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Immunobiology of neural transplants and functional incorporation of grafted dopamine neurons

Published online by Cambridge University Press:  04 February 2010

Jeffrey B. Blount ,
Takeshi Kondoh ,
Lisa L. Pundt ,
John Conrad ,
Elizabeth M. Jansen  and
Walter C. Low
Jeffrey B. Blount
Affiliation:
Departments of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455.
Takeshi Kondoh
Affiliation:
Departments of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455.
Lisa L. Pundt
Affiliation:
Departments of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455.
John Conrad
Affiliation:
Departments of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455.
Elizabeth M. Jansen
Affiliation:
Departments of Program in Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455. lowwalt@maroon.tc.umn.edu
Walter C. Low*
Affiliation:
Departments of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455. Departments of Physiology, University of Minnesota Medical School, Minneapolis, MN 55455. Departments of Program in Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455. lowwalt@maroon.tc.umn.edu
*
Address for correspondence: Walter C. Low, Dept. of Neurosurgery, University of Minnesota Medical School, 2001 Sixth Street, S.E., Minneapolis, MN 55455
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Abstract

In contrast to the views put forth by Stein & Glasier, we support the use of inbred strains of rodents in studies of the immunobiology of neural transplants. Inbred strains demonstrate homology of the major histocompatibility complex (MHC). Virtually all experimental work in transplantation immunology is performed using inbred strains, yet very few published studies of immune rejection in intracerebral grafts have used inbred animals.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 18 , Issue 1: An International Journal of Current Research and Theory with Open Peer Commentary , March 1995 , pp. 48 - 49
Copyright
Copyright © Cambridge University Press 1995

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