Skip to main content
×
Home
    • Aa
    • Aa

Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats

  • Wan-Ching Chang (a1), Huijuan Jia (a2), Wanping Aw (a2) (a3), Kenji Saito (a2), Sumio Hasegawa (a4) and Hisanori Kato (a1) (a2)...
Abstract

Jerusalem artichoke (JA) has the potential to attenuate lipid disturbances and insulin resistance (IR), but the underlying mechanisms are not well understood. In the present study, we elucidated the physiological responses and mechanisms of JA intervention with a comprehensive transcriptome analysis. Wistar rats were fed a control diet, a 60 % fructose-enriched diet (FRU), or a FRU with 10 % JA (n 6–7) for 4 weeks. An oral glucose tolerance test was carried out on day 21. Liver samples were collected for biochemical and global gene expression analyses (GeneChip® Rat Genome 230 2.0 Array, Affymetrix). Fructose feeding resulted in IR and hepatic TAG accumulation; dietary JA supplementation significantly improved these changes. Transcriptomic profiling revealed that the expression of malic enzyme 1 (Me1), associated with fatty acid synthesis; decorin (Dcn), related to fibrosis; and cytochrome P450, family 1, subfamily a, polypeptide 2 (Cyp1a2) and nicotinamide phosphoribosyltransferase (Nampt), associated with inflammation, was differentially altered by the FRU, whereas dietary JA supplementation significantly improved the expression of these genes. We established for the first time the molecular mechanisms driving the beneficial effects of JA in the prevention of type 2 diabetes and non-alcoholic fatty liver disease. We propose that 10 % JA supplementation may be beneficial for the prevention of the onset of these diseases.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats
      Available formats
      ×
Copyright
Corresponding author
* Corresponding author: Professor H. Kato, fax +81 3 5841 1607, email akatoq@mail.ecc.u-tokyo.ac.jp
References
Hide All
2 JD Browning , LS Szczepaniak , R Dobbins , et al. (2004) Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 40, 13871395.

3 H Basciano , L Federico & K Adeli (2005) Fructose, insulin resistance, and metabolic dyslipidemia. Nutr Metab (Lond) 2, 5.

5 MI Goran , SJ Ulijaszek & EE Ventura (2013) High fructose corn syrup and diabetes prevalence: a global perspective. Glob Public Health 8, 5564.

6 MB Vos & JE Lavine (2013) Dietary fructose in nonalcoholic fatty liver disease. Hepatology 57, 25252531.

7 W-S Lv , RX Sun , YY Gao , et al. (2013) Nonalcoholic fatty liver disease and microvascular complications in type 2 diabetes. World J Gastroenterol 19, 31343142.

8 MJ Franz , MA Powers , C Leontos , et al. (2010) The evidence for medical nutrition therapy for type 1 and type 2 diabetes in adults. J Am Diet Assoc 110, 18521889.

11 H Jia , K Saito , W Aw , et al. (2013) Transcriptional profiling in rats and an ex vivo analysis implicate novel beneficial function of egg shell membrane in liver fibrosis. J Funct Foods 5, 16111619.

14 J Hirosumi , G Tuncman , L Chang , et al. (2002) A central role for JNK in obesity and insulin resistance. Nature 420, 333336.

15 K Morino , KF Petersen & GI Shulman (2006) Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes 55, S9S15.

17 Y Wei & MJ Pagliassotti (2004) Hepatospecific effects of fructose on c-jun NH2-terminal kinase: implications for hepatic insulin resistance. Am J Physiol Endocrinol Metab 287, E926E933.

21 H Zhong , J Beaulaurier , PY Lum , et al. (2010) Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet 6, e1000932.

22 L Tong (2005) Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery. Cell Mol Life Sci 62, 17841803.

23 AW Alberts , AW Strauss , S Hennessy , et al. (1975) Regulation of synthesis of hepatic fatty acid synthetase: binding of fatty acid synthetase antibodies to polysomes. Proc Natl Acad Sci U S A 72, 39563960.

25 K Bolton , D Segal , J McMillan , et al. (2008) Decorin is a secreted protein associated with obesity and type 2 diabetes. Int J Obes (Lond) 32, 11131121.

28 M Murphy , C Godson , S Cannon , et al. (1999) Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. J Biol Chem 274, 58305834.

31 JR Revollo , AA Grimm & S Imai (2004) The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J Biol Chem 279, 5075450763.

34 M Congiu , ML Mashford , JL Slavin , et al. (2002) UDP glucuronosyltransferase mRNA levels in human liver disease. Drug Metab Dispos 30, 129134.

35 CD Fisher , AJ Lickteig , LM Augustine , et al. (2009) Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. Drug Metab Dispos 37, 20872094.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Type Description Title
WORD
Supplementary Materials

Chang Supplementary Material
Tables S1-S3

 Word (78 KB)
78 KB

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 33
Total number of PDF views: 293 *
Loading metrics...

Abstract views

Total abstract views: 412 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 17th October 2017. This data will be updated every 24 hours.