1WHO (2011) .
2Dewulf, EM, Cani, PD, Neyrinck, AM, et al. (2011) Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARgamma-related adipogenesis in the white adipose tissue of high-fat diet-fed mice. J Nutr Biochem 22, 712–722.
3Hotamisligil, GS (2006) Inflammation and metabolic disorders. Nature 444, 860–867.
4Hooper, LV, Wong, MH, Thelin, A, et al. (2001) Molecular analysis of commensal host–microbial relationships in the intestine. Science 291, 881–884.
5Sekirov, I, Russell, SL, Antunes, LC, et al. (2010) Gut microbiota in health and disease. Physiol Rev 90, 859–904.
6Kau, AL, Ahern, PP, Griffin, NW, et al. (2011) Human nutrition, the gut microbiome and the immune system. Nature 474, 327–336.
7Guarino, A, Wudy, A, Basile, F, et al. (2012) Composition and roles of intestinal microbiota in children. J Matern Fetal Neonatal Med 25, Suppl. 1, 63–66.
8Shanahan, F (2009) Therapeutic implications of manipulating and mining the microbiota. J Physiol 587, 4175–4179.
9Wu, GD, Chen, J, Hoffmann, C, et al. (2011) Linking long-term dietary patterns with gut microbial enterotypes. Science 334, 105–108.
10Wostmann, BS (1981) The germfree animal in nutritional studies. Ann Rev Nutr 1, 257–279.
11Nadal, I, Santacruz, A, Marcos, A, et al. (2009) Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents. Int J Obes (Lond) 33, 758–767.
12Santacruz, A, Marcos, A, Warnberg, J, et al. (2009) Interplay between weight loss and gut microbiota composition in overweight adolescents. Obesity (Silver Spring) 17, 1906–1915.
13de La Serre, CB, Ellis, CL, Lee, J, et al. (2010) Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. Am J Physiol Gastrointest Liver Physiol 299, G440–G448.
14Turnbaugh, PJ, Ley, RE, Mahowald, MA, et al. (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027–1031.
15Cani, PD, Amar, J, Iglesias, MA, et al. (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 1761–1772.
16Cani, PD, Neyrinck, AM, Fava, F, et al. (2007) Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 50, 2374–2383.
17Roberfroid, M (2007) Prebiotics: the concept revisited. J Nutr 137, 3 Suppl. 2, 830S–837S.
18Schroder, H, Marrugat, J, Vila, J, et al. (2004) Adherence to the traditional Mediterranean diet is inversely associated with body mass index and obesity in a Spanish population. J Nutr 134, 3355–3361.
19Razquin, C, Martinez, JA, Martinez-Gonzalez, MA, et al. (2009) A 3 years follow-up of a Mediterranean diet rich in virgin olive oil is associated with high plasma antioxidant capacity and reduced body weight gain. Eur J Clin Nutr 63, 1387–1393.
20Vögler, O, Lopez-Bellan, A, Alemany, R, et al. (2008) Structure–effect relation of C18 long-chain fatty acids in the reduction of body weight in rats. Int J Obes (Lond) 32, 464–473.
21Buckley, JD & Howe, PR (2010) Long-chain omega-3 polyunsaturated fatty acids may be beneficial for reducing obesity – a review. Nutrients 2, 1212–1230.
22Eckburg, PB, Bik, EM, Bernstein, CN, et al. (2005) Diversity of the human intestinal microbial flora. Science 308, 1635–1638.
23Vaughan, EE, Schut, F, Heilig, HG, et al. (2000) A molecular view of the intestinal ecosystem. Curr Issues Intest Microbiol 1, 1–12.
24Backhed, F, Ley, RE, Sonnenburg, JL, et al. (2005) Host–bacterial mutualism in the human intestine. Science 307, 1915–1920.
25Rinttila, T, Kassinen, A, Malinen, E, et al. (2004) Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR. J Appl Microbiol 97, 1166–1177.
26Backhed, F & Crawford, PA (2010) Coordinated regulation of the metabolome and lipidome at the host–microbial interface. Biochim Biophys Acta 1801, 240–245.
27Cani, PD & Delzenne, NM (2009) The role of the gut microbiota in energy metabolism and metabolic disease. Curr Pharm Des 15, 1546–1558.
28Larsen, N, Vogensen, FK, van den Berg, FW, et al. (2010) Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PloS One 5, e9085.
29Armougom, F, Henry, M, Vialettes, B, et al. (2009) Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and methanogens in anorexic patients. PloS One 4, e7125.
30Cani, PD & Delzenne, NM (2009) Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota. Curr Opin Pharmacol 9, 737–743.
31Hildebrandt, MA, Hoffmann, C, Sherrill-Mix, SA, et al. (2009) High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology 137, 1716–1724.e1-2.
32Lupp, C, Robertson, ML, Wickham, ME, et al. (2007) Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe 2, 204.
33Flint, H, Louis, P, Scott, K, et al. (2007) Commensal bacteria in health and disease. In Virulence Mechanisms of Bacterial Pathogens, pp. 101–114 [KA, Brogden and JM, Guthmiller, editors]. Washington, DC: ASM Press.
34Ley, RE, Backhed, F, Turnbaugh, P, et al. (2005) Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A 102, 11070–11075.
35Ley, RE, Turnbaugh, PJ, Klein, S, et al. (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444, 1022–1023.
36Collado, MC, Isolauri, E, Laitinen, K, et al. (2008) Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. Am J Clin Nutr 88, 894–899.
37Schwiertz, A, Taras, D, Schafer, K, et al. (2010) Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring) 18, 190–195.
38Backhed, F, Ding, H, Wang, T, et al. (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 101, 15718–15723.
39Musso, G, Gambino, R & Cassader, M (2010) Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: mechanisms and implications for metabolic disorders. Curr Opin Lipidol 21, 76–83.
40Calder, PC (2006) n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 83, 6 Suppl., 1505S–1519S.
41Ringo, E, Bendiksen, HR, Gausen, SJ, et al. (1998) The effect of dietary fatty acids on lactic acid bacteria associated with the epithelial mucosa and from faecalia of Arctic charr, Salvelinus alpinus (L.). J Appl Microbiol 85, 855–864.
42Kankaanpaa, PE, Salminen, SJ, Isolauri, E, et al. (2001) The influence of polyunsaturated fatty acids on probiotic growth and adhesion. FEMS Microbiol Lett 194, 149–153.
43Bomba, A, Nemcova, R, Gancarcikova, S, et al. (2002) Improvement of the probiotic effect of micro-organisms by their combination with maltodextrins, fructo-oligosaccharides and polyunsaturated fatty acids. Br J Nutr 88, Suppl. 1, S95–S99.
44Pachikian, BD, Neyrinck, AM, Portois, L, et al. (2011) Involvement of gut microbial fermentation in the metabolic alterations occurring in n-3 polyunsaturated fatty acids-depleted mice. Nutr Metab 8, 44.