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1 P Lips (2006) Vitamin D physiology. Prog Biophys Mol Biol 92, 4–8.
2 P Lips (2007) Vitamin D status and nutrition in Europe and Asia. J Steroid Biochem Mol Biol 103, 620–625.
4 M van Driel , M Koedam , CJ Buurman , (2006) Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells. FASEB J 20, 2417–2419.
5 JC McCann & BN Ames (2008) Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J 22, 982–1001.
6 MF Holick (2007) Vitamin D deficiency. N Engl J Med 357, 266–281.
7 PH Anderson , RK Sawyer , AJ Moore , (2008) Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model. J Bone Miner Res 23, 1789–1797.
8 JM Gomez (2006) The role of insulin-like growth factor I components in the regulation of vitamin D. Curr Pharm Biotechnol 7, 125–132.
9 JC Gallagher , BL Riggs & HF DeLuca (1980) Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis. J Clin Endocrinol Metab 51, 1359–1364.
10 S Christakos , P Dhawan , B Benn , (2007) Vitamin D: molecular mechanism of action. Ann N Y Acad Sci 1116, 340–348.
11 M Hewison , D Zehnder , R Bland , (2000) 1alpha-Hydroxylase and the action of vitamin D. J Mol Endocrinol 25, 141–148.
12 D Somjen , Y Weisman , F Kohen , (2005) 25-Hydroxyvitamin D3-1alpha-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds. Circulation 111, 1666–1671.
13 D Zehnder , R Bland , MC Williams , (2001) Extrarenal expression of 25-hydroxyvitamin D(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab 86, 888–894.
14 D Somjen , S Katzburg , N Stern , (2007) 25 Hydroxy-vitamin D(3)-1alpha hydroxylase expression and activity in cultured human osteoblasts and their modulation by parathyroid hormone, estrogenic compounds and dihydrotestosterone. J Steroid Biochem Mol Biol 107, 238–244.
15 PH Anderson , PD O'Loughlin , BK May , (2005) Modulation of CYP27B1 and CYP24 mRNA expression in bone is independent of circulating 1,25(OH)2D3 levels. Bone 36, 654–662.
16 Q Chang , S Hoefs , AW van der Kemp , (2005) The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 310, 490–493.
17 T Yamashita , M Yoshioka & N Itoh (2000) Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem Biophys Res Commun 277, 494–498.
18 B Lanske & MS Razzaque (2007) Mineral metabolism and aging: the fibroblast growth factor 23 enigma. Curr Opin Nephrol Hypertens 16, 311–318.
20 T Shimada , H Hasegawa , Y Yamazaki , (2004) FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res 19, 429–435.
21 I Urakawa , Y Yamazaki , T Shimada , (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444, 770–774.
22 Y Nabeshima & H Imura (2008) alpha-Klotho: a regulator that integrates calcium homeostasis. Am J Nephrol 28, 455–464.
23 B Lanske & MS Razzaque (2007) Vitamin D and aging: old concepts and new insights. J Nutr Biochem 18, 771–777.
26 V Chel , HA Wijnhoven , JH Smit , (2008) Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents. Osteoporos Int 19, 663–671.
27 P Lips (2001) Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 22, 477–501.
28 SJ Gallacher , C McQuillian , M Harkness , (2005) Prevalence of vitamin D inadequacy in Scottish adults with non-vertebral fragility fractures. Curr Med Res Opin 21, 1355–1361.
29 B Hintzpeter , GB Mensink , W Thierfelder , (2008) Vitamin D status and health correlates among German adults. Eur J Clin Nutr 62, 1079–1089.
30 MF Holick , ES Siris , N Binkley , (2005) Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. J Clin Endocrinol Metab 90, 3215–3224.
31 R Kuriacose & KE Olive (2008) Prevalence of vitamin D deficiency and insufficiency in northeast Tennessee. South Med J 101, 906–909.
33 J MacLaughlin & MF Holick (1985) Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 76, 1536–1538.
37 S Konradsen , H Ag , F Lindberg , (2008) Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index. Eur J Nutr 47, 87–91.
38 MB Snijder , RM van Dam , M Visser , (2005) Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab 90, 4119–4123.
39 KH Lau & DJ Baylink (1999) Vitamin D therapy of osteoporosis: plain vitamin D therapy versus active vitamin D analog (D-hormone) therapy. Calcif Tissue Int 65, 295–306.
40 LC Dukas , E Schacht , Z Mazor , (2005) A new significant and independent risk factor for falls in elderly men and women: a low creatinine clearance of less than 65 ml/min. Osteoporos Int 16, 332–338.
42 T Matkovits & S Christakos (1995) Variable in vivo regulation of rat vitamin D-dependent genes (osteopontin, Ca,Mg-adenosine triphosphatase, and 25-hydroxyvitamin D3 24-hydroxylase): implications for differing mechanisms of regulation and involvement of multiple factors. Endocrinology 136, 3971–3982.
44 DD Bikle (2007) What is new in vitamin D: 2006–2007. Curr Opin Rheumatol 19, 383–388.
45 S Shah , MN Islam , S Dakshanamurthy , (2006) The molecular basis of vitamin D receptor and beta-catenin crossregulation. Mol Cell 21, 799–809.
46 M van Driel , M Koedam , CJ Buurman , (2006) Evidence that both 1alpha,25-dihydroxyvitamin D3 and 24-hydroxylated D3 enhance human osteoblast differentiation and mineralization. J Cell Biochem 99, 922–935.
47 G Duque , K El Abdaimi , M Macoritto , (2002) Estrogens (E2) regulate expression and response of 1,25-dihydroxyvitamin D3 receptors in bone cells: changes with aging and hormone deprivation. Biochem Biophys Res Commun 299, 446–454.
48 JR Walters , S Balesaria , KM Chavele , (2006) Calcium channel TRPV6 expression in human duodenum: different relationships to the vitamin D system and aging in men and women. J Bone Miner Res 21, 1770–1777.
49 HA Bischoff-Ferrari , M Borchers , F Gudat , (2004) Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res 19, 265–269.
50 J Welsh , JA Wietzke , GM Zinser , (2002) Impact of the Vitamin D3 receptor on growth-regulatory pathways in mammary gland and breast cancer. J Steroid Biochem Mol Biol 83, 85–92.
51 G Klaus , L Weber , J Rodriguez , (1998) Interaction of IGF-I and 1 alpha, 25(OH)2D3 on receptor expression and growth stimulation in rat growth plate chondrocytes. Kidney Int 53, 1152–1161.
52 D Andress (2007) Nonclassical aspects of differential vitamin D receptor activation: implications for survival in patients with chronic kidney disease. Drugs 67, 1999–2012.
53 JL Fernandez-Martin , S Kurian , P Farmer , (1998) Tumor necrosis factor activates a nuclear inhibitor of vitamin D and retinoid-X receptors. Mol Cell Endocrinol 141, 65–72.
54 V Gonzalez Pardo , R Boland & AR de Boland (2008) Vitamin D receptor levels and binding are reduced in aged rat intestinal subcellular fractions. Biogerontology 9, 109–118.
55 C Vecino-Vecino , M Gratton , R Kremer , (2006) Seasonal variance in serum levels of vitamin D determines a compensatory response by parathyroid hormone: study in an ambulatory elderly population in Quebec. Gerontology 52, 33–39.
56 MP Bjorkman , AJ Sorva & RS Tilvis (2008) Elevated serum parathyroid hormone predicts impaired survival prognosis in a general aged population. Eur J Endocrinol 158, 749–753.
57 AV Perez , G Picotto , AR Carpentieri , (2008) Minireview on regulation of intestinal calcium absorption. Emphasis on molecular mechanisms of transcellular pathway. Digestion 77, 22–34.
58 M Visser , DJ Deeg & P Lips (2003) Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab 88, 5766–5772.
59 G Rashid , J Bernheim , J Green , (2007) Parathyroid hormone stimulates endothelial expression of atherosclerotic parameters through protein kinase pathways. Am J Physiol Renal Physiol 292, F1215–F1218.
61 SD Bianco , JB Peng , H Takanaga , (2007) Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res 22, 274–285.
62 JG Hoenderop , AW van der Kemp , CM Urben , (2004) Effects of vitamin D compounds on renal and intestinal Ca2+ transport proteins in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice. Kidney Int 66, 1082–1089.
66 F Scopacasa , JM Wishart , M Horowitz , (2004) Relation between calcium absorption and serum calcitriol in normal men: evidence for age-related intestinal resistance to calcitriol. Eur J Clin Nutr 58, 264–269.
67 M van Abel , S Huybers , JG Hoenderop , (2006) Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6. Am J Physiol Renal Physiol 291, F1177–F1183.
68 JG Hoenderop , B Nilius & RJ Bindels (2005) Calcium absorption across epithelia. Physiol Rev 85, 373–422.
69 E Lewin & K Olgaard (2006) Klotho, an important new factor for the activity of Ca2+ channels, connecting calcium homeostasis, ageing and uraemia. Nephrol Dial Transplant 21, 1770–1772.
70 JM Witkowski , M Soroczynska-Cybula , E Bryl , (2007) Klotho – a common link in physiological and rheumatoid arthritis-related aging of human CD4+ lymphocytes. J Immunol 178, 771–777.
71 JA Duce , S Podvin , W Hollander , (2008) Gene profile analysis implicates klotho as an important contributor to aging changes in brain white matter of the rhesus monkey. Glia 56, 106–117.
73 JG Hoenderop , JP van Leeuwen , BC van der Eerden , (2003) Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest 112, 1906–1914.
74 PU Torres , D Prie , V Molina-Bletry , (2007) Klotho: an antiaging protein involved in mineral and vitamin D metabolism. Kidney Int 71, 730–737.
75 KY Renkema , T Nijenhuis , BC van der Eerden , (2005) Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice. J Am Soc Nephrol 16, 3188–3195.
76 EM Worcester & FL Coe (2008) New insights into the pathogenesis of idiopathic hypercalciuria. Semin Nephrol 28, 120–132.
77 A Russo de Boland (2004) Age-related changes in the response of intestinal cells to parathyroid hormone. Mech Ageing Dev 125, 877–888.
78 V Massheimer , G Picotto , R Boland , (2000) Effect of aging on the mechanisms of PTH-induced calcium influx in rat intestinal cells. J Cell Physiol 182, 429–437.
81 S Adami , O Viapiana , D Gatti , (2008) Relationship between serum parathyroid hormone, vitamin D sufficiency, age, and calcium intake. Bone 42, 267–270.
82 R Vieth , Y Ladak & PG Walfish (2003) Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. J Clin Endocrinol Metab 88, 185–191.
84 RP Heaney (2005) The vitamin D requirement in health and disease. J Steroid Biochem Mol Biol 97, 13–19.
85 S Boonen , P Lips , R Bouillon , (2007) Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 92, 1415–1423.
88 T Richart , Y Li & JA Staessen (2007) Renal versus extrarenal activation of vitamin D in relation to atherosclerosis, arterial stiffening, and hypertension. Am J Hypertens 20, 1007–1015.
89 E Giovannucci (2008) Vitamin D status and cancer incidence and mortality. Adv Exp Med Biol 624, 31–42.
90 G Duque & BR Troen (2008) Understanding the mechanisms of senile osteoporosis: new facts for a major geriatric syndrome. J Am Geriatr Soc 56, 935–941.
91 S Kimball , H Fuleihan Gel & R Vieth (2008) Vitamin D: a growing perspective. Crit Rev Clin Lab Sci 45, 339–414.
92 R Bouillon , A Verstuyf , C Mathieu , (2006) Vitamin D resistance. Best Pract Res Clin Endocrinol Metab 20, 627–645.
99 MF Holick , RM Biancuzzo , TC Chen , (2008) Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab 93, 677–681.
102 H Tsujikawa , Y Kurotaki , T Fujimori , (2003) Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol 17, 2393–2403.
103 T Shimada , M Kakitani , Y Yamazaki , (2004) Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 113, 561–568.
104 MS Razzaque & B Lanske (2006) Hypervitaminosis D and premature aging: lessons learned from Fgf23 and klotho mutant mice. Trends Mol Med 12, 298–305.
105 CH Jacobus , MF Holick , Q Shao , (1992) Hypervitaminosis D associated with drinking milk. N Engl J Med 326, 1173–1177.
106 JS Adams & G Lee (1997) Gains in bone mineral density with resolution of vitamin D intoxication. Ann Intern Med 127, 203–206.
107 E Avila , L Diaz , D Barrera , (2007) Regulation of vitamin D hydroxylases gene expression by 1,25-dihydroxyvitamin D3 and cyclic AMP in cultured human syncytiotrophoblasts. J Steroid Biochem Mol Biol 103, 90–96.
108 J Schauber , RA Dorschner , AB Coda , (2007) Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest 117, 803–811.
109 DD Bikle , S Pillai , E Gee , (1989) Regulation of 1,25-dihydroxyvitamin D production in human keratinocytes by interferon-gamma. Endocrinology 124, 655–660.
110 Z Xie , SJ Munson , N Huang , (2002) The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytes. J Biol Chem 277, 36987–36990.
111 DD Bikle , S Pillai , E Gee , (1991) Tumor necrosis factor-alpha regulation of 1,25-dihydroxyvitamin D production by human keratinocytes. Endocrinology 129, 33–38.
112 DD Bikle , MK Nemanic , E Gee , (1986) 1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation. J Clin Invest 78, 557–566.
113 AS Dusso , J Finch , A Brown , (1991) Extrarenal production of calcitriol in normal and uremic humans. J Clin Endocrinol Metab 72, 157–164.
114 K Stoffels , L Overbergh , A Giulietti , (2006) Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes. J Bone Miner Res 21, 37–47.
115 HP Koeffler , H Reichel , JE Bishop , (1985) gamma-Interferon stimulates production of 1,25-dihydroxyvitamin D3 by normal human macrophages. Biochem Biophys Res Commun 127, 596–603.
116 MV Young , GG Schwartz , L Wang , (2004) The prostate 25-hydroxyvitamin D-1 alpha-hydroxylase is not influenced by parathyroid hormone and calcium: implications for prostate cancer chemoprevention by vitamin D. Carcinogenesis 25, 967–971.
118 H Farhan , K Wahala & HS Cross (2003) Genistein inhibits vitamin D hydroxylases CYP24 and CYP27B1 expression in prostate cells. J Steroid Biochem Mol Biol 84, 423–429.
119 C Theodoropoulos , C Demers , E Delvin , (2003) Calcitriol regulates the expression of the genes encoding the three key vitamin D3 hydroxylases and the drug-metabolizing enzyme CYP3A4 in the human fetal intestine. Clin Endocrinol (Oxf) 58, 489–499.
120 N Liu , L Nguyen & RF Chun , (2008) Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation. Endocrinology .
121 E Kallay , G Bises , E Bajna , (2005) Colon-specific regulation of vitamin D hydroxylases – a possible approach for tumor prevention. Carcinogenesis 26, 1581–1589.
122 B Diesel , J Radermacher , M Bureik , (2005) Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol. Clin Cancer Res 11, 5370–5380.