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Association between the dietary antioxidant index and relative telomere length of leucocytes in the Chinese population

Published online by Cambridge University Press:  06 November 2023

Linhai Zhao Open the ORCID record for Linhai Zhao [Opens in a new window] ,
Wenjia Jin ,
Tiantian Zhang ,
Yufu Lu Open the ORCID record for Yufu Lu [Opens in a new window] ,
Qiumei Liu ,
Jiansheng Cai ,
Lei Luo ,
Kaisheng Teng ,
Qinyi Guan  and
Songju Wu
...Show all authors
Linhai Zhao
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China
Wenjia Jin
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China
Tiantian Zhang
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China
Yufu Lu
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China
Qiumei Liu
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China
Jiansheng Cai
Affiliation:
School of Public Health, Guilin Medical University, Guangxi Zhuang Autonomous Region, Guilin, Guangxi, People’s Republic of China
Lei Luo
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China
Kaisheng Teng
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China
Qinyi Guan
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China
Songju Wu
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China
Jiahui Rong
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China
Yu Jian Liang
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China
Jiejing Cao
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China
Lidong Qin
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China
Chuwu Huang
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China
Xuexiu Wang
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China
You Li
Affiliation:
School of Public Health, Guilin Medical University, Guangxi Zhuang Autonomous Region, Guilin, Guangxi, People’s Republic of China
Zhiyong Zhang*
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China School of Public Health, Guilin Medical University, Guangxi Zhuang Autonomous Region, Guilin, Guangxi, People’s Republic of China Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care, Guilin Medical University, Guilin, Guangxi, People’s Republic of China
Jian Qin*
Affiliation:
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education
*
*Corresponding authors: Zhiyong Zhang, email rpazz@163.com; Jian Qin, email qinjian@gxmu.edu.cn
*Corresponding authors: Zhiyong Zhang, email rpazz@163.com; Jian Qin, email qinjian@gxmu.edu.cn
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Abstract

Dietary antioxidant indices (DAI) may be potentially associated with relative telomere length (RTL) of leucocytes. This study aimed to investigate the relationship between DAI and RTL. A cross-sectional study involving 1656 participants was conducted. A generalised linear regression model and a restricted cubic spline model were used to assess the correlation of DAI and its components with RTL. Generalised linear regression analysis revealed that DAI (β = 0·005, P = 0·002) and the intake of its constituents vitamin C (β = 0·043, P = 0·027), vitamin E (β = 0·088, P < 0·001), Se (β = 0·075, P = 0·003), and Zn (β = 0·075, P = 0·023) were significantly and positively correlated with RTL. Sex-stratified analysis showed that DAI (β = 0·006, P = 0·005) and its constituents vitamin E (β = 0·083, P = 0·012), Se (β = 0·093, P = 0·006), and Zn (β = 0·092, P = 0·034) were significantly and positively correlated with RTL among females. Meanwhile, among males, only vitamin E intake (β = 0·089, P = 0·013) was significantly and positively associated with RTL. Restricted cubic spline analysis revealed linear positive associations between DAI and its constituents’ (vitamin E, Se and Zn) intake and RTL in the total population. Sex-stratified analysis revealed a linear positive correlation between DAI and its constituents’ (vitamin E, Se and Zn) intake and RTL in females. Our study found a significant positive correlation between DAI and RTL, with sex differences.

Keywords

Dietary antioxidant indexRelative telomere lengthAgeingDietary intake
Type
Research Article
Information
British Journal of Nutrition , Volume 131 , Issue 6 , 28 March 2024 , pp. 1031 - 1040
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

†

These authors contributed equally to this work

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