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Drugs as instruments: A new framework for non-addictive psychoactive drug use

  • Christian P. Müller (a1) (a2) and Gunter Schumann (a1)

Most people who are regular consumers of psychoactive drugs are not drug addicts, nor will they ever become addicts. In neurobiological theories, non-addictive drug consumption is acknowledged only as a “necessary” prerequisite for addiction, but not as a stable and widespread behavior in its own right. This target article proposes a new neurobiological framework theory for non-addictive psychoactive drug consumption, introducing the concept of “drug instrumentalization.” Psychoactive drugs are consumed for their effects on mental states. Humans are able to learn that mental states can be changed on purpose by drugs, in order to facilitate other, non-drug-related behaviors. We discuss specific “instrumentalization goals” and outline neurobiological mechanisms of how major classes of psychoactive drugs change mental states and serve non-drug-related behaviors. We argue that drug instrumentalization behavior may provide a functional adaptation to modern environments based on a historical selection for learning mechanisms that allow the dynamic modification of consummatory behavior. It is assumed that in order to effectively instrumentalize psychoactive drugs, the establishment of and retrieval from a drug memory is required. Here, we propose a new classification of different drug memory subtypes and discuss how they interact during drug instrumentalization learning and retrieval. Understanding the everyday utility and the learning mechanisms of non-addictive psychotropic drug use may help to prevent abuse and the transition to drug addiction in the future.

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AdellA., BortolozziA., Diaz-MataixL., SantanaN., CeladaP. & ArtigasF. (2010) Serotonin interaction with other neurotransmitter systems. In: Handbook of the behavioral neurobiology of serotonin, ed. MüllerC. P. & JacobsB. L., pp. 259–76. Academic Press.
AghajanianG. K. & MarekG. J. (1997) Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology 36:589–99.
AlexanderB. K. (1987) The disease and adaptive models of addiction: A framework analysis. Journal of Drug Issues 17:4766.
AlexanderB. K. (1990) The empirical and theoretical bases for an adaptive model of addiction. Journal of Drug Issues 20:2937.
AllisonC. & PrattJ. A. (2003) Neuroadaptive processes in GABAergic and glutamatergic systems in benzodiazepine dependence. Pharmacology and Therapeutics 98:171–95.
AlvergneA., JokelaM. & LummaaV. (2010) Personality and reproductive success in a high-fertility human population. Proceedings of the National Academy of Sciences USA 107(26):11745–50.
AmendtG. (2003) No drugs no future. Europa Verlag.
AmeriA. (1999) The effects of cannabinoids on the brain. Progress in Neurobiology 58:315–48.
American Psychiatric Association (1994) Diagnostic statistical manual of mental disorders, 4th ed. (DSM-IV). American Psychiatric Press Inc.
AndersG. (1956) Die Antiquiertheit des Menschen, Band 1: Über die Seele im Zeitalter der zweiten industriellen Revolution [The obsolescence of human beings, volume 1: The soul in the age of the second industrial revolution]. C. H. Beck.
AndersonP. & BaumbergB. (2006) Alcohol in Europe. Institute of Alcohol Studies.
AndreassonS., AllebeckP., EngstromA. & RydbergU. (1987) Cannabis and schizophrenia. A longitudinal study of Swedish conscripts. Lancet 2(8574):1483–86.
AndreassonS., AllebeckP. & RydbergU. (1989) Schizophrenia in users and nonusers of cannabis. A longitudinal study in Stockholm County. Acta Psychiatrica Scandinavia 79(5):505–10.
ArriaA. M. & WishE. D. (2006) Nonmedical use of prescription stimulants among students. Pediatric Annals 35:565–71.
ArroyoM., MarkouA., RobbinsT. W. & EverittB. J. (1998) Acquisition, maintenance and reinstatement of intravenous cocaine self-administration under a second-order schedule of reinforcement in rats: Effects of conditioned cues and continuous access to cocaine. Psychopharmacology 140(3):331–44.
Aston-JonesG., RajkowskiJ. & CohenJ. (1999) Role of locus coeruleus in attention and behavioral flexibility. Biological Psychiatry 46:1309–20.
AxelrodR. & HamiltonW. D. (1981) The evolution of cooperation. Science 211(4489):1390–96.
BanduraA. (1977) Self-efficacy: Toward a unifying theory of behavioral change. Psychological Review 84(2):191215.
BardoM. T. (1998) Neuropharmacological mechanisms of drug reward: Beyond dopamine in the nucleus accumbens. Critical Reviews in Neurobiology 12:3767.
BardoM. T. & BevinsR. A. (2000) Conditioned place preference: What does it add to our preclinical understanding of drug reward? Psychopharmacology (Berlin) 153(1):3143.
Baum-BaickerC. (1985) The psychological benefits of moderate alcohol consumption: A review of the literature. Drug and Alcohol Dependence 15:305–22.
BelinD. & EverittB. J. (2008) Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. Neuron 57(3):432–41.
BerridgeK. C. (1996) Food reward: Brain substrates of wanting and liking. Neuroscience and Biobehavioral Reviews 20:125.
BerridgeK. C. & RobinsonT. E. (2003) Parsing reward. Trends in Neurosciences 26:507–13.
BierutL. J., DinwiddieS. H., BegleiterH., CroweR. R., HesselbrockV., NurnbergerJ. I.Jr., PorjeszB., SchuckitM. A. & ReichT. (1998) Familial transmission of substance dependence: Alcohol, marihuana, cocaine, and habitual smoking: A report from the Collaborative Study on the Genetics of Alcoholism. Archives of General Psychiatry 55:982–88.
BloklandA. (1995) Acetylcholine: A neurotransmitter for learning and memory? Brain Research Reviews 21:285300.
BlomeyerD., TreutleinJ., EsserG., SchmidtM. H., SchumannG. & LauchtM. (2008) Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use. Biological Psychiatry 63(2):146–51.
BoeningJ. A. (2001) Neurobiology of an addiction memory. Journal of Neural Transmission 108 (6):755–65.
Bonn-MillerM. O., ZvolenskyM. J. & BernsteinA. (2007) Marihuana use motives: Concurrent relations to frequency of past 30-day use and anxiety sensitivity among young adult marihuana smokers. Addictive Behavior 32:4962.
BoothC. & HaskingP. (2009) Social anxiety and alcohol consumption: The role of alcohol expectancies and reward sensitivity. Addictive Behaviors 34(9):730–36.
BorsiniF., BendottiC., CarliM., PoggesiE. & SamaninR. (1979) The roles of brain noradrenaline and dopamine in the anorectic activity of diethylpropion in rats: A comparison with d-amphetamine. Research Communications in Chemical Pathology and Pharmacology 26:311.
BoutonM. E. & MoodyE. W. (2004) Memory processes in classical conditioning. Neuroscience & Biobehavioral Reviews 28(7):663–74.
BoydC. J., McCabeS. E., CranfordJ. A. & YoungA. (2006) Adolescents' motivations to abuse prescription medications. Pediatrics 118(6):2472–80.
BoydC. J., TeterC. J., WestB. T., MoralesM. & McCabeS. E. (2009) Non-medical use of prescription analgesics: A three-year national longitudinal study. Journal of Addictive Diseases 28:232–42.
BoysA. & MarsdenJ. (2003) Perceived functions predict intensity of use and problems in young polysubstance users. Addiction 98(7):951–63.
BoysA., MarsdenJ., GriffithsP., FountainJ., StillwellG. & StrangJ. (1999) Substance use among young people: The relationship between perceived functions and intentions. Addiction 94(7):1043–50.
BoysA., MarsdenJ. & StrangJ. (2001) Understanding reasons for drug use amongst young people: A functional perspective. Health Education Research 16:457–69.
BradizzaC. M., ReifmanA. & BarnesG. M. (1999) Social and coping reasons for drinking: Predicting alcohol misuse in adolescents. Journal of Studies on Alcohol 60:491–99.
BrischouxF., ChakrabortyS., BrierleyD. I. & UnglessM. A. (2009) Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli. Proceedings of the National Academy of Sciences USA 106:4894–99.
BrittG. C. & McCance-KatzE. F. (2005) A brief overview of the clinical pharmacology of “club drugs.” Substance Use and Misuse 40:1189–201.
BronfenbrennerU. (1994) Ecological models of human development. In: International encyclopedia of education, pp. 1643–47. Elsevier Sciences.
BrowerK. J. (2002) Anabolic steroid abuse and dependence. Current Psychiatry Reports 4:377–87.
BrownJ. H. & KreftI. G. (1998) Zero effects of drug prevention programs: Issues and solutions. Evaluation Review 22:314.
BrownS. A. (1985) Expectancies versus background in the prediction of college drinking patterns. Journal of Consulting and Clinical Psychology 53:123–30.
BrownS. A., GoldmanM. S., InnA. & AndersonL. R. (1980) Expectations of reinforcement from alcohol: Their domain and relation to drinking patterns. Journal of Consulting and Clinical Psychology 48:419–26.
BruehlA. M., LendeD. H., SchwartzM., SterkC. E. & ElifsonK. (2006) Craving and control: Methamphetamine users' narratives. Journal of Psychoactive Drugs (Suppl. 3):385–92.
BurnettS., SebastianC., CohenK. K. & BlakemoreS. J. (2010) The social brain in adolescence: Evidence from functional magnetic resonance imaging and behavioural studies. Neuroscience & Biobehavioural Reviews. DOI: 10.1016/j.neubiorev.2010.10.011.
CampbellJ. C., SzumlinskiK. K. & KippinT. E. (2009) Contribution of early environmental stress to alcoholism vulnerability. Alcohol 43(7):547–54.
CareyR. J., DePalmaG., DamianopoulosE., HopkinsA., ShanahanA., MüllerC. P. & HustonJ. P. (2004) Dopaminergic and serotonergic autoreceptor stimulation effects are equivalent and additive in the suppression of spontaneous and cocaine induced locomotor activity. Brain Research 1019:134–43.
CareyR. J., HustonJ. P. & MüllerC. P. (2008) Pharmacological inhibition of dopamine and serotonin activity blocks spontaneous and cocaine-activated behaviour. Progress in Brain Research 172:347–60.
CarrG. V. & LuckiI. (2010) The role of serotonin in depression. In: Handbook of the behavioral neurobiology of serotonin, ed. MüllerC. P. & JacobsB. L., pp. 493506. Academic Press.
CarriganM. H., HamL. S., ThomasS. E. & RandallC. L. (2008) Alcohol outcome expectancies and drinking to cope with social situations. Addictive Behaviors 33(9):1162–66.
CastrenE. (2005) Is mood chemistry? Nature Reviews Neuroscience 6:241–46.
CatoB. M. (1992) Youth's recreation and drug sensations: Is there a relationship? Journal of Drug Education 22:293301.
CauliO. & MorelliM. (2005) Caffeine and the dopaminergic system. Behavioral Pharmacology 16:6377.
CharlsonF., DegenhardtL., McLarenJ., HallW. & LynskeyM. (2009) A systematic review of research examining benzodiazepine-related mortality. Pharmacoepidemiology and Drug Safety 18(2):93103.
ChenC. Y. & AnthonyJ. C. (2004) Epidemiological estimates of risk in the process of becoming dependent upon cocaine: Cocaine hydrochloride powder versus crack cocaine. Psychopharmacology (Berlin) 172:7886.
ChickJ. (1999) Can light or moderate drinking benefit mental health? European Addiction Research 5:7481.
ChildsE. & de WitH. (2009) Amphetamine-induced place preference in humans. Biological Psychiatry 65(10):900904.
ChisholmJ. S. (1993) Life-history theory and the development of reproductive strategies. Current Anthropology 34(1):124.
ChisholmJ. S. (1999) Death, hope, and sex: Steps to an evolutionary ecology of mind and mortality, Cambridge University Press.
ClarkeT. K. & SchumannG. (2009) Gene-environment interactions resulting in risk alcohol drinking behaviour are mediated by CRF and CRF1. Pharmacology Biochemistry & Behavior 93(3):230–36.
ClaytonD. H. & WolfeN. D. (1993) The adaptive significance of self-medication. Trends in Ecology & Evolution 8(2):6063.
ConrodP. J., PihlR. O., StewartS. H. & DongierM. (2000) Validation of a system of classifying female substance abusers on the basis of personality and motivational risk factors for substance abuse. Psychology of Addictive Behaviors 14:243–56.
ConrodP. J., StewartS. H., ComeauN. & MacleanA. M. (2006) Efficacy of cognitive-behavioral interventions targeting personality risk factors for youth alcohol misuse. Journal of Clinical Child and Adolescent Psychology 35:550–63.
CooperM. L. (2006) Does drinking promote risky sexual behaviour? A complex answer to a simple question. Current Directions in Psychological Science 15(1):1923.
CooperM. L., FroneM. R., RussellM. & MudarP. (1995) Drinking to regulate positive and negative emotions: A motivational model of alcohol use. Journal of Personal and Social Psychology 69:9901005.
CooperM. L., RussellM. & GeorgeW. H. (1988) Coping, expectancies, and alcohol abuse: A test of social learning formulations. Journal of Abnormal Psychology 97:218–30.
CooperM. L., RussellM., SkinnerJ. B., FroneM. R. & MudarP. (1992) Stress and alcohol use: Moderating effects of gender, coping, and alcohol expectancies. Journal of Abnormal Psychology 101:139–52.
CosmidesL. & ToobyJ. (1994) Origins of domain specificity: The evolution of functional organization. In Mapping the mind: Domain specificity in cognition and culture, ed. HirschfeldL. & GelmanS., pp. 85116. Cambridge University Press.
CosmidesL. & ToobyJ. (1999) Toward an evolutionary taxonomy of treatable conditions. Journal of Abnormal Psychology 108(3):453–64.
CrawfordC. (2000) Evolutionary psychology: Counting babies or studying information-processing mechanisms. Annals of the New York Academy of Sciences 97:2138.
CroweL. C. & GeorgeW. H. (1989) Alcohol and human sexuality: Review and integration. Psychological Bulletin 105(3):374–86.
CurranH. V. (1991) Benzodiazepines, memory and mood: A review. Psychopharmacology (Berlin) 105:18.
DaveyJ., RichardsN. & FreemanJ. (2007) Fatigue and beyond: Patterns of and motivations for illicit drug use among long-haul truck drivers. Traffic Injury Prevention 8:253–59.
DaviesJ. B. (1997) The myth of addiction, 2nd edition. Routledge.
De las CuevasC., SanzE. & De la FuenteJ. (2003) Benzodiazepines: More “behavioural” addiction than dependence. Psychopharmacology (Berlin) 167:297303.
de WitH. & StewartJ. (1981) Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology 75(2):134–43.
DeckerM. W., BrioniJ. D., BannonA. W. & ArnericS. P. (1995) Diversity of neuronal nicotinic acetylcholine receptors: Lessons from behavior and implications for CNS therapeutics. Life Sciences 56:545–70.
Del BocaF. K., DarkesJ., GoldmanM. S. & SmithG. T. (2002) Advancing the expectancy concept via the interplay between theory and research. Alcoholism, Clinical and Experimental Research 26(6):926–35.
DereE., EastonA., NadelL. & HustonJ. P. (2008) Handbook of episodic memory. Elsevier.
DevineniA. V. & HeberleinU. (2009) Preferential ethanol consumption in Drosophila models features of addiction. Current Biology 19(24):2126–32.
Di ChiaraG. (1995) The role of dopamine in drug abuse viewed from the perspective of its role in motivation. Drug and Alcohol Dependence 38:95137.
Di ChiaraG. & ImperatoA. (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proceedings of the National Academy of Sciences USA 85:5274–78.
Di ChiaraG. & NorthR. A. (1992) Neurobiology of opiate abuse. Trends in Pharmacological Sciences 13:185–93.
DonovanJ. E. & RichardJ. (1985) Structure of problem behavior in adolescence and young adulthood. Journal of Consulting and Clinical Psychology 53(6):890904.
DudleyR. (2000) Evolutionary origins of human alcoholism in primate frugivory. The Quarterly Review of Biology 75(1):315.
DudleyR. (2002) Fermenting fruit and the historical ecology of ethanol ingestion: Is alcoholism in modern humans an evolutionary hangover? Addiction 97:381–88.
EissenbergT. & BalsterR. L. (2000) Initial tobacco use episodes in children and adolescents: Current knowledge, future directions. Drug and Alcohol Dependence 59(Suppl. 1):S4160.
EMCDDA (European Monitoring Centre for Addictive Drugs) (2009) State of the drug problem 2009.
EmleyG. S. & HutchinsonR. R. (1983) Unique influences of 10 drugs upon post-shock biting attack and preshock manual responding. Pharmacology Biochemistry and Behavior 19:512.
EverittB. J. & WolfM. E. (2002) Psychomotor stimulant addiction: A neural systems perspective. Journal of Neuroscience 22(9):3312–20.
FantegrossiW. E., WoolvertonW. L., KilbournM., ShermanP., YuanJ., HatzidimitriouG., RicaurteG. A., WoodsJ. H. & WingerG. (2004) Behavioral and neurochemical consequences of long-term intravenous self-administration of MDMA and its enantiomers by rhesus monkeys. Neuropsychopharmacology 29(7):1270–81.
FeenstraM. G. P., BotterblomM. H. A. & VanuumJ. F. M. (1995) Novelty-induced increase in dopamine release in the rat prefrontal cortex in-vivo – Inhibition by diazepam. Neuroscience Letters 189:8184.
FelderC. C. & GlassM. (1998) Cannabinoid receptors and their endogenous agonists. Annual Reviews of Pharmacology and Toxicology 38:179200.
FeldmanR. S., MeyerJ. S. & QuenzerL. F. (1997) Principles of Neuropsychopharmacology. Sinauer Associates.
FischmanM. W. & SchusterC. R. (1980) Cocaine effects in sleep-deprived humans. Psychopharmacology (Berlin) 72:18.
FischmanM. W. & SchusterC. R. (1982) Cocaine self-administration in humans. Federal Proceedings 41:241–46.
FoltinR. W. & HaneyM. (2000) Conditioned effects of environmental stimuli paired with smoked cocaine in humans. Psychopharmacology (Berlin) 149(1):2433.
FriedmanL. S., LichtensteinE. & BiglanA. (1985) Smoking onset among teens: An empirical analysis of initial situations. Addictive Behaviors 10:113.
FrolovA. G. & PavlovaO. G. (2003) Instrumentalization of movements evoked by stimulation of the motor cortex by food reinforcement in dogs. Neuroscience and Behavioral Physiology 33:203207.
GableR. S. (2004) Comparison of acute lethal toxicity of commonly abused psychoactive substances. Addiction 99:686–96.
GarattiniS., BorroniE., MenniniT. & SamaninR. (1978) Differences and similarities among anorectic agents. In: Central mechanisms of anorectic drugs, ed. GarattiniS. & SamaninR.. Raven Press.
GawinF. H. (1991) Cocaine addiction: Psychology and neurophysiology. Science 251:1580–86.
GawinF. H. & KleberH. D. (1986) Abstinence symptomatology and psychiatric diagnosis in cocaine abusers. Clinical observations. Archives of General Psychiatry 43:107–13.
GeyerM. A. & VollenweiderF. X. (2008) Serotonin research: Contributions to understanding psychoses. Trends in Pharmacological Sciences 29(9):445–53.
GlanderK. E. (1994) Nonhuman primate self-medication with wild plant foods. In: Eating on the wild side: The pharmacological, ecological, and social implications of using noncultigens, ed. EtkinN. L., pp. 239–56. University of Arizona Press.
GlynnR. J., LoCastroJ. S., HermosJ. A. & BosseR. (1983) Social contexts and motives for drinking in men. Journal of Studies on Alcohol 44:1011–25.
GoldbergS. R. (1975) Stimuli associated with drug injections as events that control behavior. Pharmacological Review 27(3):325–40.
GoldmanD., OrosziG. & DucciF. (2005) The genetics of addictions: Uncovering the genes. Nature Reviews Genetics 6:521–32.
GoldmanM. S., BrownS. A., ChristiansenB. A. & SmithG. T. (1991) Alcoholism and memory: Broadening the scope of alcohol-expectancy research. Psychological Bulletin 110(1):137–46.
GoldsteinP. J. (1990) Anabolic steroids: An ethnographic approach. NIDA Research Monographs 102:7496.
Gonzalez-MaesoJ. & SealfonS. C. (2009) Psychedelics and schizophrenia. Trends in Neurosciences 32:225–32.
Gouzoulis-MayfrankE. & DaumannJ. (2009) Neurotoxicity of drugs of abuse – The case of methylenedioxyamphetamines (MDMA, ecstasy), and amphetamines. Dialogues in Clinical Neurosciences 11(3):305–17.
GreenA. R., MechanA. O., ElliottJ. M., O'SheaE. & ColadoM. I. (2003) The pharmacology and clinical pharmacology of 3, 4-methylenedioxymethamphetamine (MDMA, “ecstasy”). Pharmacological Reviews 55:463508.
GriffithsR. R., LambR. J., SannerudC. A., AtorN. A. & BradyJ. V. (1991) Self-injection of barbiturates, benzodiazepines and other sedative-anxiolytics in baboons. Psychopharmacology 103:154–61.
GrinspoonL. & HedblomP. (2005) A historical overview of amphetamines. In: Amphetamines, ed. HarrisN., pp. 1930. Thomson Gale.
GustafsonR. (1991) Is the strength and the desirability of alcohol-related expectancies positively related? A test with an adult Swedish sample. Drug and Alcohol Dependence 28:145–50.
HaberS. N., FudgeJ. L. & McFarlandN. R. (2000) Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. The Journal of Neuroscience 20(6):2369–82.
HagenE. H., SullivanR. J., SchmidtR., MorrisG., KempterR. & HammersteinP. (2009) Ecology and neurobiology of toxin avoidance and the paradox of drug reward. Neuroscience 160(1):6984.
HahnB. & StolermanI. P. (2002) Nicotine-induced attentional enhancement in rats: Effects of chronic exposure to nicotine. Neuropsychopharmacology 27:712–22.
HahnB., ShoaibM. & StolermanI. P. (2002) Nicotine-induced enhancement of attention in the five-choice serial reaction time task: The influence of task demands. Psychopharmacology (Berlin) 162:129–37.
HalberstadtA. L. & NicholsD. E. (2010) Serotonin and serotonin receptors in hallucinogen action. In: Handbook of the behavioral neurobiology of serotonin, ed. MüllerC. P. & JacobsB. L., pp. 621–36. Academic Press.
HamiltonW. D. (1964) The genetical evolution of social behaviour. I. Journal of Theoretical Biology 7:116.
HaneyM., MaccariS., LeM. M., SimonH. & PiazzaP. V. (1995) Social stress increases the acquisition of cocaine self-administration in male and female rats. Brain Research 698:4652.
HardingW. & ZinbergN. E. (1977) The effectiveness of the subculture in developing rituals and social sanctions for controlled drug use. In Drugs, rituals and altered states of consciousness, ed. Du ToitB. M., pp. 111–33. A. A. Balkema.
HarperC. (2007) The neurotoxicity of alcohol. Human & Experimental Toxicology 26(3):251–57.
HarrisR. A., TrudellJ. R. & MihicS. J. (2008) Ethanol's molecular targets. Science Signaling 1(28):re7.
HarrisonA. A., GaspariniF. & MarkouA. (2002) Nicotine potentiation of brain stimulation reward reversed by DH beta E and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats. Psychopharmacology (Berlin) 160:5666.
HeathD. B. (2000) Drinking occasions: Comparative perspectives on alcohol and culture. Brunner/Mazel.
HeberleinA., BleichS., KornhuberJ. & HillemacherT. (2009) Benzodiazepine dependence: Causalities and treatment options. Fortschritte der Neurologie und Psychiatrie 77:715.
HeiligM. & KoobG. F. (2007) A key role for corticotropin-releasing factor in alcohol dependence. Trends in Neurosciences 30:399406.
HeymanG. M. (1996) Resolving the contradictions of addiction. Behavioral and Brain Sciences 19(4):561610.
HeyneA., MayT., GollP. & WolffgrammJ. (2000) Persisting consequences of drug intake: Towards a memory of addiction. Journal of Neural Transmission 107(6):613–38.
HigginsS. T., BickelW. K., HughesJ. R., LynnM., CapelessM. A. & FenwickJ. W. (1990) Effects of intranasal cocaine on human learning, performance and physiology. Psychopharmacology (Berlin) 102:451–58.
HillE. M. & ChowK. (2002) Life-history theory and risky drinking. Addiction 97(4):401–13.
HillE. M. & NewlinD. B. (2002) Evolutionary approaches to addiction: Introduction. Addiction 97(4):375–79.
HoY. J., PawlakC. R., GuoL., SchwartingR. K. (2004) Acute and long-term consequences of single MDMA administration in relation to individual anxiety levels in the rat. Behavioural Brain Research 149(2):135–44.
HollermanJ. R. & SchultzW. (1998) Dopamine neurons report an error in the temporal prediction of reward during learning. Nature Neuroscience 1:304309.
HongZ. Y., HuangZ. L., QuW. M., EguchiN., UradeY. & HayaishiO. (2005) An adenosine A(2A) receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats. Journal of Neurochemistry 92:1542–49.
HowellL. L. & ByrdL. D. (1995) Serotonergic modulation of the behavioral effects of cocaine in the squirrel monkey. The Journal of Pharmacology and Experimental Therapeutics 275(3):1551–59.
HuffmanM. A. (2003) Animal self-medication and ethno-medicine: Exploration and exploitation of the medicinal properties of plants. Proceedings of the Nutrition Society 62(2):371–81.
HughesJ. R., HatsukamiD. K., MitchellJ. E. & DahlgrenL. A. (1986) Prevalence of smoking among psychiatric outpatients. American Journal of Psychiatry 143:993–97.
HustonJ. P., HaasH. L., BoixF., PfisterM., DeckingU., SchraderJ. & SchwartingR. K. (1996) Extracellular adenosine levels in neostriatum and hippocampus during rest and activity periods of rats. Neuroscience 73:99107.
IkemotoS. & PankseppJ. (1999) The role of nucleus accumbens dopamine in motivated behavior: A unifying interpretation with special reference to reward-seeking. Brain Research Reviews 31:641.
ItoT., SuzukiT., WellmanS. E. & HoI. K. (1996) Pharmacology of barbiturate tolerance/dependence: GABAA receptors and molecular aspects. Life Sciences 59:169–95.
IversenL. L. (2000) The science of marijuana. Oxford University Press.
JacobsB. L. & FornalC. A. (2010) Activity of brain serotonergic neurons in relation to physiology and behavior. In: Handbook of the behavioral neurobiology of serotonin, ed. MüllerC. P. & JacobsB. L., pp. 153–62. Academic Press.
JacobsenL. K., SouthwickS. M. & KostenT. R. (2001) Substance use disorders in patients with posttraumatic stress disorder: A review of the literature. American Journal of Psychiatry 158:1184–90.
JavaidJ. I., FischmanM. W., SchusterC. R., DekirmenjianH. & DavisJ. M. (1978) Cocaine plasma concentration: Relation to physiological and subjective effects in humans. Science 202:227–28.
JentschJ. D. & RothR. H. (1999) The neuropsychopharmacology of phencyclidine: From NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 20:201–25.
JessorR. (1987) Problem-behavior theory, psychosocial development, and adolescent problem drinking. British Journal of Addiction 82(4):331–42.
JoY. H., TalmageD. A. & RoleL. W. (2002) Nicotinic receptor-mediated effects on appetite and food intake. Journal of Neurobiology 53:618–32.
JohansonC. E., BalsterR. L. & BoneseK. (1976) Self-administration of psychomotor stimulant drugs: The effects of unlimited access. Pharmacology Biochemistry and Behavior 4:4551.
JohansonC. E. & FischmanM. W. (1989) The pharmacology of cocaine related to its abuse. Pharmacological Reviews 41:352.
JohnsonC., BeatonR. & HallK. (1975) Poison-based avoidance learning in nonhuman primates: Use of visual cues. Physiology & Behavior 14(4):403407.
JohnstoneB. M., LeinoE. V., AgerC. R., FerrerH. & FillmoreK. M. (1996) Determinants of life-course variation in the frequency of alcohol consumption: Meta-analysis of studies from the collaborative alcohol-related longitudinal project. Journal of Studies on Alcohol 57(5):494506.
JonesR. T. (1971) Marihuana-induced “high”: Influence of expectation, setting and previous drug experience. Pharmacological Reviews 23:359–69.
KabbajM., NortonC. S., Kollack-WalkerS., WatsonS. J., RobinsonT. E. & AkilH. (2001) Social defeat alters the acquisition of cocaine self-administration in rats: Role of individual differences in cocaine-taking behavior. Psychopharmacology (Berlin) 158:382–87.
KalivasP. W., SorgB. A. & HooksM. S. (1993) The pharmacology and neural circuitry of sensitization to psychostimulants. Behavioural Pharmacology 4:315–34.
KalivasP. W. & VolkowN. D. (2005) The neural basis of addiction: A pathology of motivation and choice. American Journal of Psychiatry 162:1403–13.
KanayamaG., BrowerK. J., WoodR. I., HudsonJ. I. & PopeH. G.Jr. (2009) Anabolic–androgenic steroid dependence: An emerging disorder. Addiction 104:1966–78.
KandelE. R. (2001) The molecular biology of memory storage: A dialogue between genes and synapses. Science 294:1030–38.
KelleyA. E., CadorM. & StinusL. (1990) Exploration and its measurement. A psychopharmacological perspective. In: Neuromethods 13 – Psychopharmacology, ed. BoultonA. A., BakerG. B. & GreenshawA. J., pp. 95143. Humana Press.
KendlerK. S., JacobsonK. C., PrescottC. A. & NealeM. C. (2003b) Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. American Journal of Psychiatry 160:687–95.
KendlerK. S., PrescottC. A., MyersJ. & NealeM. C. (2003a) The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Archives of General Psychiatry 60:929–37.
KennyP. J. & MarkouA. (2006) Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity. Neuropsychopharmacology 31:1203–11.
KesterK. M. & BarbosaP. (1994) Behavioral responses to host food plants of two populations of the insect parasitoid Cotesia congregata (Say). Oecologia 99:151–57.
KhantzianE. J. (1985) The self-medication hypothesis of addictive disorders: Focus on heroin and cocaine dependence. American Journal of Psychiatry 142:1259–64.
KhantzianE. J. (1997) The self-medication hypothesis of substance use disorders: A reconsideration and recent applications. Harvard Review of Psychiatry 4:231–44.
KidorfM., ShermanM. F., JohnsonJ. G. & BigelowG. E. (1995) Alcohol expectancies and changes in beer consumption of first-year college students. Addictive Behaviors 20(2):225–31.
KingA. J., JohnsonD. D. & Van VugtM. (2009) The origins and evolution of leadership. Current Biology 19(19):R911–16.
KochakianC. D. (1990) History of anabolic–androgenic steroids. NIDA Research Monographs 102:2959.
KoobG. F. (1992) Drugs of abuse: Anatomy, pharmacology and function of reward pathways. Trends in Pharmacological Sciences 13:177–84.
KoobG. F. (1999) Stress, corticotropin-releasing factor, and drug addiction. Annals of the New York Academy of Sciences 897:2745.
KoobG. F. & Le MoalM. (1997) Drug abuse: Hedonic homeostatic dysregulation. Science 278:5258.
KoobG. F. & Le MoalM. (2008) Addiction and the brain antireward system. Annual Review of Psychology 59:2953.
KoobG. F., SannaP. P. & BloomF. E. (1998) Neuroscience of addiction. Neuron 21:467–76.
KramerJ. C., FischmanV. S. & LittlefieldD. C. (1967) Amphetamine abuse – Pattern and effects of high doses taken intravenously. Journal of the American Medical Association 201:8993.
KreekM. J., NielsenD. A., ButelmanE. R. & LaforgeK. S. (2005) Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature Neuroscience 8:1450–57.
KuntscheE., KnibbeR., GmelG. & EngelsR. (2005) Why do young people drink? A review of drinking motives. Clinical Psychology Review 25:841–61.
KuntscheE., KnibbeR., GmelG. & EngelsR. (2006) Who drinks and why? A review of socio-demographic, personality, and contextual issues behind the drinking motives in young people. Addictive Behavior 31:1844–57.
LaderM. (1994) Anxiolytic drugs: Dependence, addiction and abuse. European Neuropsychopharmacology 4:8591.
LalandK. N., Odling-SmeeJ. & FeldmanM. W. (2000) Niche construction, biological evolution, and cultural change. Behavioral and Brain Sciences 23(1):131–46.
LalandK. N., Odling-SmeeJ. & MylesS. (2010) How culture shaped the human genome: Bringing genetics and the human sciences together. Nature Reviews Genetics 11(2):137–48.
LavikainenH. M., LintonenT. & KosunenE. (2009) Sexual behavior and drinking style among teenagers: A population-based study in Finland. Health Promotion International 24(2):108–19.
Le FollB. & GoldbergS. R. (2006) Nicotine as a typical drug of abuse in experimental animals and humans. Psychopharmacology (Berlin) 184:367–81.
LeighB. C. (1989) In search of the Seven Dwarves: Issues of measurement and meaning in alcohol expectancy research. Psychological Bulletin 105(3):361–73.
LeighB. C. & StacyA. W. (2004) Alcohol expectancies and drinking in different age groups. Addiction 99(2):215–27.
LendeD. H. (2005) Wanting and drug use: A biocultural approach to the analysis of addiction. ETHOS 33(1):100–24.
LendeD. H. (2007) Evolution and modern behavioral problems. In: Evolutionary medicine and health: New perspectives, ed. Wenda TrevathanE. O., SmithE. O. & McKennaJ. J., pp. 277–90, Oxford University Press.
LendeD. H., LeonardT., SterkC. E. & ElifsonK. (2007) Functional methamphetamine use: The insider's perspective. Addiction Research and Therapy 15(5):465–77.
LendeD. H. & SmithE. O. (2002) Evolution meets biopsychosociality: An analysis of addictive behavior. Addiction 97(4):447–58.
LeonardK. E. & Das EidenR. (1999) Husband's and wife's drinking: Unilateral or bilateral influences among newlyweds in a general population sample. Journal of Studies on Alcohol Supplement 13:130–38.
LicataA., TaylorS., BermanM. & CranstonJ. (1993) Effects of cocaine on human aggression. Pharmacology Biochemistry and Behavior 45:549–52.
LiechtiM. E., SaurM. R., GammaA., HellD. & VollenweiderF. X. (2000) Psychological and physiological effects of MDMA (“Ecstasy”) after pretreatment with the 5-HT(2) antagonist ketanserin in healthy humans. Neuropsychopharmacology 23:396404.
LiptonR. I. (1994) The effect of moderate alcohol use on the relationship between stress and depression. American Journal of Public Health 84:1913–17.
LisonbeeL. D., VillalbaJ. J., ProvenzaF. D. & HallJ. O. (2009) Tannins and self-medication: Implications for sustainable parasite control in herbivores. Behavioural Processes 82(2):184–89.
LozanoG. A. (1998) Parasitic stress and self-medication in wild animals. Advances in the Study of Behavior 27:291317.
MaierH. W. (1926) Der Kokainismus. Georg Thieme.
MaisonneuveI. M., HoA. & KreekM. J. (1995) Chronic administration of a cocaine “binge” alters basal extracellular levels in male rats: An in vivo microdialysis study. Journal of Pharmacology and Experimental Therapeutics 272:652–57.
MaloffD., BeckerH. S., FonaroffA. & RodinJ. (1981) Informal social controls and their influence on substance use. In: Control over intoxicant use: Pharmacological, psychological and social considerations, ed. ZinbergN. E. & HardingW., pp. 535. Human Science Press.
MansvelderH. D., van AerdeK. I., CoueyJ. J. & BrussaardA. B. (2006) Nicotinic modulation of neuronal networks: From receptors to cognition. Psychopharmacology (Berlin) 184:292305.
MarcuseL. (1984) Philosophie des Glücks. Diogenes.
MarkouA. (2008) Neurobiology of nicotine dependence. Philosophical Transactions of the Royal Society London B Biological Sciences 363:3159–68.
MarkouA., KostenT. R. & KoobG. F. (1998) Neurobiological similarities in depression and drug dependence: A self-medication hypothesis. Neuropsychopharmacology 18:135–74.
MarlattG. A. & GeorgeW. H. (1984) Relapse prevention: Introduction and overview of the model. British Journal of Addiction 79(3):261–73.
MarsicanoG., WotjakC. T., AzadS. C., BisognoT., RammesG., CascioM. G., HermannH., TangJ., HofmannC., ZieglgansbergerW., Di MarzoV. & LutzB. (2002) The endogenous cannabinoid system controls extinction of aversive memories. Nature 418:530–34.
MartelP. & FantinoM. (1996) Mesolimbic dopaminergic system activity as a function of food reward: A microdialysis study. Pharmacology Biochemistry and Behavior 53:221–26.
MatsumotoM. & HikosakaO. (2009) Two types of dopamine neuron distinctly convey positive and negative motivational signals. Nature 459:837–41.
MatthewsT. J., AbdelbakyP. & PfaffD. W. (2005) Social and sexual motivation in the mouse. Behavioral Neuroscience 119(6):1628–39.
McBrideW. J., LeA. D. & NoronhaA. (2002) Central nervous system mechanisms in alcohol relapse. Alcohol Clinical and Experimental Research 26:280–86.
McBrideW. J., MurphyJ. M. & IkemotoS. (1999) Localization of brain reinforcement mechanisms: Intracranial self-administration and intracranial place-conditioning studies. Behavioural Brain Research 101:129–52.
McCabeS. E., CranfordJ. A., BoydC. J. & TeterC. J. (2007b) Motives, diversion and routes of administration associated with nonmedical use of prescription opioids. Addictive Behavior 32:562–75.
McCabeS. E., KnightJ. R., TeterC. J. & WechslerH. (2005) Non-medical use of prescription stimulants among US college students: Prevalence and correlates from a national survey. Addiction 100:96106.
McCabeS. E., WestB. T. & WechslerH. (2007a) Alcohol-use disorders and nonmedical use of prescription drugs among U.S. college students. Journal of Studies on Alcohol and Drugs 68:543–7.
McGaughJ. L. (2000) Memory – A century of consolidation. Science 287:248–51.
McLellanA. T., WoodyG. E. & O'BrienC. P. (1979) Development of psychiatric illness in drug abusers: Possible role of drug preference. New England Journal of Medicine 301(24):1310–14.
McMahonL. R., FilipM. & CunninghamK. A. (2001) Differential regulation of the mesoaccumbens circuit by serotonin 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. Journal of Neuroscience 21:7781–87.
MechoulamR., FrideE. & Di MarzoV. (1998) Endocannabinoids. European Journal of Pharmacology 359:118.
MelloN. K. (1972) Behavioral studies of alcoholism. In: Biology of alcoholism, ed. KissinB. & BegleiterH., pp. 210–19, Plenum Press.
MengodG., CortesR., Teresa VilaroM. & HoyerD. (2010) Distribution of 5-HT receptors in the central nervous system. In: Handbook of the behavioral neurobiology of serotonin, ed. MüllerC. P. & JacobsB. L., pp. 123–38. Academic Press.
MillerC. S. (2001) Toxicant-induced loss of tolerance. Addiction 96(1):115–37.
MillerG. (2000) Mental traits as fitness indicators. Expanding evolutionary psychology's adaptationism. Annals of the New York Academy of Sciences 907:6274.
MillerP. M., SmithG. T. & GoldmanM. S. (1990) Emergence of alcohol expectancies in childhood: A possible critical period. Journal of Studies on Alcohol 51:343–49.
Miller-TutzauerC., LeonardK. E. & WindleM. (1991) Marriage and alcohol use: A longitudinal study of “maturing out.” Journal of Studies on Alcohol 52(5):434–40.
MilnerB., SquireL. R. & KandelE. R. (1998) Cognitive neuroscience and the study of memory. Neuron 20(3):445–68.
MitchellS. N. (1993) Role of the locus-coeruleus in the noradrenergic response to a systemic administration of nicotine. Neuropharmacology 32:937–49.
MolnarD. S., BusseriM. A., PerrierC. P. & SadavaS. W. (2009) A longitudinal examination of alcohol use and subjective well-being in an undergraduate sample. Journal of Studies on Alcohol and Drugs 70:704–13.
MondainiN., CaiT., GonteroP., GavazziA., LombardiG., BoddiV. & BartolettiR. (2009) Regular moderate intake of red wine is linked to a better women's sexual health. Journal of Sexual Medicine 6(10):2772–77.
MooneyD. K. (1995) The relationship between sexual insecurity, the alcohol expectation for enhanced sexual experience, and consumption patterns. Addictive Behaviors 20(2):243–50.
MüllerC. P. & CareyR. J. (2006) Intracellular 5-HT 2C-receptor dephosphorylation: A new target for treating drug addiction. Trends in Pharmacological Sciences 27:455–58.
MüllerC. P., CareyR. J., HustonJ. P. & De Souza SilvaM. A. (2007a) Serotonin and psychostimulant addiction: Focus on 5-HT1A-receptors. Progress in Neurobiology 81:133–78.
MüllerC. P., CareyR. J., WilkiszM., SchwenznerS., JochamG., HustonJ. P. & De Souza SilvaM. A. (2008) Acute anxiolytic effects of cocaine: The role of test latency and activity phase. Pharmacology Biochemistry & Behavior 89:218–26.
MüllerC. P., De Souza SilvaM. A. & HustonJ. P. (2007b) Double dissociating effects of sensory stimulation and cocaine on serotonin activity in the occipital and temporal cortices. Neuropharmacology 52:854–62.
MüllerC. P., PumM. E., SchumannG. & HustonJ. P. (2010) The role of serotonin in drug addiction. In: The behavioral neurobiology of serotonin, ed. MüllerC. P. & JacobsB. L., pp. 507–46. Academic Press.
MüllerC. P., ThönnessenH., BarrosM., TomazC., CareyR. J. & HustonJ. P. (2004) Hippocampus 5-HT(1A)-receptors attenuate cocaine-induced hyperlocomotion and the increase in hippocampal but not nucleus accumbens 5-HT. Hipppocampus 14:710–21.
NatCen/NFER and National Center for Social Research/National Foundation for Educational Research (2005) Smoking, drinking and drug use among young people in England 2005. London.
NathansonJ. A., HunnicuttE. J., KanthamL. & ScavoneC. (1993) Cocaine as a naturally occurring insecticide. Proceedings of the National Academy Sciences USA 90(20):9645–48.
NegreteJ. C. (1993) Effects of cannabis on schizophrenia. In: Cannabis: Pathophysiology, epidemiology, detection, ed. NahasG. G. & LatourC., pp. 105–12. CRC Press.
NesseR. M. (2002) Evolution and addiction. Addiction 97:470–71.
NesseR. M. & BerridgeK. C. (1997) Psychoactive drug use in evolutionary perspective. Science 278:6366.
NestlerE. J. & AghajanianG. K. (1997) Molecular and cellular basis of addiction. Science 278:5863.
NewlinD. B. (2002) The self-perceived survival ability and reproductive fitness (SPFit) theory of substance use disorders. Addiction 97:427–45.
NiauraR., GoldsteinM. & AbramsD. (1991) A bioinformational systems perspective on tobacco dependence. British Journal of Addiction 86(5):593–97.
NicholsD. E. (2004) Hallucinogens. Pharmacological Therapy 101(2):131–81.
NilsenP., HolmqvistM., HultgrenE., BendtsenP. & CedergrenM. (2008) Alcohol use before and during pregnancy and factors influencing change among Swedish women. Acta Obstetrics and Gynecology of Scandinavia 87(7):768–74.
NSDUH (2007) National Survey of Drug Use and Health.
NuttD., KingL. A., SaulsburyW. & BlakemoreC. (2007) Development of a rational scale to assess the harm of drugs of potential misuse. Lancet 369:1047–53.
O'BrienC. P., ChildressA. R., EhrmanR. & RobbinsS. J. (1998) Conditioning factors in drug abuse: Can they explain compulsion? Journal of Psychopharmacology 12(1):1522.
O'MalleyP. M. & JohnstonL. D. (2002) Epidemiology of alcohol and other drug use among American college students. Journal of Studies on Alcohol Supplement l:2339.
O'MalleyP. M., JohnstonL. D. & BachmanJ. G. (1985) Cocaine use among American adolescents and young adults. NIDA Research Monographs 61:5075.
OldsJ. & MilnerP. (1954) Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. Journal of Comparative and Physiological Psychology 47:419–27.
OlmsteadM. C. (2006) Animal models of drug addiction: Where do we go from here? Quarterly Journal of Experimental Psychology (Colchester.) 59(4):625–53.
OrfordJ. (2001a) Addiction as excessive appetite. Addiction 96(1):1531.
OrfordJ. (2008) Asking the right questions in the right way: The need for a shift in research on psychological treatments for addiction. Addiction 103(6):875–85.
OvertonD. A. (1968) Visual cues and shock sensitivity in the control of T-maze choice by drug conditions. Journal of Comparative and Physiological Psychology 66:216–19.
PageJ. E., BalzaF., NishidaT. & TowersG. H. (1992) Biologically active diterpenes from Aspilia mossambicensis, a chimpanzee medicinal plant. Phytochemistry 31(10):3437–39.
PankseppJ. B. & LahvisG. P. (2007) Social reward among juvenile mice. Genes Brain and Behavior 6(7):661–71.
PankseppJ., KnutsonB. & BurgdorfJ. (2002) The role of brain emotional systems in addictions: A neuro-evolutionary perspective and new “self-report” animal model. Addiction 97(4):459–69.
ParsonsO. A. (1998) Neurocognitive deficits in alcoholics and social drinkers: A continuum? Alcohol Clinical and Experimental Research 22(4):954–61.
Pascual-LeoneA., DhunaA. & AndersonD. C. (1991) Long-term neurological complications of chronic, habitual cocaine abuse. Neurotoxicology 12(3):393400.
PatrickM. E. & MaggsJ. L. (2008) Short-term changes in plans to drink and importance of positive and negative alcohol consequences. Journal of Adolescence 31:307–21.
PatrickM. E. & MaggsJ. L. (2009) Does drinking lead to sex? Daily alcohol-sex behaviors and expectancies among college students. Psychology of Addictive Behaviors 23(3):472–81.
PeeleS. & BrodskyA. (2000) Exploring psychological benefits associated with moderate alcohol use: A necessary corrective to assessments of drinking outcomes? Drug and Alcohol Dependence 60:221–47.
PerkinsH. W. (1999) Stress-motivated drinking in collegiate and postcollegiate young adulthood: Life course and gender patterns. Journal of Studies on Alcohol 60:219–27.
PerkinsK. A. (1992) Effects of tobacco smoking on caloric intake. British Journal of Addiction 87:193205.
PerryE. K. & PerryR. H. (1995) Acetylcholine and hallucinations: Disease-related compared to drug-induced alterations in human consciousness. Brain and Cognition 28:240–58.
Porkka-HeiskanenT., StreckerR. E., ThakkarM., BjorkumA. A., GreeneR. W. & McCarleyR. W. (1997) Adenosine: A mediator of the sleep-inducing effects of prolonged wakefulness. Science 276:1265–68.
PorrinoL. J., LyonsD., SmithH. R., DaunaisJ. B. & NaderM. A. (2004) Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains. Journal of Neuroscience 24(14):3554–62.
PorterA. C. & FelderC. C. (2001) The endocannabinoid nervous system: Unique opportunities for therapeutic intervention. Pharmacology and Therapeutics 90:4560.
PostR. M., KotinJ. & GoodwinF. K. (1974) The effects of cocaine on depressed patients. American Journal of Psychiatry 131:511–17.
PotvinS., StipE. & RoyJ. Y. (2003) Schizophrenia and addiction: An evaluation of the self-medication hypothesis. Encephale 29:193203.
PumM., CareyR. J., HustonJ. P. & MüllerC. P. (2007) Dissociating effects of cocaine and d-amphetamine on dopamine and serotonin in the perirhinal, entorhinal, and prefrontal cortex of freely moving rats. Psychopharmacology (Berlin) 193:375–90.
PumM. E., HustonJ. P., De Souza SilvaM. A. & MüllerC. P. (2008) Visual sensory-motor gating by serotonin activation in the medial prefrontal and occipital, but not in the rhinal, cortices in rats. Neuroscience 153:361–72.
QuadrosI. M., TakahashiA. & MiczekK. A. (2010) Serotonin and aggression. In: Handbook of the behavioral neurobiology of serotonin, ed. MüllerC. P. & JacobsB. L., pp. 687714. Academic Press.
QuednowB. B., JessenF., KuhnK. U., MaierW., DaumI. & WagnerM. (2006) Memory deficits in abstinent MDMA (ecstasy) users: Neuropsychological evidence of frontal dysfunction. Journal of Psychopharmacology 20:373–84.
QuednowB. B., KuhnK. U., HoppeC., WestheideJ., MaierW., DaumI. & WagnerM. (2007) Elevated impulsivity and impaired decision-making cognition in heavy users of MDMA (“Ecstasy”). Psychopharmacology (Berlin) 189:517530.
QuednowB. B., KuhnK. U., MossnerR., SchwabS. G., SchuhmacherA., MaierW. & WagnerM. (2008) Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms. Biological Psychiatry 64:434–37.
QuednowB. B., SchmechtigA., EttingerU., PetrovskyN., CollierD. A., VollenweiderF. X., WagnerM. & KumariV. (2009) Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: A replication study. Biological Psychiatry 66:614–20.
RayR., SchnollR. A. & LermanC. (2009) Nicotine dependence: Biology, behaviour, and treatment. Annual Review of Medicine 60:247–60.
RedishA. D., JensenS. & JohnsonA. (2008) A unified framework for addiction: Vulnerabilities in the decision process. Behavioral and Brain Sciences 31(4):415–37.
ResnickR. B., KestenbaumR. S. & SchwartzL. K. (1977) Acute systemic effects of cocaine in man: A controlled study by intranasal and intravenous routes. Science 195:696–98.
RezvaniA. H. & LevinE. D. (2001) Cognitive effects of nicotine. Biological Psychiatry 49:258–67.
RichJ. A. & SingerD. E. (1991) Cocaine-related symptoms in patients presenting to an urban emergency department. Annals of Emergency Medicine 20:616–21.
RichardsonN. R. & RobertsD. C. S. (1996) Progressive ratio schedules in drug self-administration studies in rats: A method to evaluate reinforcing efficacy. Journal of Neuroscience Methods 66(1):111.
RisnerM. E. & JonesB. E. (1980) Intravenous self-administration of cocaine and norcocaine by dogs. Psychopharmacology 71(1):8389.
RitzM. C., ConeE. J. & KuharM. J. (1990) Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: A structure-activity study. Life Sciences 46:635–45.
RitzM. C. & KuharM. J. (1989) Relationship between self-administration of amphetamine and monoamine receptors in brain – comparison with cocaine. Journal of Pharmacology and Experimental Therapeutics 248:1010–17.
RobbinsT. W. & EverittB. J. (1996) Neurobehavioural mechanisms of reward and motivation. Current Opinion in Neurobiology 6:228–36.
RobbinsT. W. & EverittB. J. (1999) Drug addiction: Bad habits add up. Nature 398(6728):567–70.
RobbinsT. W., ErscheK. D. & EverittB. J. (2008) Drug addiction and the memory systems of the brain. Annals of the New York Academy of Sciences 1141:121.
RobinsonT. E. & BerridgeK. C. (1993) The neural basis of drug craving: An incentive-sensitization theory of addiction. Brain Research Reviews 18:247–91.
RobinsonT. E. & BerridgeK. C. (2003) Addiction. Annual Reviews in Psychology 54:2553.
RoblesM., AregullinM., WestJ. & RodriguezE. (1995) Recent studies on the zoopharmacognosy, pharmacology and neurotoxicology of sesquiterpene lactones. Planta Medica 61:199203.
RodgersB., KortenA. E., JormA. F., ChristensenH., HendersonS. & JacombP. A. (2000) Risk factors for depression and anxiety in abstainers, moderate drinkers and heavy drinkers. Addiction 95:1833–45.
RodriguezE., AregullinM., NishidaT., UeharaS., WranghamR., AbramowskiZ., FinlaysonA. & TowersG. H. (1985) Thiarubrine A, a bioactive constituent of Aspilia (Asteraceae) consumed by wild chimpanzees. Experientia 41(3):419–20.
RodriguezE. & WranghamR. (1993) Zoopharmacognosy: The use of medicinal plants by animals. Recent Advances in Phytochemistry 27:89105.
RoomR. (2000) The more drinking, the more fun; but is there a calculus of fun, and should it drive policy? Drug and Alcohol Dependence 60:249–50.
RossH. E. & YoungL. J. (2009) Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior. Frontiers in Neuroendocrinology 30(4):534–47.
RozinP. & KalatJ. W. (1971) Specific hungers and poison avoidance as adaptive specializations of learning. Clinical Psychology 78(6):459–86.
SalamoneJ.D. (1996) The behavioral neurochemistry of motivation: Methodological and conceptual issues in studies of the dynamic activity of nucleus accumbens dopamine. Journal of Neuroscience Methods 64:137–49.
SamaninR. & GarattiniS. (1993) Neurochemical mechanism of action of anorectic drugs. Pharmacology and Toxicology 73:6368.
SAMHSA (2005) National survey on drug use and health, Substance Abuse and Mental Health Services Administration, Rockville (
Sanchis-SeguraC. & SpanagelR. (2006) Behavioural assessment of drug reinforcement and addictive features in rodents: An overview. Addiction Biology 11(1):238.
SareenJ., McWilliamsL., CoxB. & SteinM. B. (2004) Does a U-shaped relationship exist between alcohol use and DSM-III-R mood and anxiety disorders? Journal of Affective Disorders 82:113–18.
SarterM. & BrunoJ. P. (1997) Cognitive functions of cortical acetylcholine: Toward a unifying hypothesis. Brain Research Reviews 23:2846.
SarterM., HasselmoM. E., BrunoJ. P. & GivensB. (2005) Unraveling the attentional functions of cortical cholinergic inputs: Interactions between signal-driven and cognitive modulation of signal detection. Brain Research Reviews 48:98111.
SchultzW. (2000) Multiple reward signals in the brain. Nature Reviews Neuroscience 1:199207.
SchumannG. (2007) Okey Lecture 2006: Identifying the neurobiological mechanisms of addictive behaviour. Addiction 102:1689–95.
SchumannG., JohannM., FrankJ., PreussU., DahmenN., LauchtM., RietschelM., RujescuD., LourdusamyA., ClarkeT. K., KrauseK., DyerA., DepnerM., WellekS., TreutleinJ., SzegediA., GieglingI., CichonS., BlomeyerD., HeinzA., HeathS., LathropM., WodarzN., SoykaM., SpanagelR. & MannK. (2008) Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. Archives of General Psychiatry 65:826–38.
SchumannG., RujescuD., KisslingC., SoykaM., DahmenN., PreussU. W., WiemanS., DepnerM., WellekS., LascorzJ., BondyB., GieglingI., AnghelescuI., CowenM. S., PoustkaA., SpanagelR., MannK., HennF. A. & SzegediA. (2003) Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts. Biological Psychiatry 54:1422–26.
SchwartingR. K., ThielC. M., MüllerC. P. & HustonJ. P. (1998) Relationship between anxiety and serotonin in the ventral striatum. NeuroReport 9:1025–29.
SeefelderM. (1996) Opium. Eine Kulturgeschichte, 3 ed. Nikol.
SegalB. (1985) Confirmatory analyses of reasons for experiencing psychoactive drugs during adolescence. International Journal of Addiction 20:1649–62.
SeidenL. S. & SabolK. E. (1996) Methamphetamine and methylenedioxymethamphetamine neurotoxicity: Possible mechanisms of cell destruction. NIDA Research Monographs 163:251–76.
SeidenL. S., SabolK. E. & RicaurteG. A. (1993) Amphetamine: effects on catecholamine systems and behavior. Annual Review of Pharmacology and Toxicology 33:639–77.
SenB. (2002) Does alcohol-use increase the risk of sexual intercourse among adolescents? Evidence from the NLSY97. Journal of Health Economics 21(6):1085–93.
ShahamY., ShalevU., LuL., de WitH. & StewartJ. (2003) The reinstatement model of drug relapse: History, methodology and major findings. Psychopharmacology 168(1–2):320.
SheldonP. W. & AghajanianG. K. (1990) Serotonin (5-HT) induces IPSPs in pyramidal layer cells of rat piriform cortex – Evidence for the involvement of a 5-HT2-activated interneuron. Brain Research 506:6269.
SherK. J., GrekinE. R. & WilliamsN. A. (2005) The development of alcohol use disorders. Annual Review of Clinical Psychology 1:493523.
SiegelR. K. (1978) Cocaine hallucinations. American Journal of Psychiatry 135:309–14.
SiegelS. (1988) Drug anticipation and the treatment of dependence. NIDA Research Monograph 84:124.
SimonsJ., CorreiaC. J. & CareyK. B. (2000) A comparison of motives for marihuana and alcohol use among experienced users. Addictive Behavior 25:153–60.
SingerM. S., MaceK. C. & BernaysE. A. (2009) Self-medication as adaptive plasticity: Increased ingestion of plant toxins by parasitized caterpillars. PLoS.One. 4(3):e4796.
SkinnerB. F. (1938) The behavior of organisms. Appleton.
SkogO. J. (2000) Addicts' choice. Addiction 95(9):1309–14.
SkogenJ. C., HarveyS. B., HendersonM., StordalE. & MykletunA. (2009) Anxiety and depression among abstainers and low-level alcohol consumers. The Nord-Trondelag Health Study. Addiction 104:1519–29.
SolowijN. (1998) Cannabis and cognitive functioning. Cambridge University Press.
SpanagelR. (2009) Alcoholism: A systems approach from molecular physiology to addictive behavior. Physiological Reviews 89:649705.
SpanagelR., PendyalaG., AbarcaC., ZghoulT., Sanchis-SeguraC., MagnoneM. C., LascorzJ., DepnerM., HolzbergD., SoykaM., SchreiberS., MatsudaF., LathropM., SchumannG. & AlbrechtU. (2005) The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nature Medicine 11:3542.
SpealmanR. D. & GoldbergS. R. (1978) Drug self-administration by laboratory animals: Control by schedules of reinforcement. Annual Review of Pharmacology and Toxicology 18:313–39.
SpearL. P. (2000) The adolescent brain and age-related behavioral manifestations. Neuroscience and Biobehavioral Reviews 24:417–63.
SprouseJ. S., BradberryC. W., RothR. H. & AghajanianG. K. (1990) 3,4-Methylenedioxymethamphetamine-induced release of serotonin and inhibition of dorsal raphe cell firing: potentiation by L-tryptophan. European Journal of Pharmacology 178:313–20.
SquireL. R., KnowltonB. & MusenG. (1993) The structure and organization of memory. Annual Review of Psychology 44:453–95.
StaceyD., ClarkeT. K. & SchumannG. (2009) The genetics of alcoholism. Current Psychiatry Reports 11(5):364–69.
SteeleC. M. & JosephsR. A. (1990) Alcohol myopia. Its prized and dangerous effects. The American Psychologist 45(8):921–33.
SteriadeM., DattaS., PareD., OaksonG. & Curro DossiR. C. (1990) Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems. Journal of Neuroscience 10:2541–59.
StillmanR., JonesR. T., MooreD., WalkerJ. & WelmS. (1993) Improved performance 4 hours after cocaine. Psychopharmacology (Berlin) 110:415–20.
StolermanI. (1992) Drugs of abuse: Behavioural principles, methods and terms. Trends in Pharmacological Sciences 13:170–76.
StreatfeildD. (2001) Cocaine. An unauthorized biography. St Martin's Press.
SullivanR. J. & HagenE. H. (2002) Psychotropic substance-seeking: Evolutionary pathology or adaptation? Addiction 97(4):389400.
SullivanR. J., HagenE. H. & HammersteinP. (2008) Revealing the paradox of drug reward in human evolution. Proceedings of the Royal Society B: Biological Sciences 275:1231–41.
SussmanS., PentzM. A., Spruijt-MetzD. & MillerT. (2006) Misuse of “study drugs”: prevalence, consequences, and implications for policy. Substance Abuse Treatment and Prevention Policy 1:15.
TatarkiewiczW. (1976) Analysis of happiness. Kluwer Academic Publishers.
TaylorB., RehmJ. & GmelG. (2005) Moderate alcohol consumption and the gastrointestinal tract. Digestive Disorders 23:170–76.
TaylorJ., FulopN. & GreenJ. (1999) Drink, illicit drugs and unsafe sex in women. Addiction 94(8):1209–18.
TeterC. J., FaloneA. E., CranfordJ. A., BoydC. J. & McCabeS. E. (2010) Nonmedical use of prescription stimulants and depressed mood among college students: Frequency and routes of administration. Journal of Substance Abuse Treatment 38(3):292–98.
ThielC. M., MüllerC. P., HustonJ. P. & SchwartingR. K. (1999) High versus low reactivity to a novel environment: Behavioural, pharmacological and neurochemical assessments. Neuroscience 93(1):243–51.
TinbergenN. (1963) On aims and methods of ethology. Zeitschrift für Tierpsychologie 20:410–33.
ToobyJ. & CosmidesL. (1992) The psychological foundation of culture. In: The adapted mind: Evolutionary psychology and the generation of culture, ed. BarkowJ., CosmidesL. & ToobyJ., pp. 1939. Oxford University Press.
TupalaE. & TiihonenJ. (2004) Dopamine and alcoholism: Neurobiological basis of ethanol abuse. Progress in Neuropsychopharmacology and Biological Psychiatry 28:1221–47.
TzschentkeT. M. (2007) Measuring reward with the conditioned place preference (CPP) paradigm: Update of the last decade. Addiction Biology 12(3–4):227462.
UekermannJ. & DaumI. (2008) Social cognition in alcoholism: A link to prefrontal cortex dysfunction? Addiction 103(5):726–35.
UherR. (2009) The role of genetic variation in the causation of mental illness: An evolution-informed framework. Molecular Psychiatry 14(12):1072–82.
UsherM., CohenJ. D., Servan-SchreiberD., RajkowskiJ. & Aston-JonesG. (1999) The role of locus coeruleus in the regulation of cognitive performance. Science 283:549–54.
VanderschurenL. J. & KalivasP. W. (2000) Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: A critical review of preclinical studies. Psychopharmacology (Berlin) 151(2–3):99120.
VillalbaJ. J., ProvenzaF. D., HallJ. O. & LisonbeeL. D. (2010) Selection of tannins by sheep in response to gastrointestinal nematode infection. Journal of Animal Science 88(6):2189–98.
VolkowN. D., HitzemannR., WangG. J., FowlerJ. S., WolfA. P., DeweyS. L. & HandlesmanL. (1992) Long-term frontal brain metabolic changes in cocaine abusers. Synapse 11(3):184–90.
VolkowN. D., WangG. J., FischmanM. W., FoltinR. W., FowlerJ. S., AbumradN. N., VitkunS., LoganJ., GatleyS. J., PappasN., HitzemannR. & SheaC. E. (1997) Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature 386:827–30.
VolkowN. D., WangG. J., MaY. M., FowlerJ. S., WongC., JayneM., TelangF. & SwansonJ. M. (2006) Effects of expectation on the brain metabolic responses to methylphenidate and to its placebo in non-drug abusing subjects. Neuroimage 32(4):1782–92.
VolkowN. D., WangG. J., MaY. M., FowlerJ. S., ZhuW., MaynardL., TelangF., VaskaP., DingY. S., WongC. & SwansonJ. M. (2003) Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers. The Journal of Neuroscience 23(36):11461–68.
WackJ. T. & RodinJ. (1982) Smoking and its effects on body weight and the systems of caloric regulation. American Journal of Clinical Nutrition 35:366–80.
WagnerF. A. & AnthonyJ. C. (2002) From first drug use to drug dependence; developmental periods of risk for dependence upon marihuana, cocaine, and alcohol. Neuropsychopharmacology 26:479–88.
WakefieldJ. C. (1999) Evolutionary versus prototype analyses of the concept of disorder. Journal of Abnormal Psychology 108(3):374–99.
WaldorfD., ReinarmanC. & MurphyS. (1991) Cocaine changes: The experience of using and quitting, Temple University Press.
WardR. J., LallemandF. & deW. P. (2009) Biochemical and neurotransmitter changes implicated in alcohol-induced brain damage in chronic or “binge drinking” alcohol abuse. Alcohol and Alcoholism 44(2):128–35.
WaskowI. E., OlssonJ. E., SalzmanC. & KatzM. M. (1970) Psychological effects of tetrahydrocannabinol. Archives of General Psychiatry 22:97107.
WeilA. T. (1998) The natural mind. Houghton Mifflin Co.
WeirE. (2000) Raves: A review of the culture, the drugs and the prevention of harm. Canadian Medical Association Journal 162:1843–48.
WeissR. D., MirinS. M., MichaelJ. L. & SollogubA. C. (1986) Psychopathology in chronic cocaine abusers. American Journal of Drug and Alcohol Abuse 12:1729.
WellsB. E., KellyB. C., GolubS. A., GrovC. & ParsonsJ. T. (2010) Patterns of alcohol consumption and sexual behavior among young adults in nightclubs. American Journal of Drug and Alcohol Abuse 36(1):3945.
WestR. (2006) Theory of addiction. Blackwell.
WhiteB. P., Becker-BleaseK. A. & Grace-BishopK. (2006) Stimulant medication use, misuse, and abuse in an undergraduate and graduate student sample. Journal of the American College of Health 54:261–68.
WhiteN. M. (1989) Reward or reinforcement: What's the difference? Neuroscience and Biobehavioral Reviews 13(2–3):181–86.
WhiteN. M. (1996) Addictive drugs as reinforcers: Multiple partial actions on memory systems. Addiction 91:921–49.
WiensF., ZitzmannA., LachanceM. A., YeglesM., PragstF., WurstF. M., von HolstD., GuanS. L. & SpanagelR. (2008) Chronic intake of fermented floral nectar by wild treeshrews. Proceedings of the National Academy of Sciences U.S.A 105(30):10426–31.
WiklerA. (1973) Dynamics of drug dependence. Implications of a conditioning theory for research and treatment. Archives of General Psychiatry 28(5):611–16.
WilliamsG. C. (1957) Pleiotropy, natural selection, and the evolution of senescence. Evolution 11:398411.
WilliamsM. J. & AdinoffB. (2007) The role of acetylcholine in cocaine addiction. Neuropsychopharmacology 33:1779–97.
WilliamsonE. M. & EvansF. J. (2000) Cannabinoids in clinical practice. Drugs 60:1303–14.
WilsnackS. C. (1974) The effects of social drinking on women's fantasy. Journal of Personality 42:4361.
WiseR. A. (1980) The dopamine synapse and the notion of “pleasure centers” in the brain. Trends in Neurosciences 9195.
WiseR. A. (1994) A brief history of the anhedonia hypothesis. In: Appetite: Neural and behavioural base, ed. LeggC. R. & BothD. A., pp. 234–63, Oxford University Press.
WiseR. A. (2002) Brain reward circuitry: Insights from unsensed incentives. Neuron 36(2):229–40.
WitkinJ. M., SavtchenkoN., MashkovskyM., BeekmanM., MunzarP., GasiorM., GoldbergS. R., UngardJ. T., KimJ., ShippenbergT. & CheferV. (1999) Behavioral, toxic, and neurochemical effects of sydnocarb, a novel psychomotor stimulant: Comparisons with methamphetamine. The Journal of Pharmacology and Experimental Therapeutics 288(3):1298–310.
WoicikP. A., StewartS. H., PihlR. O. & ConrodP. J. (2009) The Substance Use Risk Profile Scale: A scale measuring traits linked to reinforcement-specific substance use profiles. Addictive Behavior 34:1042–55.
WolffK. & WinstockA. R. (2006) Ketamine: From medicine to misuse. CNS Drugs 20:199218.
WonnacottS. (1997) Presynaptic nicotinic ACh receptors. Trends in Neurosciences 20:9298.
WoodR. I. (2004) Reinforcing aspects of androgens. Physiology Behavior 83(2):279–89.
WoodR. I. (2008) Anabolic-androgenic steroid dependence? Insights from animals and humans. Frontiers in Neuroendocrinology 29:490506.
WranghamR. & NishidaT. (1983) Aspilla spp. Leaves: A puzzle in the feeding behavior of wild chimpanzees. Primates 24(2):276–82.
WyattR. J., KaroumF., SuddathR. & FawcettR. (1988) Persistently decreased brain dopamine levels and cocaine. Journal of the American Medical Association 259:2996.
YokelR. A. & PickensR. (1973) Self-administration of optical isomers of amphetamine and methylamphetamine by rats. The Journal of Pharmacology and Experimental Therapeutics 187(1):2733.
YoungA. M., JosephM. H. & GrayJ. A. (1993) Latent inhibition of conditioned dopamine release in rat nucleus accumbens. Neuroscience 54:59.
ZacnyJ. P. & LichtorS. A. (2008) Nonmedical use of prescription opioids: Motive and ubiquity issues. Journal of Pain 9:473–86.
ZinbergN. E. (1984) Drug, set, and setting: The basis for controlled intoxicant use. Yale University Press.
ZinbergN. E., HardingW. M., StelmackS. M. & MarblestoneR. A. (1978) Patterns of heroin use. Annals of the New York of Academy Sciences 311:1024.
ZinbergN. E. & JacobsonR. C. (1976) The natural history of “chipping.” The American Journal of Psychiatry 133(1):3740.
ZuckermanM. (1990) The psychophysiology of sensation seeking. Journal of Personality 58:313–45.
ZvolenskyM. J., VujanovicA. A., BernsteinA., Bonn-MillerM. O., MarshallE. C. & LeyroT. M. (2007) Marijuana use motives: A confirmatory test and evaluation among young adult marijuana users. Addictive Behavior 32:3122–30.
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