Skip to main content
×
Home

Benefits of whole ginger extract in prostate cancer

  • Prasanthi Karna (a1), Sharmeen Chagani (a1), Sushma R. Gundala (a1), Padmashree C. G. Rida (a1), Ghazia Asif (a1), Vibhuti Sharma (a1), Meenakshi V. Gupta (a2) and Ritu Aneja (a1)...
Abstract

It is appreciated far and wide that increased and regular consumption of fruits and vegetables is linked with noteworthy anticancer benefits. Extensively consumed as a spice in foods and beverages worldwide, ginger (Zingiber officinale Roscoe) is an excellent source of several bioactive phenolics, including non-volatile pungent compounds such as gingerols, paradols, shogaols and gingerones. Ginger has been known to display anti-inflammatory, antioxidant and antiproliferative activities, indicating its promising role as a chemopreventive agent. Here, we show that whole ginger extract (GE) exerts significant growth-inhibitory and death-inductory effects in a spectrum of prostate cancer cells. Comprehensive studies have confirmed that GE perturbed cell-cycle progression, impaired reproductive capacity, modulated cell-cycle and apoptosis regulatory molecules and induced a caspase-driven, mitochondrially mediated apoptosis in human prostate cancer cells. Remarkably, daily oral feeding of 100 mg/kg body weight of GE inhibited growth and progression of PC-3 xenografts by approximately 56 % in nude mice, as shown by measurements of tumour volume. Tumour tissue from GE-treated mice showed reduced proliferation index and widespread apoptosis compared with controls, as determined by immunoblotting and immunohistochemical methods. Most importantly, GE did not exert any detectable toxicity in normal, rapidly dividing tissues such as gut and bone marrow. To the best of our knowledge, this is the first report to demonstrate the in vitro and in vivo anticancer activity of whole GE for the management of prostate cancer.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Benefits of whole ginger extract in prostate cancer
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Benefits of whole ginger extract in prostate cancer
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Benefits of whole ginger extract in prostate cancer
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: R. Aneja, fax +1 404 413 5301, email raneja@gsu.edu
References
Hide All
1 Syed DN, Khan N, Afaq F, et al. (2007) Chemoprevention of prostate cancer through dietary agents: progress and promise. Cancer Epidemiol Biomarkers Prev 16, 21932203.
2 Nelson WG, De Marzo AM & Isaacs WB (2003) Prostate cancer. N Engl J Med 349, 366381.
3 Sporn MB (1976) Approaches to prevention of epithelial cancer during the preneoplastic period. Cancer Res 36, 26992702.
4 Mann JR, Backlund MG & DuBois RN (2005) Mechanisms of disease: inflammatory mediators and cancer prevention. Nat Clin Pract Oncol 2, 202210.
5 Kaur M, Agarwal C & Agarwal R (2009) Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products. J Nutr 139, 1806S1812S.
6 Cooke D, Steward WP, Gescher AJ, et al. (2005) Anthocyans from fruits and vegetables – does bright colour signal cancer chemopreventive activity? Eur J Cancer 41, 19311940.
7 Yang CS, Landau JM, Huang MT, et al. (2001) Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr 21, 381406.
8 Traka M, Gasper AV, Melchini A, et al. (2008) Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate. PLoS One 3, e2568.
9 Steinkellner H, Rabot S, Freywald C, et al. (2001) Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. Mutat Res 480–481, 285297.
10 Colli JL & Amling CL (2009) Chemoprevention of prostate cancer: what can be recommended to patients? Curr Urol Rep 10, 165171.
11 Craig WJ (1999) Health-promoting properties of common herbs. Am J Clin Nutr 70, Suppl. 3, 491S499S.
12 Surh YJ (2003) Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3, 768780.
13 Zick SM, Djuric Z, Ruffin MT, et al. (2008) Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects. Cancer Epidemiol Biomarkers Prev 17, 19301936.
14 Shukla Y & Singh M (2007) Cancer preventive properties of ginger: a brief review. Food Chem Toxicol 45, 683690.
15 Shobana S & Naidu KA (2000) Antioxidant activity of selected Indian spices. Prostaglandins Leukot Essent Fatty Acids 62, 107110.
16 Katiyar SK, Agarwal R & Mukhtar H (1996) Inhibition of tumor promotion in SENCAR mouse skin by ethanol extract of Zingiber officinale rhizome. Cancer Res 56, 10231030.
17 Surh YJ (2002) Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol 40, 10911097.
18 Kim EC, Min JK, Kim TY, et al. (2005) [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo. Biochem Biophys Res Commun 335, 300308.
19 Kim SO, Kundu JK, Shin YK, et al. (2005) [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. Oncogene 24, 25582567.
20 Fuhrman B, Rosenblat M, Hayek T, et al. (2000) Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice. J Nutr 130, 11241131.
21 Liu RH (2003) Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 78 (Suppl. 3), 517S520S.
22 Yang CS (1997) Inhibition of carcinogenesis by tea. Nature 389, 134135.
23 Jankun J, Selman SH, Swiercz R, et al. (1997) Why drinking green tea could prevent cancer. Nature 387, 561.
24 Liu RH (2004) Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr 134, Suppl. 12, 3479S3485S.
25 Nociari MM, Shalev A, Benias P, et al. (1998) A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity. J Immunol Methods 213, 157167.
26 Karna P, Zughaier S, Pannu V, et al. (2010) Induction of reactive oxygen species-mediated autophagy by a novel microtubule-modulating agent. J Biol Chem 285, 1873718748.
27 Waterhouse NJ, Goldstein JC, von Ahsen O, et al. (2001) Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process. J Cell Biol 153, 319328.
28 Lee HS, Seo EY, Kang NE, et al. (2008) [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. J Nutr Biochem 19, 313319.
29 Jeong CH, Bode AM, Pugliese A, et al. (2009) [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. Cancer Res 69, 55845591.
30 Aggarwal BB & Shishodia S (2006) Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71, 13971421.
31 Meeran SM & Katiyar SK (2008) Cell cycle control as a basis for cancer chemoprevention through dietary agents. Front Biosci 13, 21912202.
32 Park YJ, Wen J, Bang S, et al. (2006) [6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells. Yonsei Med J 47, 688697.
33 Grana X & Reddy EP (1995) Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11, 211219.
34 Besson A, Dowdy SF & Roberts JM (2008) CDK inhibitors: cell cycle regulators and beyond. Dev Cell 14, 159169.
35 Green DR & Reed JC (1998) Mitochondria and apoptosis. Science 281, 13091312.
36 Adams JM & Cory S (1998) The Bcl-2 protein family: arbiters of cell survival. Science 281, 13221326.
37 Kelloff GJ, Sigman CC & Greenwald P (1999) Cancer chemoprevention: progress and promise. Eur J Cancer 35, 20312038.
38 Bidoli E, Talamini R, Bosetti C, et al. (2005) Macronutrients, fatty acids, cholesterol and prostate cancer risk. Ann Oncol 16, 152157.
39 Saha S, Smith RM, Lenz E, et al. (2003) Analysis of a ginger extract by high-performance liquid chromatography coupled to nuclear magnetic resonance spectroscopy using superheated deuterium oxide as the mobile phase. J Chromatogr A 991, 143150.
40 Jolad SD, Lantz RC, Solyom AM, et al. (2004) Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production. Phytochemistry 65, 19371954.
41 Kato A, Higuchi Y, Goto H, et al. (2006) Inhibitory effects of Zingiber officinale Roscoe derived components on aldose reductase activity in vitro and in vivo. J Agric Food Chem 54, 66406644.
42 Park KK, Chun KS, Lee JM, et al. (1998) Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer Lett 129, 139144.
43 Yoshimi N, Wang A, Morishita Y, et al. (1992) Modifying effects of fungal and herb metabolites on azoxymethane-induced intestinal carcinogenesis in rats. Jpn J Cancer Res 83, 12731278.
44 Wang W, Li CY, Wen XD, et al. (2009) Plasma pharmacokinetics, tissue distribution and excretion study of 6-gingerol in rat by liquid chromatography–electrospray ionization time-of-flight mass spectrometry. J Pharm Biomed Anal 49, 10701074.
45 The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 330, 10291035.
46 Omenn GS, Goodman GE, Thornquist MD, et al. (1996) Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 334, 11501155.
47 Reagan-Shaw S, Nihal M & Ahmad N (2008) Dose translation from animal to human studies revisited. FASEB J 22, 659661.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Type Description Title
PDF
Supplementary Material

Aneja Supplementary Material
Aneja Supplementary Material

 PDF (1.1 MB)
1.1 MB

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 173
Total number of PDF views: 667 *
Loading metrics...

Abstract views

Total abstract views: 3224 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 20th November 2017. This data will be updated every 24 hours.