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Cognitive and mood effects in healthy children during 12 weeks' supplementation with multi-vitamin/minerals

  • Crystal F. Haskell (a1), Andrew B. Scholey (a2), Philippa A. Jackson (a1), Jade M. Elliott (a1), Margaret A. Defeyter (a3), Joanna Greer (a1), Bernadette C. Robertson (a1), Tom Buchanan (a4), Brian Tiplady (a1) and David O. Kennedy (a1)...
Abstract

Adequate levels of vitamins and minerals are essential for optimal neural functioning. A high proportion of individuals, including children, suffer from deficiencies in one or more vitamins or minerals. This study investigated whether daily supplementation with vitamins/minerals could modulate cognitive performance and mood in healthy children. In this randomised, double-blind, placebo-controlled, parallel groups investigation, eighty-one healthy children aged from 8 to 14 years underwent laboratory assessments of their cognitive performance and mood pre-dose and at 1 and 3 h post-dose on the first and last days of 12 weeks' supplementation with a commercially available vitamins/mineral product (Pharmaton Kiddi™). Interim assessments were also completed at home after 4 and 8 weeks at 3 h post-dose. Each assessment comprised completion of a cognitive battery, delivered over the Internet, which included tasks assessing mood and the speed and accuracy of attention and aspects of memory (secondary, semantic and spatial working memory). The vitamin/mineral group performed more accurately on two attention tasks: ‘Arrows’ choice reaction time task at 4 and 8 weeks; ‘Arrow Flankers’ choice reaction time task at 4, 8 and 12 weeks. A single task outcome (Picture Recognition errors) evinced significant decrements at 12 weeks. Mood was not modulated in any interpretable manner. Whilst it is possible that the significant improvements following treatment were due to non-significant numerical differences in performance at baseline, these results would seem to suggest that vitamin/mineral supplementation has the potential to improve brain function in healthy children. This proposition requires further investigation.

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Corresponding author
*Corresponding author: David Kennedy, fax +44 191 2274800, email david.kennedy@unn.ac.uk
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2 E Huskisson , S Maggini & M Ruf (2007) The influence of micronutrients on cognitive function and performance. J Int Med Res 35, 277289.

3 DM Kado , AS Karlamangla , MH Huang , A Troen , JW Rowe , J Selhub & TE Seeman (2005) Homocysteine vs. the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur studies of successful aging. Am J Med 118, 161167.

4 J Durga , MP van Boxtel , EG Schouten , ML Bots , FJ Kok & P Verhoef (2006) Folate and the methylenetetrahydrofolate reductase 677C → T mutation correlate with cognitive performance. Neurobiol Aging 27, 334343.

6 M Paleologos , RG Cumming & R Lazarus (1998) Cohort study of vitamin C intake and cognitive impairment. Am J Epidemiol 148, 4550.

7 MC Morris , DA Evans , JL Bienias , CC Tangney , DA Bennett , N Aggarwal , RS Wilson & PA Scherr (2002) Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA 287, 32303237.

8 EM Balk , G Raman , A Tatsioni , M Chung , J Lau & IH Rosenberg (2007) Vitamin B6, B12 and folic acid supplementation and cognitive function. A systematic review of randomized trials. Arch Intern Med 167, 2130.

9 A Del Parigi , F Panza , C Capurso & V Solfrizzi (2006) Nutritional factors, cognitive decline, and dementia. Brain Res Bull 69, 119.

10 RK Chandra (2001) Effect of vitamin and trace-element supplementation on cognitive function in elderly subjects. Nutrition 17, 709712(Retraction in Meguid MM, Nutrition21, 286).

11 M Wolters , M Hickstein , A Flintermann , U Tewes & A Hahn (2005) Cognitive performance in relation to vitamin status in healthy elderly German women – the effect of 6-month multivitamin supplementation. Prev Med 41, 253259.

12 R Pathansali , AA Mangoni , B Creagh-Brown , ZC Lan , GL Ngow , XF Yuan , EL Ouldred , RA Sherwood , CG Swift & SH Jackson (2006) Effects of folic acid supplementation on psychomotor performance and hemorheology in healthy elderly subjects. Arch Gerontol Geriatr 43, 127137.

13 JA McMahon , TJ Green , CM Skeaff , RG Knight , JI Mann & SM Williams (2006) A controlled trial of homocysteine lowering and cognitive performance. N Engl J Med 354, 27642772.

14 D Benton (2001) Micro-nutrient supplementation and the intelligence of children. Neurosci Biobehav Rev 25, 297309.

18 BT Drewel , DW Giraud , SR Davy & JA Driskell (2005) Less than adequate vitamin E status observed in a group of preschool boys and girls living in the United States. J Nutr Biochem 17, 132138.

19 S Paeratakul , DP Ferdinand , CM Champagne , DH Ryan & GA Bray (2003) Fast-food consumption among US adults and children: dietary and nutrient intake profile. J Am Diet Assoc 103, 13321338.

20 AB Scholey , MC Moss & KA Wesnes (1998) Oxygen and cognitive performance: the temporal relationship between hyperoxia and enhanced memory. Psychopharmacology 140, 123126.

21 AB Scholey , MC Moss , N Neave & KA Wesnes (1999) Cognitive performance, hyperoxia and heart rate following oxygen administration in healthy young adults. Physiol Behav 67, 783789.

22 JG Snodgrass & M Vanderwart (1980) Standardized set of 260 pictures – norms for name agreement, image agreement, familiarity, and visual complexity. J Exp Psychol (Hum Learn) 6, 174215.

23 CF Haskell , DO Kennedy , KA Wesnes & AB Scholey (2005) Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology 179, 813825.

25 T Chalder , G Berelowitz , T Pawlikowska , L Watts , S Wessely , D Wright & EP Wallace (1993) Development of a fatigue scale. J Psychosom Res 37, 147153.

27 KA Wesnes , C Pincock , D Richardson , G Helm & S Hails (2003) Breakfast reduces declines in attention and memory over the morning in schoolchildren. Appetite 41, 329331.

29 SN Doshi , IFW McDowell , SJ Moat , N Payne , HJ Durrant , MJ Lewis & J Goodfellow (2002) Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering circulation. Circulation 105, 2226.

30 A Obad , I Palada , Z Valic , V Ivancev , D Baković , U Wisløff , AO Brubakk & Z Dujić (2007) The effects of acute oral antioxidants on diving-induced alterations in human cardiovascular function. J Physiol 578, 859870.

31 DL Katz , H Nawaz , J Boukhalil , V Giannamore , W Chan , R Ahmadi & PM Sarrel (2001) Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am J Prev Med 20, 124129.

33 TJ Cole , MC Bellizzi , KM Flegal & WH Dietz (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. Br Med J 320, 12401243.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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