1 Powers, SK & Jackson, MJ (2008) Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev 88, 1243–1276.
2 Ji, LL (2008) Modulation of skeletal muscle antioxidant defense by exercise: role of redox signaling. Free Radic Biol Med 44, 142–152.
3 Gomez-Cabrera, MC, Domenech, E, Romagnoli, M, et al. (2008) Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr 87, 142–149.
4 Ristow, M, Zarse, K, Oberbach, A, et al. (2009) Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A 106, 8665–8670.
5 Vina, J, Gomez-Cabrera, MC & Borras, C (2007) Fostering antioxidant defences: up-regulation of antioxidant genes or antioxidant supplementation? Br J Nutr 98, Suppl. 1, S36–S40.
6 Margaritis, I & Rousseau, AS (2008) Does physical exercise modify antioxidant requirements? Nutr Res Rev 21, 3–12.
7 Millet, GP, Dreano, P & Bentley, DJ (2003) Physiological characteristics of elite short- and long-distance triathletes. Eur J Appl Physiol 88, 427–430.
8 Jeukendrup, AE, Jentjens, RL & Moseley, L (2005) Nutritional considerations in triathlon. Sports Med 35, 163–181.
9 Lee, IM, Hsieh, CC & Paffenbarger, RS Jr (1995) Exercise intensity and longevity in men. The Harvard Alumni Health Study. JAMA 273, 1179–1184.
10 Knez, WL, Coombes, JS & Jenkins, DG (2006) Ultra-endurance exercise and oxidative damage: implications for cardiovascular health. Sports Med 36, 429–441.
11 Mastaloudis, A, Morrow, JD, Hopkins, DW, et al. (2004) Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. Free Radic Biol Med 36, 1329–1341.
12 Nieman, DC, Henson, DA, McAnulty, SR, et al. (2004) Vitamin E and immunity after the Kona Triathlon World Championship. Med Sci Sports Exerc 36, 1328–1335.
13 Knez, WL, Jenkins, DG & Coombes, JS (2007) Oxidative stress in half and full ironman triathletes. Med Sci Sports Exerc 39, 283–288.
14 Nieman, DC, Henson, DA, McAnulty, SR, et al. (2002) Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon. J Appl Physiol 92, 1970–1977.
15 Neubauer, O, König, D & Wagner, KH (2008) Recovery after an Ironman triathlon: sustained inflammatory responses and muscular stress. Eur J Appl Physiol 104, 417–426.
16 König, D, Neubauer, O, Nics, L, et al. (2007) Biomarkers of exercise-induced myocardial stress in relation to inflammatory and oxidative stress. Exerc Immunol Rev 13, 15–36.
17 Neubauer, O, König, D, Kern, N, et al. (2008) No indications of persistent oxidative stress in response to an ironman triathlon. Med Sci Sports Exerc 40, 2119–2128.
18 Reichhold, S, Neubauer, O, Ehrlich, V, et al. (2008) No acute and persistent DNA damage after an Ironman triathlon. Cancer Epidemiol Biomarkers Prev 17, 1913–1919.
19 Reichhold, S, Neubauer, O, Hoelzl, C, et al. (2009) DNA damage in response to an Ironman triathlon. Free Radic Res 43, 753–760.
20 Neubauer, O, Reichhold, S, Nersesyan, A, et al. (2008) Exercise-induced DNA damage: is there a relationship with inflammatory responses? Exerc Immunol Rev 14, 51–72.
21 Food and Nutrition Board/Institute of Medicine (2000) Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academies Press.
22 DACH (2000)
23 Ramel, A, Wagner, KH & Elmadfa, I (2004) Plasma antioxidants and lipid oxidation after submaximal resistance exercise in men. Eur J Nutr 43, 2–6.
24 Knasmuller, S, Nersesyan, A, Misik, M, et al. (2008) Use of conventional and -omics based methods for health claims of dietary antioxidants: a critical overview. Br J Nutr 99, Suppl. 1, ES3–ES52.
25 Tomasch, R, Wagner, KH & Elmadfa, I (2001) Antioxidative power of plant oils in humans: the influence of alpha- and gamma-tocopherol. Ann Nutr Metab 45, 110–115.
26 Benzie, IF & Strain, JJ (1996) The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem 239, 70–76.
27 Benzie, IF & Strain, JJ (1999) Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods Enzymol 299, 15–27.
28 Ou, B, Hampsch-Woodill, M & Prior, RL (2001) Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. J Agric Food Chem 49, 4619–4626.
29 Huang, D, Ou, B, Hampsch-Woodill, M, et al. (2002) High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format. J Agric Food Chem 50, 4437–4444.
30 Wagner, KH, Reichhold, S, Knasmuller, S, et al. (2010) Does an Ironman triathlon consistently influence oxidative stress, antioxidant status and DNA stability? Toxicology .
31 Tice, RR, Agurell, E, Anderson, D, et al. (2000) Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35, 206–221.
32 Collins, AR, Duthie, SJ & Dobson, VL (1993) Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis 14, 1733–1735.
33 Dill, DB & Costill, DL (1974) Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 37, 247–248.
34 Shaskey, DJ & Green, GA (2000) Sports haematology. Sports Med 29, 27–38.
35 Gleeson, M, Robertson, JD & Maughan, RJ (1987) Influence of exercise on ascorbic acid status in man. Clin Sci (Lond) 73, 501–505.
36 Prior, RL & Cao, G (1999) In vivo total antioxidant capacity: comparison of different analytical methods. Free Radic Biol Med 27, 1173–1181.
37 Nikolaidis, MG & Jamurtas, AZ (2009) Blood as a reactive species generator and redox status regulator during exercise. Arch Biochem Biophys 490, 77–84.
38 Liu, ML, Bergholm, R, Makimattila, S, et al. (1999) A marathon run increases the susceptibility of LDL to oxidation in vitro and modifies plasma antioxidants. Am J Physiol 276, E1083–E1091.
39 Buehler, PW & Alayash, AI (2005) Redox biology of blood revisited: the role of red blood cells in maintaining circulatory reductive capacity. Antioxid Redox Signal 7, 1755–1760.
40 Suzuki, K, Peake, J, Nosaka, K, et al. (2006) Changes in markers of muscle damage, inflammation and HSP70 after an Ironman triathlon race. Eur J Appl Physiol 98, 525–534.
41 Viguie, CA, Frei, B, Shigenaga, MK, et al. (1993) Antioxidant status and indexes of oxidative stress during consecutive days of exercise. J Appl Physiol 75, 566–572.
42 Rousseau, AS, Hininger, I, Palazzetti, S, et al. (2004) Antioxidant vitamin status in high exposure to oxidative stress in competitive athletes. Br J Nutr 92, 461–468.
43 Mastaloudis, A, Leonard, SW & Traber, MG (2001) Oxidative stress in athletes during extreme endurance exercise. Free Radic Biol Med 31, 911–922.
44 Levine, M, Conry-Cantilena, C, Wang, Y, et al. (1996) Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A 93, 3704–3709.
45 Palazzetti, S, Rousseau, AS, Richard, MJ, et al. (2004) Antioxidant supplementation preserves antioxidant response in physical training and low antioxidant intake. Br J Nutr 91, 91–100.
46 Avula, CP, Muthukumar, AR, Zaman, K, et al. (2001) Inhibitory effects of voluntary wheel exercise on apoptosis in splenic lymphocyte subsets of C57BL/6 mice. J Appl Physiol 91, 2546–2552.
47 Dotan, Y, Lichtenberg, D & Pinchuk, I (2004) Lipid peroxidation cannot be used as a universal criterion of oxidative stress. Prog Lipid Res 43, 200–227.