1Robinson, DG, Woerner, MG, McMeniman, M, Mendelowitz, A, Bilder, RM. Symptomatic and functional recovery from a first episode of schizophrenia or schizoaffective disorder. Am J Psychiatry 2004; 161: 473–9.
2Robinson, D, Woerner, M, Alvir, J, Bilder, R, Goldman, R, Geisler, S. Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder. Arch Gen Psychiatry 1999; 56: 241–7.
3Kane, J. Treatment strategies to prevent relapse and encourage remission. J Clin Psychiatry 2007; 68(suppl 14): 27–30.
4Emsley, R, Chiliza, B, Asmal, L, Harvey, B. The nature of relapse in schizophrenia. BMC Psychiatry 2013; 13: 50.
5Lieberman, JA, Alvir, JM, Koreen, A, Geisler, S, Chakos, M, Sheitman, BB, et al. Psychobiologic correlates of treatment response in schizophrenia. Neuropsychopharmacol 1996; 14: 13S–21S.
6National Institute for Health and Care Excellence. Psychosis and Schizophrenia in Adults: Treatment and Management. National Institute for Health and Care Excellence, 2014.
7Early Psychosis Guidelines Writing Group and EPPIC National Support Program. Australian Clinical Guidelines for Early Psychosis (2nd edn, update). Orygen, The National Centre of Excellence in Youth Mental Health, 2016.
8Wunderink, L, Nieboer, RM, Wiersma, D, Sytema, S, Nienhuis, FJ. Recovery in remitted first-episode psychosis at 7 years of follow-up of an early dose reduction/discontinuation or maintenance treatment strategy: long-term follow-up of a 2-year randomized clinical trial. JAMA Psychiatry 2013; 70: 913–20.
9Gaebel, W, Riesbeck, M, Wolwer, W, Klimke, A, Eickhoff, M, Von, W. Relapse prevention in first-episode schizophrenia-maintenance vs intermittent drug treatment with prodrome-based early intervention: results of a randomized controlled trial within the German Research Network on Schizophrenia. J Clin Psychiatry 2011; 72: 205–18.
10Ho, B-C, Andreasen, NC, Ziebell, S, Pierson, R, Magnotta, V. Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia. Arch Gen Psychiatry 2011; 68: 128–37.
11Thompson, A, Singh, S, Birchwood, M. Views of early psychosis clinicians on discontinuation of antipsychotic medication following symptom remission in first episode psychosis. Early Interv Psychiatry 2016; 10: 355–61.
12Hogman, G, Sandamas, G. A Question of Choice. National Schizophrenia Fellowship, 2001.
13Zipursky, RB, Menezes, NM, Streiner, DL. Risk of symptom recurrence with medication discontinuation in first-episode psychosis: a systematic review. Schizophr Res 2014; 152: 408–14.
14Leucht, S, Tardy, M, Komossa, K, Heres, S, Kissling, W, Davis, JM. Maintenance treatment with antipsychotic drugs for schizophrenia. Cochrane Database Syst Rev 2012; 5: Cd008016.
15Leucht, S, Tardy, M, Komossa, K, Heres, S, Kissling, W, Salanti, G. Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis. Lancet 2012; 379: 2063–71.
16De Hert, M, Sermon, J, Geerts, P, Vansteelandt, K, Peuskens, J, Detraux, J. The use of continuous treatment versus placebo or intermittent treatment strategies in stabilized patients with schizophrenia: a systematic review and meta-analysis of randomized controlled trials with first- and second-generation antipsychotics. CNS Drugs 2015; 29: 637–58.
17Karson, C, Duffy, RA, Eramo, A, Nylander, AG, Offord, SJ. Long-term outcomes of antipsychotic treatment in patients with first-episode schizophrenia: a systematic review. Neuropsychiatr Dis Treat 2016; 12: 57–67.
18McGorry, P, Alvarez-Jimenez, M, Killackey, E. Antipsychotic medication during the critical period following remission from first-episode psychosis: less is more. JAMA Psychiatry 2013; 70: 898–900.
19Murray, RM, Quattrone, D, Natesan, S, van Os, J, Nordentoft, M, Howes, O, et al. Should psychiatrists be more cautious about the long-term prophylactic use of antipsychotics? Brit J Psychiatry 2016; 209: 361–5.
20Henry, LP, Amminger, GP, Harris, MG, Yuen, HP, Harrigan, SM, Prosser, AL, et al. The EPPIC follow-up study of first-episode psychosis: longer-term clinical and functional outcome 7 years after index admission. J Clin Psychiatry 2010; 71: 716–28.
21Moncrieff, J. Does antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivity psychosis) and withdrawal-related relapse. Acta Psychiatr Scand 2006; 114: 3–13.
22Wunderink, L, Nienhuis, F, Sytema, S, Slooff, C, Knegtering, R, Wiersma, D. Guided discontinuation versus maintenance treatment in remitted first-episode psychosis: relapse rates and functional outcome. J Clin Psychiatry 2007; 68: 654–61.
23Gaebel, W, Janner, M, Frommann, N, Pietzcker, A, Kopcke, W, Linden, M, et al. First vs multiple episode schizophrenia: two-year outcome of intermittent and maintenance medication strategies. Schizophr Res 2002; 53: 145–59.
24Higgins, JP, Altman, DG, Gotzsche, PC, Juni, P, Moher, D, Oxman, AD, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011; 343: d5928.
25Moher, D, Liberati, A, Tetzlaff, J, Altman, DG, Group, P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. Open Med 2009; 3: e123–30.
26Heyn, P, Abreu, BC, Ottenbacher, KJ. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil 2004; 85: 1694–704.
27Kane, J, Rifkin, A, Quitkin, F, Nayak, D, Ramos-Lorenzi, J. Fluphenazine vs placebo in patients with remitted, acute first-episode schizophrenia. Arch Gen Psychiatry 1982; 39: 70–73.
28Crow, T, MacMillan, J, Johnson, A, Johnstone, E. A randomised controlled trial of prophylactic neuroleptic treatment. Br J Psychiatry 1986; 148: 120–7.
29McCreadie, RG, Wiles, D, Grant, S, Crockett, GT, Mahmood, Z, Livingston, MG, et al. The Scottish first episode schizophrenia study. VII. Two-year follow-up. Scottish Schizophrenia Research Group. Acta Psychiatr Scand 1989; 80: 597–602.
30Chen, E, Hui, C, Lam, M, Chiu, C, Law, C, Chung, D. Maintenance treatment with quetiapine versus discontinuation after one year of treatment in patients with remitted first episode psychosis: randomised controlled trial. BMJ 2010; 341: c4024.
31Boonstra, G, Burger, H, Grobbee, D, Kahn, R. Antipsychotic prophylaxis is needed after remission from a first psychotic episode in schizophrenia patients: results from an aborted randomised trial. Int J Psychiatry Clin Pract 2011; 15: 128–34.
32Leucht, S, Barnes, TR, Kissling, W, Engel, RR, Correll, C, Kane, JM. Relapse prevention in schizophrenia with new-generation antipsychotics: a systematic review and exploratory meta-analysis of randomized, controlled trials. Am J Psychiatry 2003; 160: 1209–22.
33Rich, JT, Neely, JG, Paniello, RC, Voelker, CC, Nussenbaum, B, Wang, EW. A practical guide to understanding Kaplan-Meier curves. Otolaryngol Head Neck Surg 2010; 143: 331–6.
34Sterne, JA, Bradburn, MJ, Egger, M. Meta–Analysis in Stata™ Systematic Reviews in Health Care: Meta-Analysis in Context (2nd edn). BMJ Books, 2001, pp. 347–69.
35Field, AP, Gillett, R. How to do a meta-analysis. Br J Math Stat Psychol 2010; 63: 665–94.
36Nyaga, V, Arbyn, M, Aerts, M. Metaprop: a Stata command to perform meta-analysis of binomial data. Arch Public Health 2014; 72: 39.
37Gleeson, JF, Alvarez-Jimenez, M, Cotton, SM, Parker, AG, Hetrick, S. A systematic review of relapse measurement in randomized controlled trials of relapse prevention in first-episode psychosis. Schizophr Res 2010; 119: 79–88.
38Higgins, JPT, Green, S (eds). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011.
39Winsper, C, Ganapathy, R, Marwaha, S, Large, M, Birchwood, M, Singh, SP. A systematic review and meta-regression analysis of aggression during the first episode of psychosis. Acta Psychiatr Scand 2013; 128: 413–21.
40Slade, M, Amering, M, Farkas, M, Hamilton, B, O'Hagan, M, Panther, G, et al. Uses and abuses of recovery: implementing recovery-oriented practices in mental health systems. World Psychiatry 2014; 13: 12–20.
41Rifkin, A, Quitkin, F, Rabiner, CJ, Klein, DF. Fluphenazine decanoate, fluphenazine hydrochloride given orally, and placebo in remitted schizophrenics. I. Relapse rates after one year. Arch Gen Psychiatry 1977; 34: 43–7.
42Pietzcker, A, Gaebel, W, Köpcke, W, Linden, M, Müller, P, Müller-Spahn, F, et al. Intermittent versus maintenance neuroleptic long-term treatment in Schizophrenia—2-year results of a German multicenter study. J Psychiatr Res 1993; 27: 321–39.
43Hogarty, GE, Goldberg, SC. Drug and sociotherapy in the aftercare of schizophrenic patients; one year relapse rates. Arch Gen Psychiatry 1973; 28: 54–64.
44Emsley, R, Oosthuizen, P, Koen, L, Niehaus, D, Martinez, L. Symptom recurrence following intermittent treatment in first episode schizophrenia successfully treated for two years. J Clin Psychiatry 2012; 73: e541–7.
45Gitlin, M, Nuechterlein, K, Subotnik, K, Ventura, J, Mintz, J, Fogelson, D. Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia. Am J Psychiatry 2001; 158: 1835–42.
46Sturup, AE, Jensen, HD, Dolmer, S, Birk, M, Albert, N, Nielsen, M, et al. TAILOR – tapered discontinuation versus maintenance therapy of antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder in remission of psychotic symptoms: study protocol for a randomized clinical trial. Trials 2017; 18: 445.
47Killackey, E. Dose reduction, relapse and functional recovery in first episode psychosis. Aust N Z J Psychiatry 2017; 51: 638–9.
48Sterne, JAC, Egger, M, Smith, GD. Investigating and dealing with publication and other biases in meta-analysis. BMJ 2001; 323: 101–5.
49Alvarez-Jimenez, M, O'Donoghue, B, Thompson, A, Gleeson, JF, Bendall, S, Gonzalez-Blanch, C, et al. Beyond clinical remission in first Episode psychosis: Thoughts on antipsychotic maintenance vs. guided discontinuation in the functional recovery era. CNS Drugs 2016; 30: 357–68.
50Gardos, G, Cole, JO. Maintenance antipsychotic therapy: is the cure worse than the disease? Am J Psychiatry 1976; 133: 32–6.
51Alvarez-Jimenez, M, Gleeson, JF, Henry, LP, Harrigan, SM, Harris, MG, Amminger, GP, et al. Prediction of a single psychotic episode: a 7.5-year, prospective study in first-episode psychosis. Schizophr Res 2011; 125: 236–46.
52Gaebel, W, Riesbeck, M, Wölwer, W, Klimke, A, Eickhoff, M, von Wilmsdorff, M, et al. Predictors for symptom re-exacerbation after targeted stepwise drug discontinuation in first-episode schizophrenia: results of the first-episode study within the German research network on schizophrenia. Schizophr Res 2016; 170: 168–76.