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Benefits of whole ginger extract in prostate cancer

  • Prasanthi Karna (a1), Sharmeen Chagani (a1), Sushma R. Gundala (a1), Padmashree C. G. Rida (a1), Ghazia Asif (a1), Vibhuti Sharma (a1), Meenakshi V. Gupta (a2) and Ritu Aneja (a1)...


It is appreciated far and wide that increased and regular consumption of fruits and vegetables is linked with noteworthy anticancer benefits. Extensively consumed as a spice in foods and beverages worldwide, ginger (Zingiber officinale Roscoe) is an excellent source of several bioactive phenolics, including non-volatile pungent compounds such as gingerols, paradols, shogaols and gingerones. Ginger has been known to display anti-inflammatory, antioxidant and antiproliferative activities, indicating its promising role as a chemopreventive agent. Here, we show that whole ginger extract (GE) exerts significant growth-inhibitory and death-inductory effects in a spectrum of prostate cancer cells. Comprehensive studies have confirmed that GE perturbed cell-cycle progression, impaired reproductive capacity, modulated cell-cycle and apoptosis regulatory molecules and induced a caspase-driven, mitochondrially mediated apoptosis in human prostate cancer cells. Remarkably, daily oral feeding of 100 mg/kg body weight of GE inhibited growth and progression of PC-3 xenografts by approximately 56 % in nude mice, as shown by measurements of tumour volume. Tumour tissue from GE-treated mice showed reduced proliferation index and widespread apoptosis compared with controls, as determined by immunoblotting and immunohistochemical methods. Most importantly, GE did not exert any detectable toxicity in normal, rapidly dividing tissues such as gut and bone marrow. To the best of our knowledge, this is the first report to demonstrate the in vitro and in vivo anticancer activity of whole GE for the management of prostate cancer.

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Corresponding author

*Corresponding author: R. Aneja, fax +1 404 413 5301, email


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1 Syed, DN, Khan, N, Afaq, F, et al. (2007) Chemoprevention of prostate cancer through dietary agents: progress and promise. Cancer Epidemiol Biomarkers Prev 16, 21932203.
2 Nelson, WG, De Marzo, AM & Isaacs, WB (2003) Prostate cancer. N Engl J Med 349, 366381.
3 Sporn, MB (1976) Approaches to prevention of epithelial cancer during the preneoplastic period. Cancer Res 36, 26992702.
4 Mann, JR, Backlund, MG & DuBois, RN (2005) Mechanisms of disease: inflammatory mediators and cancer prevention. Nat Clin Pract Oncol 2, 202210.
5 Kaur, M, Agarwal, C & Agarwal, R (2009) Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products. J Nutr 139, 1806S1812S.
6 Cooke, D, Steward, WP, Gescher, AJ, et al. (2005) Anthocyans from fruits and vegetables – does bright colour signal cancer chemopreventive activity? Eur J Cancer 41, 19311940.
7 Yang, CS, Landau, JM, Huang, MT, et al. (2001) Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr 21, 381406.
8 Traka, M, Gasper, AV, Melchini, A, et al. (2008) Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate. PLoS One 3, e2568.
9 Steinkellner, H, Rabot, S, Freywald, C, et al. (2001) Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. Mutat Res 480–481, 285297.
10 Colli, JL & Amling, CL (2009) Chemoprevention of prostate cancer: what can be recommended to patients? Curr Urol Rep 10, 165171.
11 Craig, WJ (1999) Health-promoting properties of common herbs. Am J Clin Nutr 70, Suppl. 3, 491S499S.
12 Surh, YJ (2003) Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3, 768780.
13 Zick, SM, Djuric, Z, Ruffin, MT, et al. (2008) Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects. Cancer Epidemiol Biomarkers Prev 17, 19301936.
14 Shukla, Y & Singh, M (2007) Cancer preventive properties of ginger: a brief review. Food Chem Toxicol 45, 683690.
15 Shobana, S & Naidu, KA (2000) Antioxidant activity of selected Indian spices. Prostaglandins Leukot Essent Fatty Acids 62, 107110.
16 Katiyar, SK, Agarwal, R & Mukhtar, H (1996) Inhibition of tumor promotion in SENCAR mouse skin by ethanol extract of Zingiber officinale rhizome. Cancer Res 56, 10231030.
17 Surh, YJ (2002) Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol 40, 10911097.
18 Kim, EC, Min, JK, Kim, TY, et al. (2005) [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo. Biochem Biophys Res Commun 335, 300308.
19 Kim, SO, Kundu, JK, Shin, YK, et al. (2005) [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. Oncogene 24, 25582567.
20 Fuhrman, B, Rosenblat, M, Hayek, T, et al. (2000) Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice. J Nutr 130, 11241131.
21 Liu, RH (2003) Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 78 (Suppl. 3), 517S520S.
22 Yang, CS (1997) Inhibition of carcinogenesis by tea. Nature 389, 134135.
23 Jankun, J, Selman, SH, Swiercz, R, et al. (1997) Why drinking green tea could prevent cancer. Nature 387, 561.
24 Liu, RH (2004) Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr 134, Suppl. 12, 3479S3485S.
25 Nociari, MM, Shalev, A, Benias, P, et al. (1998) A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity. J Immunol Methods 213, 157167.
26 Karna, P, Zughaier, S, Pannu, V, et al. (2010) Induction of reactive oxygen species-mediated autophagy by a novel microtubule-modulating agent. J Biol Chem 285, 1873718748.
27 Waterhouse, NJ, Goldstein, JC, von Ahsen, O, et al. (2001) Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process. J Cell Biol 153, 319328.
28 Lee, HS, Seo, EY, Kang, NE, et al. (2008) [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. J Nutr Biochem 19, 313319.
29 Jeong, CH, Bode, AM, Pugliese, A, et al. (2009) [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. Cancer Res 69, 55845591.
30 Aggarwal, BB & Shishodia, S (2006) Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71, 13971421.
31 Meeran, SM & Katiyar, SK (2008) Cell cycle control as a basis for cancer chemoprevention through dietary agents. Front Biosci 13, 21912202.
32 Park, YJ, Wen, J, Bang, S, et al. (2006) [6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells. Yonsei Med J 47, 688697.
33 Grana, X & Reddy, EP (1995) Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11, 211219.
34 Besson, A, Dowdy, SF & Roberts, JM (2008) CDK inhibitors: cell cycle regulators and beyond. Dev Cell 14, 159169.
35 Green, DR & Reed, JC (1998) Mitochondria and apoptosis. Science 281, 13091312.
36 Adams, JM & Cory, S (1998) The Bcl-2 protein family: arbiters of cell survival. Science 281, 13221326.
37 Kelloff, GJ, Sigman, CC & Greenwald, P (1999) Cancer chemoprevention: progress and promise. Eur J Cancer 35, 20312038.
38 Bidoli, E, Talamini, R, Bosetti, C, et al. (2005) Macronutrients, fatty acids, cholesterol and prostate cancer risk. Ann Oncol 16, 152157.
39 Saha, S, Smith, RM, Lenz, E, et al. (2003) Analysis of a ginger extract by high-performance liquid chromatography coupled to nuclear magnetic resonance spectroscopy using superheated deuterium oxide as the mobile phase. J Chromatogr A 991, 143150.
40 Jolad, SD, Lantz, RC, Solyom, AM, et al. (2004) Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production. Phytochemistry 65, 19371954.
41 Kato, A, Higuchi, Y, Goto, H, et al. (2006) Inhibitory effects of Zingiber officinale Roscoe derived components on aldose reductase activity in vitro and in vivo. J Agric Food Chem 54, 66406644.
42 Park, KK, Chun, KS, Lee, JM, et al. (1998) Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer Lett 129, 139144.
43 Yoshimi, N, Wang, A, Morishita, Y, et al. (1992) Modifying effects of fungal and herb metabolites on azoxymethane-induced intestinal carcinogenesis in rats. Jpn J Cancer Res 83, 12731278.
44 Wang, W, Li, CY, Wen, XD, et al. (2009) Plasma pharmacokinetics, tissue distribution and excretion study of 6-gingerol in rat by liquid chromatography–electrospray ionization time-of-flight mass spectrometry. J Pharm Biomed Anal 49, 10701074.
45 The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 330, 10291035.
46 Omenn, GS, Goodman, GE, Thornquist, MD, et al. (1996) Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 334, 11501155.
47 Reagan-Shaw, S, Nihal, M & Ahmad, N (2008) Dose translation from animal to human studies revisited. FASEB J 22, 659661.


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