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The People with Asperger syndrome and anxiety disorders (PAsSA) trial: a pilot multicentre, single-blind randomised trial of group cognitive–behavioural therapy

  • Peter E. Langdon (a1), Glynis H. Murphy (a2), Lee Shepstone (a3), Edward C.F. Wilson (a4), David Fowler (a5), David Heavens (a6), Alexandra Russell (a7), Alice Rose (a8), Aida Malovic (a9) and Louise Mullineaux (a9)...
Abstract
Background

There is a growing interest in using cognitive–behavioural therapy (CBT) with people who have Asperger syndrome and comorbid mental health problems.

Aims

To examine whether modified group CBT for clinically significant anxiety in an Asperger syndrome population is feasible and likely to be efficacious.

Method

Using a randomised assessor-blind trial, 52 individuals with Asperger syndrome were randomised into a treatment arm or a waiting-list control arm. After 24 weeks, those in the waiting-list control arm received treatment, while those initially randomised to treatment were followed up for 24 weeks.

Results

The conversion rate for this trial was high (1.6:1), while attrition was 13%. After 24 weeks, there was no significant difference between those randomised to the treatment arm compared with those randomised to the waiting-list control arm on the primary outcome measure, the Hamilton Rating Scale for Anxiety.

Conclusions

Trials of psychological therapies with this population are feasible. Larger definitive trials are now needed.

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Copyright
This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence (http://creativecommons.org/licenses/by/4.0/).
Corresponding author
Peter Langdon, Tizard Centre, University of Kent, Canterbury CT2 7LR, UK. Email: P.E.Langdon@kent.ac.uk
Footnotes
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Declaration of interest

None.

Copyright and usage

© The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence.

Footnotes
References
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The People with Asperger syndrome and anxiety disorders (PAsSA) trial: a pilot multicentre, single-blind randomised trial of group cognitive–behavioural therapy

  • Peter E. Langdon (a1), Glynis H. Murphy (a2), Lee Shepstone (a3), Edward C.F. Wilson (a4), David Fowler (a5), David Heavens (a6), Alexandra Russell (a7), Alice Rose (a8), Aida Malovic (a9) and Louise Mullineaux (a9)...
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