Skip to main content
×
×
Home

Antioxidant phytochemicals against type 2 diabetes

  • Aldona Dembinska-Kiec (a1), Otto Mykkänen (a2), Beata Kiec-Wilk (a1) and Hannu Mykkänen (a2)
Abstract

Dietary phytochemicals, of which polyphenols form a considerable part, may affect the risk of obesity-associated chronic diseases such as type 2 diabetes. This article presents an overview on how phytochemicals, especially polyphenols in fruits, vegetables, berries, beverages and herbal medicines, may modify imbalanced lipid and glucose homeostasis thereby reducing the risk of the metabolic syndrome and type 2 diabetes complications.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Antioxidant phytochemicals against type 2 diabetes
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Antioxidant phytochemicals against type 2 diabetes
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Antioxidant phytochemicals against type 2 diabetes
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: A. Dembinska-Kiec, phone +48 12 421 40 06, fax +48 12 421 40 73, email mbkiec@cyf-kr.edu.pl
References
Hide All
1Kopelman PG (2000) Obesity as a medical problem. Nature 4004, 635643.
2Wild S, Roglic G, Green A, Sicree R & King H (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27, 10471053.
3van Dam RM, Willett WC, Rimm EB, Stampfer MJ & Hu FB (2002) Dietary fat and meat intake in relation to risk of type 2 diabetes in men. Diabetes Care 25, 417424.
4Baynes JW & Thorpe SR (1999) Perspectives in diabetes. Role of oxidative stress in diabetic complications. A new perspective on an old paradigm. Diabetes 48, 19.
5Pickup JC (2004) Inflammation and activated innate immunity in the pathogenesis of type 2 diabetres. Diabetes Care 27, 813823.
6Chertow B (2004) Advances in diabetes for the millennium. Vitamins and oxidative stress in diabetes and its complications. Med Gen Med 6, Suppl. 4, http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool = pubmedid = 15647709 2004. Accessed October 13.
7Polidori MC, Mecocci P, Stahl W, et al. (2000) Plasma level of lypophilic antioxidants in very old patients with type 2 diabetes. Diabetes Metab Res Rev 16, 1519.
8Polidori MC, Stahl W, Eichler O, et al. (2001) Profile of antioxidants in human plasma. Free Radic Biol Med 30, 456462.
9Price KD, Price CSC & Reynolds RD (2001) Hyperglycemia-induced ascorbic acid deficiency promotes endothelial dysfunction and the development of atherosclerosis. Atherosclerosis 158, 112.
10Valabhji J, McColi AJ, Richmond W, et al. (2001) Antioxidant status and coronary artery calcification in type 1 diabetes. Diabetes Care 24, 16081613.
11Pietta PG (2000) Flavonoids as antioxidant. J Nat Prod 63, 10351042.
12Middleton M, Kandaswami C & Theoharides C (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev 52, 673751.
13Noguchi C & Nikki E (2000) Phenolic antioxidants. A rationale for design and evaluation of novel antioxidant drugs for atherosclerosis. Free Radic Biol Med 28, 15381546.
14Clarke R & Armitage J (2002) Antioxidant vitamins and risk of cardiovascular disease. Review of large scale randomized trials. Cardiovasc Drugs Ther 16, 411415.
15Pickup JC (2004) Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 27, 813823.
16Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J & Feve B (2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17, 412.
17Manach C, Mazur A & Scalbert A (2005) Polyphenols and prevention of cardiovascular disease. Curr Opin Lipidol 16, 7784.
18Norata G, Marchesi P, Passamonti S, et al. (2007) Anti-inflammatory and antiatherogenic effects of catechin, caffeic acid and trans-resveratrol in apoprotein E deficient mice. Atherosclerosis 191, 265271.
19Hayek T, Fuhrman B, Vaya J, et al. (1997) Reduced progression of atherosclerosis in in apoprotein deficient E mice following consumption of red wine and its polyphenols quercetin or catechin is associated with reduced susceptibility of LDL to oxidation and aggregation. Arterioscler Thromb Vasc Biol 17, 27442752.
20Waddington E, Puddey IB & Croft KD (2004) Red vine polyphenolic compounds inhibit atherosclerosis in apoprotein E deficient mice independently of effects on lipid peroxidation. Am J Clin Nutr 79, 5461.
21Pellegatta F, Bertelli AA, Staels B, et al. (2003) Different short- and long-term effects of resveratrol on nuclear factor kappa B phosphorylation and nuclear appearance in human endothelial cells. Am J Clin Nutr 77, 12201228.
22Russell JA (2007) Vasopressin in septic shock. Crit Care Med 35, S609S615.
23Youdim KA, McDonald J, Kalt W & Joseph JA (2002) Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults (small star, filled). J Nutr Biochem 13, 282288.
24Hou DX, Yanagita T, Uto T, Masuzaki S & Fujii M (2005) Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure–activity relationship and molecular mechanisms involved. Biochem Pharmacol 70, 417425.
25Pergola C, Rossi A, Dugo P, Cuzzocrea S & Sautebin L (2006) Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract. Nitric Oxide 15, 3039.
26Karlsen A, Retterstøl L, Laake P, Paur I, Kjølsrud-Bøhn S, Sandvik L & Blomhoff R (2007) Anthocyanins inhibit nuclear factor-kappaB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults. J Nutr 137, 19511954.
27Lindsley JE & Rutter J (2004) Nutrient sensing and metabolic decisions. Comp Biochem Biophys Part B 134, 543559.
28McCue P, Kwon YI & Shetty K (2005) Anti-diabetic and anti-hypertensive potential of sprouted and solid-state bioprocessed soybean. Asia Pac J Clin Nutr 14, 145152.
29Heilbronn L, Smith SS & Ravussin E (2004) Faliure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus. Obesity 28, S12S21.
30Kobayashi K, Saito Y, Nakazawa I & Yoshizaki F (2000) Screening of crude drugs for influence on amylase activity and postprandial blood glucose in mouse plasma. Biol Pharm Bull 23, 12501253.
31Tiwari AK & Rao JM (2002) Diabetes mellitus and multiple therapeutic approaches of phytochemicals: present atatus and future prospects. Curr Sci 83, 3038.
32Francis G, Kerem Z, Makkar HP & Becker K (2002) The biological action of saponins in animal systems: a review. Br J Nutr 88, 587605.
33Watanabe J, Kawabata J, Kurihara H & Niki R (1997) Isolation and identification of alpha-glucosidase inhibitors from tochu-cha (Eucommia ulmoides). Biosci Biotechnol Biochem 61, 177178.
34Tsuda T, Horio F, Uchida K, Aoki H & Osawa T (2003) Dietary cyanidin 3-O-beta-d-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr 133, 21252130.
35Tsuda T, Ueno Y, Kojo H, Yoshikawa T & Osawa T (2005) Gene expression profile of isolated rat adipocytes treated with anthocyanins. Biochim Biophys Acta 15, 137147.
36Jayaprakasam B, Vareed SK, Olson LK & Nair MG (2005) Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. J Agric Food Chem 53, 2831.
37Martineau LC, Couture A, Spoor D, Benhaddou-Andaloussi A, Harris C, Meddah B, Leduc C, Burt A, Vuong T, Mai Le P, Prentki M, Bennett SA, Arnason JT & Haddad PS (2006) Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait. Phytomedicine 13, 612623.
38Tsuda T, Ueno Y, Yoshikawa T, Kojo H & Osawa T (2006) Microarray profiling of gene expression in human adipocytes in response to anthocyanins. Biochem Pharmacol 71, 11841197.
39Xia X, Ling W, Ma J, Xia M, Hou M, Wang Q, Zhu H & Tang Z (2006) An anthocyanin-rich extract from black rice enhances atherosclerotic plaque stabilization in apolipoprotein E-deficient mice. J Nutr 136, 22202225.
40Johnston KL, Clifford MN & Morgan LM (2003) Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr 78, 728733.
41Simeonov SB, Botushanov NP, Karahanian EB, Pavlova MB, Husianitis HK & Troev DM (2002) Effects of Aronia melanocarpa juice as part of the dietary regimen in patients with diabetes mellitus. Folia Med (Plovdiv) 44, 2023.
42Jahromi MAF & Ray AB (1993) Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. J Nat Prod 7, 989994.
43Chakravarthy BK, Gupta S & Gode KD (1981) Pancreatic beta-cell regeneration in rats by ( − )-epicatecin. Lancet ii, 759760.
44Ignacimuthy S & Amalraj T (1998) Effect of leaf extracts of Zizyphus jujuba on diabetic rats. Indian J Pharmacol 30, 107108.
45Ravicumar P & Anuradha C (1999) Effect of fenugreek seeds on blood lipid peroxidation and antioxidants in diabetic rats. Phytother Res 13, 197201.
46Young JF, Dragstedt LO, Haraldsdottir J, Daneshvar B, Kal MA, Loft S, Nilsson L, Nielsen SE, Mayer B, Skibsted LH, Huynh-Ba T, Hermetter A & Sandstrom B (2002) Green tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet. Br J Nutr 87, 343355.
47Shanmugasundaram ER, Rajeswari G, Baskaran K, et al. (1990) Use of Gymnea sylvestre leaf extract in the control of blond glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 30, 281294.
48Sharma RD & Raghuram TC (1990) Hypoglycemic effect of fenugreek seeds in non-insulin dependent diabetic subjects. Nutr Res 10, 731739.
49Sharma RD, Raghuram TC & Dayasagar Rao V (1991) Hypolipidaemic effect of fenugreek seeds. A clinical study. Phytother Res 5, 145147.
50Iwata S, Nagat N, Omae A, et al. (1999) Inhibitory effect of chalcone derivatives on recombinant human aldose reductase. Biol Pharm Bull 22, 323325.
51Yoshikawa M, Morikawa T, Murakami T, et al. (1999) Medicinal flowers I. Aldose reductase inhibitors and three new eudesmane-type sesquiterpenes, kikkanols A, B, and C from the flowers of Chrysanthemum indicum L. Chem Pharm Bull (Tokyo) 47, 340345.
52Lim SS, Jung SH, Shin KH & Keum SR (2001) Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetes rat tissues. J Pharm Pharmacol 53, 653668.
53Stoclet JC, Chataigneau T, Ndiaye M, et al. (2004) Vascular protection by dietary polyphenols. Eur J Pharmacol 500, 299313.
54Chyu KY, Babbidge SM, Zhayo X, et al. (2004) Differential effect of green tea-derived catechin on developing versus established atherosclerosis in apoprotein E-null mice. Circulation 109, 24482453.
55Flesch M, Schwarz A & Bohm M (1998) Effects of red and white wine on endothelium-dependent vasorelaxation of rat aorta and human coronary arteries. Am J Physiol 275, H1183H1190.
56Liu JC, Chen JJ, Chan P, et al. (2003) Inhibition of cyclic strain-induced endothelin-1 gene expression by resveratrol. Hypertension 42, 11981205.
57Rupnick MA, Panigrahy D, Zhang CY, et al. (2002) Adipose trissue mass can be regulated through the vasculature. Proc Natl Acad Sci U S A 99, 1073010735.
58Higami Y, Barger JL, Page GP, et al. (2006) Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue. J Nutr 136, 343352.
59Fain JN, Madan AK, Hiler L, et al. (2004) Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 145, 22732282.
60Losso JN (2003) Targeting excessive angiogenesis with functional foods and nutraceuticals. Trends Food Sci Technol 14, 455468.
61Oak MH, Chataigneau M, Keravis T, et al. (2003) Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway. Atheroscler Thromb Vasc Biol 23, 10011007.
62Dembinska-Kiec A, Polus A, Kiec-Wilk B, et al. (2005) Proangiogenic activity of beta-carotene is coupled with the activation of endothelial cell chemotaxis. Biochim Biophys Acta 1740, 2, 222239.
63Brakenhielm E, Cao R & Cao Y (2001) Supression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes. FASEB J 15, 17981800.
64Meydani M (2001) Nutrition interventions in aging and age-associated disease. Ann N Y Acad Sci 928, 226235.
65Cao Y (2007) Angiogenesis modulates adipogenesis and obesity. J Clin Invest 117, 23622368.
66Thirunavukkarasu M, Penumathsa SV, Koneru S, Juhasz B, Zhan L, Otani H, Bagchi D, Das DK & Maulik N (2007) Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of nitric oxide, thioredoxin, and heme oxygenase. Free Radic Biol Med 43, 720729.
67Das UN (1999) GLUT-4, tumor necrosis factor, essential fatty acids and daf-genes and their role in insulin resistance and non-insulin dependent diabetes mellitus. Prostaglandins Leukot Essent Fatty Acids 60, 1320.
68Moskaug , Carlsen H, Myhrstad M & Blomhoff R (2004) Molecular imaging of the biological effects of quercetin and quercetin-rich foods. Mech Ageing Dev 125, 315324.
69Abahusian MA, Wright J, Dickerson JWT & Vol EB (1993) Retinol, α-tocopherol and carotenoids in diabetes. Eur J Clin Nutr 53, 630635.
70Coyne T, Ibiebele TI, Baade PD, et al. (2005) Diabetes mellitus and serum carotenoids: findings of a population-based study in Queensland, Australia. Am J Clin Nutr 82, 685693.
71Ylönen K, Alfthan G, Groop L, et al. (2003) Dietary intakes and plasma concentrations of carotenoids and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: the Botnia Dietary Study. Am J Clin Nutr 77, 14341441.
72Sargeant L, Khaw K, Bingham S, et al. (2001) Fruit and vegetable intake and population glycosylated haemoglobin levels: the EPIC-Norfolk Study. Eur J Clin Nutr 55, 342348.
73Ford ES, Will JC, Bowman BA & Narayan KMV (1999) Diabetes mellitus and serum carotenoids. Findings from the Third National Health and Nutritional examination. Am J Epidemiol 149, 168176.
74Montonen J, Knekt P, Harkanen T, Jarvinen R, Heliovaara M, Aromaa A & Reunaner A (2005) Dietary patterns and the incidence of type 2 diabetes. Am J Epidemiol 161, 219227.
75Nettleton JA, Harnack LJ, Scrafford CG, Mink PJ, Barraj LM & Jacobs DR Jr (2006) Dietary flavonoids and flavonoid-rich foods are not associated with risk of type 2 diabetes in postmenopausal women. J Nutr 136, 30393045.
76Wang L, Liu S, Pradhan AD, et al. (2006) Plasma lycopene, other carotenoids and the risk of type 2 diabetes in women. Am J Epidemiol 164, 576585.
77Liu S, Ajani U, Chae C, Hennekens C, et al. (1999) Long-term beta-carotene supplementation and risk of type-2 diabetes mellitus: a randomized, controlled trial. JAMA 282, 10731075.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 101
Total number of PDF views: 943 *
Loading metrics...

Abstract views

Total abstract views: 1010 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 19th January 2018. This data will be updated every 24 hours.