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Bioavailability of angiotensin I converting enzyme inhibitory peptides

  • Vanessa Vermeirssen (a1) (a2), John Van Camp (a2) and Willy Verstraete (a1)
  • DOI: http://dx.doi.org/10.1079/BJN20041189
  • Published online: 01 March 2007
Abstract

Hypertension or high blood pressure is a significant health problem worldwide. Bioactive peptides that inhibit angiotensin I converting enzyme (ACE) in the cardiovascular system can contribute to the prevention and treatment of hypertension. These ACE inhibitory peptides are derived from many food proteins, especially milk proteins. An ACE inhibitory activity in vitro does not always imply an antihypertensive effect in vivo. Even if it does, it is very difficult to establish a direct relationship between in vitro and in vivo activity. This is mainly due to the bioavailability of the ACE inhibitory peptides after oral administration and the fact that peptides may influence blood pressure by mechanisms other than ACE inhibition. To exert an antihypertensive effect after oral ingestion, ACE inhibitory peptides have to reach the cardiovascular system in an active form. Therefore, they need to remain active during digestion by human proteases and be transported through the intestinal wall into the blood. The bioavailability of some ACE inhibitory peptides has been studied. It is also known that (hydroxy)proline-containing peptides are generally resistant to degradation by digestive enzymes. Peptides can be absorbed intact through the intestine by paracellular and transcellular routes, but the potency of the bioactivity after absorption is inversely correlated to chain length. In addition, some strategies are proposed to increase the bioavailability of ACE inhibitory peptides. Further research into the bioavailability of ACE inhibitory peptides will lead to the development of more effective ACE inhibitory peptides and foods.

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*Corresponding author: fax + 32 92 64 62 48, Email willy.verstrete@UGent.be
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

DA Clare & HE Swaisgood Bioactive milk peptides: a prospectus J Dairy Sci. (2000) 83, 11871195

DW Cushman & HS Cheung Spectrophotometric assay and properties of the angiotensin converting enzyme of rabbit lung Biochem Pharmacol (1971) 20 16371648

DW Cushman &MA Ondetti Design of angiotensin converting enzyme inhibitors Nat Med (1999) 5 11101112

CT Dooley &RA Houghten New opioid peptides, peptidomimetics, and heterocyclic compounds from combinatorial libraries Biopolymers (1999) 51 379390

DJ Drucker , Q Shi , A Crivici , M Sumner Smith , W Tavares , M Hill , L DeForest , S Cooper &PL Brubaker Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV Nat Biotechnol (1997) 15 673677

D Duprez , P Van Helshoecht , W Van den Eynde &M Leeman Prevalence of hypertension in the adult population of Belgium: report of a worksite study, Attention Hypertension J Hum Hypertens (2002) 16 4752

G Elbl &H Wagner A new method for the in vitro screening of inhibitors of angiotensin-converting enzyme (ACE), using the chromophore- and fluorophore-labelled substrate, dansyltriglycine Planta Med (1991) 57 137141

U Eriksson , U Danilczyk &JM Penninger Just the beginning: novel functions for angiotensin-converting enzymes Curr Biol (2002) 12 745752

H Fujita , H Usui , K Kurahashi & M Yoshikawa Isolation and characterization of ovokinin, a bradykinin B-1 agonist peptide derived from ovalbumin. Peptides (1995) 16, 785790.

H Fujita & M Yoshikawa LKPNM: a prodrug-type ACE inhibitory peptide derived from fish protein. Immunopharmacology (1999) 44, 123127.

M Furushiro , S Hashimoto , M Hamura & T Yokokura Mechanism for the antihypertensive effect of a polysaccharide–glycopeptide complex from Lactobacillus casei in spontaneously hypertensive rats (SHR). Biosci Biotechnol Biochem (1993) 57, 978981.

M Furushiro , H Sawada , K Hirai , M Motoike , H Sansawa , S Kobayashi , M Watanuki & T Yokokura Blood-pressure-lowering effect of extract from Lactobacillus casei in spontaneously hypertensive rats (SHR). Agric Biol Chem (1990) 54, 21932198.

MLG Gardner Intestinal assimilation of intact peptides and proteins from the diet – a neglected field?. Biol Rev (1984) 59, 289331.

MLG Gardner Gastrointestinal absorption of intact proteins. Annu Rev Nutr (1988) 8, 329350.

DW Harsha , PH Lin , E Obarzanek , N Karanja , T Moore & B Caballero Dietary approaches to stop hypertension: a summary of study results. J Am Diet Assoc (1999) 99, S35S39.

B Holmquist , P Bünning & JF Riordan A continuous spectrophotometric assay for the angiotensin converting enzyme. Anal Biochem (1979) 95, 540548.

H Korhonen & A Pihlanto Food-derived bioactive peptides – opportunities for designing future foods. Curr Pharm Des (2003) 9, 12971308.

C Krüger , Y Hu , Q Pan , et al.. In situ delivery of passive immunity by lactobacilli producing single-chain antibodies. Nat Biotechnol (2002) 20, 702706.

M Maeno , N Yamamoto & T Takano Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. J Dairy Sci (1996) 79, 13161321.

W Maes , J Van Camp , V Vermeirssen , M Hemeryck , JM Ketelslegers , J Schrezenmeir , P Van Oostveldt & A Huyghebaert Influence of the lactokinin Ala-Leu-Pro-Met-His-Ile-Arg (ALPMHIR) on the release of endothelin-1 by endothelial cells. Regul Pept (2004) 118, 105109.

S Maruyama , H Mitachi , H Tanaka , N Tomizuka & H Suzuki Studies on the active site and antihypertensive activity of angiotensin I-converting enzyme inhibitors derived from casein. Agric Biol Chem (1987) 51, 15811586.

N Matoba , H Usui , H Fujita & M Yoshikawa A novel anti-hypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorelaxation in an isolated SHR mesenteric artery. FEBS Lett (1999) 452, 181184.

N Matoba , Y Yamada , H Usui , R Nakagiri & M Yoshikawa Designing potent derivatives of ovokinin(2–7), an anti-hypertensive peptide derived from ovalbumin. Biosci Biotechnol Biochem (2001) 65, 736739.

T Matsui , CH Li & Y Osajima Preparation and characterization of novel bioactive peptides responsible for angiotensin I-converting enzyme inhibition from wheat germ. J Pept Sci (1999) 5, 289297.

T Matsui , CH Li , T Tanaka , T Maki , Y Osajima & K Matsumoto Depressor effect of wheat germ hydrolysate and its novel angiotensin I-converting enzyme inhibitory peptide, Ile-Val-Tyr, and the metabolism in rat and human plasma. Biol Pharm Bull (2000) 23, 427431.

T Matsui , K Tamaya , E Seki , K Osajima , K Matsumoto & T Kawasaki Absorption of Val-Tyr with in vitro angiotensin I-converting enzyme inhibitory activity into the circulating blood system of mild hypertensive subjects. Biol Pharm Bull (2002 a) 25, 12281230.

T Matsui , K Tamaya , E Seki , K Osajima , K Matsumoto & T Kawasaki Val-Tyr as a natural antihypertensive dipeptide can be absorbed into the human circulatory blood system. Clin Exp Pharmacol Physiol (2002 b) 29, 204208.

KH Mayo Recent advances in the design and construction of synthetic peptides: for the love of basics or just for the technology of it. Trends Biotechnol (2000) 18, 212217.

H Meisel Biochemical properties of bioactive peptides derived from milk proteins: potential nutraceuticals for food and pharmaceutical applications. Livest Prod Sci (1997 a) 50, 125138.

H Meisel Biochemical properties of regulatory peptides derived from milk proteins. Biopolymers (1997 b) 43, 119128.

H Meisel Overview on milk protein-derived peptides. Int Dairy J (1998) 8, 363373.

H Meisel & W Bockelmann Bioactive peptides encrypted in milk proteins: proteolytic activation and thropho-functional properties. Antonie Van Leeuwenhoek (1999) 76, 207215.

MC Morris , J Depollier , J Mery , F Heitz & G Divita A peptide carrier for the delivery of biologically active proteins into mammalian cells. Nat Biotechnol (2001) 19, 1173

DW Moskowitz Is angiotensin I-converting enzyme a "master" disease gene?. Diabetes Technol Ther (2002) 4, 683711.

DW Moskowitz Is 'somatic' angiotensin-I-converting enzyme a mechanosensor?. Diabetes Technol Ther (2003) 4, 841858.

K Nakajima , Y Hata , Y Osono , M Hamura , S Kobayashi & M Watanuki Antihypertensive effect of extracts of Lactobacillus casei in patients with hypertension. J Clin Biochem Nutr (1995) 18, 181187.

Y Nakamura , N Yamamoto , K Sakai , A Okubo , S Yamazaki & T Takano Purification and characterization of angiotensin I-converting enzyme inhibitors from a sour milk. J Dairy Sci (1995) 78, 777783.

ML Nurminen , M Sipola , H Kaarto , A Pihlanto-Leppala , K Piilola , R Korpela , O Tossavainen , H Korhonen & H Vapaatalo α-Lactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats. Life Sci (2000) 66, 15351543.

M Okitsu , A Morita , M Kakitani , M Okada & H Yokogoshi Inhibition of the endothelin-converting enzyme by pepsin digests of food proteins. Biosci Biotechnol Biochem (1995) 59, 325326.

A Pihlanto-Leppälä Bioactive peptides derived from bovine whey proteins: opioid and ACE inhibitory peptides. Trends Food Sci Technol (2001) 11, 347356.

JF Riordan Angiotensin-I-converting enzyme and its relatives. Genome Biol (2003) 4, 225.

PR Roberts , JD Burney , KW Black & GP Zaloga Effect of chain length on absorption of biologically active peptides from the gastrointestinal tract. Digestion (1999) 60, 332337.

LA Rubio & I Seiquer Transport of amino acids from in vitro digested legume proteins or casein in Caco-2 cell cultures. J Agric Food Chem (2002) 50, 52025206.

T Saito , T Nakamura , H Kitazawa , Y Kawai & T Itoh Isolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese. J Dairy Sci (2000) 83, 14341440.

M Satake , M Enjoh , Y Nakamura , T Takano , Y Kawamura , S Arai & M Shimizu Transepithelial transport of the bioactive tripeptide, Val-Pro-Pro, in human intestinal Caco-2 cell monolayers. Biosci Biotechnol Biochem (2002) 66, 378384.

M Shimizu Modulation of intestinal functions by food substances. Nahrung (1999) 43, 154158.

M Shimizu , M Tsunogai & S Arai Transepithelial transport of oligopeptides in the human intestinal cell, Caco-2. Peptides (1997) 18, 681687.

J Stamler , P Elliott , H Kesteloot , R Nichols , G Claeys , AR Dyer & R Stamler Inverse relation of dietary protein markers with blood pressure. Findings for 10 020 men and women in the INTERSALT study. INTERSALT Cooperative Research Group: INTERnational study of SALT and blood pressure. Circulation (1996) 94, 16291634.

L Steidler In situ delivery of cytokines by genetically engineered Lactococcus lactis. Antonie Van Leeuwenhoek (2002) 82, 323331.

K Suetsuna Isolation and characterization of angiotensin I-converting enzyme inhibitor dipeptides derived from Allium sativum L (garlic). J Nutr Biochem (1998) 9, 415419.

J Svedberg , J de Haas , G Leimenstoll , F Paul & H Teschemacher Demonstration of β-casomorphin immunoreactive materials in in vitro digests of bovine milk and in small intestine contents after bovine milk ingestion in adult humans. Peptides (1985) 6, 825830.

T Takano Milk derived peptides and hypertension reduction. Int Dairy J (1998) 8

AJ Turner & NM Hooper The angiotensin-converting enzyme gene family: genomics and pharmacology. Trends Pharmacol Sci (2002) 23, 177183.

M Umbach , H Teschemacher , K Praetorius , R Hirschhäuser & H Bostedt Demonstration of a β-casomorphin immunoreactive material in the plasma of newborn calves after milk intake. Regul Pept (1985) 12, 223230.

V Vermeirssen , B Deplancke , KA Tappenden , J Van Camp , HR Gaskins & W Verstraete Intestinal transport of the lactokinin Ala-Leu-Pro-Met-His-Ile-Arg through a Caco-2 Bbe monolayer. J Pept Sci (2002 a) 8, 95100.

V Vermeirssen , J Van Camp , K Decroos , L Van Wijmelbeke & W Verstraete The impact of fermentation and in vitro digestion on the formation of ACE inhibitory activity from pea and whey protein. J Dairy Sci (2003 a) 86, 429438.

V Vermeirssen , J Van Camp , L Devos & W Verstraete Release of angiotensin I converting enzyme (ACE) inhibitory activity during in vitro gastrointestinal digestion: from batch experiment to semi-continuous model. J Agric Food Chem (2003 b) 51, 56805687.

V Vermeirssen , J Van Camp & W Verstraete Optimisation and validation of an angiotensin converting enzyme (ACE) inhibition assay for the screening of bioactive peptides. J Biochem Biophys Methods (2002 b) 51, 7587.

KE Webb Jr Intestinal absorption of protein hydrolysis products: a review. J Anim Sci (1990) 68, 30113022.

G Wilson , IF Hassan , CJ Dix , I Williamson , R Shah , M Mackay & P Artursson Transport and permeability properties of human caco-2 cells – an in vitro model of the intestinal epithelial-cell barrier. J Control Releasege (1990) 11, 2540.

JP Wu & XL Ding Hypotensive and physiological effect of angiotensin converting enzyme inhibitory peptides derived from soy protein on spontaneously hypertensive rats. J Agric Food Chem (2001) 49, 501506.

N Yamamoto Antihypertensive peptides derived from food proteins. Biopolymers (1997) 43, 129134.

N Yamamoto , M Ejiri & S Mizuno Biogenic peptides and their potential use. Curr Pharm Des (2003) 9, 13451355.

N Yamamoto , M Maeno & T Takano Purification and characterization of an antihypertensive peptide from a yogurt-like product fermented by Lactobacillus helveticus CPN4 J Dairy Sci (1999) 82, 13881393.

CY Yang , AH Dantzig & C Pidgeon Intestinal peptide transport systems and oral drug availability. Pharm Res (1999) 16, 13311343.

M Yoshikawa , H Fujita , N Matoba , Y Takenaka , T Yamamoto , R Yamauchi , H Tsuruki & K Takahata Bioactive peptides derived from food proteins preventing lifestyle-related diseases. Biofactors (2000) 12, 143146.

E Ziv & M Bendayan Intestinal absorption of peptides through the enterocytes. Microsc Res Tech (2000) 49, 346352.

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