Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 7
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Çelen, İlker Müezzinoğlu, Talha Ataman, O. Yavuz Bakırdere, Sezgin Korkmaz, Mehmet Neşe, Nalan Şenol, Feriye and Lekili, Murat 2015. Selenium, nickel, and calcium levels in cancerous and non-cancerous prostate tissue samples and their relation with some parameters. Environmental Science and Pollution Research, Vol. 22, Issue. 17, p. 13070.


    Park, Song-Yi and Kolonel, Laurence N. 2013. Nutrition in the Prevention and Treatment of Disease.


    Quirosa Flores, Susana Varsavsky, Mariela Valle Díaz De La Guardia, Francisco Miján Ortiz, Jose Luis Muñoz Torres, Manuel Raya Álvarez, Enrique and Zuluaga Gómez, Armando 2010. Hiperparatiroidismo secundario en el cáncer de próstata avanzado. Endocrinología y Nutrición, Vol. 57, Issue. 3, p. 100.


    Centeno, Viviana Díaz de Barboza, Gabriela Marchionatti, Ana Rodríguez, Valeria and Tolosa de Talamoni, Nori 2009. Molecular mechanisms triggered by low-calcium diets. Nutrition Research Reviews, Vol. 22, Issue. 02, p. 163.


    Halthur, C. Johansson, A. L. V. Almquist, M. Malm, J. Grönberg, H. Manjer, J. and Dickman, P. W. 2009. Serum calcium and the risk of prostate cancer. Cancer Causes & Control, Vol. 20, Issue. 7, p. 1205.


    Givens, D. I. Morgan, R. and Elwood, P. C. 2008. Relationship between milk consumption and prostate cancer: a short review. Nutrition Bulletin, Vol. 33, Issue. 4, p. 279.


    Mordan-McCombs, Sarah Valrance, Meggan Zinser, Glendon Tenniswood, Martin and Welsh, JoEllen 2008. Calcium, Vitamin D and the Vitamin D Receptor: Impact on Prostate and Breast Cancer in Preclinical Models. Nutrition Reviews, Vol. 65, p. S131.


    ×

Calcium intake and vitamin D metabolism and action, in healthy conditions and in prostate cancer

  • Jean-Philippe Bonjour (a1), Thierry Chevalley (a1) and Patrice Fardellone (a2)
  • DOI: http://dx.doi.org/10.1017/S0007114507657961
  • Published online: 01 April 2007
Abstract

An association between Ca intake and the risk of prostate cancer has been reported in some but not all epidemiological studies. Assuming that a pathophysiological relationship would underlie this association, a favoured hypothesis proposes that relatively high Ca consumption could promote prostate cancer by reducing the production of 1,25-dihydroxyvitamin D (1,25(OH)2D; calcitriol), the hormonal form of vitamin D. The present review analyses the plausibility of this hypothesis by considering the quantitative relationships linking Ca intake to 1,25(OH)2D production and action in healthy conditions and in prostate cancer. Changes in the plasma level of 1,25(OH)2D in response to Ca intake are of very small magnitude as compared with the variations required to influence the proliferation and differentiation of prostate cancer cells. In most studies, 1,25(OH)2D plasma level was not found to be reduced in patients with prostate cancer. The possibility that the level of 1,25(OH)2D in prostate cells is decreased with a high-Ca diet has not been documented. Furthermore, a recent randomised placebo-controlled trial did not indicate that Ca supplementation increases the relative risk of prostate cancer in men. In conclusion, the existence of a pathophysiological link between relatively high Ca intake and consequent low production and circulation level of 1,25(OH)2D that might promote the development of prostate cancer in men remains so far an hypothesis, the plausibility of which is not supported by the analysis of available clinical data.

Copyright
Corresponding author
*Corresponding author: Professor Jean-Philippe Bonjour, fax +41 22 3829973, email jean-philippe.bonjour@medecine.unige.ch
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

ND Adams , RW Gray & J Lemann Jr (1979) The effects of oral CaCO3 loading and dietary calcium deprivation on plasma 1,25-dihydroxyvitamin D concentrations in healthy adults. J Clin Endocrinol Metab 48, 10081016.

MH Ahonen , L Tenkanen , L Teppo , M Hakama & P Tuohimaa (2000) Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland). Cancer Causes Control 11, 847852.

KC Balaji , RF Huryk , S Verhulst & WR Fair (2001) Growth of heterotopic LNCaP prostate cancer tumor in nude mice is not affected by dietary calcium. Prostate 48, 265273.

JA Baron , M Beach , JS Mandel , (1999) Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group. N Engl J Med 340, 101107.

JA Baron , M Beach , K Wallace , MV Grau , RS Sandler , JS Mandel , D Heber & ER Greenberg (2005) Risk of prostate cancer in a randomized clinical trial of calcium supplementation. Cancer Epidemiol Biomarkers Prev 14, 586589.

NH Bell (1998) Renal and nonrenal 25-hydroxyvitamin D-1α-hydroxylases and their clinical significance. J Bone Miner Res 13, 350353.

NH Bell , PH Stern , E Pantzer , TK Sinha & HF DeLuca (1979) Evidence that increased circulating 1 α, 25-dihydroxyvitamin D is the probable cause for abnormal calcium metabolism in sarcoidosis. J Clin Invest 64, 218225.

SI Berndt , HB Carter , PK Landis , KL Tucker , LJ Hsieh , EJ Metter & EA Platz (2002) Calcium intake and prostate cancer risk in a long-term aging study: the Baltimore Longitudinal Study of Aging. Urology 60, 11181123.

MM Braun , KJ Helzlsouer , BW Hollis & GW Comstock (1995) Prostate cancer and prediagnostic levels of serum vitamin D metabolites (Maryland, United States). Cancer Causes Control 6, 235239.

J Caverzasio , C Montessuit & JP Bonjour (1990) Stimulatory effect of insulin-like growth factor-1 on renal Pi transport and plasma 1,25-dihydroxyvitamin D3. Endocrinology 127, 453459.

JM Chan & EL Giovannucci (2001) Dairy products, calcium, and vitamin D and risk of prostate cancer. Epidemiol Rev 23, 8792.

JM Chan , P Pietinen , M Virtanen , N Malila , J Tangrea , D Albanes & J Virtamo (2000) Diet and prostate cancer risk in a cohort of smokers, with a specific focus on calcium and phosphorus (Finland). Cancer Causes Control 11, 859867.

D Feldman , P Malloy & C Gross (2001) Vitamin D: biology, action, and clinical implication. In Osteoporosis, pp. 257303 [R Marcus , D Feldman and J Kelsey , editors]. San Diego, CA: Academic Press.

SL Ferrari , JP Bonjour & R Rizzoli (2005) Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men. J Clin Endocrinol Metab 90, 15191524.

JC Gallagher , BL Riggs , J Eisman , A Hamstra , SB Arnaud & HF DeLuca (1979) Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium. J Clin Invest 64, 729736.

X Gao , MP LaValley & KL Tucker (2005) Prospective studies of dairy product and calcium intakes and prostate cancer risk: a meta-analysis. J Natl Cancer Inst 97, 17681777.

X Gao , ML Valley & KL Tucker (2006) Prospective studies of dairy and calcium intakes and prostate risk: a meta-analyisis. J Natl Cancer Inst 98, 795.

E Giovannucci (2005) The epidemiology of vitamin D and cancer incidence and mortality: a review (United States). Cancer Causes Control 16, 83–95.

E Giovannucci , Y Liu , MJ Stampfer & WC Willett (2006) A prospective study of calcium intake and incident and fatal prostate cancer. Cancer Epidemiol Biomarkers Prev 15, 203210.

WB Grant (2002) An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation. Cancer 94, 18671875.

GH Guyatt , DL Sackett , JC Sinclair , R Hayward , DJ Cook & RJ Cook (1995) Users' guides to the medical literature. IX. A method for grading health care recommendations. Evidence-Based Medicine Working Group. JAMA 274, 18001804.

MF Holick (2003) Vitamin D: a millenium perspective. J Cell Biochem 88, 296–307.

HJ Kalkwarf & BL Specker (2002) Bone mineral changes during pregnancy and lactation. Endocrine 17, 49–53.

E Kesse , S Bertrais , P Astorg , A Jaouen , N Arnault , P Galan & S Hercberg (2006) Dairy products, calcium and phosphorus intake, and the risk of prostate cancer: results of the French prospective SU.VI.MAX (Supplementation en Vitamines et Mineraux Antioxydants) study. Br J Nutr 95, 539545.

JF Ma , L Nonn , MJ Campbell , M Hewison , D Feldman & DM Peehl (2004) Mechanisms of decreased Vitamin D 1α-hydroxylase activity in prostate cancer cells. Mol Cell Endocrinol 221, 67–74.

WJ Maierhofer , RW Gray & J Lemann Jr (1984) Phosphate deprivation increases serum 1,25-(OH)2-vitamin D concentrations in healthy men. Kidney Int 25, 571575.

GJ Miller (1998) Vitamin D and prostate cancer: biologic interactions and clinical potentials. Cancer Metastasis Rev 17, 353–360.

AM Nomura , GN Stemmermann , J Lee , LN Kolonel , TC Chen , A Turner & MF Holick (1998) Serum vitamin D metabolite levels and the subsequent development of prostate cancer (Hawaii, United States). Cancer Causes Control 9, 425432.

DM Peehl & D Feldman (2003) The role of vitamin D and retinoids in controlling prostate cancer progression. Endocr Relat Cancer 10, 131–140.

EA Platz , MF Leitzmann , BW Hollis , WC Willett & E Giovannucci (2004) Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D and subsequent risk of prostate cancer. Cancer Causes Control 15, 255265.

LQ Qin , PY Wang , T Kaneko , K Hoshi & A Sato (2004 a) Estrogen: one of the risk factors in milk for prostate cancer. Med Hypotheses 62, 133–142.

LQ Qin , JY Xu , PY Wang , T Kaneko , K Hoshi & A Sato (2004 b) Milk consumption is a risk factor for prostate cancer: meta-analysis of case-control studies. Nutr Cancer 48, 22–27.

AG Renehan , M Zwahlen , C Minder , ST O'Dwyer , SM Shalet & M Egger (2004) Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet 363, 13461353.

AG Schuurman , PA van den Brandt , E Dorant & RA Goldbohm (1999) Animal products, calcium and protein and prostate cancer risk in The Netherlands Cohort Study. Br J Cancer 80, 11071113.

G Severi , DR English , JL Hopper & GG Giles (2006 a) Re: Prospective studies of dairy product and calcium intakes and prostate cancer risk: a meta-analysis. J Natl Cancer Inst 98, 794795, author reply 795.

G Severi , HA Morris , RJ MacInnis , DR English , WD Tilley , JL Hopper , P Boyle & GG Giles (2006 b) Circulating insulin-like growth factor-I and binding protein-3 and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 15, 11371141.

GA Sonn , W Aronson & MS Litwin (2005) Impact of diet on prostate cancer: a review. Prostate Cancer Prostatic Dis 8, 304–310.

A Tavani , P Bertuccio , C Bosetti , R Talamini , E Negri , S Franceschi , M Montella & C La Vecchia (2005) Dietary intake of calcium, vitamin D, phosphorus and the risk of prostate cancer. Eur Urol 48, 27–33.

A Tavani , S Gallus , S Franceschi & C La Vecchia (2001) Calcium, dairy products, and the risk of prostate cancer. Prostate 48, 118121.

TC Woo , R Choo , M Jamieson , S Chander & R Vieth (2005) Pilot study: potential role of vitamin D (cholecalciferol) in patients with PSA relapse after definitive therapy. Nutr Cancer 51, 32–36.

MV Young , GG Schwartz , L Wang , DP Jamieson , LW Whitlatch , JN Flanagan , BL Lokeshwar , MF Holick & TC Chen (2004) The prostate 25-hydroxyvitamin D-1 α-hydroxylase is not influenced by parathyroid hormone and calcium: implications for prostate cancer chemoprevention by vitamin D. Carcinogenesis 25, 967971.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: