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Pains, brains, and opium

Published online by Cambridge University Press:  01 September 1997

Anthony H. Dickenson
Department of Pharmacology, University College London, London WC1E 6BT,


In this response, I discuss the roles of the peripheral afferent drive in the maintenance of persistent pain, the concept of pre-emptive analgesia and the importance of the brain, the detailed involvement of which in pain is far less well understood compared to the events in the spinal cord. A comparison of pain to other sensory modalities is then made together with a discussion of learning and pain. These facets of pain are discussed in the light of treatment strategies for this condition.

Author's Response
© 1997 Cambridge University Press

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