Agheli, N, Kabir, M, Berni-Canani, S, Petitjean, E, Boussairi, A, Luo, J, Bornet, F, Slama, G & Rizkalla, SW (1998) Plasma lipids and fatty acid synthase activity are regulated by short-chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats. Journal of Nutrition 128, 1283–1288.
Aldoori, WH, Giovannucci, EL, Rimm, EB, Wing, AL, Trichopoulos, DV & Willett, WC (1994) A prospective study of diet and the risk of symptomatic diverticular disease in men. American Journal of Clinical Nutrition 60, 757–764.
Alfieri, MA, Pomerleau, J, Grace, DM & Anderson, L (1995) Fiber intake of normal weight, moderately obese and severely obese subjects. Obesity Research 3, 541–547.
Alverdy, JC, Aoys, E & Moss, GS (1990) Effect of commercially available chemically defined liquid diets on the intestinal microflora and bacterial translocation from the gut. Journal of Parenteral and Enteral Nutrition 14, 1–5.
Aminosharie, ME & Weber, FL (1993) Comparison of starch and lactulose, alone and in combination with antibiotics, on ammonia production in a fecal incubation system. Gastroenterology 104, A859.
Ascherio, A, Hennekens, C, Willett, WC, Sacks, F, Rosner, B, Manson, J, Witteman, J & Stampfer, MJ (1996) Prospective study of nutritional factors, blood pressure, and hypertension among US women. Hypertension 27, 1065–1072.
Ascherio, A, Rimm, EB, Giovannucci, EL, Colditz, GA, Rosner, B, Willett, WC, Sacks, F & Stampfer, MJ (1992) A prospective study of nutritional factors and hypertension among US men. Circulation 86, 1475–1484.
Ascherio, A, Rimm, EB, Hernan, MA, Giovannucci, EL, Kawachi, I, Stampfer, MJ & Willett, WC (1998) Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men. Circulation 98, 1198–1204.
Bagger, M, Andersen, O, Nielsen, JB & Ryttig, KR (1996) Dietary fibres reduce blood pressure, serum total cholesterol and platelet aggregation in rats. British Journal of Nutrition 75, 483–493.
Barber, AE, Jones, WG, Minei, JP, Fahey, TJ, Moldawer, LL, Rayburn, JL, Fischer, E, Keogh, CV, Shires, GT & Lowry, SF (1990) Glutamine or fiber supplementation of a defined formula diet: Impact on bacterial translocation, tissue composition, and response to endotoxin. Journal of Parenteral and Enteral Nutrition 14, 335–343.
Bartram, HP, Scheppach, W, Schmid, H, Hofmann, A, Dusel, G, Richter, F, Richter, A & Kasper, H (1993) Proliferation of human colonic mucosa as an intermediate biomarker of carcinogenesis: effects of butyrate, deoxycholate, calcium, ammonia, and pH. Cancer Research 53, 3283–3288.
Bircher, J, Müller, J, Guggenheim, P & Haemmerli, UP (1966) Treatment of chronic portal-systemic encephalopathy with lactulose. Lancet i, 890–892.
Blackburn, NA & Johnson, IT (1983) The influence of guar gum on the movement of inulin, glucose and fluid in rat intestine during perfusion in vivo. Pfluegers Archiv 397, 144–148.
Blackburn, NA, Redfern, JS, Jarjis, H, Holgate, AM, Hanning, I, Scarpello, JHB, Johnson, IT & Read, NW (1984) The mechanism of action of guar gum in improving glucose tolerance in man. Clinical Science 66, 329–336.
Bouhnik, Y, Vahedi, K, Achour, L, Attar, A, Salfati, J, Pochart, P, Marteau, P, Flourie, B, Bornet, F & Rambaud, JC (1999) Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. Journal of Nutrition 129, 113–116.
Breuer, RI, Soergel, KH, Lashner, BA, Christ, ML, Hanauer, SB, Vanaguas, A, Harig, JM, Keshavarzian, A, Robinson, M, Sellin, JH, Weinberg, D, Vidican, DE, Flemal, KL & Rademaker, AW (1997) Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: a randomised, placebo controlled trial. Gut 40, 485–491.
Brodribb, AJM & Humphreys, DM (1976) Diverticular disease: three studies. British Medical Journal i, 424–430.
Brown, L, Rosner, B, Willett, WC & Sacks, FM (1999) Cholesterol-lowering effects of dietary fiber: a meta-analysis. American Journal of Clinical Nutrition 69, 30–42.
Burkitt, DP (1969) Related disease, related cause?. Lancet ii, 1229–1231.
Burkitt, DP (1971) Epidemiology of cancer of the colon and rectum. Cancer 28, 3–13.
Carpaneto, EM, Mariani, MR & Ferrini, S (1991) Stimulation of DNA synthesis in primary culture of human lymphocytes by sodium butyrate. Proceedings of the American Association of Cancer Research 32, 331–336.
Cassidy, A, Bingham, SA & Cummings, JH (1994) Starch intake and colorectal cancer risk: an international comparison. British Journal of Cancer 69, 937–942.
Catala, I, Butel, MJ, Bensaada, M, Popot, F, Tessedre, AC, Rimbault, A & Szylit, O (1999) Oligofructose contributes to the protective role of bifidobacteria in experimental necrotising enterocolitis in quails. Journal of Medical Microbiology 48, 89–94.
Cook, IJ, Irvine, EJ, Campbell, D, Shannon, S, Reddy, SN & Collins, SM (1990) Effect of dietary fiber on symptoms and rectosigmoid motility in patients with irritable bowel syndrome. Gastroenterology 98, 66–72.
Cummings, JH, Branch, W, Jenkins, DJA, Southgate, DAT, Houston, H & James, WPT (1978) Colonic response to dietary fibre from carrot, cabbage, apple, bran, and guar gum. Lancet i, 5–9.
Cummings, JH (1997) Short-chain fatty acid enemas in the treatment of distal ulcerative colitis. European Journal of Gastroenterology and Hepatology 9, 149–153.
DaZhong, X & Deitch, EA (1998) Elemental diet-induced bacterial translocation associated with systemic and intestinal immune suppression. Journal of Parenteral and Enteral Nutrition 22, 37–41.
Deng, G, Liu, G, Hu, L, Gum, JR & Kim, YS (1992) Transcriptional regulation of the human placental-like alkaline phosphatase gene and mechanisms involved in its induction by sodium butyrate. Cancer Research 52, 3378–3383.
Drossman, DA, Whitehead, WE & Camillieri, M (1997) American Gastroenterological Association medical position statement: irritable bowel syndrome. Gastroenterology 112, 2118–2137.
Fearon, ER & Vogelstein, B (1990) A genetic model for colorectal tumorigenesis. Cell 61, 759–767.
Fisher, N, Berry, CS, Fearn, T, Gregory, JA & Hardy, J (1985) Cereal dietary fibre consumption and diverticular disease: a lifespan study in rats. American Journal of Clinical Nutrition 42, 788–804.
Fuchs, CS, Giovannucci, EL, Colditz, GA, Hunter, DJ, Stampfer, MJ, Rosner, B, Speizer, FE & Willett, WC (1999) Dietary fiber and the risk of colorectal cancer and adenoma in women. New England Journal of Medicine 340, 169–176.
Gear, JS, Ware, A, Fursdon, P, Mann, JI, Nolan, DJ, Brodribb, AJ & Vessey, MP (1979) Symptomless diverticular disease and intake of dietary fibre. Lancet i, 511–514.
Gibson, GR, Beatty, ER, Wang, X & Cummings, JH (1995) Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108, 975–982.
Gibson, GR, Moeller, I, Kagelari, O, Folino, M & Young, GP (1992) Contrasting effects of butyrate on the expression of phenotypic markers of differentiation in neoplastic and non-neoplastic colonic epithelial cells in vitro. Journal of Gastroenterology and Hepatology 7, 165–172.
Gibson, GR & Roberfroid, MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. Journal of Nutrition 125, 1401–1412.
Goodlad, RA, Ratcliffe, B, Fordham, JP & Wright, NA (1989) Does dietary fibre stimulate intestinal epithelial cell proliferation in germ free rats? Gut 30, 820–825.
Goodlad, RA & Wright, NA (1983) Effects of addition of kaolin or cellulose to an elemental diet in intestinal cell proliferation in the mouse. British Journal of Nutrition 50, 91–98.
Hague, A, Diaz, GD, Hicks, DJ, Krajewski, S, Reed, JC & Paraskeva, C (1997) Bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells; however over expression of bcl-2 does not protect against bak-mediated apoptosis. International Journal of Cancer 72, 898–905.
Hague, A, Elder, DJE, Hicks, DJ & Paraskeva, C (1995) Apoptosis in colorectal tumour cells: induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate. International Journal of Cancer 60, 400–406.
Hague, A, Manning, AM, Hanlon, KA, Huschtscha, LI, Hart, D & Paraskeva, C (1993) Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer. International Journal of Cancer 55, 498–505.
Havenaar, R, Brink, BT, Huis in't Veld, JHT (1992) Selection of strains for probiotic use. In Probiotics: The Scientific Basis. 209–224. [R, Fuller, editor]. London: Chapman and Hall.
Howe, GR, Benito, E, Castelleto, R, Cornee, J, Esteve, J, Gallgher, RP, Iscovich, JM, Deng-ao, J, Kaaks, R, Kune, GA, Kune, S, L'Abbe, KA, Lee, HP, Lee, M, Miller, AB, Peters, RK, Potter, JD, Riboli, E, Slattery, ML, Trichopoulos, D, Tuyns, A, Tzonou, A, Whittemore, AS, Wu-Williams, AH & Shu, Z (1992) Dietary intake of fiber and decreased risk of cancers of the colon and rectum: evidence from the combined analysis of 13 case-control studies. Journal of the National Cancer Institute 84, 1887–1896.
Humble, CG, Malarcher, AM & Tyroler, HA (1993) Dietary fiber and coronary heart disease in middle-aged hypercholesterolemic men. American Journal of Preventive Medicine 9, 197–202.
Hylla, S, Gostner, A, Dusel, G, Anger, H, Bartram, H-P, Christl, SU, Kasper, H & Scheppach, W (1998) Effects of resistant starch on the colon in healthy volunteers: possible implications for cancer prevention. American Journal of Clinical Nutrition 67, 136–142.
Jacobs, LR & Lupton, JR (1984) Effect of dietary fibers on rat large bowel mucosal growth and cell proliferation. American Journal of Physiology 246, G378–G385.
Jenkins, DJA, Wolever, TMS, Taylor, RH, Barker, H, Fielden, H, Baldwin, JM, Bowling, AC, Newman, HC, Jenkins, AL & Goff, DV (1981) Glycemic index of foods: a physiological basis for carbohydrate exchange. American Journal of Clinical Nutrition 34, 362–366.
Kasper, H (1988) Einfluss von Ballaststoffen auf die Serum-Lipidkonzentration. Aktuelle Ernährungsmedizin 13, 75–76.
Khaw, KT & Barret-Connor, E (1987) Dietary fiber and reduced ischemic disease mortality rates in men and women: a 12-year prospective study. American Journal of Epidemiology 126, 1093–1102.
Koruda, MJ, Rolandelli, RH, Settle, RG, Saul, SH & Rombeau, JL (1986) The effect of a pectin supplemented elemental diet on intestinal adaptation to massive small bowel resection. Journal of Parenteral and Enteral Nutrition 10, 343–350.
Kripke, SA, Fox, AD, Berman, JM, Settle, RG & Rombeau, JL (1989) Stimulation of intestinal mucosal growth with intracolonic infusion of short-chain fatty acids. Journal of Parenteral and Enteral Nutrition 12, 109–116.
Kruh, J, Tichonicky, L & Defer, N (1994) Effect of butyrate on gene expression. In Short Chain Fatty Acids, pp. 135–147. [HJ, Binder, JH, Cummings & K, Soergel, editors]. Dordrecht: Kluwer.
Lucey, MR, Clark, ML, Lowndes, J & Dawson, AM (1987) Is bran efficacious in irritable bowel syndrome? A double-blind placebo-controlled crossover study. Gut 28, 221–225.
Luehrs, H, Schauber, J, Boxberger, F, Dusel, G, Krott, K, Kelber, E, Menzel, T & Scheppach, W (1999) Butyrate-mediated inhibition of nuclear factor kappa B activation. Gastroenterology 116, A563.
Macfarlane, GT & Cummings, JH (1991) The colonic flora, fermentation, and large bowel digestive function. In The Large Intestine: Physiology, Pathophysiology, and Disease. pp. 51–91. [SP, Phillips, JH, Pemberton & RG, Shorter, editors]. New York: Raven Press.
Pasman, WJ, Saris, WH, Wauters, MA & Westerterp-Plantenga, MS (1997) Effect of one week of fibre supplementation on hunger and satiety ratings and energy intake. Appetite 29, 77–87.
Pierre, F, Perrin, P, Champ, M, Bornet, F, Meflah, K & Menanteau, J (1997) Short-chain fructo-oligosaccharides reduce the occurrence of colonic tumors and develop gut-associated lymphoid tissue in Min mice. Cancer Research 57, 225–228.
Prynne, CJ & Southgate, DAT (1979) The effects of a supplement of dietary fibre on faecal excretion by human subjects. British Journal of Nutrition 41, 495–503.
Reddy, BS, Hamid, R & Rao, CV (1997) Effect of dietary oligofructose and inulin on colonic preneoplastic aberrant crypt foci inhibition. Carcinogenesis 18, 1371–1374.
Rimm, EB, Ascherio, A, Giovannucci, E, Spiegelman, D, Stampfer, MJ & Willett, WC (1996) Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men. Journal of the American Medical Association 275, 447–451.
Roberfroid, MB (1997) Health benefits of non-digestible oligosaccharides. Advances in Experimental Medicine and Biology 427, 211–219.
Roediger, WEW (1980 a) Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut 21, 793–798.
Roediger, WEW (1980 b) The colonic epithelium in ulcerative colitis: an energy-deficiency disease? Lancet ii, 712–715.
Roediger, WEW (1990) The starved colon – diminished mucosal nutrition, diminished absorption, and colitis. Diseases of the Colon and Rectum 33, 858–862.
Rolandelli, RH, Koruda, MJ, Settle, RG & Rombeau, JL (1986) Effects of intraluminal infusion of short-chain acids on the healing of colonic anastomosis in the rat. Surgery 100, 198–203.
Schauber, J, Luehrs, H, Boxberger, F, Dusel, G, Krott, K, Kelber, E, Scheppach, W & Menzel, T (1999) Additive effects of combined treatment with butyrate and aspirin on human colon cancer cells. Gastroenterology 116, A498.
Scheppach, W, Bartram, P, Richter, A, Richter, F, Liepold, H, Dusel, G, Hofstetter, G, Rüthlein, J & Kasper, H (1992) The effect of short-chain fatty acids on the human colonic mucosa in vitro. Journal of Parenteral and Enteral Nutrition 16, 43–48.
Scheppach, W, Bingham, S, Boutron-Ruault, MC, de Verdier, MG, Moreno, V, Nagengast, FM, Reifen, R, Riboli, E, Seitz, HK & Wahrendorf, J (1999) WHO consensus statement on the role of nutrition in colorectal cancer. European Journal of Cancer Prevention 8, 57–62.
Scheppach, W, Fabian, C, Ahrens, F, Spengler, M & Kasper, H (1988) Effect of starch malabsorption on colonic function and metabolism in humans. Gastroenterology 95, 1549–1555.
Scheppach, W & German-Austrian SCFA Study Group (1996) Treatment of distal ulcerative colitis with short-chain fatty acid enemas. A placebo-controlled trial. Digestive Diseases and Sciences 41, 2254–2259.
Scheppach, W, Müller, JG, Boxberger, F, Dusel, G, Richter, F, Bartram, HP, Dempfle, CE & Kasper, H (1997) Histological changes of the colonic mucosa following irrigation with short-chain fatty acids. European Journal of Gastroenterology and Hepatology 9, 163–168.
Sedman, PC, Macfie, J, Sagar, P, Mitchell, CJ, May, J, Mancey-Jones, B & Johnstone, D (1994) The prevalence of gut translocation in humans. Gastroenterology 107, 643–649.
Spaeth, G, Specian, RD, Berg, RD & Deitch, EA (1990) Bulk prevents bacterial translocation induced by the oral administration of total parenteral nutrition solution. Journal of Parenteral and Enteral Nutrition 14, 442–447.
Stephen, AM & Cummings, JH (1980) The microbial contribution to human faecal mass. Journal of Medical Microbiology 13, 45–56.
Toeller, M, Buyken, AE, Heitkamp, G, de Pergola, G, Giorgino, F & Fuller, JH (1999) Fiber intake, serum cholesterol levels, and cardiovascular disease in European individuals with type 1 diabetes. EURODIAB IDDM complications study group. Diabetes Care 22, Suppl. 2, B21–B28.
Toscani, A, Soprano, DR & Soprano, KJ (1988) Molecular analysis of sodium butyrate-induced growth arrest. Onocogene Research 3, 223–238.
Trock, B, Lanza, E & Greenwald, P (1990) Dietary fiber, vegetables, and colon cancer; critical review and meta-analyses of the epidemiologic evidence. Journal of the National Cancer Institute 82, 650–661.
Tsujii, M & DuBois, RN (1995) Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxidase synthase 2. Cell 83, 493–501.
Uribe-Esquivel, M, Moran, S, Poo, JL & Munoz, RM (1997) In vitro and in vivo lactose and lactulose effects on colonic fermentation and portal-systemic encephalopathy parameters. Scandinavian Journal of Gastroenterology 32(Suppl. 222), 49–52.
Voderholzer, WA, Schatke, W, Mühldorfer, BE, Klauser, AG, Birkner, B & Müller-Lissner, SA (1997) Clinical response to dietary fiber treatment of chronic constipation. American Journal of Gastroenterology 92, 95–98.
Wang, J & Friedman, EA (1998) Short-chain fatty acids induce cell cycle inhibitors in colonocytes. Gastroenterology 114, 940–946.
Weber, FL, Banwell, JG, Fresard, KM & Cummings, JH (1987) Nitrogen in fecal bacterial, fiber, and soluble fractions of patients with cirrhosis: effects of lactulose and lactulose plus neomycin. Journal of Laboratory and Clinical Medicine 110, 256–263.
Whitlock, JP, Galeazzi, D & Schulman, H (1983) Acetylation and calcium-dependent phosphorylation of histone H3 in nuclei from butyrate-treated HeLa cells. Journal of Biological Chemistry 258, 1299–1304.
Willett, WC, Stampfer, MJ, Colditz, GA, Rosner, BA & Speizer, FE (1990) Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. New England Journal of Medicine 323, 1664–1672.