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Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with α-linolenic acid on postprandial endothelial function in healthy men

  • F. Fuentes (a1) (a2), J. López-Miranda (a1) (a2), P. Pérez-Martínez (a1) (a2), Y. Jiménez (a1) (a2), C. Marín (a1) (a2), P. Gómez (a1) (a2), J. M. Fernández (a1) (a2), J. Caballero (a3), J. Delgado-Lista (a1) (a2) and F. Pérez-Jiménez (a1) (a2)
  • DOI: http://dx.doi.org/10.1017/S0007114508888708
  • Published online: 01 July 2008
Abstract

Traditional cardiovascular risk factors are associated with endothelial dysfunction. The vascular endothelium plays a key role in local vascular tone regulation and can be modulated by dietary fat. We propose to determine the chronic effect of three diets with different fat compositions on postprandial endothelial function and inflammatory biomarkers. Twenty healthy men followed three 4-week diets in a randomised cross-over design: a Western diet, rich in saturated fat (22 % SFA, 12 % MUFA and 0·4 % α-linolenic acid (ALA), all fractions are % of energy); a Mediterranean diet, rich in MUFA ( < 10 % SFA, 24 % MUFA and 0·4 % ALA); a low-fat diet enriched in ALA ( < 10 % SFA, 12 % MUFA and 2 % ALA). At the end of each dietary period all subjects underwent a postprandial study. Plasma concentrations of lipid parameters, soluble intercellular cell-adhesion molecule-1, soluble vascular cell-adhesion molecule-1 (sVCAM-1), nitrates and nitrites (NOx) and endothelial function studied by laser Doppler were examined at 0, 2, 4, 6 and 8 h. The endothelium-dependent vasodilatory response was greater 4 h after the ingestion of the MUFA-rich diet than after the SFA or ALA low-fat diets (P = 0·031). The 4 h postprandial plasma sVCAM-1 levels were lower after the MUFA meals than after the ALA low-fat diet (P = 0·043). The bioavailability of NOx was higher following the MUFA diet than after the SFA and ALA low-fat diets (P = 0·027). We found no differences in the other parameters measured. Chronic ingestion of a Mediterranean diet avoids the postprandial deterioration of endothelial function associated with Westernised diets in healthy individuals.

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*Corresponding author: Dr Francisco José Fuentes Jiménez, fax +34 957204763, email fjfuentesjimenez@yahoo.es
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2J Ruano , J López-Miranda , F Fuentes , JA Moreno , C Bellido , P Pérez-Martínez , A Lozano , P Gomez , Y Jimenez & F Perez-Jimenez (2005) Phenolic content of virgin olive oil improves ischemic reactive hyperemia in hypercholesterolemic patients. J Am Coll Cardiol 46, 18641868.

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11JT Brenna (2002) Efficiency of conversion of α-linolenic acid to long chain n-3 fatty acids in man. Curr Opin Clin Nutr Metab Care 5, 127132.

12E Ros , I Núñez , A Pérez-Heras , M Serra , R Gilabert , E Casals & R Deulofeu (2004) A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation 109, 16091614.

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15P Pérez-Martínez , J López-Miranda , L Blanco-Colio , C Bellido , Y Jimenez , JA Moreno , J Delgado-Lista , J Egido & F Perez-Jimenez (2007) The chronic intake of a Mediterranean diet enriched in virgin olive oil, decreases nuclear transcription factor κB activation in peripheral blood mononuclear cells from healthy men. Atherosclerosis 194, e141e146.

16XL Wang , L Zhang , Y Keith , MX Zhang , J Wang , SA Le Marie , JS Coselli & YH Shen (2006) Free fatty acids inhibit insulin signalling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN of inhibiting Akt kinase. Diabetes 55, 23012310.

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25WC Tsai , YH Li , CC Lin , TH Chao & JH Chen (2004) Effect of oxidative stress on endothelial function after a high-fat meal. Clin Sci 106, 315319.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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