Hostname: page-component-8448b6f56d-cfpbc Total loading time: 0 Render date: 2024-04-24T00:32:35.965Z Has data issue: false hasContentIssue false
  • English
  • Français

Biomarkers of bone health appropriate for evaluating functional foods designed to reduce risk of osteoporosis

Published online by Cambridge University Press:  09 March 2007

Connie M. Weaver  and
Michael Liebman
Connie M. Weaver*
Affiliation:
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907-1264, USA
Michael Liebman
Affiliation:
Department of Family and Consumer Sciences (Human Nutrition), University of Wyoming, Laramie, WY 82071-3354, USA
*
*Corresponding author: Dr C. M. Weaver, fax +1 765 494 0674, email weavercm@cfs.purdue.edu
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Osteoporosis is a growing global problem. The health care costs and decreased productivity and quality of life are staggering. Much research is invested in life-style approaches to build peak bone mass during growth to prevent osteoporosis as well as to treat the disease in later life. Functional foods have enjoyed a niche in bone health. Foods fortified with Ca are most popular. Other bone nutrients such as vitamin D, Mg and vitamin K are sometimes added. Future products are likely to include enhancers of Ca absorption such as inulin or whey proteins. Dietary factors that reduce urinary Ca loss (plant proteins) or suppress bone resorption (possibly phyto-oestrogens) are also gaining attention. Methodologies for evaluating the effectiveness of functional foods on bone health include measures of bone quality such as bone densitometry or measures of Ca metabolism, particularly absorption. Biochemical markers for bone turnover are less satisfactory for diet-related effects. Use of a rare isotope, 41Ca, and accelerator mass spectrometry offers a new approach for assessing the ability of functional foods to suppress bone resorption.

Keywords

OsteoporosisBone healthFood fortificationBiochemical biomarkersCalcium
Type
Research Article
Information
British Journal of Nutrition , Volume 88 , Issue S2 , November 2002 , pp. S225 - S232
Copyright
Copyright © The Nutrition Society 2002

References

Ames, SK, Ellis, KJ, Gunn, SK, Copeland, K & Abrams, SA (1999) Vitamin D receptor gene Fok1 polymorphism predicts calcium absorption and bone mineral density in children. Journal of Bone and Mineral Research 14, 740–746.CrossRefGoogle ScholarPubMed
Bonjour, JP, Carrie, AL, Ferriri, S, Clavien, H, Slosman, D, Thientz, G & Rizzoli, R (1997) Calcium-enriched foods and bone mass growth in prepubertal girls — a randomized, double-blind, placebo-controlled trial. Journal of Clinical Investigation 99, 1287–1298.CrossRefGoogle ScholarPubMed
Bronner, F & Pansu, D (1999) Nutritional aspects of calcium absorption. Journal of Nutrition 129, 9–12.CrossRefGoogle ScholarPubMed
Bronner, F, Pansu, D & Stein, WD (1986) An analysis of intestinal calcium transport across the rat intestine. American Journal of Physiology 250, G561–G569.Google ScholarPubMed
Bryant, RJ, Cadogan, J & Weaver, CM (1999) The new Dietary Reference Intakes for calcium: implications for osteoporosis. Journal of the American College of Nutrition 18, 406S–412S.CrossRefGoogle ScholarPubMed
Coudray, C, Bellanger, J, Castiglia-Delavaud, C, Remesy, C, Vermorel, M & Rayssignuier, Y (1997) Effect of soluble or partly soluble dietary fibres supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men. European Journal of Clinical Nutrition 51, 375–380.CrossRefGoogle ScholarPubMed
Eaton, SB & Konner, M (1985) Paleolithic nutrition: a consideration of its nature and current implications. New England Journal of Medicine 312, 283–289.CrossRefGoogle ScholarPubMed
Fleet, JC & Wood, RJ (1999) Specific 1,25 (OH)2D3-mediated regulation of transcellular calcium transport in Caco-2 cells. American Journal of Physiology 276, G958–G964.Google ScholarPubMed
Food and Nutrition Board (1997) Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Washington, DC: National Academy Press.Google Scholar
Hanes, DA, Weaver, CM, Heaney, RP & Wastney, ME (1999 a) Absorption of calcium oxalate does not require dissociation in rats. Journal of Nutrition 129, 170–173.CrossRefGoogle ScholarPubMed
Hanes, DA, Weaver, CM & Wastney, ME (1999 b) Calcium and oxalic acid kinetics are different in rats. Journal of Nutrition 129, 165–169.CrossRefGoogle ScholarPubMed
Hargreaves, T & Rose, GA (1965) The reproducibility of the balance method in man as applied to calcium and phosphorus. Clinical Science 28, 537–542.Google Scholar
Heaney, RP, Dowell, S, Bierman, J, Hale, C & Bendich, A (2001) Absorbability and cost effectiveness in calcium supplementation. Journal of the American College of Nutrition 20, 239–246.CrossRefGoogle ScholarPubMed
Heaney, RP, Recker, RR & Hinders, SM (1988) Variability of calcium absorption. American Journal of Clinical Nutrition 47, 2–264.CrossRefGoogle ScholarPubMed
Heaney, RP, Recker, RR & Weaver, CM (1990 a) Absorbability of calcium sources. The limited role of solubility. Calcified Tissue International 46, 300–304.CrossRefGoogle ScholarPubMed
Heaney, RP, Saito, Y & Orimo, H (1994) Effect of caseinphosphopeptide on absorbability of co-ingested calcium in normal postmenopausal women. Journal of Bone and Mineral Metabolism 12, 77–81.CrossRefGoogle Scholar
Heaney, RP & Weaver, CM (1989) Oxalate: effect on calcium absorbability. American Journal of Clinical Nutrition 50, 830–832.CrossRefGoogle ScholarPubMed
Heaney, RP & Weaver, CM (1995) Effect of psyllium on absorption of co-ingested calcium. Journal of American Geriatric Society 43, 1–3.CrossRefGoogle ScholarPubMed
Heaney, RP, Weaver, CM & Fitzsimmsons, L (1990 b) The influence of calcium load on absorption fraction. American Journal of Clinical Nutrition 5, 1135–1138.Google ScholarPubMed
Heaney, RP, Weaver, CM & Fitzsimmons, ML (1991) Soybean phytate content: effect on calcium absorption. American Journal of Clinical Nutrition 53, 745–747.CrossRefGoogle ScholarPubMed
Heller, JH (1999) The role of calcium in the prevention of kidney stones. Journal of American College of Nutrition 18, 373S–378S.CrossRefGoogle ScholarPubMed
Holt, PR (1999) Dairy foods and prevention of colon cancer: human studies. Journal of the American College of Nutrition 18, 379S–391S.CrossRefGoogle ScholarPubMed
Jackman, LA, Millane, SS, Martin, BR, Wood, OB, McCabe, GP, Peacock, M & Weaver, CM (1997) Calcium retention in relation to calcium intake and postmenarcheal age in adolescent females. American Journal of Clinical Nutrition 66, 327–333.CrossRefGoogle ScholarPubMed
Kelsay, JL & Prather, ES (1983) Mineral balances of human subjects consuming spinach in a low-fiber diet and in a diet containing fruits and vegetables. American Journal of Clinical Nutrition 38, 12–19.CrossRefGoogle Scholar
Koo, J, Weaver, CM, Neylan, MJ & Miller, GD (1993) Isotopic tracer techniques for assessing calcium absorption in rats. Journal of Nutritional Biochemistry 4, 72–76.CrossRefGoogle Scholar
Liebman, M & Doane, L (1989) Calcium and zinc balances during consumption of high and low oxalate-containing vegetables. Nutrition Research 9, 947–955.CrossRefGoogle Scholar
Liebman, M & Landis, W (1989) Calcium and zinc balances of premenopausal women consuming tofu- compared to cheesecontaining diets. Nutrition Research 9, 5–14.CrossRefGoogle Scholar
Lin, Y-C, Lyle, RM, McCabe, LD, McCabe, GP, Weaver, CM & Teegarden, D (2000) Calcium intake relates to change in body weight in young women. Journal of the American College of Nutrition 19, 754–760.CrossRefGoogle ScholarPubMed
Lipkin, M & Newmark, HL (1999) Vitamin D calcium and prevention of breast cancer: a review. Journal of the American College of Nutrition 18, 392S–397S.CrossRefGoogle ScholarPubMed
McCance, RA & Widdowson, EM (1942) Mineral metabolism of healthy adults on white and brown bread dietaries. Journal of Physiology 101, 44–85.CrossRefGoogle Scholar
McCarron, DA & Reusser, ME (1999) Finding consensus in the dietary calcium-blood pressure debate. Journal of the American College of Nutrition 18, 398S–405S.CrossRefGoogle ScholarPubMed
Matkovic, V & Heaney, RP (1992) Calcium balance during human growth: evidence for threshold behavior. American Journal of Clinical Nutrition 55, 992–996.CrossRefGoogle ScholarPubMed
Miller, JZ, Smith, DL, Flora, L, Slemenda, C, Juang, X & Johnston, CC (1988) Calcium absorption from calcium carbonate and a new form of calcium (CCM) in healthy male and female adolescents. American Journal of Clinical Nutrition 48, 1291–1294.CrossRefGoogle Scholar
Morris, ER & Ellis, R (1985) Bioavailability of dietary calcium: effect of phytate on adult men consuming nonvegetarian diets. In Nutritional Bioavailability of Calcium, pp. 63–72 [Kies, C, editor]. Washington, DC: American Chemical Society.CrossRefGoogle Scholar
O'Brien, KO, Abrams, SA, Liang, LK, Ellis, KJ & Gagel, RF (1998) Bone turnover response to changes in calcium intake is altered in girls and adult women in families with histories of osteoporosis. Journal of Bone and Mineral Research 13, 491–499.CrossRefGoogle ScholarPubMed
Pansu, D, Bellaton, C, Roche, C & Bronner, F (1983) Duodenal and ileal calcium absorption in the rat and effects of vitamin D. American Journal of Physiology 244, G695–G700.Google ScholarPubMed
Pappenheimer, JR & Reiss, KZ (1987) Contribution of solvent drag through intracellular to absorption of nutrients by the small intestine of the rat. Journal of Membrane Biology 100, 123–136.CrossRefGoogle Scholar
Pinto, M, Robine-Leon, S, Appay, M, Kedinger, M, Triadou, N, Dussaulx, E, Lacroix, B, Simon-Assmann, P, Haffen, K, Fogh, J & Zweibaum, A (1983) Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture. Biology of the Cell 47, 323–330.Google Scholar
Schanler, R & Abrams, SA (1995) Postnatal attainment of intrauterine mineral accretion rates in low birth weight infants fed fortified human milk. Journal of Pediatrics 126, 441–447.CrossRefGoogle ScholarPubMed
Shen, X, Weaver, CM, Kempa-Steczko, A, Martin, BR, Phillippy, BQ & Heaney, RP (1998) An inositol phosphate as a calcium absorption enhancer in rats. Journal of Nutritional Biochemistry 9, 298–301.CrossRefGoogle Scholar
Thys-Jacobs, S, Starkey, P, Bernstein, D & Tian, J (1998) Premenstrual Syndrome Study Group. Calcium carbonate and premenstrual syndrome: effects on premenstrual and menstrual symptoms. American Journal of Obstetrics and Gynecology 179, 444–452.CrossRefGoogle Scholar
Tsugawa, N, Yamabe, T, Takeuchi, A, Kamao, M, Nakagawa, K, Nishijima, K & Okano, T (1999) Intestinal absorption of calcium from calcium ascorbate in rats. Journal of Bone and Mineral Metabolism 17, 30–36.CrossRefGoogle ScholarPubMed
van den Heuvel, E, Muys, T, van Dokskum, W & Schaafsma, G (1999) Oligofructose stimulates calcium absorption in adolescents. American Journal of Clinical Nutrition 69, 544–548.CrossRefGoogle ScholarPubMed
Wastney, ME, Martin, BR, Peacock, M, Smith, D, Jiang, X-Y, Jackman, LA & Weaver, CM (2000) Changes in calcium kinetics in adolescent girls induced by high calcium intake. Journal of Clinical Endocrinology and Metabolism 85, 4470–4475.Google ScholarPubMed
Wastney, ME, Ng, J, Smith, D, Martin, BR, Peacock, M & Weaver, CM (1996) Differences in calcium kinetics between adolescent girls and young women. American Journal of Physiology 271, R208–R216.Google ScholarPubMed
Weaver, CM (1998) Use of calcium tracers and biomarkers to determine calcium kinetics and bone turnover. Bone 22, 103S–104S.CrossRefGoogle ScholarPubMed
Weaver, CM, Heaney, RP, Martin, BR & Fitzsimmons, ML (1991) Human calcium absorption from whole wheat products. Journal of Nutrition 121, 1769–1775.CrossRefGoogle ScholarPubMed
Weaver, CM, Heaney, RP, Teegarden, D & Hinders, SM (1996) Wheat bran abolishes the inverse relationship between calcium load size and absorption fraction in women. Journal of Nutrition 126, 303–307.CrossRefGoogle ScholarPubMed
Weaver, CM, Proulx, WR & Heaney, RP (1999) Choices for achieving dietary calcium within a vegetarian diet. American Journal of Clinical Nutrition 70, 543S–548S.CrossRefGoogle ScholarPubMed
Weaver, CM, Spence, LA & Lipscomb, ER (2001) Phytoestrogens and bone health. In Nutritional Aspects of OsteoporosisM, pp. 315–324 [Burckhardt, P, Dawson-Hughes, B and Heaney, RP editors]. New York: Academic Press.Google Scholar
Yee, S (1997) In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man — fact or myth. Pharmaceutical Research 14, 763–766.CrossRefGoogle ScholarPubMed
Zemel, MB, Shi, H, Greer, B, Direnzo, D & Zemel, PC (2000) Regulation of adiposity by dietary calcium. FASEB Journal 14, 1132–1138.CrossRefGoogle ScholarPubMed