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Is this conjectural phenotypic dichotomy a plausible outcome of genomic imprinting?

  • Benjamin James Alexander Dickins (a1), David William Dickins (a2) and Thomas Edmund Dickins (a3)
  • DOI:
  • Published online: 01 June 2008

What is the status of the dichotomy proposed and the nosological validity of the contrasting pathologies described in the target article? How plausibly can dysregulated imprinting explain the array of features described, compared with other genetic models? We believe that considering alternative models is more likely to lead in the long term to the correct classification and explanation of the component behaviours.

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N. D. Allen , K. Logan , G. Lally , D. J. Drage , M. L. Norris & E. B. Keverne (1995) Distribution of parthenogenetic cells in the mouse brain and their influence on brain development and behavior. Proceedings of the National Academy of Sciences USA 92:10782–86.

W. M. Brown & N. S. Consedine (2004) Just how happy is the happy puppet? An emotion signaling and kinship theory perspective on the behavioral phenotype of children with Angelman syndrome. Medical Hypotheses 63(3):377–85.

W. Davies , A. R. Isles & L. S. Wilkinson (2005) Imprinted gene expression in the brain. Neuroscience and Biobehavioral Reviews 29:421–30.

T. Day & R. Bonduriansky (2004) Intralocus sexual conflict can drive the evolution of genomic imprinting. Genetics 167:1537–46.

D. Haig & M. Westoby (1989) Parent specific gene expression and the triploid endosperm. American Naturalist 134:147–55.

F. Happé , A. Ronald & R. Plomin (2006) Time to give up on a single explanation for autism. Nature Neuroscience 9(10):1218–20.

E. B. Keverne , R. Fundele , M. Narasimha , S. C. Barton & M. A. Surani (1996) Genomic imprinting and the differential roles of parental genomes in brain development. Brain Research, Developmental Brain Research 92:91100.

M. Lalande & M. A. Calciano (2007) Molecular epigenetics of Angelman syndrome. Cellular and Molecular Life Sciences 64:947–60.

T. Moore & D. Haig (1991) Genomic imprinting in mammalian development: A parental tug-of-war. Trends in Genetics 7:4549.

D. Nettle & H. Clegg (2006) Schizotypy, creativity and mating success in humans. Proceedings of the Royal Society of London Series B, Biological Sciences 273:611–15.

A. Ronald , F. Happé , P. Bolton , L. M. Butcher , T. S. Price , S. Wheelwright , S. Baron-Cohen & R. Plomin (2006) Genetic heterogeneity between the three components of the autism spectrum: A twin study. Journal of the American Academy of Child and Adolescent Psychiatry 45(6):691–99.

I. K. Temple & J. P. H. Shield (2002) Transient neonatal diabetes, a disorder of imprinting. Journal of Medical Genetics 39:872–75.

I. C. G. Weaver , N. Cervoni , F. A. Champagne , A. C. D'Alessio , S. Sharma , J. R. Seckl , S. Dymov , M. Szyf & M. J. Meaney (2004) Epigenetic programming by maternal behavior. Nature Neuroscience 7:847–54.

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Behavioral and Brain Sciences
  • ISSN: 0140-525X
  • EISSN: 1469-1825
  • URL: /core/journals/behavioral-and-brain-sciences
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