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Lurasidone: a novel antipsychotic agent for the treatment of schizophrenia and bipolar depression

  • Antony Loebel (a1) and Leslie Citrome (a2)
Summary

Lurasidone is a novel antipsychotic agent approved for the treatment of schizophrenia in a number of countries including the UK, and is also approved in the USA and Canada for the treatment of major depressive episodes associated with bipolar I disorder as either a monotherapy or adjunctive therapy with lithium or valproate. In addition to full antagonist activity at dopamine D2 (K i(D2) = 1 nM) and serotonin 5-HT2A (K i(5-HT2A) = 0.5 nM) receptors, the pharmacodynamic profile of lurasidone is notable for its high affinity for serotonin 5-HT7 receptors (K i(5-HT7) = 0.5 nM) and its partial agonist activity at 5-HT1A receptors (K i(5-HT1A) = 6.4 nM). Long-term treatment of schizophrenia with lurasidone has been shown to reduce the risk of relapse. Lurasidone appears associated with minimal effects on body weight and low risk for clinically meaningful alterations in glucose, lipids or electrocardiogram parameters.

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Copyright
This is an open-access article published by the Royal College of Psychiatrists and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Corresponding author
Correspondence to: Leslie Citrome (citrome@cnsconsultant.com)
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Declaration of interest

A.L. is a full-time employee of Sunovion Pharmaceuticals. In the past 12 months, L.C. was a consultant for, has received honoraria from, or has conducted clinical research supported by: Actavis (Forest Laboratories), Alexza Pharmaceuticals, Alkermes, AstraZeneca, Bristol–Myers Squibb, Eli Lilly & Company, Forum Pharmaceuticals, Genentech, Janssen Pharmaceuticals, Jazz Pharmaceuticals, Lundbeck, Medivation, Merck Worldwide, Mylan Laboratories, Novartis Pharmaceuticals, Noven Pharmaceuticals, Otsuka Pharmaceutical Group, Pfizer, Reckitt Benckiser, Reviva Pharmaceuticals, Shire, Sunovion Pharmaceuticals, Takeda Pharmaceutical Company, and Teva Pharmaceutical Industries

Footnotes
References
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Lurasidone: a novel antipsychotic agent for the treatment of schizophrenia and bipolar depression

  • Antony Loebel (a1) and Leslie Citrome (a2)
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