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Carob pulp preparation rich in insoluble dietary fibre and polyphenols increases plasma glucose and serum insulin responses in combination with a glucose load in humans

  • Sindy Gruendel (a1), Baerbel Otto (a2), Ada L. Garcia (a1), Karen Wagner (a1), Corinna Mueller (a1), Martin O. Weickert (a3) (a4), Walter Heldwein (a2) and Corinna Koebnick (a1) (a5)...
Abstract

Dietary fibre consumption is associated with improved glucose homeostasis. In contrast, dietary polyphenols have been suggested to exert both beneficial and detrimental effects on glucose and insulin metabolism. Recently, we reported that a polyphenol-rich insoluble dietary fibre preparation from carob pulp (carob fibre) resulted in lower postprandial acylated ghrelin levels after a liquid meal challenge test compared with a control meal without supplementation. The effects may, however, differ when a different food matrix is used. Thus, we investigated the effects of carob fibre on glucose, insulin and ghrelin responses in healthy humans in combination with a glucose load. In a randomized single-blind cross-over study involving twenty healthy subjects (aged 22–62 years), plasma glucose, total and acylated ghrelin, and serum insulin were repeatedly assessed before and after the ingestion of 200 ml water with 50 g glucose and 0, 5, 10 or 20 g carob fibre over a period of 180 min. The intake of 5 and 10 g carob fibre increased the plasma glucose by 47 % and 64 % (P < 0·001), and serum insulin by 19·9 and 24·8 % (P < 0·001), compared with the control. Plasma acylated ghrelin concentrations did not change significantly after the consumption of carob-enriched glucose solution. Total ghrelin decreased only after 10 g carob fibre (P < 0·001) compared with control. In conclusion, we showed that polyphenol-rich carob fibre, administered within a water–glucose solution, increases postprandial glucose and insulin responses, suggesting a deterioration in glycaemic control.

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Corresponding author
*Corresponding author: Dr Corinna Koebnick, fax +33 1 323 422 4103, email koebnick@usc.edu
References
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Bonfield C (1995) Dietary fiber and weight management. In Dietary Fiber in Health and Disease, pp. 459465 [Kritchevsky D and Bonfield C, editors]. St. Paul, MN: Eagan Press.
Chau CF, Chen CH & Lee MH (2004) Characterization and physicochemical properties of some potential fibres derived from Averrhoa carambola. Nahrung 48, 4346.
Del Toma E, Lintas C, Clementi A & Marcelli M (1988) Soluble and insoluble dietary fibre in diabetic diets. Eur J Clin Nutr 42, 313319.
Erdmann J, Lippl F & Schusdziarra V (2003) Differential effect of protein and fat on plasma ghrelin levels in man. Regul Pept 116, 101107.
Erdmann J, Topsch R, Lippl F, Gussmann P & Schusdziarra V (2004) Postprandial response of plasma ghrelin levels to various test meals in relation to food intake, plasma insulin, and glucose. J Clin Endocrinol Metab 89, 30483054.
Feinle-Bisset C, Patterson M, Ghatei MA, Bloom SR & Horowitz M (2005) Fat digestion is required for the suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide secretion by intraduodenal lipid. Am J Physiol Endocrinol Metab 289, E948953.
Friedewald WT, Levy RI & Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18, 499502.
Gruendel S, Garcia AL, Otto B, Mueller C, Steiniger J, Weickert MO, Speth M, Katz N & Koebnick C (2006) Carob pulp preparation rich in insoluble dietary fiber and polyphenols enhances lipid oxidation and lowers postprandial acylated ghrelin in humans. J Nutr 136, 15331538.
Harmon AW & Patel YM (2003) Naringenin inhibits phosphoinositide 3-kinase activity and glucose uptake in 3T3-L1 adipocytes. Biochem Biophys Res Commun 305, 229234.
Harmon AW & Patel YM (2004) Naringenin inhibits glucose uptake in MCF-7 breast cancer cells: a mechanism for impaired cellular proliferation. Breast Cancer Res Treat 85, 103110.
Howarth NC, Saltzman E, McCrory MA, Greenberg AS, Dwyer J, Ausman L, Kramer DG & Roberts SB (2003) Fermentable and nonfermentable fiber supplements did not alter hunger, satiety or body weight in a pilot study of men and women consuming self-selected diets. J Nutr 133, 31413144.
Howarth NC, Saltzman E & Roberts SB (2001) Dietary fiber and weight regulation. Nutr Rev 59, 129139.
Kamei R, Kitagawa Y, Kadokura M, Hattori F, Hazeki O, Ebina Y, Nishihara T & Oikawa S (2002) Shikonin stimulates glucose uptake in 3T3-L1 adipocytes via an insulin-independent tyrosine kinase pathway. Biochem Biophys Res Commun 292, 642651.
Kandra L, Gyemant G, Zajacz A & Batta G (2004) Inhibitory effects of tannin on human salivary alpha-amylase. Biochem Biophys Res Commun 319, 12651271.
Kimmel SE, Michel KE, Hess RS & Ward CR (2000) Effects of insoluble and soluble dietary fiber on glycemic control in dogs with naturally occurring insulin-dependent diabetes mellitus. J Am Vet Med Assoc 216, 10761081.
Korbonits M, Goldstone AP, Gueorguiev M & Grossman AB (2004) Ghrelin – a hormone with multiple functions. Front Neuroendocrinol 25, 2768.
Krotkiewski M (1985) Use of fibres in different weight reduction programs. In Current Topics on Nutrition and Disease: Dietary Fiber and Obesity, pp. 85109 [Bjorntorp P, Vahouny GV and Kritchevsky D, editors]. New York: Alan R. Liss.
McDougall GJ, Shapiro F, Dobson P, Smith P, Blake A & Stewart D (2005) Different polyphenolic components of soft fruits inhibit alpha-amylase and alpha-glucosidase. J Agric Food Chem 53, 27602766.
Monteleone P, Bencivenga R, Longobardi N, Serritella C & Maj M (2003) Differential responses of circulating ghrelin to high-fat or high-carbohydrate meal in healthy women. J Clin Endocrinol Metab 88, 55105514.
Saltzman E & Roberts SB (1997) Soluble fiber and energy regulation. Current knowledge and future directions. Adv Exp Med Biol 427, 8997.
Slavin JL (2005) Dietary fiber and body weight. Nutrition 21, 411418.
Strobel P, Allard C, Perez-Acle T, Calderon R, Aldunate R & Leighton F (2005) Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes. Biochem J 386, 471478.
Tabatabai A & Li S (2000) Dietary fiber and type 2 diabetes. Clin Excell Nurse Pract 4, 272276.
Thompson LU, Yoon JH, Jenkins DJ, Wolever TM & Jenkins AL (1984) Relationship between polyphenol intake and blood glucose response of normal and diabetic individuals. Am J Clin Nutr 39, 745751.
Weickert MO, Mohlig M, Schofl C, Arafat AM, Otto B, Viehoff H, Koebnick C, Kohl A, Spranger J & Pfeiffer AF (2006 a) Cereal fiber improves whole-body insulin sensitivity in overweight and obese women. Diabetes Care 29, 775780.
Weickert MO, Spranger J, Holst JJ, Otto B, Koebnick C, Mohlig M & Pfeiffer AF (2006 b) Wheat-fibre induced changes of postprandial peptide YY (PYY) and ghrelin responses are not associated with acute alterations of satiety. Br J Nutr 96, 795798.
Wolever T & Jenkins DJA (1993) Effects of dietary fiber and foods on carbohydrate metabolism. In CRC Handbook of Dietary Fiber in Human Nutrition, pp. 111152 [Spiller G, editor]. Boca Raton, FL: CRC Press.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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