Skip to main content
×
×
Home

Generalised joint hypermobility and neurodevelopmental traits in a non-clinical adult population

  • Martin Glans (a1), Susanne Bejerot (a2) and Mats B. Humble (a3)
Abstract
Background

Generalised joint hypermobility (GJH) is reportedly overrepresented among clinical cases of attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and developmental coordination disorder (DCD). It is unknown if these associations are dimensional and, therefore, also relevant among non-clinical populations.

Aims

To investigate if GJH correlates with sub-syndromal neurodevelopmental symptoms in a normal population.

Method

Hakim-Grahame's 5-part questionnaire (5PQ) on GJH, neuropsychiatric screening scales measuring ADHD and ASD traits, and a DCD-related question concerning clumsiness were distributed to a non-clinical, adult, Swedish population (n=1039).

Results

In total, 887 individuals met our entry criteria. We found no associations between GJH and sub-syndromal symptoms of ADHD, ASD or DCD.

Conclusions

Although GJH is overrepresented in clinical cases with neurodevelopmental disorders, such an association seems absent in a normal population. Thus, if GJH serves as a biomarker cutting across diagnostic boundaries, this association is presumably limited to clinical populations.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Generalised joint hypermobility and neurodevelopmental traits in a non-clinical adult population
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Generalised joint hypermobility and neurodevelopmental traits in a non-clinical adult population
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Generalised joint hypermobility and neurodevelopmental traits in a non-clinical adult population
      Available formats
      ×
Copyright
This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.
Corresponding author
Susanne Bejerot, School of Medical Sciences, Örebro University, SE-70182 Örebro, Sweden. E-mail: susanne.bejerot@oru.se
Footnotes
Hide All

Declaration of interest

None.

Footnotes
References
Hide All
1 Juul-Kristensen, B, Schmedling, K, Rombaut, L, Lund, H, Engelbert, RHH. Measurement properties of clinical assessment methods for classifying generalized joint hypermobility: A systematic review. Am J Med Genet Part C Semin Med Genet 2017; 175: 116–47.
2 Castori, M, Colombi, M. Generalized joint hypermobility, joint hypermobility syndrome and Ehlers–Danlos syndrome, hypermobility type. Am J Med Genet Part C Semin Med Genet 2015; 169: 15.
3 Hakim, A, Grahame, R. Joint hypermobility. Best Pract Res Clin Rheumatol 2003; 17: 9891004.
4 Beighton, P, Solomon, L, Soskolne, CL. Articular mobility in an African population. Ann Rheum Dis 1973; 32: 413–8.
5 Hakim, AJ, Grahame, R. A simple questionnaire to detect hypermobility: an adjunct to the assessment of patients with diffuse musculoskeletal pain. Int J Clin Pract 2003; 57: 163–6.
6 Sinibaldi, L, Ursini, G, Castori, M. Psychopathological manifestations of joint hypermobility and joint hypermobility syndrome/Ehlers–Danlos syndrome, hypermobility type: the link between connective tissue and psychological distress revised. Am J Med Genet Part C Semin Med Genet 2015; 169: 97106.
7 Baeza-Velasco, C, Pailhez, G, Bulbena, A, Baghdadli, A. Joint hypermobility and the heritable disorders of connective tissue: clinical and empirical evidence of links with psychiatry. Gen Hosp Psychiatry 2015; 37: 2430.
8 Bulbena, A, Baeza-Velasco, C, Bulbena-Cabré, A, Pailhez, G, Critchley, H, Chopra, P, et al . Psychiatric and psychological aspects in the Ehlers–Danlos syndromes. Am J Med Genet Part C Semin Med Genet 2017; 175: 237–45.
9 Celletti, C, Mari, G, Ghibellini, G, Celli, M, Castori, M, Camerota, F. Phenotypic variability in developmental coordination disorder: clustering of generalized joint hypermobility with attention deficit/hyperactivity disorder, atypical swallowing and narrative difficulties. Am J Med Genet Part C Semin Med Genet 2015; 169: 117–22.
10 Baeza-Velasco, C, Grahame, R, Bravo, JF. A connective tissue disorder may underlie ESSENCE problems in childhood. Res Dev Disabil 2016; 60: 232–42.
11 Bulbena, A, Agulló, A, Pailhez, G, Martín-Santos, R, Porta, M, Guitart, J, et al . Is joint hypermobility related to anxiety in a nonclinical population also? Psychosomatics 2004; 45: 432–7.
12 Sanches, SB, Osório, FL, Louzada-Junior, P, Moraes, D, Crippa, JAS, Martín-Santos, R. Association between joint hypermobility and anxiety in Brazilian university students: gender-related differences. J Psychosom Res 2014; 77: 558–61.
13 Mallorquí-Bagué, N, Garfinkel, SN, Engels, M, Eccles, JA, Pailhez, G, Bulbena, A, et al. Neuroimaging and psychophysiological investigation of the link between anxiety, enhanced affective reactivity and interoception in people with joint hypermobility. Front Psychol 2014; 5: 1162.
14 Plenty, S, Bejerot, S, Eriksson, K. Humor style and motor skills: understanding vulnerability to bullying. Eur J Psychol 2014; 10: 480–91.
15 Bejerot, S, Plenty, S, Humble, A, Humble, MB. Poor motor skills: a risk marker for bully victimization. Aggress Behav 2013; 39: 453–61.
16 Hakim, AJ, Cherkas, LF, Grahame, R, Spector, TD, MacGregor, AJ. The genetic epidemiology of joint hypermobility: a population study of female twins. Arthritis Rheum 2004; 50: 2640–4.
17 Kessler, RC, Adler, L, Ames, M, Demler, O, Faraone, S, Hiripi, E, et al. The World Health Organization Adult ADHD Self-Report Scale (ASRS): a short screening scale for use in the general population. Psychol Med 2005; 35: 245–56.
18 Fasmer, OB, Halmøy, A, Oedegaard, KJ, Haavik, J. Adult attention deficit hyperactivity disorder is associated with migraine headaches. Eur Arch Psychiatry Clin Neurosci 2011; 261: 595602.
19 Allison, C, Auyeung, B, Baron-Cohen, S. Toward brief ‘red flags’ for autism screening: the short Autism Spectrum Quotient and the short Quantitative Checklist in 1,000 cases and 3,000 controls. J Am Acad Child Adolesc Psychiatry 2012; 51: 202–12.
20 Baron-Cohen, S, Wheelwright, S, Skinner, R, Martin, J, Clubley, E. The autism-spectrum quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. J Autism Dev Disord 2001; 31: 517.
21 Murray, AL, Booth, T, McKenzie, K, Kuenssberg, R. What range of trait levels can the autism-spectrum quotient (AQ) measure reliably? An item response theory analysis. Psychol Assess 2016; 28: 673–83.
22 Insel, TR. The NIMH Research Domain Criteria (RDoC) Project: precision medicine for psychiatry. Am J Psychiatry 2014; 171: 395–7.
23 Kapur, S, Phillips, AG, Insel, TR. Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it? Mol Psychiatry 2012; 17: 1174–9.
24 Cederlöf, M, Larsson, H, Lichtenstein, P, Almqvist, C, Serlachius, E, Ludvigsson, JF. Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers–Danlos syndrome or hypermobility syndrome and their siblings. BMC Psychiatry 2016; 16: 207.
25 Malfait, F, Francomano, C, Byers, P, Belmont, J, Berglund, B, Black, J, et al. The 2017 international classification of the Ehlers–Danlos syndromes. Am J Med Genet Part C Semin Med Genet 2017; 175: 826.
26 Eccles, JA, Beacher, FDC, Gray, MA, Jones, CL, Minati, L, Harrison, NA, et al . Brain structure and joint hypermobility: relevance to the expression of psychiatric symptoms. Br J Psychiatry 2012; 200: 508–9.
27 Gazit, Y, Nahir, AM, Grahame, R, Jacob, G. Dysautonomia in the joint hypermobility syndrome. Am J Med 2003; 115: 3340.
28 Cairney, J, Veldhuizen, S, Szatmari, P. Motor coordination and emotional–behavioral problems in children. Curr Opin Psychiatry 2010; 23: 324–9.
29 Bejerot, S, Humble, MB. Childhood clumsiness and peer victimization: a case–control study of psychiatric patients. BMC Psychiatry 2013; 13: 68.
30 Bulbena, A, Duró, JC, Porta, M, Faus, S, Vallescar, R, Martín-Santos, R. Clinical assessment of hypermobility of joints: assembling criteria. J Rheumatol 1992; 19: 115–22.
31 Moraes, DA De, Baptista, CA, Alexandre, J, Crippa, S, Louzada-Junior, P. Translation into Brazilian Portuguese and validation of the five-part questionnaire for identifying hypermobility. Rev Bras Reumatol 2011; 51: 5369.
32 Kessler, RC, Berglund, P, Demler, O, Jin, R, Koretz, D, Merikangas, KR, et al . The epidemiology of major depressive disorder. JAMA 2003; 289: 3095.
33 Moffitt, TE, Caspi, A, Taylor, A, Kokaua, J, Milne, BJ, Polanczyk, G, et al. How common are common mental disorders? Evidence that lifetime prevalence rates are doubled by prospective versus retrospective ascertainment. Psychol Med 2010; 40: 899909.
34 Bulbena, A, Mallorquí-Bagué, N, Pailhez, G, Rosado, S, González, I Blanch-Rubió, J, et al. Self-reported screening questionnaire for the assessment of Joint Hypermobility Syndrome (SQ-CH), a collagen condition, in Spanish population. Eur J Psychiatry 2014; 28: 1726.
35 Remvig, L, Jensen, DV, Ward, RC. Epidemiology of general joint hypermobility and basis for the proposed criteria for benign joint hypermobility syndrome: review of the literature. J Rheumatol 2007; 34: 804–9.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

BJPsych Open
  • ISSN: -
  • EISSN: 2056-4724
  • URL: /core/journals/bjpsych-open
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×
Type Description Title
PDF
Supplementary materials

Glans et al. supplementary material
Supplementary Material

 PDF (195 KB)
195 KB

Metrics

Altmetric attention score

Generalised joint hypermobility and neurodevelopmental traits in a non-clinical adult population

  • Martin Glans (a1), Susanne Bejerot (a2) and Mats B. Humble (a3)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *