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On the biological basis of human laterality: I. Evidence for a maturational left–right gradient

  • Michael C. Corballis (a1) and Michael J. Morgan (a2)


In this paper, we consider human handedness and cerebral lateralization in a general biological context, and attempt to arrive at some conclusions common to the growth of human laterality and of other structural asymmetries. We suggest that many asymmetries appear to be under the influence of a left-right maturational gradient, which often seems to favor earlier or more rapid development on the left than on the right. If the leading side is damaged or restricted, this gradient may be reversed so that growth occurs with the opposite polarity. A mechanism of this sort appears to underlie the phenomenon of situs inversus viscerum et cordis, and the same principle may help explain the equipotentiality of the two sides of the human brain with respect to the representation of language in the early years of life. However we must also suppose that the leading side normally exerts an inhibitory influence on the lagging side, for otherwise one would expect language ultimately to develop in both halves of the brain. Examples of an inhibitory influence of this kind can also be found in other biological asymmetries; for instance, in the crab Alpheus heterochelis, one claw is normally greatly enlarged relative to the other, but if the larger claw is removed the smaller one is apparently released from its inhibitory influence and grows larger.

This last example is particularly interesting because it suggests a mechanism comparable to that proposed by Annett to account for the distribution of handedness in the human population. She argued, in effect, that there is a “right shift” factor among the majority of the population, but that among a minority who lack this factor handedness is determined at random. If it is supposed that cerebral lateralization is also determined at random among this recessive minority, the model can be extended to provide a reasonable fit to the data on the correlation between handedness and cerebral lateralization. However this genetic model (or any other) still fails to account for the near-binomial distribution of handedness among twins and among nontwin siblings. We suggest that right-handedness and leftcerebral dominance for language are manifestations of an underlying gradient which is probably coded in the cytoplasm rather than in the genes. We must leave open the question as to whether departures from this pattern are due to a recessive gene which effectively cancels the asymmetry to environmental influences, or to both genetic and cytoplasmic factors.



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Annett, M.The distribution of manual asymmetry. British Journal of Psychology. 63:343–58. 1972.
Atkinson, J., & Egeth, H.Right hemisphere superiority in visual orientation matching. Canadian Journal of Psychology. 27:152–58. 1973.
Basser, L. S.Hemiplegia of early onset and the faculty of speech with special reference to the effects of hemispherectomy. Brain. 85:427–60. 1962.
Bever, T. G. The nature of cerebral dominance in speech behavior of the child and adult. In: Huxley, R. & Ingram, E. (eds.), Language acquisition: Models and methods. London: Academic Press, 1971.
Bogen, J. E.The other side of the brain I: Dysgraphia and dyscopia following cerebral commissurotomy. Bulletin of the Los Angeles Neurological Society. 34:73105. 1969a.
Bogen, J. E.The other side of the brain II: An appositional mind. Bulletin of the Los Angeles Neurological Society. 34:135–62. 1969b.
Bogen, J. E. & Bogen, G. M.The other side of the brain III: The corpus callosum and creativity. Bulletin of the Los Angeles Neurological Society. 34:191220. 1969.
Braitenberg, V., & Kemali, N.Exceptions to bilateral symmetry in the epithalamus of lower vertebrates. Journal of Comparative Neurology. 138:137–46. 1970.
Broca, P.Sur la faculte du langage articulé. Bulletin of Social Anthropology. 6:493–94. 1865.
Carey, S., & Diamond, R.From piecemeal to configurational representation of faces. Science. 195:312–14. 1977.
Carmichael, E. A.Hemispherectomy and the localization of function. Lectures on the Scientific Basis of Medicine, 3:93103. 1953–54.
Chan, K. S. F., Hsu, F. K., Chan, S. T., & Chan, Y. B.Scrotal asymmetry and handedness. Journal of Anatomy. 94:543–48. 1960.
Chaney, R. B., & Webster, J. C.Information in certain multidimensional sounds. Journal of the Acoustical Society of America. 40:449–55. 1966.
Cheung, T. S.A biostatistical study of the functional consistency in the reversed claws of the adult male stone crabs. Menippe mercenaria (Say). Crustaceana. 31:137–44. 1976.
Child, C. M.Patterns and problems of development. Chicago, Ill.: University of Chicago Press, 1941.
Chorazyna, H.Shifts in laterality in a baby chimpanzee. Neuropsychologia. 14:381–84. 1976.
Collins, R. L. The sound of one paw clapping: An inquiry into the origin of left-handedness. In: Lindzey, G. & Thiessen, D. D. (eds.), Contributions to behavior-genetic analysis - The mouse as a prototype. New York: Meredith Corporation, 1970.
Collins, R. L., & Ward, R.Evidence for an asymmetry of cerebral function in mice tested for audiogenic seizures. Nature: 226:1062–63. 1970.
Corballis, M. C., & Beale, I. L.Bilateral symmetry and behavior. Psychological Review. 77:451–64. 1970.
Corballis, M. C., The psychology of left and right. Hillsdale, N.J.: Lawrence Erlbaum Associates, 1976.
Crowell, D. H., Jones, R. H., Kapuniai, L. E., & Nakagawa, J. K.Unilateral cortical activity in newborn humans: An early index of cerebral dominance? Science. 180:205–8. 1973.
Curry, F.A comparison of left-handed and right-handed subjects on verbal and nonverbal dichotic listening tasks. Cortex. 3:343–52. 1967.
Davidoff, J.Hemispheric sensitivity differences in the perception of colour. Quarterly Journal of Experimental Psychology. 28:387–94. 1976.
Dennis, M., & Komi, B.Comprehension of syntax in infantile hemiplegics after cerebral hemidecortication: Left hemisphere superiority. Brain & Language. 2:472–82. 1975.
Dennis, M., & Whitaker, H. A.Language acquisition following hemidecortication: Linguistic superiority of the left over the right hemisphere. Brain & Language. 3:404–33. 1976.
Dimond, S. J., & Beaumont, J. G.Hemisphere function in the human brain. New York: Wiley, 1974.
Durnford, M., & Kimura, D.Right hemisphere specialization for depth perception reflected in visual field differences. Nature. 231:394–95. 1971.
Eccles, J. C.The brain and the unity of conscious experience. 19th Eddington Memorial Lecture. London: Cambridge University Press, 1965.
Eccles, J. C.The understanding of the brain. New York: McGraw-Hill, 1973.
Entus, A. K. Hemisphere asymmetry in processing of dichotically presented speech and nonspeech by infants. In: Segalowitz, S. J. & Gruber, F. (eds.), Language development and neurological theory. New York: Academic Press, 1977.
Finch, G.Chimpanzee handedness. Science. 94:117–18. 1941.
Friedman, H., & Davis, M.Left handedness in parrots. Auk. 55:478–80. 1938.
Gardiner, M. F., & Walter, D. O. Evidence of hemispheric specialization from infant EEG. In: Hamad, S. R., Doty, R. W., Goldstein, L., Jaynes, J., & Krauthamer, G. (eds.), Lateralization in the nervous system. New York: Academic Press, 1977.
Gazzaniga, M. S., Bogen, J. E., & Sperry, R. W.Dyspraxia following division of the cerebral commissures. Archives of Neurology. 16:606–12. 1967.
Geffen, G., Bradshaw, J. L., & Wallace, G.Interhemispheric effects on reaction time to verbal and nonverbal stimuli. Journal of Experimental Psychology. 87:415–22. 1971.
Geffner, D. S., & Hochberg, I.Ear laterality performance of children from low and middle socioeconomic levels on a verbal dichotic listening task. Cortex. 7:193203. 1971.
Geschwind, N.The apraxias: Neural mechanisms of disorders of learned movement. American Scientist. 63:188–95. 1976.
Geschwind, N., & Levitsky, W.Human brain: Left-right asymmetries in temporal speech region. Science. 161:186–87. 1968.
Gesell, A., & Ames, L. B.The development of handedness. Journal of Genetic Psychology. 70:155–75. 1947.
Goldsmith, O.A history of the earth and animated nature. Glasgow: Blackie and Son, 1862.
Gordon, H. W.Hemispheric asymmetries in the perception of musical chords. Cortex. 6:387–98. 1970.
Groves, C. P., & Humphrey, N. K.Asymmetry in gorilla skulls: Evidence of lateralized brain function? Nature. 244:5354. 1973.
Hammer, M., & Turkewitz, G.A sensory basis for the lateral difference in the newborn infant's responses to somesthetic stimulation. Journal of Experimental Child Psychology. 18:304–12. 1974.
Hécaen, H., & Sauguet, J.Cerebral dominance in left-handed subjects. Cortex. 7:1948. 1971.
Horstadius, S.Experimental embryology of echinoderms. Oxford: Clarendon, 1973.
Ingram, D.Cerebral speech lateralization in young children. Neuropsychologia. 13:103–6. 1975.
Jackson, J. H.Abstract of the Goulstonian lectures on certain points in the study and classification of diseases of the nervous system. Lancet. 1:344. 1869.
Jacob, F., & Monod, J.Genetic regulatory mechanisms and the synthesis of proteins. Journal of Molecular Biology. 3:318–56. 1961.
Kallman, H. J., & Corballis, M. C.Ear asymmetry in reaction time to musical sounds. Perception ir Psychophysics. 17:368–70. 1975.
Kimura, D.Left-right differences in the perception of melodies. Quarterly Journal of Experimental Psychology. 16:355–58. 1964.
Kimura, D.Functional asymmetry of the brain in dichotic listening. Cortex. 3:163–78. 1967.
Kimura, D.Spatial localization in left and right visual fields. Canadian Journal of Psychology. 23:445–58. 1969.
Kinsbourne, M., & Smith, W. L. (eds.). Hemispheric disconnection and cerebral function. Springfield, III: Charles C. Thomas, 1974.
Kohn, B., & Dennis, M. Patterns of hemispheric specialization after hemidecortication for infantile hemiplegia. In: Kinsbourne, M. & Smith, W. L. (eds.), Hemispheric disconnection and cerebral function. Springfield, Ill.: Charles C. Thomas, 1974.
Krynauw, R. A.Infantile hemiplegia treated by removing one cerebral hemisphere. Journal of Neurology, Neurosurgery, & Psychiatry. 13:243–67. 1950.
Layton, W. M.Random determination of a developmental process: Reversal of normal visceral asymmetry in the mouse. Journal of Heredity. 67:336–38. 1976.
LeMay, M. Cerebral asymmetries in nonhuman primates, Neanderthal man, and modern man. In: Hamad, S. R., Steklis, H. D., & Lancaster, J. B. (eds.), Origins and evolution of language and speech. Annals of the New York Academy of Sciences 280, 1976.
LeMay, M., & Geschwind, N.Hemispheric differences in the brains of great apes. Brain, Behavior, & Evolution. 11:4852. 1975.
Lemon, R. E.Nervous control of the syrinx in white-throated sparrows (Zonotrichia albicollis). Journal of Zoology, London. 71:131–40. 1973.
Lenneberg, E.Biological foundations of language. New York: Wiley, 1967.
Lepori, N. G.Sur la genèse des structures asymetriques chez l'embryon des oiseaux. Monitore Zoologico Italiano. 3:3353. 1969.
Levy, J., & Nagylaki, T.A model for the genetics of handedness. Genetics. 72:117–28. 1972.
Levy, J., & Trevarthen, C.Metacontrol of hemispheric function in human split-brain patients. Journal of Experimental Psychology: Human Perception & Performance: 2:229312. 1976.
Milner, B.Interhemispheric differences in the localization of psychological processes in man. British Medical Bulletin. 27:272–77. 1971.
Milner, B. Psychological aspects of focal epilepsy and its neurosurgical management. In: Purpura, D. P., Penry, J. K., & Walter, R. D. (eds.), Advances in neurology, Vol. 8. New York: Raven Press, 1975.
Mittwoch, U. Lateral asymmetry and the function of the mammalian Y chromosome. In: Jones, K. & Brandham, P. E. (eds.), Current chromosome research. Amsterdam: North-Holland Publishing Co., 1976.
Mittwoch, U.To be right is to be born male. New Scientist. 73 (1034):7476. 1917.
Molfese, D. L., Freeman, R. B. Jr., & Palermo, D. S.The ontogeny of brain lateralization for speech and nonspeech sounds. Brain & Language. 2:356–68. 1975.
Morgan, M. J. Embryology and inheritance of asymmetry. In: Hamad, S. R., Doty, R. W., Goldstein, L., Jaynes, J., & Krauthamer, G. (eds.), Lateralization in the nervous system. New York: Academic Press, 1977.
Morgan, M. J., & Corballis, M. C.Scrotal asymmetry and Rodin's dyslexia. Nature. 264:295–96. 1976.
Morgan, M. J., O'Donnell, J. M., & Oliver, R. F.Development of left-right asymmetry in the habenular nuclei of Rana temporaria. Journal of Comparative Neurology. 149:203–14. 1973.
Nottebohm, F.Neural lateralization of vocal control in a passerine bird. I. Song. Journal of Experimental Zoology. 177:229–62. 1971.
Nottebohm, F.Neural lateralization of vocal control in a passerine bird. II. Subsong, calls, and a theory of vocal learning. Journal of Experimental Zoology. 179:2550. 1972.
Nottebohm, F. Asymmetries in neural control of vocalization in the canary. In: Hamad, S. R., Doty, R. W., Goldstein, L., Jaynes, J., & Krauthamer, G. (eds.), Lateralization in the nervous system. New York: Academic Press, 1977.
Oppenheimer, J. M.Asymmetry revisited. American Zoologist. 14:867879. 1974.
Peterson, G. M.Mechanisms of handedness in the rat. Comparative Psychology Mongraphs. 9, No. 46. 1934.
Phippard, D.Hemifield differences in visual perception in deaf and hearing subjects. Neuropsychologia. 15:555–62. 1977.
Rife, D. C.Handedness, with special reference to twins. Genetics. 25:178–86. 1940.
Romer, A. S.The vertebrate body. London: W. B. Saunders, 1962.
Rossi, G. F., & Rosadini, G. Experimental analysis of cerebral dominance in man. In: Millikan, C. H. & Darley, F. L. (eds.), Brain mechanisms underlying speech and language. New York: Grune & Stratton, 1967.
Smith, A.Nondominant hemispherectomy. Neurology. 19:442–45. 1969.
Spemann, H., & Falkenberg, H.Über asymmetrische Entwicklung und Situs inversus bei Zwillingen und Doppelbildungen. Wilhelm Roux Archiv für Entwicklungsmechanik. 45:371422. 1919.
Taylor, D. C. Differential rates of cerebral maturation between sexes and between hemispheres. Lancet. 140–42. 1969 (July 19).
Turkewitz, G., Gordon, E. W., & Birch, H. G.Head-turning in the human neonate: Effect of prandial condition and lateral preference. Journal of Comparative & Physiological Psychology. 59:189–92. 1965.
Turkewitz, G., Moreau, T., Birch, H. G., & Crystal, D.Relationships between prior head position and lateral differences in responsiveness to somesthetic stimulation in the human neonate. Journal of Experimental Child Psychology. 5:548–61. 1967.
Vargha-Khadem, F., & Corballis, M. C.Cerebral asymmetry in infants.Paper presented at the Biennial Meeting of the Society for Research in Child Developmentin New Orleans, Louisiana,March, 1977.
von Kraft, A.Situs inversus beim Alpenmolch (Trifurus alvestris) nach UV-Bestrahlung von Gastrula-Keimen. Wilhelm Roux Archiv für Entwicklungsmechanik. 161:351–74. 1968.
von Woellwarth, C.Experimentelle Untersuchungen über dem Situs inversus der Eingeweide und der Habenula des Zwischenhirns bei Amphibien. Wilhelm Roux Archiv für Entwicklungsmechanik. 144:178256. 1950.
Wada, J. A., Clarke, R., & Hamm, A.Cerebral hemispheric asymmetry in humans. Archives of Neurology. 32:239–46. 1975.
Warren, J. M.In discussion of paper session on “Functional Lateralization of the Brain.”Conference on Evolution and Lateralization of the Brain, New York Academy of Sciences,New York,October, 1977.
Warren, J. M. Handedness and cerebral dominance in monkeys. In: Harnad, S. R., Doty, R. W., Goldstein, L., Jaynes, J., & Krauthamer, G. (eds.), Lateralization in the nervous system. New York: Academic Press, 1977.
Wilhelmi, H.Experimentelle untersuchungen über situs inversus viscerum. Wilhelm Roux Archiv für Entwicklungsmechanik. 48:517532. 1921.
Wilson, E. B.Notes on the reversal of asymmetry in the regeneration of chelae in Alpheus heterochelis. Biological Bulletin (of the Marine Biological Laboratory, Woods Hole, Mass.), 4:197210. 1903.
Witelson, S. F.Hemispheric specialization for linguistic and nonlinguistic tactual perception using a dichotomous stimulation technique. Cortex. 10:317. 1974.
Witelson, S. F.Sex and the single hemisphere: Specialization of the right hemisphere for spatial processing. Science. 193:425–27. 1976.
Witelson, S. F., & Pallie, W.Left hemisphere specialization for language in the newborn: Neuroanatomical evidence of asymmetry. Brain. 96:641–46. 1973.
Yeni-Komshian, G. H., & Benson, D. A.Anatomical study of cerebral asymmetry in the temporal lobe of humans, chimpanzees, and rhesus monkeys. Science. 192:387–89. 1976.
Youngren, O. M., Peek, F. W., & Phillips, R. E.Repetitive vocalizations evoked by local electrical stimulation of avian brains. Brain, Behavior, & Evolution. 9:393421. 1974.
Zangwill, O. L.Cerebral dominance and its relation to psychological function. Edinburgh: Oliver & Boyd, 1960.
Zangwill, O. L.Thought and the brain. British Journal of Psychology. 67:301–14. 1976.
Zollinger, R.Removal of left cerebral hemisphere: Report of a case. Archives of Neurology & Psychiatry. 34:1055–64. 1935.



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