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Neuroticism and suicide in a general population cohort: results from the UK Biobank Project

  • Evyn M. Peters (a1), Ann John (a2), Rudy Bowen (a1), Marilyn Baetz (a1) and Lloyd Balbuena (a1)...
Abstract
Background

Neuroticism has often been linked to suicidal thoughts and behaviour.

Aims

To examine whether neuroticism is associated with suicide deaths after adjusting for known risks.

Method

UK Biobank participants (n = 389 365) were assessed for neuroticism as well as social, demographic and health-related variables at study entry and followed for up to 10 years. Suicide risk was modelled using Cox regression stratified by gender.

Results

Neuroticism increased the risk of suicide in both men (hazard ratio (HR) = 1.15, 95% CI 1.09–1.22) and women (HR = 1.16, 95% CI 1.06–1.27). In a subsample who were assessed for mood disorders, neuroticism remained a significant predictor for women (HR 1.25, 95% CI 1.03–1.51) but not for men.

Conclusions

Screening and therapeutic interventions for neuroticism may be important for early suicide prevention.

Declaration of interest

None.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
Corresponding author
Correspondence Lloyd Balbuena, Department of Psychiatry, University of Saskatchewan, Saskatoon, SK S7N0W8, Canada. E-mail: lloyd.balbuena@gmail.com
References
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Neuroticism and suicide in a general population cohort: results from the UK Biobank Project

  • Evyn M. Peters (a1), Ann John (a2), Rudy Bowen (a1), Marilyn Baetz (a1) and Lloyd Balbuena (a1)...
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