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Identification of biomarkers for vascular dementia: a literature review

Published online by Cambridge University Press:  15 February 2023

Qutub Jamali Open the ORCID record for Qutub Jamali [Opens in a new window] ,
Akinloye Akinfala Open the ORCID record for Akinloye Akinfala [Opens in a new window]  and
Amulya Upendram Open the ORCID record for Amulya Upendram [Opens in a new window]
Qutub Jamali*
Affiliation:
Specialist grade doctor in old age psychiatry with Lancashire and South Cumbria NHS Foundation Trust, Preston, UK.
Akinloye Akinfala
Affiliation:
Specialty registrar in the psychiatry of learning disability with Lancashire and South Cumbria NHS Foundation Trust, Preston, UK.
Amulya Upendram
Affiliation:
Foundation Year-2 Doctor with MediCiti Institute of Medical Sciences, Ghanpur, India.
*
Correspondence Dr Qutub Jamali. Email: qutub.jamali@lscft.nhs.uk
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Summary

Alzheimer's disease and vascular dementia are the two most common types of dementia. It becomes difficult to distinguish between the two, especially when there are no specific genetic causes or vascular changes apparent. The aim of this review was to identify specific biomarkers supporting the diagnosis of vascular dementia by conducting a literature search for systematic reviews and observational studies. We found seven studies meeting our inclusion/exclusion criteria, and from these we identified four specific biomarkers supporting the diagnosis of vascular dementia: high levels of thyroid-stimulating hormone, lipoprotein(a), homocysteine and N-terminal prosomatostatin. However, the studies were small and a well-conducted study with larger populations is recommended to strengthen the evidence base.

Keywords

Dementiabiomarkershomocysteinethyroid-stimulating hormonelipoprotein
Type
Article
Information
BJPsych Advances , Volume 30 , Issue 2 , March 2024 , pp. 89 - 96
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Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of Royal College of Psychiatrists

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