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Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation

  • Christian Oudshoorn (a1), Tischa J. M. van der Cammen (a1), Marion E. T. McMurdo (a2), Johannes P. T. M. van Leeuwen (a3) and Edgar M. Colin (a4)
  • DOI: http://dx.doi.org/10.1017/S0007114509338842
  • Published online: 27 April 2009
Abstract

Vitamin D is a fat-soluble, seco-steroid hormone. In man, the vitamin D receptor is expressed in almost all tissues, enabling effects in multiple systems of the human body. These effects can be endocrine, paracrine and autocrine. The present review summarises the effects of ageing on the vitamin D endocrine system and on Ca homeostasis. Furthermore, consequences for vitamin D supplementation are discussed.

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*Corresponding author: Edgar M. Colin, fax +31 10 704 4593, email e.colin@erasmusmc.nl
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