1Kokotkiewicz, A, Jaremicz, Z & Luczkiewicz, M (2010) Aronia plants: a review of traditional use, biological activities, and perspectives for modern medicine. J Med Food 13, 255–269.
2Wu, X, Gu, L, Prior, RL, et al. (2004) Characterization of anthocyanins and proanthocyanidins in some cultivars of Ribes, Aronia, and Sambucus and their antioxidant capacity. J Agric Food Chem 52, 7846–7856.
3Wu, X, Beecher, GR, Holden, JM, et al. (2006) Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. J Agric Food Chem 54, 4069–4075.
4Zheng, W & Wang, SY (2003) Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 51, 502–509.
5Bell, DR & Gochenaur, K (2006) Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts. J Appl Physiol 100, 1164–1170.
6Utzschneider, KM, Carr, DB, Barsness, SM, et al. (2004) Diet-induced weight loss is associated with an improvement in beta-cell function in older men. J Clin Endocrinol Metab 89, 2704–2710.
7Valcheva-Kuzmanova, S, Kuzmanov, K, Mihova, V, et al. (2007) Antihyperlipidemic effect of Aronia melanocarpa fruit juice in rats fed a high-cholesterol diet. Plant Foods Hum Nutr 62, 19–24.
8Naruszewicz, M, Laniewska, I, Millo, B, et al. (2007) Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infarction (MI). Atherosclerosis 194, e179–e184.
9Cao, G, Muccitelli, HU, Sanchez-Moreno, C, et al. (2001) Anthocyanins are absorbed in glycated forms in elderly women: a pharmacokinetic study. Am J Clin Nutr 73, 920–926.
10Kay, CD, Mazza, GJ & Holub, BJ (2005) Anthocyanins exist in the circulation primarily as metabolites in adult men. J Nutr 135, 2582–2588.
11Talavera, S, Felgines, C, Texier, O, et al. (2004) Anthocyanins are efficiently absorbed from the small intestine in rats. J Nutr 134, 2275–2279.
12Felgines, C, Texier, O, Garcin, P, et al. (2009) Tissue distribution of anthocyanins in rats fed a blackberry anthocyanin-enriched diet. Mol Nutr Food Res 53, 1098–1103.
13Hajer, GR, van Haeften, TW & Visseren, FL (2008) Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 29, 2959–2971.
14Blüher, M (2009) Adipose tissue dysfunction in obesity. Exp Clin Endocrinol Diabetes 117, 241–250.
15Tsuda, T, Ueno, Y, Aoki, H, et al. (2004) Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. Biochem Biophys Res Commun 316, 149–157.
16Tsuda, T, Ueno, Y, Kojo, H, et al. (2005) Gene expression profile of isolated rat adipocytes treated with anthocyanins. Biochim Biophys Acta 1733, 137–147.
17Guo, H, Ling, W, Wang, Q, et al. (2008) Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF-alpha-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation. Biochem Pharmacol 75, 1393–1401.
18Tsuda, T, Horio, F, Uchida, K, et al. (2003) Dietary cyanidin 3-O-beta-d-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr 133, 2125–2130.
19Prior, RL, Wu, X, Gu, L, et al. (2009) Purified berry anthocyanins but not whole berries normalize lipid parameters in mice fed an obesogenic high fat diet. Mol Nutr Food Res 53, 1406–1418.
20Qin, B, Polansky, MM, Harry, D, et al. (2010) Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats. Mol Nutr Food Res 54, Suppl. 1, S14–S23.
21Qin, B, Anderson, RA & Adeli, K (2008) Tumor necrosis factor-alpha directly stimulates the overproduction of hepatic apolipoprotein B100-containing VLDL via impairment of hepatic insulin signaling. Am J Physiol Gastrointest Liver Physiol 294, G1120–G1129.
22Elliott, SS, Keim, NL, Stern, J, et al. (2002) Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 76, 911–922.
23Qin, B, Nagasaki, M, Ren, M, et al. (2004) Cinnamon extract prevents the insulin resistance induced by a high-fructose diet. Horm Metab Res 36, 119–125.
24Qin, B, Polansky, MM & Anderson, RA (2010) Cinnamon extract regulates plasma levels of adipose-derived factors and expression of multiple genes related to carbohydrate metabolism and lipogenesis in adipose tissue of fructose-fed rats. Horm Metab Res 42, 187–193.
25Alzamendi, A, Giovambattista, A, Raschia, A, et al. (2009) Fructose-rich diet-induced abdominal adipose tissue endocrine dysfunction in normal male rats. Endocrine 35, 227–232.
26Havel, PJ (2004) Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism. Diabetes 53, Suppl. 1, S143–S151.
27Guilherme, A, Virbasius, JV, Puri, V, et al. (2008) Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol 9, 367–377.
28Bogardus, C, Ravussin, E, Robbins, DC, et al. (1984) Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus. Diabetes 33, 311–318.
29Kong, WH, Oh, SH, Ahn, YR, et al. (2008) Antiobesity effects and improvement of insulin sensitivity by 1-deoxynojirimycin in animal models. J Agric Food Chem 56, 2613–2619.
30Taghibiglou, C, Rashid-Kolvear, F, van Iderstine, SC, et al. (2002) Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein–tyrosine phosphatase 1B in a fructose-fed hamster model of insulin resistance. J Biol Chem 277, 793–803.
31Komazawa, N, Matsuda, M, Kondoh, G, et al. (2004) Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice. Nat Med 10, 1208–1215.
32Eldar-Finkelman, H, Schreyer, SA, Shinohara, MM, et al. (1999) Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice. Diabetes 48, 1662–1666.
33Ukkola, O & Santaniemi, M (2002) Adiponectin: a link between excess adiposity and associated comorbidities? J Mol Med 80, 696–702.
34Hu, E, Liang, P & Spiegelman, BM (1996) AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 271, 10697–10703.
35Berg, AH, Combs, TP & Scherer, PE (2002) ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 13, 84–89.
36Hotta, K, Funahashi, T, Arita, Y, et al. (2000) Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20, 1595–1599.
37Hotta, K, Funahashi, T, Bodkin, NL, et al. (2001) Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50, 1126–1133.
38Combs, TP, Pajvani, UB, Berg, AH, et al. (2004) A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 145, 367–383.
39Rodriguez-Acebes, S, Palacios, N, Botella-Carretero, JI, et al. (2010) Gene expression profiling of subcutaneous adipose tissue in morbid obesity using a focused microarray: distinct expression of cell-cycle- and differentiation-related genes. BMC Med Genomics 3, 61.
40Tontonoz, P, Hu, E, Graves, RA, et al. (1994) mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 8, 1224–1234.
41Tontonoz, P & Spiegelman, BM (2008) Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem 77, 289–312.
42Rosen, ED & MacDougald, OA (2006) Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 7, 885–896.
43Shih, CC, Lin, CH, Lin, WL, et al. (2009) Momordica charantia extract on insulin resistance and the skeletal muscle GLUT4 protein in fructose-fed rats. J Ethnopharmacol 123, 82–90.
44Tso, AW, Xu, A, Sham, PC, et al. (2007) Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort. Diabetes Care 30, 2667–2672.
45Xu, A, Tso, AW, Cheung, BM, et al. (2007) Circulating adipocyte–fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation 115, 1537–1543.
46Boord, JB, Maeda, K, Makowski, L, et al. (2004) Combined adipocyte–macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation 110, 1492–1498.
47Makowski, L, Boord, JB, Maeda, K, et al. (2001) Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat Med 7, 699–705.
48Guichard, C, Dugail, I, Le, LX, et al. (1992) Genetic regulation of fatty acid synthetase expression in adipose tissue: overtranscription of the gene in genetically obese rats. J Lipid Res 33, 679–687.
49Lee, MS, Kim, CT & Kim, Y (2009) Green tea ( − )-epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice. Ann Nutr Metab 54, 151–157.
50Ibrahimi, A & Abumrad, NA (2002) Role of CD36 in membrane transport of long chain fatty acids. Curr Opin Clin Nutr Metab Care 5, 139–145.
51Memon, RA, Fuller, J, Moser, A, et al. (1999) Regulation of putative fatty acid transporters and acyl-CoA synthetase in liver and adipose tissue in ob/ob mice. Diabetes 48, 121–127.
52Hotamisligil, GS (2003) Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord 27, Suppl. 3, S53–S55.
53Schenk, S, Saberi, M & Olefsky, JM (2008) Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 118, 2992–3002.
54Wilson, PW (2008) Evidence of systemic inflammation and estimation of coronary artery disease risk: a population perspective. Am J Med 121, S15–S20.
55Zhang, B, Berger, J, Hu, E, et al. (1996) Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha. Mol Endocrinol 10, 1457–1466.
56Carballo, E, Lai, WS & Blackshear, PJ (1998) Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 281, 1001–1005.
57Bouchard, L, Vohl, MC, Deshaies, Y, et al. (2007) Visceral adipose tissue zinc finger protein 36 mRNA levels are correlated with insulin, insulin resistance index, and adiponectinemia in women. Eur J Endocrinol 157, 451–457.