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Bone remodelling is not affected by consumption of a sodium-rich carbonated mineral water in healthy postmenopausal women

  • Stefanie Schoppen (a1), Ana M. Pérez-Granados (a1), Ángeles Carbajal (a2), Concepción de la Piedra (a3) and M. Pilar Vaquero (a1)...

This study was designed to investigate the possible effects of consuming Na-rich carbonated mineral water on bone remodelling and urinary mineral excretion in postmenopausal women. Women (n 18) included were amenorrhoeic (>1 year), healthy and not obese (BMI <30 kg/m2). No woman was taking oestrogen replacement therapy, mineral and vitamin supplements, phyto-oestrogens or medications known to affect bone and lipid metabolism. In two consecutive interventions that lasted 8 weeks each, women drank 1 litre of control mineral water daily and 1 litre of carbonated mineral water, rich in Na, HCO3 inf super and Cl, daily. Body weight and height were measured, BMI was calculated and blood pressure was measured. Blood samples were taken from fasting subjects and serum obtained to analyse the biochemical bone markers, procollagen I amino-terminal propeptide (PINP) and β-carboxy-terminal telopeptide of collagen (β-CTX). At the end of each period, 24 h urine samples were collected to determine Ca, Mg, P, Na+, K+, Cl, urine excretion and urinary pH. No changes in body weight, BMI or blood pressure were observed during the experimental period. Ca excretion was lower after the intake of carbonated water than after intake of the control water (P=0·037) while P excretion was higher (P=0·015). Total urine, Na and Cl excretion did not differ between the two periods but urinary pH was increased after the intake of carbonated mineral water. PINP and β-CTX did not differ between the two periods. Daily consumption of 1 litre of Na-rich carbonated mineral water for 8 weeks does not affect bone remodelling in healthy postmenopausal women.

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      Bone remodelling is not affected by consumption of a sodium-rich carbonated mineral water in healthy postmenopausal women
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Corresponding author
*Corresponding author: Dr Stefanie Schoppen, fax +34 915493627, email,,
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Abbott, M (1997) Portion Photos of Popular Foods Stout, WI The American Dietetic Association and Centre for Nutrition Education, University of Wisconsin.
Alaimo, K, McDowell, MA, Briefel, RR, Bischof, AM, Caughman, CR, Loria, CM & Johnson, CL (1994) Dietary intakes of vitamins, minerals and fiber of persons ages 20 months and over in the United States: Third National Health and Nutrition Examination Survey (NHANES), Phase 1, 1988–91. Advance Data from Vital and Health Statistic, no. 258 Hyattsville, MD National Center for Health Statistics.
Alvarez, L, Ricos, C, Peris, P, GuaNabens, N, Monegal, A, Pons, F & Ballesta, AM (2000) Components of biological variation of biochemical markers of bone turnover in Paget's bone disease. Bone 26, 571576.
Aptel, I, Cance-Rouzaud, A & Grandjean, H (1999) Association between calcium ingested from drinking water and femoral bone density in elderly women: evidence from the EPIDOS cohort. J Bone Miner Res 14, 829833.
Aranceta, J, Serra-Majem, L (2001) Estructura general de las guías alimentarias para la población española. Decálogo para una dieta saludable. (General structure of the Spanish population food guides. A decalogue for a healthy diet). In Guías Alimentarias para la Población Española, pp. 183194, Sociedad Española, de, Nutrición Comunitaria, editors.] Madrid: IM&C.
Barzel, US & Massey, LK (1998) Excess dietary protein can adversely affect bone. J Nutr 128, 10511053.
Böhmer, H, Müller, H & Resch, KL (2000) Calcium supplementation with calcium rich mineral waters: a systematic review and meta-analysis of its bioavailability. Osteoporos Int 11, 938943.
Buclin, T, Cosma, M, Appenzeller, M, Jacquet, AF, Decosterd, LA, Biollaz, J & Burckhardt, P (2001) Diet acids and alkalis influence calcium retention in bone. Osteoporos Int 12, 439499.
Bushinsky, DA (2001) Acid–base imbalance and the skeleton. Eur J Nutr 40, 238244.
Carbajal, A & Ortega, RM (2001) La dieta mediterránea como modelo de dieta prudente y saludable (The Mediterranean diet as model for a prudent and healthy diet). Rev Chil Nutr 28, 224236.
Cepollaro, C, Orlandi, G, Gonnelli, S, Ferrucci, G, Arditti, JC, Borracelli, D, Toti, E & Gennari, C (1996) Effect of calcium supplementation as a high-calcium mineral water on bone loss in early postmenopausal women. Calcif Tissue Int 59, 238239.
De Groot, CPGM, van Staveren, WA, Dirren, H & Hautvast, JGAJ (1996) Summary and conclusions of the report on the second data collection period and longitudinal analyses of the SENECA study. Eur J Clin Nutr 50, S123S124.
De la, Piedra, C, Traba, ML, Domínguez, C, Sosa M (1997) New biological markers of bone resorption in the study of postmenopausal osteoporosis. Clin Chim Acta 265, 225234.
Department of HealthDepartment of Health (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects, no. 41 London: HMSO.
Devine, A, Criddle, AR, Dick, IM, Kerr, DA & Prince, RL (1995) A longitudinal study of the effect of sodium and calcium intakes on regional bone density in postmenopausal women. Am J Clin Nutr 62, 740745.
Díaz, Curiel, M, Carrasco, de la, Peña, JL, Honorato, Pérez, J, Pérez, Cano, R, Rapado, A, Ruiz, Martínez, I (1997) Study of bone mineral density in lumbar spine and femoral neck in a Spanish population. Osteoporosis Int 7, 5964.
Domínguez, C, Sosa, M, Traba, ML, Alvarez, E, de la, Piedra C (1998) Biochemical markers of bone formation in the study of postmenopausal osteoporosis. Osteoporos Int 8, 147151.
Evans, CE, Chughtai, AY, Blumsohn, A, Gils, M & Eastell, R (1997) The effect of dietary sodium on calcium metabolism in premenopausal and postmenopausal women. Eur J Clin Nutr 51, 394399.
Food and, Agriculture Organization/World, Health Organization/United & Nations University (1985) Energy and Protein Requirements. Technical Report SeriesGeneva:WHO.
Fledelius, C, Johnsen, AH, Cloos, PA, Bonde, M & Qvist, P (1997) Characterization of urinary degradation products derived from type I collagen. Identification of a β-isomerized Asp–Gly sequence within the C-terminal telopeptide (α1) region. J Biol Chem 272, 97559763.
Frasetto, L, Morris, RC, Jr, Sellmeyer, DE Todd, K & Sebastian, A (2001) Diet, evolution and aging – the pathophysiologic effects of the post agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet. Eur J Nutr 40, 200213.
Garnero, P, Borel, O & Delmas, PD (2001) Evaluation of a fully automated serum assay for C-terminal cross-linking telopeptide of type I collagen in osteoporosis. Clin Chem 47, 694702.
Ginty, F, Flynn, A & Cashman, KD (1998) The effect of dietary sodium intake on biochemical markers of bone metabolism in young women. Br J Nutr 79, 343350.
Goulding, A (1990) Osteoporosis: why consuming less sodium chloride helps to conserve bone. N Z Med J 103, 120122.
Guillemant, J, Le HT, Accarie, C, du, Montcel, ST, Delabroise, AM, Arnaud, MJ & Guillemant, S (2000) Mineral water as a source of dietary calcium: acute effects on parathyroid function and bone resorption in young men. Am J Clin Nutr 71, 9991002.
Institute of MedicineInstitute of Medicine (1997) Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride 175 Washington, DC National Academic Press.
Kessler, T & Hesse, A (2000) Cross-over study of the influence of bicarbonate-rich mineral water on urinary composition in comparison with sodium potassium citrate in healthy male subjects. Br J Nutr 84, 865871.
Lemann, J, Jr, Pluess, J, Gray, RW, Hoffmann RG (1991) Potassium administration reduces and potassium deprivation increases urinary calcium excretion in healthy adults. Kidney Int 39, 973983.
Lin, PH, Ginty, F, Appel, LJ, Aickin, M, Bohannon, A, Garnero, P, Barclay, D & Svetkey, LP (2003) The DASH diet and sodium reduction improve markers of bone turnover and calcium metabolism in adults. J Nutr 133, 31303136.
Lina, BAR & Kuijpers, MHM (2004) Toxicity and carcinogenic or alkalogenic diets in rats; effects of feeding NH 4 Cl, KHCO 3 or KCl. Food Chem Toxicol 42, 135153.
Luft, FC, Zemel, MB, Sowers, JA, Fineberg, NS & Weinberger, MH (1990) Sodium bicarbonate and sodium chloride: effects on blood pressure and electrolyte homeostasis in normal and hypertensive man. J Hypertens 8, 663670.
McDowell, MA, Briefel, RR, Alaimo, K, Bischof, AM, Caughman, CR, Carroll, MD, Loria, CM & Johnson, CL (1994) Energy and macronutrient intakes of persons aged 20 months and over in the United States: Third National Health and Nutrition Examination Survey (NHANES), Phase 1, 1988-91 Advance Data from Vital and Health Statistics no. 255 Hyattsville, MD National Center for Health Statistics.
McFarlane, SI, Muniyappa, R, Shin, JJ, Bahtiyar, G & Sowers, JR (2004) Osteoporosis and cardiovascular disease: brittle bones and boned arteries, is there a link?. Endocrine 23, 110.
Masse, PG, Dosy, J, Tranchant, CC & Dallaire, R (2004) Dietary macro- and micronutrient intakes of nonsupplemented pre- and postmenopausal women with a perspective on menopause-associated diseases. J Hum Nutr Diet 17, 121132.
Massey, LK (2003) Dietary animal and plant protein and human bone health: a whole foods approach. J Nutr 133 862S – 865S.
Maurer, M, Riesen, W, Muser, J, Hulter, HN & Krapf, R (2003) Neutralisation of Western diet inhibits bone resorption independently of K intake and reduces cortisol secretion in humans. Am J Physiol Renal Physiol 284, F32F40.
Melkko, J, Kauppila, S, Niemi, S, Risteli, L, Haukipuro, K, Jukkola, A & Risteli, J (1996) Immunoassay for intact amino-terminal propeptide of human type I procollagen. Clin Chem 42, 947954.
Moreiras, O, Carbajal, A, Cabrera, L & Cuadrado, C (2001) Tablas de Composición de Alimentos (Food Composition Tables) Madrid Ediciones Pirámide, SA.
Neville, CE, Robson, PJ, Murray, LJ, Strain, JJ, Twisk, J, Gallagher, AM, McGuinness, M, Cran, GW, Ralston, SH & Boreham, CA (2002) The effect of nutrient intake on bone mineral status in young adults: The Northern Ireland Young Hearts Projects. Calcif Tissue Int 70, 8998.
New, S (2002) The role of the skeleton in acid–base homeostasis. Proc Nutr Soc 61, 151164.
Qi, L, Shen, H & Ordovas, JM (2003) Hearts and bones. Nutr Metab Cardiovasc Dis 13, 165174.
Schoppen, S, Pérez-Granados, AM, Sarría, B, Navas, S, Carbajal, A, Sanchez-Muniz, FJ & Vaquero, MP (2003) Influence of an alkaline mineral water on postprandial lipaemia in postmenopausal women. Proc Nutr Soc 62, 43.
Schoppen, S, Pérez-Granados, AM, Carbajal, A, Oubina, P, Sanchez-Muniz, FJ, Gomez-Gerique, JA & Vaquero, MP (2004) A sodium-rich carbonated mineral water reduces cardiovascular risk in postmenopausal women. J Nutr 134, 10581063.
Schorr, U, Distler, A & Sharma, AM (1996) Effect of sodium chloride- and sodium bicarbonate-rich mineral water on blood pressure and metabolic parameters en elderly normotensive individuals: a randomised double-blind crossover trial. J Hypertens 14, 131135.
Schroll, K, Carbajal, A, Decarli, B, Martins, I, Grunenberger, F, Blauw, YH, de Groot, CP (1996) Food patterns of elderly Europeans. SENECA Investigators. Eur J Clin Nutr 50, S86S100.
Sebastian, A, Harris, ST, Ottaway, JH, Todd, KM & Morris, RC (1994) Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. N Engl J Med 330, 17761781.
Seibel, MJ (2000) Molecular markers of bone turnover: biochemical, technical and analytical aspects. Osteoporos Int 11, S18S29.
Siener, R, Jahnen, A & Hesse, A (2004) Influence of a mineral water rich in calcium, magnesium and bicarbonate on urine composition and the risk of calcium oxalate crystallization. Eur J Clin Nutr 58, 270276.
Smit, E, Nieto, FJ, Crespo, CJ & Mitchell, P (1999) Estimates of animal and plant protein intake in US adults: results from the Third National Health and Nutrition Examination Survey, 1988–91. J Am Diet Assoc 99, 813820.
Tilney, C, Torgerson, DJ, Al-Janabi, M & New, S (2003) Is salt an important risk factor for osteoporosis? A systematic review of the evidence. Proc Nutr Soc 62 57A.
Trichopoulou, A & Lagiou, P (1997) Healthy traditional Mediterranean diet: an expression of culture, history and lifestyle. Nutr Rev 55, 383389.
Tucker, KL, Hannan, MT, Chen, H, Cupples, LA, Wilson, PW & Kiel, DP (1999) Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 69, 727736.
Van Dokkum, W, de la, Gueronniere, V, Schaafsma, G, Bouley, C, Luten, J Latge, C (1996) Bioavailability of calcium of fresh cheeses, enteral food and mineral water. A study with stable calcium isotopes in young adult women. Br J Nutr 75, 893903.
Vaquero, MP, Pérez-Granados, AM & Schoppen, S (2001) Propiedades fisiológicos y nutricionales de las aguas minerales naturales carbónicas (Physiological and nutritional properties of carbonated natural mineral waters). Rev Nutr Práctica 5, 4352.
Willett, W (1998) Nutritional Epidemiology, 2nd ed New York: Oxford University Press.
World Health OrganizationWorld Health Organization (1994) Assessment of Fracture Risk and Its Application to Screening for Postmenopausal Osteoporosis. Technical Report SeriesGeneva:WHO.
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