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Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: functional MRI study

  • Shinichiro Takiguchi (a1), Takashi X. Fujisawa (a2), Sakae Mizushima (a2), Daisuke N. Saito (a3), Yuko Okamoto (a4), Koji Shimada (a3), Michiko Koizumi (a5), Hirokazu Kumazaki (a2), Minyoung Jung (a2), Hirotaka Kosaka (a6), Michio Hiratani (a7), Yusei Ohshima (a8), Martin H. Teicher (a9) and Akemi Tomoda (a10)...
Abstract
Background

Child maltreatment is a major risk factor for psychopathology, including reactive attachment disorder (RAD).

Aims

To examine whether neural activity during reward processing was altered in children and adolescents with RAD.

Method

Sixteen children and adolescents with RAD and 20 typically developing (TD) individuals performed tasks with high and low monetary rewards while undergoing functional magnetic resonance imaging.

Results

Significantly reduced activity in the caudate and nucleus accumbens was observed during the high monetary reward condition in the RAD group compared with the TD group (P=0.015, family-wise error-corrected cluster level). Significant negative correlations between bilateral striatal activity and avoidant attachment were observed in the RAD and TD groups.

Conclusions

Striatal neural reward activity in the RAD group was markedly decreased. The present results suggest that dopaminergic dysfunction occurs in the striatum of children and adolescents with RAD, leading towards potential future risks for psychopathology.

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Copyright
This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Corresponding author
Akemi Tomoda, Research Center for Child Mental Development, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-cho, Fukui 910-1193, Japan. Email: atomoda@u-fukui.ac.jp
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Declaration of interest

None.

Footnotes
References
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Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: functional MRI study

  • Shinichiro Takiguchi (a1), Takashi X. Fujisawa (a2), Sakae Mizushima (a2), Daisuke N. Saito (a3), Yuko Okamoto (a4), Koji Shimada (a3), Michiko Koizumi (a5), Hirokazu Kumazaki (a2), Minyoung Jung (a2), Hirotaka Kosaka (a6), Michio Hiratani (a7), Yusei Ohshima (a8), Martin H. Teicher (a9) and Akemi Tomoda (a10)...
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