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    Manukumar, H. M Shiva Kumar, J. Chandrashekar, B. Raghava, Sri and Umesha, S. 2016. Evidences for Diabetes and Insulin Mimetic Activity of Medicinal Plants: Present Status and Future Prospects. Critical Reviews in Food Science and Nutrition, p. 00.


    Goyal, Manoj 2015. Traditional plants used for the treatment of diabetes mellitus in Sursagar constituency, Jodhpur, Rajasthan – An ethnomedicinal survey. Journal of Ethnopharmacology, Vol. 174, p. 364.


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Antihyperglycaemic activity of Asparagus racemosus roots is partly mediated by inhibition of carbohydrate digestion and absorption, and enhancement of cellular insulin action

  • J. M. A. Hannan (a1), Liaquat Ali (a2), Junaida Khaleque (a1), Masfida Akhter (a2), Peter R. Flatt (a3) and Yasser H. A. Abdel-Wahab (a3)
  • DOI: http://dx.doi.org/10.1017/S0007114511004284
  • Published online: 08 September 2011
Abstract

Asparagus racemosus roots have been shown to enhance insulin secretion in perfused pancreas and isolated islets. The present study investigated the effects of ethanol extracts of A. racemosus roots on glucose homeostasis in diabetic rats, together with the effects on insulin action in 3T3 adipocytes. When administered orally together with glucose, A. racemosus extract improved glucose tolerance in normal as well as in two types of diabetic rats. To investigate the possible effects on carbohydrate absorption, the sucrose content of the gastrointestinal tract was examined in 12 h fasted rats after an oral sucrose load (2·5 g/kg body weight). The extract significantly suppressed postprandial hyperglycaemia after sucrose ingestion and reversibly increased unabsorbed sucrose content throughout the gut. The extract also significantly inhibited the absorption of glucose during in situ gut perfusion with glucose. Furthermore, the extract enhanced glucose transport and insulin action in 3T3-L1 adipocytes. Daily administration of A. racemosus to type 2 diabetic rats for 28 d decreased serum glucose, increased pancreatic insulin, plasma insulin, liver glycogen and total oxidant status. These findings indicate that antihyperglycaemic activity of A. racemosus is partly mediated by inhibition of carbohydrate digestion and absorption, together with enhancement of insulin secretion and action in the peripheral tissue. Asparagus racemosus may be useful as a source of novel antidiabetic compounds or a dietary adjunct for the management of diabetes.

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Corresponding author
*Corresponding author: Dr Y. H. Abdel-Wahab, fax +44 28 70 324965, email y.abdel-wahab@ulster.ac.uk
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3Y Shao , C-K Chin , C-T Ho , (1996) Anti-tumour activity of the crude saponins obtained from asparagus. Cancer Lett 104, 3136.

4M Shimoyamada , M Suzuki , H Sonta , (1990) Antifungal activity of the saponin fraction obtained from asparagus and its active principle. Agric Biol Chem 54, 25532557.

8JN Dhuley (1997) Effect of some Indian herbs on macrophage functions in ochratoxin A treated mice. J Ethnopharmacol 58, 1520.

11JP Kamat , KK Boloor , TPA Devasagayam , (2000) Antioxidant properties of Asparagus racemosus against damage induced by gamma-radiation in rat liver mitochondria. J Ethnopharmacol 71, 425435.

17PA Nwafor , FK Okwuasaba & LG Binda (2000) Antidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats. J Ethnopharmacol 72, 421427.

21JMA Hannan , L Marenah , L Ali , (2007) Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic β-cells. J. Endocrinol 192, 159168.

27J van der Vries (1954) Two methods for the determination of glycogen in liver. Biochem J 57, 410416.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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