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Adding MUFA to a dietary portfolio of cholesterol-lowering foods reduces apoAI fractional catabolic rate in subjects with dyslipidaemia

  • Marie-Ève Labonté (a1), David J. A. Jenkins (a2), Gary F. Lewis (a3), Laura Chiavaroli (a2), Julia M. W. Wong (a4) (a5), Cyril W. C. Kendall (a2) (a6) (a7), Jean-Charles Hogue (a1), Patrick Couture (a1) and Benoît Lamarche (a1)...
Abstract

The present randomised parallel study assessed the impact of adding MUFA to a dietary portfolio of cholesterol-lowering foods on the intravascular kinetics of apoAI- and apoB-containing lipoproteins in subjects with dyslipidaemia. A sample of sixteen men and postmenopausal women consumed a run-in stabilisation diet for 4 weeks. Subjects were then randomly assigned to an experimental dietary portfolio either high or low in MUFA for another 4 weeks. MUFA substituted 13·0 % of total energy from carbohydrate (CHO) in the high-MUFA dietary portfolio. Lipoprotein kinetics were assessed after the run-in and portfolio diets using a primed, constant infusion of [2H3]leucine and multicompartmental modelling. The high-MUFA dietary portfolio resulted in higher apoAI pool size (PS) compared with the low-MUFA dietary portfolio (15·9 % between-diet difference, P= 0·03). This difference appeared to be mainly attributable to a reduction in apoAI fractional catabolic rate (FCR) after the high-MUFA diet ( − 5·6 %, P= 0·02 v. pre-diet values), with no significant change in production rate. The high-MUFA dietary portfolio tended to reduce LDL apoB100 PS compared with the low-MUFA dietary portfolio ( − 28·5 % between-diet difference, P= 0·09), predominantly through an increase in LDL apoB100 FCR (23·2 % between-diet difference, P= 0·04). These data suggest that adding MUFA to a dietary portfolio of cholesterol-lowering foods provides the added advantage of raising HDL primarily through a reduction in HDL clearance rate. Replacing CHO with MUFA in a dietary portfolio may also lead to reductions in LDL apoB100 concentrations primarily by increasing LDL clearance rate, thus potentiating further the well-known cholesterol-lowering effect of this diet.

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Corresponding author
*Corresponding author: Dr B. Lamarche, fax +1 418 656 5877, email benoit.lamarche@fsaa.ulaval.ca
References
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1Jenkins DJA, Kendall CWC, Marchie A, et al. (2003) Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein. JAMA 290, 502510.
2Jenkins DJA, Kendall CWC, Marchie A, et al. (2003) The effect of combining plant sterols, soy protein, viscous fibers, and almonds in treating hypercholesterolemia. Metabolism 52, 14781483.
3Jenkins DJA, Kendall CWC, Marchie A, et al. (2005) Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants. Am J Clin Nutr 81, 380387.
4Jenkins DJA, Kendall CWC, Faulkner DA, et al. (2006) Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia. Am J Clin Nutr 83, 582591.
5Mensink RP, Zock PL, Kester ADM, et al. (2003) Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 77, 11461155.
6Jansen S, Lopez-Miranda J, Castro P, et al. (2000) Low-fat and high-monounsaturated fatty acid diets decrease plasma cholesterol ester transfer protein concentrations in young, healthy, normolipemic men. Am J Clin Nutr 72, 3641.
7Mensink RP & Katan MB (1987) Effect of monounsaturated fatty-acids versus complex carbohydrates on high-density-lipoproteins in healthy-men and women. Lancet i, 122125.
8Desroches S, Paradis ME, Perusse M, et al. (2004) Apolipoprotein A-I, A-II, and VLDL-B-100 metabolism in men: comparison of a low-fat diet and a high-monounsaturated fatty acid diet. J Lipid Res 45, 23312338.
9Mattson FH & Grundy SM (1985) Comparison of effects of dietary saturated, mono-unsaturated, and poly-unsaturated fatty-acids on plasma-lipids and lipoproteins in man. J Lipid Res 26, 194202.
10Grundy SM (1986) Comparison of monounsaturated fatty-acids and carbohydrates for lowering plasma-cholesterol. N Engl J Med 314, 745748.
11Grundy SM, Florentin L, Nix D, et al. (1988) Comparison of monounsaturated fatty-acids and carbohydrates for reducing raised levels of plasma-cholesterol in man. Am J Clin Nutr 47, 965969.
12Jenkins DJA, Chiavaroli L, Wong JMW, et al. (2010) Adding monounsaturated fatty acids to a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia. Can Med Assoc J 182, 19611967.
13NCEP Expert Panel (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285, 24862497.
14Tremblay AJ, Lamarche B, Ruel I, et al. (2004) Lack of evidence for reduced plasma apo B48 catabolism in patients with heterozygous familial hypercholesterolemia carrying the same null LDL receptor gene mutation. Atherosclerosis 172, 367373.
15Mauger JF, Couture P, Paradis ME, et al. (2005) Comparison of the impact of atorvastatin and simvastatin on apoA-I kinetics in men. Atherosclerosis 178, 157163.
16Havel RJ, Eder HA & Bragdon JH (1955) Distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34, 13451353.
17Kotite L, Bergeron N & Havel RJ (1995) Quantification of apolipoprotein B-100, apolipoprotein B-48, and apolipoprotein-E in human triglyceride-rich lipoproteins. J Lipid Res 36, 890900.
18Zilversmit DB & Shea TM (1989) Quantitation of apoB-48 and apoB-100 by gel scanning or radio-iodination. J Lipid Res 30, 16391646.
19Batal R, Tremblay M, Krimbou L, et al. (1998) Familial HDL deficiency characterized by hypercatabolism of mature apoA-I but not proapoA-I. Arterioscler Thromb Vasc Biol 18, 655664.
20Welty FK, Lichtenstein AH, Barrett PHR, et al. (1999) Human apolipoprotein (apo) B-48 and apoB-100 kinetics with stable isotopes. Arterioscler Thromb Vasc Biol 19, 29662974.
21Dwyer KP, Barrett PHR, Chan D, et al. (2002) Oxazolinone derivative of leucine for GC–MS: a sensitive and robust method for stable isotope kinetic studies of lipoproteins. J Lipid Res 43, 344349.
22Cobelli C, Toffolo G, Bier DM, et al. (1987) Models to interpret kinetic data in stable isotope tracer studies. Am J Physiol 253, E551E564.
23Tremblay AJ, Lamarche B, Hogue JC, et al. (2009) Effects of ezetimibe and simvastatin on apolipoprotein B metabolism in males with mixed hyperlipidemia. J Lipid Res 50, 14631471.
24Welty FK, Lichtenstein AH, Barrett PHR, et al. (1997) Decreased production and increased catabolism of apolipoprotein B-100 in apolipoprotein B-67/B-100 heterozygotes. Arterioscler Thromb Vasc Biol 17, 881888.
25Cohn JS, Wagner DA, Cohn SD, et al. (1990) Measurement of very low-density and low-density-lipoprotein apolipoprotein (apo)-B-100 and high-density-lipoprotein apo-A-I production in human-subjects using deuterated leucine – effect of fasting and feeding. J Clin Invest 85, 804811.
26Abbey M & Nestel PJ (1994) Plasma cholesteryl ester transfer protein-activity is increased when trans-elaidic acid is substituted for cis-oleic acid in the diet. Atherosclerosis 106, 99107.
27Lamarche B, Uffelman KD, Carpentier A, et al. (1999) Triglyceride enrichment of HDL enhances in vivo metabolic clearance of HDL apo A-I in healthy men. J Clin Invest 103, 11911199.
28Osada J, Fernandezsanchez A, Diazmorillo JL, et al. (1991) Hepatic expression of apolipoprotein-A-I gene in rats is up-regulated by monounsaturated fatty-acid diet. Biochem Biophys Res Commun 180, 162168.
29Brinton EA, Eisenberg S & Breslow JL (1990) A low-fat diet decreases high-density lipoprotein (HDL) cholesterol levels by decreasing HDL apolipoprotein transport rates. J Clin Invest 85, 144151.
30Velez-Carrasco W, Lichtenstein AH, Welty FK, et al. (1999) Dietary restriction of saturated fat and cholesterol decreases HDL apoA-I secretion. Arterioscler Thromb Vasc Biol 19, 918924.
31Gill JMR, Brown JC, Caslake MJ, et al. (2003) Effects of dietary monounsaturated fatty acids on lipoprotein concentrations, compositions, and subfraction distributions and on VLDL apolipoprotein B kinetics: dose-dependent effects on LDL. Am J Clin Nutr 78, 4756.
32Daumerie CM, Woollett LA & Dietschy JM (1992) Fatty-acids regulate hepatic low-density-lipoprotein receptor activity through redistribution of intracellular cholesterol pools. Proc Natl Acad Sci U S A 89, 1079710801.
33Kurushima H, Hayashi K, Shingu T, et al. (1995) Opposite effects on cholesterol-metabolism and their mechanisms induced by dietary oleic-acid and palmitic acid in hamsters. Biochim Biophys Acta 1258, 251256.
34Rumsey SC, Galeano NF, Lipschitz B, et al. (1995) Oleate and other long-chain fatty-acids stimulate low-density-lipoprotein receptor activity by enhancing acyl-coenzyme A: cholesterol acyltransferase activity and altering intracellular regulatory cholesterol pools in cultured-cells. J Biol Chem 270, 1000810016.
35Kurushima H, Hayashi K, Toyota Y, et al. (1995) Comparison of hypocholesterolemic effects induced by dietary linoleic-acid and oleic-acid in hamsters. Atherosclerosis 114, 213221.
36Kolovou GD, Anagnostopoulou KK, Daskalopoulou SS, et al. (2005) Clinical relevance of postprandial lipaemia. Curr Med Chem 12, 19311945.
37Jenkins DJ, Jones PJ, Lamarche B, et al. (2011) Effect of a dietary portfolio of cholesterol-lowering foods given at 2 levels of intensity of dietary advice on serum lipids in hyperlipidemia: a randomized controlled trial. JAMA 306, 831839.
38Matthan NR, Jalbert SM, Barrett PHR, et al. (2008) Gender-specific differences in the kinetics of nonfasting TRL, IDL, and LDL apoB-100 in men and premenopausal women. Arterioscler Thromb Vasc Biol 28, 18381843.
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