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Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation

  • Christian Oudshoorn (a1), Tischa J. M. van der Cammen (a1), Marion E. T. McMurdo (a2), Johannes P. T. M. van Leeuwen (a3) and Edgar M. Colin (a4)...
Abstract

Vitamin D is a fat-soluble, seco-steroid hormone. In man, the vitamin D receptor is expressed in almost all tissues, enabling effects in multiple systems of the human body. These effects can be endocrine, paracrine and autocrine. The present review summarises the effects of ageing on the vitamin D endocrine system and on Ca homeostasis. Furthermore, consequences for vitamin D supplementation are discussed.

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Corresponding author
*Corresponding author: Edgar M. Colin, fax +31 10 704 4593, email e.colin@erasmusmc.nl
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1 P Lips (2006) Vitamin D physiology. Prog Biophys Mol Biol 92, 48.

2 P Lips (2007) Vitamin D status and nutrition in Europe and Asia. J Steroid Biochem Mol Biol 103, 620625.

4 M van Driel , M Koedam , CJ Buurman , (2006) Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells. FASEB J 20, 24172419.

5 JC McCann & BN Ames (2008) Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J 22, 9821001.

6 MF Holick (2007) Vitamin D deficiency. N Engl J Med 357, 266281.

7 PH Anderson , RK Sawyer , AJ Moore , (2008) Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model. J Bone Miner Res 23, 17891797.

8 JM Gomez (2006) The role of insulin-like growth factor I components in the regulation of vitamin D. Curr Pharm Biotechnol 7, 125132.

9 JC Gallagher , BL Riggs & HF DeLuca (1980) Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis. J Clin Endocrinol Metab 51, 13591364.

10 S Christakos , P Dhawan , B Benn , (2007) Vitamin D: molecular mechanism of action. Ann N Y Acad Sci 1116, 340348.

11 M Hewison , D Zehnder , R Bland , (2000) 1alpha-Hydroxylase and the action of vitamin D. J Mol Endocrinol 25, 141148.

12 D Somjen , Y Weisman , F Kohen , (2005) 25-Hydroxyvitamin D3-1alpha-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds. Circulation 111, 16661671.

13 D Zehnder , R Bland , MC Williams , (2001) Extrarenal expression of 25-hydroxyvitamin D(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab 86, 888894.

14 D Somjen , S Katzburg , N Stern , (2007) 25 Hydroxy-vitamin D(3)-1alpha hydroxylase expression and activity in cultured human osteoblasts and their modulation by parathyroid hormone, estrogenic compounds and dihydrotestosterone. J Steroid Biochem Mol Biol 107, 238244.

15 PH Anderson , PD O'Loughlin , BK May , (2005) Modulation of CYP27B1 and CYP24 mRNA expression in bone is independent of circulating 1,25(OH)2D3 levels. Bone 36, 654662.

16 Q Chang , S Hoefs , AW van der Kemp , (2005) The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 310, 490493.

17 T Yamashita , M Yoshioka & N Itoh (2000) Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem Biophys Res Commun 277, 494498.

18 B Lanske & MS Razzaque (2007) Mineral metabolism and aging: the fibroblast growth factor 23 enigma. Curr Opin Nephrol Hypertens 16, 311318.

20 T Shimada , H Hasegawa , Y Yamazaki , (2004) FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res 19, 429435.

21 I Urakawa , Y Yamazaki , T Shimada , (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444, 770774.

22 Y Nabeshima & H Imura (2008) alpha-Klotho: a regulator that integrates calcium homeostasis. Am J Nephrol 28, 455464.

23 B Lanske & MS Razzaque (2007) Vitamin D and aging: old concepts and new insights. J Nutr Biochem 18, 771777.

26 V Chel , HA Wijnhoven , JH Smit , (2008) Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents. Osteoporos Int 19, 663671.

27 P Lips (2001) Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 22, 477501.

28 SJ Gallacher , C McQuillian , M Harkness , (2005) Prevalence of vitamin D inadequacy in Scottish adults with non-vertebral fragility fractures. Curr Med Res Opin 21, 13551361.

29 B Hintzpeter , GB Mensink , W Thierfelder , (2008) Vitamin D status and health correlates among German adults. Eur J Clin Nutr 62, 10791089.

30 MF Holick , ES Siris , N Binkley , (2005) Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. J Clin Endocrinol Metab 90, 32153224.

31 R Kuriacose & KE Olive (2008) Prevalence of vitamin D deficiency and insufficiency in northeast Tennessee. South Med J 101, 906909.

33 J MacLaughlin & MF Holick (1985) Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 76, 15361538.

37 S Konradsen , H Ag , F Lindberg , (2008) Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index. Eur J Nutr 47, 8791.

38 MB Snijder , RM van Dam , M Visser , (2005) Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab 90, 41194123.

39 KH Lau & DJ Baylink (1999) Vitamin D therapy of osteoporosis: plain vitamin D therapy versus active vitamin D analog (D-hormone) therapy. Calcif Tissue Int 65, 295306.

40 LC Dukas , E Schacht , Z Mazor , (2005) A new significant and independent risk factor for falls in elderly men and women: a low creatinine clearance of less than 65 ml/min. Osteoporos Int 16, 332338.

42 T Matkovits & S Christakos (1995) Variable in vivo regulation of rat vitamin D-dependent genes (osteopontin, Ca,Mg-adenosine triphosphatase, and 25-hydroxyvitamin D3 24-hydroxylase): implications for differing mechanisms of regulation and involvement of multiple factors. Endocrinology 136, 39713982.

44 DD Bikle (2007) What is new in vitamin D: 2006–2007. Curr Opin Rheumatol 19, 383388.

45 S Shah , MN Islam , S Dakshanamurthy , (2006) The molecular basis of vitamin D receptor and beta-catenin crossregulation. Mol Cell 21, 799809.

46 M van Driel , M Koedam , CJ Buurman , (2006) Evidence that both 1alpha,25-dihydroxyvitamin D3 and 24-hydroxylated D3 enhance human osteoblast differentiation and mineralization. J Cell Biochem 99, 922935.

47 G Duque , K El Abdaimi , M Macoritto , (2002) Estrogens (E2) regulate expression and response of 1,25-dihydroxyvitamin D3 receptors in bone cells: changes with aging and hormone deprivation. Biochem Biophys Res Commun 299, 446454.

48 JR Walters , S Balesaria , KM Chavele , (2006) Calcium channel TRPV6 expression in human duodenum: different relationships to the vitamin D system and aging in men and women. J Bone Miner Res 21, 17701777.

49 HA Bischoff-Ferrari , M Borchers , F Gudat , (2004) Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res 19, 265269.

50 J Welsh , JA Wietzke , GM Zinser , (2002) Impact of the Vitamin D3 receptor on growth-regulatory pathways in mammary gland and breast cancer. J Steroid Biochem Mol Biol 83, 8592.

51 G Klaus , L Weber , J Rodriguez , (1998) Interaction of IGF-I and 1 alpha, 25(OH)2D3 on receptor expression and growth stimulation in rat growth plate chondrocytes. Kidney Int 53, 11521161.

52 D Andress (2007) Nonclassical aspects of differential vitamin D receptor activation: implications for survival in patients with chronic kidney disease. Drugs 67, 19992012.

53 JL Fernandez-Martin , S Kurian , P Farmer , (1998) Tumor necrosis factor activates a nuclear inhibitor of vitamin D and retinoid-X receptors. Mol Cell Endocrinol 141, 6572.

54 V Gonzalez Pardo , R Boland & AR de Boland (2008) Vitamin D receptor levels and binding are reduced in aged rat intestinal subcellular fractions. Biogerontology 9, 109118.

55 C Vecino-Vecino , M Gratton , R Kremer , (2006) Seasonal variance in serum levels of vitamin D determines a compensatory response by parathyroid hormone: study in an ambulatory elderly population in Quebec. Gerontology 52, 3339.

56 MP Bjorkman , AJ Sorva & RS Tilvis (2008) Elevated serum parathyroid hormone predicts impaired survival prognosis in a general aged population. Eur J Endocrinol 158, 749753.

57 AV Perez , G Picotto , AR Carpentieri , (2008) Minireview on regulation of intestinal calcium absorption. Emphasis on molecular mechanisms of transcellular pathway. Digestion 77, 2234.

58 M Visser , DJ Deeg & P Lips (2003) Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab 88, 57665772.

59 G Rashid , J Bernheim , J Green , (2007) Parathyroid hormone stimulates endothelial expression of atherosclerotic parameters through protein kinase pathways. Am J Physiol Renal Physiol 292, F1215F1218.

61 SD Bianco , JB Peng , H Takanaga , (2007) Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res 22, 274285.

62 JG Hoenderop , AW van der Kemp , CM Urben , (2004) Effects of vitamin D compounds on renal and intestinal Ca2+ transport proteins in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice. Kidney Int 66, 10821089.

66 F Scopacasa , JM Wishart , M Horowitz , (2004) Relation between calcium absorption and serum calcitriol in normal men: evidence for age-related intestinal resistance to calcitriol. Eur J Clin Nutr 58, 264269.

67 M van Abel , S Huybers , JG Hoenderop , (2006) Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6. Am J Physiol Renal Physiol 291, F1177F1183.

68 JG Hoenderop , B Nilius & RJ Bindels (2005) Calcium absorption across epithelia. Physiol Rev 85, 373422.

69 E Lewin & K Olgaard (2006) Klotho, an important new factor for the activity of Ca2+ channels, connecting calcium homeostasis, ageing and uraemia. Nephrol Dial Transplant 21, 17701772.

70 JM Witkowski , M Soroczynska-Cybula , E Bryl , (2007) Klotho – a common link in physiological and rheumatoid arthritis-related aging of human CD4+ lymphocytes. J Immunol 178, 771777.

71 JA Duce , S Podvin , W Hollander , (2008) Gene profile analysis implicates klotho as an important contributor to aging changes in brain white matter of the rhesus monkey. Glia 56, 106117.

73 JG Hoenderop , JP van Leeuwen , BC van der Eerden , (2003) Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest 112, 19061914.

74 PU Torres , D Prie , V Molina-Bletry , (2007) Klotho: an antiaging protein involved in mineral and vitamin D metabolism. Kidney Int 71, 730737.

75 KY Renkema , T Nijenhuis , BC van der Eerden , (2005) Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice. J Am Soc Nephrol 16, 31883195.

76 EM Worcester & FL Coe (2008) New insights into the pathogenesis of idiopathic hypercalciuria. Semin Nephrol 28, 120132.

77 A Russo de Boland (2004) Age-related changes in the response of intestinal cells to parathyroid hormone. Mech Ageing Dev 125, 877888.

78 V Massheimer , G Picotto , R Boland , (2000) Effect of aging on the mechanisms of PTH-induced calcium influx in rat intestinal cells. J Cell Physiol 182, 429437.

81 S Adami , O Viapiana , D Gatti , (2008) Relationship between serum parathyroid hormone, vitamin D sufficiency, age, and calcium intake. Bone 42, 267270.

82 R Vieth , Y Ladak & PG Walfish (2003) Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. J Clin Endocrinol Metab 88, 185191.

84 RP Heaney (2005) The vitamin D requirement in health and disease. J Steroid Biochem Mol Biol 97, 1319.

85 S Boonen , P Lips , R Bouillon , (2007) Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 92, 14151423.

88 T Richart , Y Li & JA Staessen (2007) Renal versus extrarenal activation of vitamin D in relation to atherosclerosis, arterial stiffening, and hypertension. Am J Hypertens 20, 10071015.

89 E Giovannucci (2008) Vitamin D status and cancer incidence and mortality. Adv Exp Med Biol 624, 3142.

90 G Duque & BR Troen (2008) Understanding the mechanisms of senile osteoporosis: new facts for a major geriatric syndrome. J Am Geriatr Soc 56, 935941.

91 S Kimball , H Fuleihan Gel & R Vieth (2008) Vitamin D: a growing perspective. Crit Rev Clin Lab Sci 45, 339414.

92 R Bouillon , A Verstuyf , C Mathieu , (2006) Vitamin D resistance. Best Pract Res Clin Endocrinol Metab 20, 627645.

99 MF Holick , RM Biancuzzo , TC Chen , (2008) Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab 93, 677681.

102 H Tsujikawa , Y Kurotaki , T Fujimori , (2003) Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol 17, 23932403.

103 T Shimada , M Kakitani , Y Yamazaki , (2004) Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 113, 561568.

104 MS Razzaque & B Lanske (2006) Hypervitaminosis D and premature aging: lessons learned from Fgf23 and klotho mutant mice. Trends Mol Med 12, 298305.

105 CH Jacobus , MF Holick , Q Shao , (1992) Hypervitaminosis D associated with drinking milk. N Engl J Med 326, 11731177.

106 JS Adams & G Lee (1997) Gains in bone mineral density with resolution of vitamin D intoxication. Ann Intern Med 127, 203206.

107 E Avila , L Diaz , D Barrera , (2007) Regulation of vitamin D hydroxylases gene expression by 1,25-dihydroxyvitamin D3 and cyclic AMP in cultured human syncytiotrophoblasts. J Steroid Biochem Mol Biol 103, 9096.

108 J Schauber , RA Dorschner , AB Coda , (2007) Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest 117, 803811.

109 DD Bikle , S Pillai , E Gee , (1989) Regulation of 1,25-dihydroxyvitamin D production in human keratinocytes by interferon-gamma. Endocrinology 124, 655660.

110 Z Xie , SJ Munson , N Huang , (2002) The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytes. J Biol Chem 277, 3698736990.

111 DD Bikle , S Pillai , E Gee , (1991) Tumor necrosis factor-alpha regulation of 1,25-dihydroxyvitamin D production by human keratinocytes. Endocrinology 129, 3338.

112 DD Bikle , MK Nemanic , E Gee , (1986) 1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation. J Clin Invest 78, 557566.

113 AS Dusso , J Finch , A Brown , (1991) Extrarenal production of calcitriol in normal and uremic humans. J Clin Endocrinol Metab 72, 157164.

114 K Stoffels , L Overbergh , A Giulietti , (2006) Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes. J Bone Miner Res 21, 3747.

115 HP Koeffler , H Reichel , JE Bishop , (1985) gamma-Interferon stimulates production of 1,25-dihydroxyvitamin D3 by normal human macrophages. Biochem Biophys Res Commun 127, 596603.

116 MV Young , GG Schwartz , L Wang , (2004) The prostate 25-hydroxyvitamin D-1 alpha-hydroxylase is not influenced by parathyroid hormone and calcium: implications for prostate cancer chemoprevention by vitamin D. Carcinogenesis 25, 967971.

118 H Farhan , K Wahala & HS Cross (2003) Genistein inhibits vitamin D hydroxylases CYP24 and CYP27B1 expression in prostate cells. J Steroid Biochem Mol Biol 84, 423429.

119 C Theodoropoulos , C Demers , E Delvin , (2003) Calcitriol regulates the expression of the genes encoding the three key vitamin D3 hydroxylases and the drug-metabolizing enzyme CYP3A4 in the human fetal intestine. Clin Endocrinol (Oxf) 58, 489499.

120 N Liu , L Nguyen & RF Chun , (2008) Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation. Endocrinology (Epublication ahead of print version).

121 E Kallay , G Bises , E Bajna , (2005) Colon-specific regulation of vitamin D hydroxylases – a possible approach for tumor prevention. Carcinogenesis 26, 15811589.

122 B Diesel , J Radermacher , M Bureik , (2005) Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol. Clin Cancer Res 11, 53705380.

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