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Temporal order of cancers and mental disorders in an adult population

  • David Cawthorpe (a1), Marc Kerba (a2), Aru Narendran (a3), Harleen Ghuttora (a4), Gabrielle Chartier (a5) and Norman Sartorius (a6)...
Abstract
Background

Population-based examination of comorbidity is an emerging field of study.

Aims

The purpose of the present population level study is to expand our understanding of how cancer and mental illness are temporally associated.

Method

A sample of 83 648 056 physician billing records for 664 838 (56% female) unique individuals over the age of 18 was stratified on ages 19–49 years and 50+ years, with temporal order of mental disorder and cancer forming the basis of comparison.

Results

Mental disorders preceded cancers for both genders within each age strata. The full range of cancers and mental disorders preceding or following each pivot ICD class are described in terms of frequency of diagnosis and duration in days, with specific examples illustrated.

Conclusions

The temporal comorbidity between specific cancers and mental disorders may be useful in screening or clinical planning and may represent indicators of disease mechanism that warrant further screening or investigation.

Declaration of interest

None.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
Corresponding author
Correspondence: David Cawthorpe, Richmond Road Diagnostic and Treatment Center, 2nd Floor, RM 2603, 1820 Richmond Road S.W. Calgary, Alberta T2T 5C7, Canada. Email: cawthord@ucalgary.ca
References
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1Jakovljevic, M, Ostojic, L. Comorbidity and multimorbidity in medicine today: challenges and opportunities for bringing separated branches of medicine closer to each other. Psychiatr Danub 2013; 25(suppl 1): 1828.
2Feinstein, AR. The pre-therapeutic classification of co-morbidity in chronic disease. J Chronic Dis 1970; 23: 455–68.
3Ahern, TP, Horvath-Puho, E, Spindler, KL, Sorensen, HT, Ording, AG, Erichsen, R. Colorectal cancer, comorbidity, and risk of venous thromboembolism: assessment of biological interactions in a Danish nationwide cohort. Br J Cancer 2016; 114: 96102.
4Alexander, M, Evans, SM, Stirling, RG, Wolfe, R, Officer, A, MacManus, M, et al. The influence of comorbidity and the simplified comorbidity score on overall survival in non-small cell lung cancer – a prospective cohort study. J Thorac Oncol 2016; 11: 748–57.
5Asano, T, Yamada, S, Fujii, T, et al. The Charlson age comorbidity index predicts prognosis in patients with resected pancreatic cancer. Int J Surg 2017; 39: 169–175.
6Baumeister, P, Rauch, J, Jacobi, C, et al. Impact of comorbidity and anemia in patients with oropharyngeal cancer primarily treated with surgery in the human papillomavirus era. Head Neck 2017; 39: 716.
7Boehm, K, Dell'Oglio, P, Tian, Z, et al. Comorbidity and age cannot explain variation in life expectancy associated with treatment of non-metastatic prostate cancer. World J Urol 2016; 35: 1031–6.
8Corraini, P, Ording, AG, Henderson, VW, Szepligeti, S, Horvath-Puho, E, Sorensen, HT. Cancer, other comorbidity, and risk of venous thromboembolism after stroke: a population-based cohort study. Thromb Res 2016; 147: 8893.
9Elshaikh, MA, Vance, S, Kamalignant, M, et al. Influence of comorbidity on the risk of death: a single institution study of 1132 women with early-stage uterine cancer. Am J Clin Oncol 2017; 40: 183–8.
10Gollnitz, I, Inhestern, J, Wendt, TG, et al. Role of comorbidity on outcome of head and neck cancer: a population-based study in Thuringia, Germany. Cancer Med 2016; 5: 3260–71.
11Halvorsen, TO, Sundstrom, S, Flotten, O, et al. Comorbidity and outcomes of concurrent chemo- and radiotherapy in limited disease small cell lung cancer. Acta Oncol 2016; 55: 1349–54.
12Hiyoshi, A, Fall, K, Bergh, C, Montgomery, S. Comorbidity trajectories in working age cancer survivors: a national study of Swedish men. Cancer Epidemiol 2017; 48: 4855.
13Ichikawa, H, Kosugi, SI, Kanda, T, et al. Surgical and long-term outcomes following oesophagectomy in oesophageal cancer patients with comorbidity. Int J Surg 2016; 36: 212–8.
14Kaul, S, Veeranki, SP, Rodriguez, AM, Kuo, YF. Cigarette smoking, comorbidity, and general health among survivors of adolescent and young adult cancer. Cancer 2016; 122: 2895–905.
15Chang, CM, Yin, WY, Wei, CK, et al. Correction: adjusted age-adjusted Charlson comorbidity index score as a risk measure of perioperative mortality before cancer surgery. PLoS One 2016; 11: e0157900.
16Froehner, M, Koch, R, Hubler, M, Wirth, MP. Validation of an age-adjusted prostate cancer-specific comorbidity index. Eur Urol 2016; 69: 764–6.
17Giugliano, FM, Falivene, S, Esposito, E, et al. Short-course radiotherapy in elderly women with breast cancer: comparison by age, comorbidity index and toxicity. Int J Surg 2016; 33(suppl 1): S926.
18Guldberg, TL, Christensen, S, Zachariae, R, Jensen, AB. Prognostic factors in early breast cancer associated with body mass index, physical functioning, physical activity, and comorbidity: data from a nationwide Danish cohort. Breast Cancer Res Treat 2017; 162: 159–67.
19Keshtgarpour, M, Tan, WS, Zwanziger, J, Awadalla, S, Langi, FG, Dudek, AZ. Prognostic value of serum proteomic test and comorbidity index in diversified population with lung cancer. Anticancer Res 2016; 36: 1759–65.
20Lee, JY, Kang, HW, Rha, KH et al. Age-adjusted Charlson comorbidity index is a significant prognostic factor for long-term survival of patients with high-risk prostate cancer after radical prostatectomy: a Bayesian model averaging approach. J Cancer Res Clin Oncol 2016; 142: 849–58.
21Noer, MC, Sperling, CD, Antonsen, SL, Ottesen, B, Christensen, IJ, Hogdall, C. A new clinically applicable age-specific comorbidity index for preoperative risk assessment of ovarian cancer patients. Gynecol Oncol 2016; 141: 471–8.
22Otake, S, Ohtsuka, T, Asakura, K, Kamiyama, I, Kohno, M. Impact of comorbidity index on morbidity and survival in non-small cell lung cancer. Asian Cardiovasc Thorac Ann 2016; 24: 30–3.
23Singh, N, Singh, PS, Aggarwal, AN, Behera, D. Comorbidity assessment using Charlson comorbidity index and simplified comorbidity score and its association with clinical outcomes during first-line chemotherapy for lung cancer. Clin Lung Cancer 2016; 17: 205–13.
24Tanaka, H, Takenaka, Y, Nakahara, S, et al. Age-adjusted Charlson comorbidity index as a prognostic factor of hypopharyngeal cancer treated with chemoradiation therapy. Acta Otolaryngol 2017; 137: 668–73.
25Tian, Y, Xu, B, Yu, G, Li, Y, Liu, H. Age-adjusted Charlson comorbidity index score as predictor of prolonged postoperative ileus in patients with colorectal cancer who underwent surgical resection. Oncotarget 2017; 8: 20794–801.
26Keszte, J, Danker, H, Dietz, A, et al. Course of psychiatric comorbidity and utilization of mental health care after laryngeal cancer: a prospective cohort study. Eur Arch Otorhinolaryngol 2017; 274: 1591–9.
27Ng, HS, Roder, D, Koczwara, B, Vitry, A. Comorbidity, physical and mental health among cancer patients and survivors: an Australian population-based study. Asia Pac J Clin Oncol 2017; DOI: 10.1111/ajco.12677.
28Faller, H, Weis, J, Koch, U, et al. Perceived need for psychosocial support depending on emotional distress and mental comorbidity in men and women with cancer. J Psychosom Res 2016; 81: 2430.
29Nakash, O, Levav, I, Guilar-Gaxiola, S, et al. Comorbidity of common mental disorders with cancer and their treatment gap: findings from the World Mental Health Surveys. Psychooncology 2014; 23: 4051.
30Lu, D, Andersson, TM, Fall, K, et al. Clinical diagnosis of mental disorders immediately before and after cancer diagnosis: a nationwide matched cohort study in Sweden. JAMA Oncol 2016; 2: 1188–96.
31Cawthorpe, D, Davidson, M. Temporal comorbidity of mental disorder and ulcerative colitis. Perm J 2015; 19: 52–7.
32Mantovani, A, Allavena, P, Sica, A, Balkwill, F. Cancer-related inflammation. Nature 2008; 454: 436–44.
33Coussens, LM, Werb, Z. Inflammation and cancer. Nature 2002; 420: 860–7.
34Mantovani, A, Marchesi, F, Porta, C, Sica, A, Allavena, P. Inflammation and cancer: breast cancer as a prototype. Breast 2007; 16(suppl 2): S2733.
35Chiang, AC, Massague, J. Molecular basis of metastasis. N Engl J Med 2008; 359: 2814–23.
36Paul, B, Barnes, S, Mark-Wahnefried, W, et al. Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases. Clin Epigenetics 2015; 7: 112.
37Alam, R, Abdolmaleky, HM, Zhou, JR. Microbiome, inflammation, epigenetic alterations, and mental diseases. Am J Med Genet B Neuropsychiatr Genet 2017; 174: 651–60.
38Batlle, E, Wilkinson, DG. Molecular mechanisms of cell segregation and boundary formation in development and tumorigenesis. Cold Spring Harb Perspect Biol 2012; 4: a008227.
39Zhu, J, Fang, F, Sjolander, A, Fall, K, Adami, HO, Valdimarsdottir, U. First-onset mental disorders after cancer diagnosis and cancer-specific mortality: a nationwide cohort study. Ann Oncol 2017; 28: 1964–9.
40Trakhtenberg, EF, Goldberg, JL. The role of serotonin in axon and dendrite growth. Int Rev Neurobiol 2012; 106: 105–26.
41Kenis, C, Decoster, L, Bastin, J, et al. Functional decline in older patients with cancer receiving chemotherapy: a multicenter prospective study. J Geriatr Oncol 2017; 8: 196205.
42Owusu, C, Margevicius, S, Schluchter, M, Koroukian, SM, Schmitz, KH, Berger, NA. Vulnerable elders survey and socioeconomic status predict functional decline and death among older women with newly diagnosed nonmetastatic breast cancer. Cancer 2016; 122: 2579–86.
43Granger, CL, McDonald, CF, Irving, L, et al. Low physical activity levels and functional decline in individuals with lung cancer. Lung Cancer 2014; 83: 292–9.
44Hoppe, S, Rainfray, M, Fonck, M, et al. Functional decline in older patients with cancer receiving first-line chemotherapy. J Clin Oncol 2013; 31: 3877–82.
45Atlas, A, Grimmer, K, Kennedy, K. Early indications that low mental quality of life scores in recently unwell older people predict downstream functional decline. Clin Interv Aging 2015; 10: 703–12.
46Lee, Y. The predictive value of self assessed general, physical, and mental health on functional decline and mortality in older adults. J Epidemiol Community Health 2000; 54: 123–9.
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Temporal order of cancers and mental disorders in an adult population

  • David Cawthorpe (a1), Marc Kerba (a2), Aru Narendran (a3), Harleen Ghuttora (a4), Gabrielle Chartier (a5) and Norman Sartorius (a6)...
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