:497533. [MC]CrossRefGoogle ScholarPubMed
Suzuki, W. A. & Amaral, D. G. (1994b) Topographic organization of the reciprocal connections between the monkey entorhinal cortex and the perirhinal and parahippocampal cortices. Journal of Neurosdence 14:1856–77. [MC]Google ScholarPubMed
Toates, F. (1994a) Hierarchies of control: Changing weightings of levels. In: Perceptual control theory, ed. Rodrigues, M. A. & Lee, M. H.. University of Wales, Aberystwyth. [FT]Google Scholar
Toates, F. (1994b) What is cognitive and what is not cognitive? In: From animals to animats 3, ed. Cliff, D., Husbands, P., Meyer, J. A. & Wilson, W. W.. MIT Press. [FT]Google Scholar
Toates, F. (1996) Cognition and evolution: An organization of action perspective. Beliavimiral Processes 35:239–50. [FT]CrossRefGoogle Scholar
Tulving, E. & Markowitsch, H. J. (1994) What do animal models of memory model? Behavioral and Brain Sciences 17: 498–99. [MM]Google Scholar
van Daal, J. H. H. M., Jenks, B. G., Crusio, W. E., Lemmens, W. A. J. G. & van Abeelen, J. H. F. (1991) A genetic-correlational study of hippocampal neurochemical variation and variation in exploratory activities of mice. Behavioral Brain Research 43:6572. [WEC]CrossRefGoogle Scholar
Vidyasagar, T. R., Salzmann, E. & Creutzfeldt, O. D. (1991) Unit activity in the hippocampus and the parahippocampal temporobasal association cortex related to memory and complex behaviour in the awake monkey. Brain Research 544:269–78. [MC]CrossRefGoogle ScholarPubMed
Watanabe, T. & Niki, H. (1985) Hippocampal unit activity and delayed response in the monkey. Brain Research 325:241–54. [MC]CrossRefGoogle ScholarPubMed
Weiskrantz, L. (1986) Blindsight: A case study and implications. Oxford University Press. [MM]Google Scholar
Weiskrantz, L. (1988) Some contributions of neuropsychology of vision and memory to the problems of consciousness. In: Consciousness in contemporary science, ed. Marcel, A. J. & Bisiach, E.. Clarendon Press. [MM]Google Scholar
Wiig, K. A. & Bilkey, D. K. (1994a) Subtotal perirhinal cortex lesions increase exploratory behavior in the rat without producing deficits in the Morris water maze. Psychobiology 22:195202. [DGM]Google Scholar
Wiig, K. A. & Bilkey, D. K. (1994b) The effects of perirhinal cortical lesions on spatial reference memory in the rat. Behavioral Brain Research 63:101–9. [DGM]CrossRefGoogle ScholarPubMed
Wilson, F. A. W., Riches, I. P. & Brown, M. W. (1990) Hippocampus and medial temporal cortex: Neuronal activity related to behavioral responses during the performance of memory task by primates. Behavioral Brain Research 40:728. [MC]CrossRefGoogle ScholarPubMed
Witter, M. P. (1993) Organization of the entorhinal-hippocampal system: A review of current anatomical data. Hippocampus 3:3344. [MC]Google ScholarPubMed
Young, A. W. (1994) Conscious and nonconscious recognition of familiar faces. In: Attention and performance 15: Conscious and nonconscious information processing, ed. Umilta, C. & Moscovitch, M.. MIT/Bradford Press.Google Scholar
Young, B. J., Otto, T., Fox, G. D. & Eichenbaum, H. (1995) Neuronal activity in the parahippocampal region of rats performing a delayed non-match to sample task. Society for Neuroscience Abstracts 21:943. [HE]Google Scholar
Zola-Morgan, S. & Squire, L. R. (1993) Neuroanatomy of memory. Annual Review of Neuroscience 16:547563. [MC]CrossRefGoogle Scholar
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