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Association of adipose tissue arachidonic acid content with BMI and overweight status in children from Cyprus and Crete

  • Savvas C. Savva (a1), Charalambos Chadjigeorgiou (a1), Christos Hatzis (a2), Michael Kyriakakis (a2), George Tsimbinos (a2), Michael Tornaritis (a1) and Anthony Kafatos (a2)...
Abstract

The relationships between n-3 and n-6 fatty acids in subcutaneous fat, BMI and overweight status were investigated in eighty-eight children from Crete and Cyprus. Overweight status, BMI and serum lipid levels were similar in children at both locations, but Cretan children had higher levels of total MUFA than Cypriot children (62·2 (sd 2·8) v. 52·2 (sd 2·8)% area, respectively, P<0·001) and consequently Cypriot children had higher levels of total saturated, polyunsaturated, trans, n-3 and n-6 fatty acids. Cypriot children had also higher levels of individual n-3 and n-6 fatty acids, specifically linoleic, α-linolenic and dihomo-γ-linolenic acids. The variance of BMI was better explained (38·2%) by adipose tissue arachidonic acid content than any other n-3 and n-6 fatty acids. Mean levels of arachidonic acid, dihomo-γ-linolenic acid and docosahexaenoic acid were higher in overweight and obese subjects. All obese subjects fell in the 4th quartile of arachidonic acid levels, whereas 88·9% of overweight subjects fell in the 3rd and 4th quartile of arachidonic acid. These results indicate positive associations between adipose tissue arachidonic acid and BMI and overweight status. Further research could clarify whether this association is causal.

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Corresponding author
*Corresponding author: Dr Savvas C. Savva, fax +357 22 510903, email samar1@cytanet.com.cy
References
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Ahren, B, Magrum, LJ, Havel, PJ, Greene, SF, Phinney, SD, Johnson, PR & Stern, JS (2000) Augmented insulinotropic action of arachidonic acid through the lipoxygenase pathway in the obese Zucker rat. Obes Res 8, 475480.
Aravanis, C, Mensink, RP, Karalias, N, Christodoulou, B, Kafatos, A & Katan, MB (1988) Serum lipids, apoproteins and nutrient intake in rural Cretan boys consuming high-olive-oil diets. J Clin Epidemiol 11, 11171123.
Barham, JB, Edens, MB, Fonteh, AN, Johnson, MM, Easter, L & Chilon, FH (2000) Addition of eicosapentaenoic acid to α-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans. J Nutr 130, 19251930.
Bartsch, H, Nair, J & Owen, RW (1999) Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers. Carcinogenesis 20, 22092218.
Berk, PD, Zhou, S-L, Kiang, C-L, Stump, D, Bradbury, M & Isola, LM (1997) Uptake of long chain free fatty acids is selectively up-regulated in adipocytes of Zucker rats with genetic obesity and non-insulin-dependent diabetes mellitus. J Biol Chem 272, 88308835.
Beynen, AKatan, MB (1985) Rapid sampling and long-term storage of subcutaneous adipose tissue biopsies for determination of fatty acid composition. Am J Clin Nutr 42, 317322.
Bolton-Smith, C, Woodward, M & Tavendale, R, (1997) Evidence for age-related differences in the fatty acid composition of human adipose tissue, independent of diet. Eur J Clin Nutr 51, 619624.
Bray, GA & Popkin, BM (1998) Dietary fat intake does affect obesity! Am J Clin Nutr 68, 11571173.
Cantwell, MM (2000) Assessment of individual fatty acid intake. Proc Nutr Soc 59, 187191.
Cole, TJ, Bellizi, MC, Flegal, KM & Dietz, WH (2000) Establishing a standard definition for child overweight and obesity worldwide. Br Med J 320, 12401243.
Darimont, C, Vassaux, G, Ailhaud, G & Negrel, R (1994) Differentiation of preadipose cells: paracrine role of prostacyclin upon stimulation of adipose cells by angiotensin-II. Endocrinology 135, 20302036.
Decsi, T, Molnar, D & Koletzko, B (1996) Long-chain polyunsaturated fatty acids in plasma lipids of obese children. Lipids 31, 305311.
Decsi, T, Molnar, D & Koletzko, B (1998) The effect of under- and overnutrition on essential fatty acid metabolism in childhood. Eur J Clin Nutr 52, 541548.
Decsi, T, Csabi, G, Torok, K, Erhardt, E, Minda, H, Burus, IMolnar, S & Molnar, D (2000) Polyunsaturated fatty acids in plasma lipids of obese children with and without metabolic cardiovascular syndrome. Lipids 35, 11791184.
Garland, M, Sacks, FM, Colditz, GA, Rimm, EB, Sampson, LA, Willett, WC & Hunter, DJ (1998) The relation between dietary intake and adipose tissue composition of selected fatty acids in US women Am J Clin Nutr 67, 2530.
Holub, BJ (2002) Clinical nutrition: Omega n -3 fatty acids in cardiovascular care. Can Med Assoc J 166, 608615.
Hooper, L, Summerbell, CD, Higgins, JPT, Thompson, RL, Capps, NE, Smith, GD, Riemersma, RA & Ebrahim, S (2001) Dietary fat intake and prevention of cardiovascular disease: systematic review. Br Med J 322, 757763.
Kalant, D, Phelis, S, Fielding, BA, Frayan, KN, Cianflone, K & Sniderman, AD (2000) Increased postprandial fatty acid trapping in subcutaneous adipose tissue in obese women. J Lipid Res 41, 19631968.
Katan, MB, Van Staveren, WA, Deurenberg, P, Van Leeuwen, JB, Germing-Nouwen, C, Soffers, A, Benkel, J & Beynen, AC (1986) Linoleic and trans-unsaturated fatty acid content of adipose tissue biopsies as objective indicators of the dietary habits of individuals. Prog Lipid Res 25, 193195.
Kris-Etherton, PM, Taylor, DS, Yu-Poth, S, Huth, P, Moriarty, KFishell, V, Hargrove, RLZhao, G & Etherton, TD (2000) Polyunsaturated fatty acids in the food chain in the United States. Am J Clin Nutr 71, Suppl.179S188S.
Long, SD & Pekala, PH (1996) Regulation of GLUT4 gene expression by arachidonic acid J Biol Chem 271, 11381144.
Mamalakis, G, Kafatos, A, Manios, Y, Anagnostopoulos, T & Apostolaki, I (2000) Obesity indices in a cohort of primary school children in Crete: a six year prospective study. Int J Obes 24, 765771.
Massiera, F, Saint-Marc, P, Seydoux, Jet al. (2003) Arachidonic acid and prostacyclin tissue development: a human health concern? J Lipid Res 44, 271279.
Metcalfe, LD, Schmitz, AA & Pekka, JR, (1966) Rapid preparation of fatty acid esters from lipids for gas chromatographic analysis Ann Chem 18, 514515.
Mokhad, AH, Ford, ES, Bowman, BA, Dietz, WH, Vinicor, F, Bates, VS & Marks, JS, (2003) Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. J Am Med Assoc 289, 7679.
Nicklas, TA, Baranowski, T, Cullen, KW & Berenson, G (2001) Eating patterns, dietary quality and obesity. J Am Coll Nutr 20, 599608.
Nkondjock, A, Shatenstein, B, Maisonneuve, P & Ghadirian, P (2003) Specific fatty acids and human colorectal cancer: an overview Cancer Detect Prev 27, 5562.
Plakke, T, Berkel, J, Beynen, AC, Hermus, RJJ & Katan, MB (1983) Relationship between the fatty acid composition of the diet and that of the subcutaneous adipose tissue in individual human subjects Hum Nutr Appl Nutr 37A 365372.
Prentice, AM (2001) Overeating: The health risks Obes Res 9 Suppl., 234S238S.
Reginato, MJ, Krakow, SL, Bailey, ST & Lazar, MA (1998) Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator activated receptor α. J Biol Chem 273, 18551858.
Sanders, TAB (2000) Polyunsaturated fatty acids in the food chain in Europe. Am J Clin Nutr 71, Suppl., 176S178S.
Savva, SC, Kourides, Y, Tornaritis, M, Epiphaniou-Savva, M, Chadjigeorgiou, C & Kafatos, A (2002) Obesity in children and adolescents in Cyprus. Prevalence and predisposing factors. Int J Obes 26, 10361045.
Seidell, J (1998) Dietary fat and obesity: an epidemiologic perspective. Am J Clin Nutr 67, Suppl., 546S550S
Seidell, JC, Cigolini, M, Deslypere, JP, Charzewska, J & Ellsinger, BM (1991) Polyunsaturated fatty acids in adipose tissue in European men aged 38 years in relation to serum lipids, smoking habits, and fat distribution. Am J Epidemiol 134, 583589.
Simopoulos, AP (1999) Essential fatty acids in health and chronic disease. Am J Clin Nutr 70, Suppl., 560S569S.
Van Staveren, WA, Deurenberg, P, Katan, MB, Burema, JDe Groot, LCPGM & Hoffmans, MDAF (1986) Validity of the fatty acid composition of subcutaneous fat tissue microbiopsies as an estimate of the long-term average fatty acid composition of the diet of separate individuals. Am J Epidemiol 123, 455463.
Zhou, L & Nilsson, A (2001) Sources of eicosanoids precursor fatty acid pools in tissues. J Lipid Res 42, 15211542.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
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