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Studying restoration of brain function with fetal tissue grafts: Optimal models

  • Rae Silver (a1) and Joseph LeSauter (a1)
Abstract
Abstract

We concur that basic research on the use of CNS grafts is needed. Two important model systems for functional studies of grafts are ignored by Stein & Glasier. In the first, reproductive function is restored in hypogonadal mice by transplantation of GnRH-synthesizing neurons. In the second, circadian rhythmicity is restored by transplantation of the suprachiasmatic nucleus.

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References
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E. O. Backlund , P. -O. Granberg , B. Hamberger , G. Sedwall , A. Seiger & L. Olson (1985) Transplantation of adrenal medullary tissue to striatum in Parkinsonism. In: Neural grafting in the mammalian CNS, ed. A. Björklund & U. Stenevi . Elsevier . [aDGS]

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E. A. Neuwelt (1989) Implications of the blood-brain barrier and its manipulation. Vol. I: Basic science aspects. Vol. 2: Clinical aspects. Plenum. aEAN

D. G. Stein & B. A. Sabel (1988) Pharmacological, approaches to the treatment of brain and spinal cord injury. Plenum Press. [arDGS]

D. G. Stein & B. A. Sabel (1988) Pharmacological, approaches to the treatment of brain and spinal cord injury. Plenum Press. [arDGS]

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Behavioral and Brain Sciences
  • ISSN: 0140-525X
  • EISSN: 1469-1825
  • URL: /core/journals/behavioral-and-brain-sciences
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