Skip to main content
    • Aa
    • Aa

Impulsivity, dual diagnosis, and the structure of motivated behavior in addiction

  • R. Andrew Chambers (a1)

Defining brain mechanisms that control and adapt motivated behavior will not only advance addiction treatment. It will help society see that addiction is a disease that erodes free will, rather than representing a free will that asks for or deserves consequences of drug-use choices. This science has important implications for understanding addiction's comorbidity in mental illness and reducing associated public health and criminal justice burdens.

Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

M. T. Bardo , R. L. Donohew & N. G. Harrington (1996) Psychobiology of novelty seeking and drug seeking behavior. Behavioral Brain Research 77(1–2):2343.

D. Belin & B. J. Everitt (2008) Cocaine-seeking habits depend upon dopamine-dependent serial connectivity linking the ventral and dorsal striatum. Neuron 57:432–41.

R. A. Chambers (2007) Animal modeling and neurocircuitry of dual diagnosis. Journal of Dual Diagnosis 3(2):1929.

R. A. Chambers , W. K. Bickel & M. N. Potenza (2007) A scale-free systems theory of motivation and addiction. Neuroscience and Biobehavioral Reviews 31(7):1017–45.

R. A. Chambers , R. M. Jones , S. Brown & J. R. Taylor (2005) Natural reward related learning in rats with neonatal ventral hippocampal lesions and prior cocaine exposure. Psychopharmacology 179(2):470–78.

R. A. Chambers & M. N. Potenza (2003) Neurodevelopment, impulsivity, and adolescent gambling. Journal of Gambling Studies 19(1):5384.

R. A. Chambers & D. W. Self (2002) Motivational responses to natural and drug rewards in rats with neonatal ventral hippocampal lesions: An animal model of dual diagnosis schizophrenia. Neuropsychopharmacology 27(6):889905.

R. A. Chambers , J. R. Taylor & M. N. Potenza (2003) Developmental neurocircuitry of motivation in adolescence: A critical period of addiction vulnerability. American Journal of Psychiatry 160(6):1041–52.

L. Dixon (1999) Dual diagnosis of substance abuse in schizophrenia: Prevalence and impact on outcomes. Schizophrenia Research 35 (Suppl.):S93100.

B. J. Everitt & T. W. Robbins (2005) Neural systems of reinforcement for drug addiction: From actions to habits to compulsion. Nature Neuroscience 8(11):1481–89.

J. M. Finlay & M. J. Zigmond (1997) The effects of stress on central dopaminergic neurons: Possible clinical implications. Neurochemical Research 22(11):1387–94.

G. L. Gerdeman , J. G. Partridge , C. R. Lupica & D. M. Lovinger (2003) It could be habit forming: Drugs of abuse and striatal synaptic plasticity. Trends in Neuroscience 26(4):184–92.

Y. Goto & A. A. Grace (2005a) Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: Disruption by cocaine sensitization. Neuron 47(2):255–66.

A. M. Graybiel (1998) The basal ganglia and chunking of action repertoires. Neurobiology of Learning and Memory 70(1–2):119–36.

H. J. Groenewegen , C. I. Wright , A. V. Beijer & P. Voorn (1999) Convergence and segregation of ventral striatal inputs and outputs. Annals of the New York Academy of Sciences 877:4963.

S. N. Haber (2003) The primate basal ganglia: Parallel and integrative networks. Journal of Chemical Neuroanatomy 26:317–30.

S. E. Hyman & R. C. Malenka (2001) Addiction and the brain: The neurobiology of compulsion and its persistence. Nature Reviews Neuroscience 2:695703.

A. E. Kelley (2004b) Ventral striatal control of appetitive motivation: Role in ingestive behavior and reward related learning. Neuroscience and Biobehavioral Reviews 27:765–76.

R. C. Kessler (2004) The epidemiology of dual diagnosis. Biological Psychiatry 56:730–37.

K. Lasser , J. W. Boyd , S. Woolhandler , D. Heimmerlstein , D. McCormick & D. Bor (2000) Smoking in mental illness: A population-based prevalence study. Journal of the American Medical Association 284(20):2606–10.

B. K. Lipska , D. N. Lerman , Z. Z. Khaing & D. R. Weinberger (2003) The neonatal ventral hippocampal lesion model of schizophrenia: Effects on dopamine and GABA mRNA markers in the rat midbrain. European Journal of Neuroscience 18:30973104.

P. O'Donnell , J. Greene , N. Pabello , B. L. Lewis & A. A. Grace (1999) Modulation of cell firing in the nucleus accumbens. Annals of the New York Academy of Sciences 877:157–75.

J. RachBeisel , J. Scott & L. Dixon (1999) Co-occurring severe mental illness and substance use disorders: A review of recent research. Psychiatric Services 50(11):1427–34.

M. I. Rosen , R. A. Rosenheck , A. Shaner , T. Eckman , G. Gamache & C. Krebs (2002) Veterans who may need a payee to prevent misuse of funds for drugs. Psychiatric Services 53(8):9951000.

A. D. Schmetzer (2006) Deinstitutionalization and dual diagnosis. Journal of Dual Diagnosis 3:95101.

R. Spanagel & F. Weiss (1999) The dopamine hypothesis of reward: Past and current status. Trends in Neurosciences 22(11):521–27.

L. W. Swanson (2000) Cerebral hemisphere regulation of motivated behavior. Brain Research 886(1–2):113–64.

K. Y. Tseng , B. L. Lewis , B. K. Lipska & P. O'Donnell (2007) Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophrenia. Biological Psychiatry 62:730–38.

L. J. M. J. Vanderschuren & P. Kalivas (2000) Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: A critical review of preclinical studies. Psychopharmacology 151:99120.

N. D. Volkow , G. J. Wang , F. Telang , J. S. Fowler , J. Logan , A. R. Childress , M. Jayne , Y. Ma & C. Wong (2006) Cocaine cues and dopamine in dorsal striatum: Mechanism of craving in cocaine addiction. Journal of Neuroscience 26:6583–88.

H. H. Yin & B. J. Knowlton (2006) The role of the basal ganglia in habit formation. Nature Reviews Neuroscience 7:464–76.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Behavioral and Brain Sciences
  • ISSN: 0140-525X
  • EISSN: 1469-1825
  • URL: /core/journals/behavioral-and-brain-sciences
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Full text views

Total number of HTML views: 6
Total number of PDF views: 25 *
Loading metrics...

Abstract views

Total abstract views: 142 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 26th May 2017. This data will be updated every 24 hours.

This erratum applies to the following article(s)