1Bach Knudsen KE (2001) The nutritional significance of ‘dietary fibre’ analysis. Anim Feed Sci Technol 90, 3–20.
2Danielsen V & Vestergaard EM (2001) Dietary fibre for pregnant sows: effect on performance and behaviour. Anim Feed Sci Technol 90, 71–80.
3de Leeuw JA, Bolhuis JE, Bosch G, et al. (2008) Effects of dietary fibre on behaviour and satiety in pigs. Proc Nutr Soc 67, 334–342.
4Salas-Salvado J, Farres X, Luque X, et al. (2008) Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a randomised trial. Br J Nutr 99, 1380–1387.
5Trowell H (1972) Ischemic-heart disease and dietary fiber. Am J Clin Nutr 25, 926–932.
6Chandalia M, Garg A, Lutjohann D, et al. (2000) Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus. N Engl J Med 342, 1392–1398.
7Roberfroid MB (2005) Introducing inulin-type fructans. Br J Nutr 93, S13–S25.
8Solanky KS, Bailey NJC, Holmes E, et al. (2003) NMR-based metabonomic studies on the biochemical effects of epicatechin in the rat. J Agric Food Chem 51, 4139–4145.
9Wishart DS (2008) Metabolomics: applications to food science and nutrition research. Trends Food Sci Technol 19, 482–493.
10Nicholson JK, Lindon JC & Holmes E (1999) ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29, 1181–1189.
11Rerat AA, Vaissade P & Vaugelade P (1984) Absorption kinetics of some carbohydrates in conscious pigs .2. Quantitative aspects. Br J Nutr 51, 517–529.
12Bach Knudsen KE, Laerke HN, Steenfeldt S, et al. (2006) In vivo methods to study the digestion of starch in pigs and poultry. Anim Feed Sci Technol 130, 114–135.
13Bock JL (1982) Analysis of serum by high-field proton nuclear magnetic-resonance. Clin Chem 28, 1873–1877.
14Salek RM, Xia J, Innes A, et al. (2010) A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease. Neurochem Int 56, 937–947.
15Nicholson JK, Buckingham MJ & Sadler PJ (1983) High-resolution H-1-NMR studies of vertebrate blood and plasma. Biochem J 211, 605–615.
16Nicholson JK, Connelly J, Lindon JC, et al. (2002) Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov 1, 153–161.
17Bertram HC, Bach Knudsen KE, Serena A, et al. (2006) NMR-based metabonomic studies reveal changes in the biochemical profile of plasma and urine from pigs fed high-fibre rye bread. Br J Nutr 95, 955–962.
18Bertram HC, Hoppe C, Petersen BO, et al. (2007) An NMR-based metabonomic investigation on effects of milk and meat protein diets given to 8-year-old boys. Br J Nutr 97, 758–763.
19Bertram HC, Malmendal A, Nielsen NC, et al. (2009) NMR-based metabonomics reveals that plasma betaine increases upon intake of high-fiber rye buns in hypercholesterolemic pigs. Mol Nutr Food Res 53, 1055–1062.
20Fardet A, Canlet C, Gottardi G, et al. (2007) Whole-grain and refined wheat flours show distinct metabolic profiles in rats as assessed by a H-1 NMR-based metabonomic approach. J Nutr 137, 923–929.
21Solanky KS, Bailey NJ, Beckwith-Hall BM, et al. (2005) Biofluid H-1 NMR-based metabonomic techniques in nutrition research metabolic effects of dietary isoflavones in humans. J Nutr Biochem 16, 236–244.
22Solanky KS, Bailey NJC, Holmes E, et al. (2003) NMR-based metabonomic studies on the biochemical effects of epicatechin in the rat. J Agri Food Chem 51, 4139–4145.
23Serena A, Jorgensen H & Bach Knudsen KE (2007) The absorption of lactic acid is more synchronized with the absorption of glucose than with the absorption of short-chain fatty acids – a study with sows fed diets varying in dietary fibre. Liv Sci 109, 118–121.
24Serena A, Jorgensen H & Bach Knudsen KE (2009) Absorption of carbohydrate-derived nutrients in sows as influenced by types and contents of dietary fiber. J Anim Sci 87, 136–147.
25Yde CC, Bertram HC & Bach Knudsen KE (2010) NMR-based metabonomics reveals distinct metabolic profiles of plasma from sows after consumption of diets with contrasting dietary fibre levels and composition. Liv Sci 133, 26–29.
26Serena A, Jorgensen H & Bach Knudsen KE (2008) Digestion of carbohydrates and utilization of energy in sows fed diets with contrasting levels and physicochemical properties of dietary fiber. J Anim Sci 86, 2208–2216.
27Meiboom S & Gill D (1958) Modified spin-echo method for measuring nuclear relaxation times. Rev Sci Instrum 29, 688–691.
28van Velzen EJJ, Westerhuis JA, van Duynhoven JPM, et al. (2008) Multilevel data analysis of a crossover designed human nutritional intervention study. J Proteome Res 7, 4483–4491.
29van Velzen EJJ, Westerhuis JA, van Duynhoven JPM, et al. (2009) Phenotyping tea consumers by nutrikinetic analysis of polyphenolic end-metabolites. J Proteome Res 8, 3317–3330.
30Westerhuis JA, Hoefsloot HCJ, Smit S, et al. (2008) Assessment of PLSDA cross validation. Metabolomics 4, 81–89.
31Anderssen E, Dyrstad K, Westad F, et al. (2006) Reducing over-optimism in variable selection by cross-model validation. Chemometr Intell Lab Syst 84, 69–74.
32Smit S, van Breemen MJ, Hoefsloot HCJ, et al. (2007) Assessing the statistical validity of proteomics based biomarkers. Anal Chim Acta 592, 210–217.
33Breitling R, Armengaud P, Amtmann A, et al. (2004) Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Lett 573, 83–92.
34Martens HA & Dardenne P (1998) Validation and verification of regression in small data sets. Chemometr Intell Lab Syst 44, 99–121.
35Littell RC, Milliken GA, Storup, et al. (1996) SAS (R) System for Mixed Models. Cary, NC: SAS Institute, Inc.
36Finkelstein JD & Martin JJ (1984) Methionine metabolism in mammals – distribution of homocysteine between competing pathways. J Biol Chem 259, 9508–9513.
37Olthof MR & Verhoef P (2005) Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr Drug Metab 6, 15–22.
38Sakamoto A, Nishimura Y, Ono H, et al. (2002) Betaine and homocysteine concentrations in foods. Pediatr Int 44, 409–413.
39Wyss M & Kaddurah-Daouk R (2000) Creatine and creatinine metabolism. Physiol Rev 80, 1107–1213.
40Brosnan JT, Wijekoon EP, Warford-Woolgar L, et al. (2009) Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance. J Nutr 139, 1292–1297.
41Hoffman JR, Ratamess NA, Kang J, et al. (2009) Effect of betaine supplementation on power performance and fatigue. J Int Soc Sports Nutr 6 .
42Liu ML, Nicholson JK & London JC (1996) High-resolution diffusion and relaxation edited one- and two-dimensional H-1 NMR spectroscopy of biological fluids. Anal Chem 68, 3370–3376.
43Tiziani S, Einwas AH, Lodi A, et al. (2008) Optimized metabolite extraction from blood serum for H-1 nuclear magnetic resonance spectroscopy. Anal Biochem 377, 16–23.