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Impulsivity, dual diagnosis, and the structure of motivated behavior in addiction

  • R. Andrew Chambers (a1)
Abstract
Abstract

Defining brain mechanisms that control and adapt motivated behavior will not only advance addiction treatment. It will help society see that addiction is a disease that erodes free will, rather than representing a free will that asks for or deserves consequences of drug-use choices. This science has important implications for understanding addiction's comorbidity in mental illness and reducing associated public health and criminal justice burdens.

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M. T. Bardo , R. L. Donohew & N. G. Harrington (1996) Psychobiology of novelty seeking and drug seeking behavior. Behavioral Brain Research 77(1–2):2343.

D. Belin & B. J. Everitt (2008) Cocaine-seeking habits depend upon dopamine-dependent serial connectivity linking the ventral and dorsal striatum. Neuron 57:432–41.

R. A. Chambers (2007) Animal modeling and neurocircuitry of dual diagnosis. Journal of Dual Diagnosis 3(2):1929.

R. A. Chambers , W. K. Bickel & M. N. Potenza (2007) A scale-free systems theory of motivation and addiction. Neuroscience and Biobehavioral Reviews 31(7):1017–45.

R. A. Chambers , R. M. Jones , S. Brown & J. R. Taylor (2005) Natural reward related learning in rats with neonatal ventral hippocampal lesions and prior cocaine exposure. Psychopharmacology 179(2):470–78.

R. A. Chambers & M. N. Potenza (2003) Neurodevelopment, impulsivity, and adolescent gambling. Journal of Gambling Studies 19(1):5384.

R. A. Chambers & D. W. Self (2002) Motivational responses to natural and drug rewards in rats with neonatal ventral hippocampal lesions: An animal model of dual diagnosis schizophrenia. Neuropsychopharmacology 27(6):889905.

R. A. Chambers , J. R. Taylor & M. N. Potenza (2003) Developmental neurocircuitry of motivation in adolescence: A critical period of addiction vulnerability. American Journal of Psychiatry 160(6):1041–52.

L. Dixon (1999) Dual diagnosis of substance abuse in schizophrenia: Prevalence and impact on outcomes. Schizophrenia Research 35 (Suppl.):S93100.

B. J. Everitt & T. W. Robbins (2005) Neural systems of reinforcement for drug addiction: From actions to habits to compulsion. Nature Neuroscience 8(11):1481–89.

J. M. Finlay & M. J. Zigmond (1997) The effects of stress on central dopaminergic neurons: Possible clinical implications. Neurochemical Research 22(11):1387–94.

G. L. Gerdeman , J. G. Partridge , C. R. Lupica & D. M. Lovinger (2003) It could be habit forming: Drugs of abuse and striatal synaptic plasticity. Trends in Neuroscience 26(4):184–92.

Y. Goto & A. A. Grace (2005a) Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: Disruption by cocaine sensitization. Neuron 47(2):255–66.

A. M. Graybiel (1998) The basal ganglia and chunking of action repertoires. Neurobiology of Learning and Memory 70(1–2):119–36.

H. J. Groenewegen , C. I. Wright , A. V. Beijer & P. Voorn (1999) Convergence and segregation of ventral striatal inputs and outputs. Annals of the New York Academy of Sciences 877:4963.

S. N. Haber (2003) The primate basal ganglia: Parallel and integrative networks. Journal of Chemical Neuroanatomy 26:317–30.

S. E. Hyman & R. C. Malenka (2001) Addiction and the brain: The neurobiology of compulsion and its persistence. Nature Reviews Neuroscience 2:695703.

A. E. Kelley (2004b) Ventral striatal control of appetitive motivation: Role in ingestive behavior and reward related learning. Neuroscience and Biobehavioral Reviews 27:765–76.

R. C. Kessler (2004) The epidemiology of dual diagnosis. Biological Psychiatry 56:730–37.

K. Lasser , J. W. Boyd , S. Woolhandler , D. Heimmerlstein , D. McCormick & D. Bor (2000) Smoking in mental illness: A population-based prevalence study. Journal of the American Medical Association 284(20):2606–10.

B. K. Lipska , D. N. Lerman , Z. Z. Khaing & D. R. Weinberger (2003) The neonatal ventral hippocampal lesion model of schizophrenia: Effects on dopamine and GABA mRNA markers in the rat midbrain. European Journal of Neuroscience 18:30973104.

P. O'Donnell , J. Greene , N. Pabello , B. L. Lewis & A. A. Grace (1999) Modulation of cell firing in the nucleus accumbens. Annals of the New York Academy of Sciences 877:157–75.

J. RachBeisel , J. Scott & L. Dixon (1999) Co-occurring severe mental illness and substance use disorders: A review of recent research. Psychiatric Services 50(11):1427–34.

M. I. Rosen , R. A. Rosenheck , A. Shaner , T. Eckman , G. Gamache & C. Krebs (2002) Veterans who may need a payee to prevent misuse of funds for drugs. Psychiatric Services 53(8):9951000.

A. D. Schmetzer (2006) Deinstitutionalization and dual diagnosis. Journal of Dual Diagnosis 3:95101.

R. Spanagel & F. Weiss (1999) The dopamine hypothesis of reward: Past and current status. Trends in Neurosciences 22(11):521–27.

L. W. Swanson (2000) Cerebral hemisphere regulation of motivated behavior. Brain Research 886(1–2):113–64.

K. Y. Tseng , B. L. Lewis , B. K. Lipska & P. O'Donnell (2007) Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophrenia. Biological Psychiatry 62:730–38.

L. J. M. J. Vanderschuren & P. Kalivas (2000) Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: A critical review of preclinical studies. Psychopharmacology 151:99120.

N. D. Volkow , G. J. Wang , F. Telang , J. S. Fowler , J. Logan , A. R. Childress , M. Jayne , Y. Ma & C. Wong (2006) Cocaine cues and dopamine in dorsal striatum: Mechanism of craving in cocaine addiction. Journal of Neuroscience 26:6583–88.

H. H. Yin & B. J. Knowlton (2006) The role of the basal ganglia in habit formation. Nature Reviews Neuroscience 7:464–76.

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Behavioral and Brain Sciences
  • ISSN: 0140-525X
  • EISSN: 1469-1825
  • URL: /core/journals/behavioral-and-brain-sciences
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