Skip to main content Accesibility Help
×
×
Home

Biomarkers of bone health appropriate for evaluating functional foods designed to reduce risk of osteoporosis

  • Connie M. Weaver (a1) and Michael Liebman (a2)
Abstract

Osteoporosis is a growing global problem. The health care costs and decreased productivity and quality of life are staggering. Much research is invested in life-style approaches to build peak bone mass during growth to prevent osteoporosis as well as to treat the disease in later life. Functional foods have enjoyed a niche in bone health. Foods fortified with Ca are most popular. Other bone nutrients such as vitamin D, Mg and vitamin K are sometimes added. Future products are likely to include enhancers of Ca absorption such as inulin or whey proteins. Dietary factors that reduce urinary Ca loss (plant proteins) or suppress bone resorption (possibly phyto-oestrogens) are also gaining attention. Methodologies for evaluating the effectiveness of functional foods on bone health include measures of bone quality such as bone densitometry or measures of Ca metabolism, particularly absorption. Biochemical markers for bone turnover are less satisfactory for diet-related effects. Use of a rare isotope, 41Ca, and accelerator mass spectrometry offers a new approach for assessing the ability of functional foods to suppress bone resorption.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Biomarkers of bone health appropriate for evaluating functional foods designed to reduce risk of osteoporosis
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Biomarkers of bone health appropriate for evaluating functional foods designed to reduce risk of osteoporosis
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Biomarkers of bone health appropriate for evaluating functional foods designed to reduce risk of osteoporosis
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr C. M. Weaver, fax +1 765 494 0674, email weavercm@cfs.purdue.edu
References
Hide All
Ames, SK, Ellis, KJ, Gunn, SK, Copeland, K & Abrams, SA (1999) Vitamin D receptor gene Fok1 polymorphism predicts calcium absorption and bone mineral density in children. Journal of Bone and Mineral Research 14, 740746.
Bonjour, JP, Carrie, AL, Ferriri, S, Clavien, H, Slosman, D, Thientz, G & Rizzoli, R (1997) Calcium-enriched foods and bone mass growth in prepubertal girls — a randomized, double-blind, placebo-controlled trial. Journal of Clinical Investigation 99, 12871298.
Bronner, F & Pansu, D (1999) Nutritional aspects of calcium absorption. Journal of Nutrition 129, 912.
Bronner, F, Pansu, D & Stein, WD (1986) An analysis of intestinal calcium transport across the rat intestine. American Journal of Physiology 250, G561G569.
Bryant, RJ, Cadogan, J & Weaver, CM (1999) The new Dietary Reference Intakes for calcium: implications for osteoporosis. Journal of the American College of Nutrition 18, 406S412S.
Coudray, C, Bellanger, J, Castiglia-Delavaud, C, Remesy, C, Vermorel, M & Rayssignuier, Y (1997) Effect of soluble or partly soluble dietary fibres supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men. European Journal of Clinical Nutrition 51, 375380.
Eaton, SB & Konner, M (1985) Paleolithic nutrition: a consideration of its nature and current implications. New England Journal of Medicine 312, 283289.
Fleet, JC & Wood, RJ (1999) Specific 1,25 (OH)2D3-mediated regulation of transcellular calcium transport in Caco-2 cells. American Journal of Physiology 276, G958G964.
Food and Nutrition Board (1997) Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Washington, DC: National Academy Press.
Hanes, DA, Weaver, CM, Heaney, RP & Wastney, ME (1999 a) Absorption of calcium oxalate does not require dissociation in rats. Journal of Nutrition 129, 170173.
Hanes, DA, Weaver, CM & Wastney, ME (1999 b) Calcium and oxalic acid kinetics are different in rats. Journal of Nutrition 129, 165169.
Hargreaves, T & Rose, GA (1965) The reproducibility of the balance method in man as applied to calcium and phosphorus. Clinical Science 28, 537542.
Heaney, RP, Dowell, S, Bierman, J, Hale, C & Bendich, A (2001) Absorbability and cost effectiveness in calcium supplementation. Journal of the American College of Nutrition 20, 239246.
Heaney, RP, Recker, RR & Hinders, SM (1988) Variability of calcium absorption. American Journal of Clinical Nutrition 47, 2264.
Heaney, RP, Recker, RR & Weaver, CM (1990 a) Absorbability of calcium sources. The limited role of solubility. Calcified Tissue International 46, 300304.
Heaney, RP, Saito, Y & Orimo, H (1994) Effect of caseinphosphopeptide on absorbability of co-ingested calcium in normal postmenopausal women. Journal of Bone and Mineral Metabolism 12, 7781.
Heaney, RP & Weaver, CM (1989) Oxalate: effect on calcium absorbability. American Journal of Clinical Nutrition 50, 830832.
Heaney, RP & Weaver, CM (1995) Effect of psyllium on absorption of co-ingested calcium. Journal of American Geriatric Society 43, 13.
Heaney, RP, Weaver, CM & Fitzsimmsons, L (1990 b) The influence of calcium load on absorption fraction. American Journal of Clinical Nutrition 5, 11351138.
Heaney, RP, Weaver, CM & Fitzsimmons, ML (1991) Soybean phytate content: effect on calcium absorption. American Journal of Clinical Nutrition 53, 745747.
Heller, JH (1999) The role of calcium in the prevention of kidney stones. Journal of American College of Nutrition 18, 373S378S.
Holt, PR (1999) Dairy foods and prevention of colon cancer: human studies. Journal of the American College of Nutrition 18, 379S391S.
Jackman, LA, Millane, SS, Martin, BR, Wood, OB, McCabe, GP, Peacock, M & Weaver, CM (1997) Calcium retention in relation to calcium intake and postmenarcheal age in adolescent females. American Journal of Clinical Nutrition 66, 327333.
Kelsay, JL & Prather, ES (1983) Mineral balances of human subjects consuming spinach in a low-fiber diet and in a diet containing fruits and vegetables. American Journal of Clinical Nutrition 38, 1219.
Koo, J, Weaver, CM, Neylan, MJ & Miller, GD (1993) Isotopic tracer techniques for assessing calcium absorption in rats. Journal of Nutritional Biochemistry 4, 7276.
Liebman, M & Doane, L (1989) Calcium and zinc balances during consumption of high and low oxalate-containing vegetables. Nutrition Research 9, 947955.
Liebman, M & Landis, W (1989) Calcium and zinc balances of premenopausal women consuming tofu- compared to cheesecontaining diets. Nutrition Research 9, 514.
Lin, Y-C, Lyle, RM, McCabe, LD, McCabe, GP, Weaver, CM & Teegarden, D (2000) Calcium intake relates to change in body weight in young women. Journal of the American College of Nutrition 19, 754760.
Lipkin, M & Newmark, HL (1999) Vitamin D calcium and prevention of breast cancer: a review. Journal of the American College of Nutrition 18, 392S397S.
McCance, RA & Widdowson, EM (1942) Mineral metabolism of healthy adults on white and brown bread dietaries. Journal of Physiology 101, 4485.
McCarron, DA & Reusser, ME (1999) Finding consensus in the dietary calcium-blood pressure debate. Journal of the American College of Nutrition 18, 398S405S.
Matkovic, V & Heaney, RP (1992) Calcium balance during human growth: evidence for threshold behavior. American Journal of Clinical Nutrition 55, 992996.
Miller, JZ, Smith, DL, Flora, L, Slemenda, C, Juang, X & Johnston, CC (1988) Calcium absorption from calcium carbonate and a new form of calcium (CCM) in healthy male and female adolescents. American Journal of Clinical Nutrition 48, 12911294.
Morris, ER & Ellis, R (1985) Bioavailability of dietary calcium: effect of phytate on adult men consuming nonvegetarian diets. In Nutritional Bioavailability of Calcium, pp. 6372 [Kies, C, editor]. Washington, DC: American Chemical Society.
O'Brien, KO, Abrams, SA, Liang, LK, Ellis, KJ & Gagel, RF (1998) Bone turnover response to changes in calcium intake is altered in girls and adult women in families with histories of osteoporosis. Journal of Bone and Mineral Research 13, 491499.
Pansu, D, Bellaton, C, Roche, C & Bronner, F (1983) Duodenal and ileal calcium absorption in the rat and effects of vitamin D. American Journal of Physiology 244, G695G700.
Pappenheimer, JR & Reiss, KZ (1987) Contribution of solvent drag through intracellular to absorption of nutrients by the small intestine of the rat. Journal of Membrane Biology 100, 123136.
Pinto, M, Robine-Leon, S, Appay, M, Kedinger, M, Triadou, N, Dussaulx, E, Lacroix, B, Simon-Assmann, P, Haffen, K, Fogh, J & Zweibaum, A (1983) Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture. Biology of the Cell 47, 323330.
Schanler, R & Abrams, SA (1995) Postnatal attainment of intrauterine mineral accretion rates in low birth weight infants fed fortified human milk. Journal of Pediatrics 126, 441447.
Shen, X, Weaver, CM, Kempa-Steczko, A, Martin, BR, Phillippy, BQ & Heaney, RP (1998) An inositol phosphate as a calcium absorption enhancer in rats. Journal of Nutritional Biochemistry 9, 298301.
Thys-Jacobs, S, Starkey, P, Bernstein, D & Tian, J (1998) Premenstrual Syndrome Study Group. Calcium carbonate and premenstrual syndrome: effects on premenstrual and menstrual symptoms. American Journal of Obstetrics and Gynecology 179, 444452.
Tsugawa, N, Yamabe, T, Takeuchi, A, Kamao, M, Nakagawa, K, Nishijima, K & Okano, T (1999) Intestinal absorption of calcium from calcium ascorbate in rats. Journal of Bone and Mineral Metabolism 17, 3036.
van den Heuvel, E, Muys, T, van Dokskum, W & Schaafsma, G (1999) Oligofructose stimulates calcium absorption in adolescents. American Journal of Clinical Nutrition 69, 544548.
Wastney, ME, Martin, BR, Peacock, M, Smith, D, Jiang, X-Y, Jackman, LA & Weaver, CM (2000) Changes in calcium kinetics in adolescent girls induced by high calcium intake. Journal of Clinical Endocrinology and Metabolism 85, 44704475.
Wastney, ME, Ng, J, Smith, D, Martin, BR, Peacock, M & Weaver, CM (1996) Differences in calcium kinetics between adolescent girls and young women. American Journal of Physiology 271, R208R216.
Weaver, CM (1998) Use of calcium tracers and biomarkers to determine calcium kinetics and bone turnover. Bone 22, 103S104S.
Weaver, CM, Heaney, RP, Martin, BR & Fitzsimmons, ML (1991) Human calcium absorption from whole wheat products. Journal of Nutrition 121, 17691775.
Weaver, CM, Heaney, RP, Teegarden, D & Hinders, SM (1996) Wheat bran abolishes the inverse relationship between calcium load size and absorption fraction in women. Journal of Nutrition 126, 303307.
Weaver, CM, Proulx, WR & Heaney, RP (1999) Choices for achieving dietary calcium within a vegetarian diet. American Journal of Clinical Nutrition 70, 543S548S.
Weaver, CM, Spence, LA & Lipscomb, ER (2001) Phytoestrogens and bone health. In Nutritional Aspects of OsteoporosisM, pp. 315324 [Burckhardt, P, Dawson-Hughes, B and Heaney, RP editors]. New York: Academic Press.
Yee, S (1997) In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man — fact or myth. Pharmaceutical Research 14, 763766.
Zemel, MB, Shi, H, Greer, B, Direnzo, D & Zemel, PC (2000) Regulation of adiposity by dietary calcium. FASEB Journal 14, 11321138.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed