Skip to main content
    • Aa
    • Aa
  • Access
  • Cited by 23
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Chang, Sui Kiat Alasalvar, Cesarettin and Shahidi, Fereidoon 2016. Review of dried fruits: Phytochemicals, antioxidant efficacies, and health benefits. Journal of Functional Foods, Vol. 21, p. 113.

    Herrero, Soledad and Pico, Yolanda 2016. Can a healthy life prevent us from post-menopausal osteoporosis? Myths and truths. PharmaNutrition, Vol. 4, Issue. 2, p. 45.

    Hooshmand, S. Kern, M. Metti, D. Shamloufard, P. Chai, S. C. Johnson, S. A. Payton, M. E. and Arjmandi, B. H. 2016. The effect of two doses of dried plum on bone density and bone biomarkers in osteopenic postmenopausal women: a randomized, controlled trial. Osteoporosis International, Vol. 27, Issue. 7, p. 2271.

    Igwe, Ezinne O. and Charlton, Karen E. 2016. A Systematic Review on the Health Effects of Plums (Prunus domesticaandPrunus salicina). Phytotherapy Research, Vol. 30, Issue. 5, p. 701.

    Léotoing, Laurent Wauquier, Fabien Davicco, Marie-Jeanne Lebecque, Patrice Gaudout, David Rey, Stéphane Vitrac, Xavier Massenat, Laurent Rashidi, Salim Wittrant, Yohann and Coxam, Véronique 2016. The phenolic acids of Agen prunes (dried plums) or Agen prune juice concentrates do not account for the protective action on bone in a rat model of postmenopausal osteoporosis. Nutrition Research, Vol. 36, Issue. 2, p. 161.

    Shahnazari, Mohammad and Halloran, Bernard 2016. Nutritional Influences on Bone Health.

    2016. Clinical Roundup: Selected Treatment Options for Osteoporosis. Alternative and Complementary Therapies, Vol. 22, Issue. 3, p. 125.

    2016. Outpatient Nutrition Care and Home Nutrition Support.

    Benarba, Bachir 2015. Biomarkers in Bone Disease.

    Đudarić, Luka Fužinac-Smojver, Ariana Muhvić, Damir and Giacometti, Jasminka 2015. The role of polyphenols on bone metabolism in osteoporosis. Food Research International, Vol. 77, p. 290.

    Hooshmand, Shirin Kumar, Ajay Zhang, Ji Yao Johnson, Sarah A. Chai, Sheau C. and Arjmandi, Bahram H. 2015. Evidence for anti-inflammatory and antioxidative properties of dried plum polyphenols in macrophage RAW 264.7 cells. Food Funct., Vol. 6, Issue. 5, p. 1719.

    Wicks, Sheila and Mahady, Gail 2015. Nutrition, Fertility, and Human Reproductive Function.

    Ziegenfuss, Tim N Habowski, Scott M Lemieux, Robert Sandrock, Jennifer E Kedia, A Kerksick, Chad M and Lopez, Hector L 2015. Effects of a dietary supplement on golf drive distance and functional indices of golf performance. Journal of the International Society of Sports Nutrition, Vol. 12, Issue. 1, p. 4.

    Hooshmand, Shirin Brisco, Jayme R. Y. and Arjmandi, Bahram H. 2014. The effect of dried plum on serum levels of receptor activator of NF-κB ligand, osteoprotegerin and sclerostin in osteopenic postmenopausal women: a randomised controlled trial. British Journal of Nutrition, Vol. 112, Issue. 01, p. 55.

    Hubert, Patrice Lee, Sang Lee, Sun-Kyeong and Chun, Ock 2014. Dietary Polyphenols, Berries, and Age-Related Bone Loss: A Review Based on Human, Animal, and Cell Studies. Antioxidants, Vol. 3, Issue. 1, p. 144.

    Lee, Kyung-Jin Kim, Kyung-Soo Kim, Ha-Na Seo, Jin-A and Song, Sang-Wook 2014. Association between dietary calcium and phosphorus intakes, dietary calcium/phosphorus ratio and bone mass in the Korean population. Nutrition Journal, Vol. 13, Issue. 1,

    Shen, Chwan-Li Mo, Huanbiao Smith, Brenda J Chen, Chung-Hwan Chen, Lixia Chyu, Ming-Chien and Kwun, In-Sook 2014. Polyphenols in Human Health and Disease.

    Simonavice, Emily Liu, Pei-Yang Ilich, Jasminka Z. Kim, Jeong-Su Arjmandi, Bahram and Panton, Lynn B. 2014. The effects of a 6-month resistance training and dried plum consumption intervention on strength, body composition, blood markers of bone turnover, and inflammation in breast cancer survivors1. Applied Physiology, Nutrition, and Metabolism, Vol. 39, Issue. 6, p. 730.

    Smith, B. J. Graef, J. L. Wronski, T. J. Rendina, E Williams, A. A. Clark, K. A. Clarke, S. L. Lucas, E. A. and Halloran, B. P. 2014. Effects of Dried Plum Supplementation on Bone Metabolism in Adult C57BL/6 Male Mice. Calcified Tissue International, Vol. 94, Issue. 4, p. 442.

    Smith, Brenda J. Bu, So Young Wang, Yan Rendina, Elizabeth Lim, Yin F. Marlow, Denver Clarke, Stephen L. Cullen, Diane M. and Lucas, Edralin A. 2014. A comparative study of the bone metabolic response to dried plum supplementation and PTH treatment in adult, osteopenic ovariectomized rat. Bone, Vol. 58, p. 151.


Comparative effects of dried plum and dried apple on bone in postmenopausal women

  • Shirin Hooshmand (a1), Sheau C. Chai (a1), Raz L. Saadat (a1), Mark E. Payton (a2), Kenneth Brummel-Smith (a3) and Bahram H. Arjmandi (a1)
  • DOI:
  • Published online: 31 May 2011

Aside from existing drug therapies, certain lifestyle and nutritional factors are known to reduce the risk of osteoporosis. Among the nutritional factors, dried plum or prunes (Prunus domestica L.) is the most effective fruit in both preventing and reversing bone loss. The objective of the present study was to examine the extent to which dried plum reverses bone loss in osteopenic postmenopausal women. We recruited 236 women, 1–10 years postmenopausal, not on hormone replacement therapy or any other prescribed medication known to influence bone metabolism. Qualified participants (n 160) were randomly assigned to one of the two treatment groups: dried plum (100 g/d) or dried apple (comparative control). Participants received 500 mg Ca plus 400 IU (10 μg) vitamin D daily. Bone mineral density (BMD) of lumbar spine, forearm, hip and whole body was assessed at baseline and at the end of the study using dual-energy X-ray absorptiometry. Blood samples were collected at baseline, 3, 6 and 12 months to assess bone biomarkers. Physical activity recall and 1-week FFQ were obtained at baseline, 3, 6 and 12 months to examine physical activity and dietary confounders as potential covariates. Dried plum significantly increased BMD of ulna and spine in comparison with dried apple. In comparison with corresponding baseline values, only dried plum significantly decreased serum levels of bone turnover markers including bone-specific alkaline phosphatase and tartrate-resistant acid phosphatase-5b. The findings of the present study confirmed the ability of dried plum in improving BMD in postmenopausal women in part due to suppressing the rate of bone turnover.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Comparative effects of dried plum and dried apple on bone in postmenopausal women
      Available formats
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Comparative effects of dried plum and dried apple on bone in postmenopausal women
      Available formats
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Comparative effects of dried plum and dried apple on bone in postmenopausal women
      Available formats
Corresponding author
*Corresponding author: Dr B. H. Arjmandi, fax +1 850 645 5000, email
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

6KL Tucker , MT Hannan & DP Kiel (2001) The acid-base hypothesis: diet and bone in the Framingham Osteoporosis Study. Eur J Nutr 40, 231237.

9M Franklin , SY Bu , MR Lerner , (2006) Dried plum prevents bone loss in a male osteoporosis model via IGF-I and the RANK pathway. Bone 39, 13311342.

10F Deyhim , BJ Stoecker , GH Brusewitz , (2005) Dried plum reverses bone loss in an osteopenic rat model of osteoporosis. Menopause 12, 755762.

12SY Bu , EA Lucas , M Franklin , (2007) Comparison of dried plum supplementation and intermittent PTH in restoring bone in osteopenic orchidectomized rats. Osteoporos Int 18, 931942.

15BH Arjmandi (2001) The role of phytoestrogens in the prevention and treatment of osteoporosis in ovarian hormone deficiency. J Am Coll Nutr 20, 398S402S.

16EA Lucas , RD Wild , LJ Hammond , (2002) Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. J Clin Endocrinol Metab 87, 15271532.

17BH Arjmandi , DA Khalil , EA Lucas , (2002) Dried plums improve indices of bone formation in postmenopausal women. J Womens Health Gend Based Med 11, 6168.

18NE Lane , D Haupt , DB Kimmel , (1999) Early estrogen replacement therapy reverses the rapid loss of trabecular bone volume and prevents further deterioration of connectivity in the rat. J Bone Miner Res 14, 206214.

19DN Kalu , BH Arjmandi , CC Liu , (1994) Effects of ovariectomy and estrogen on the serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3. Bone Miner 25, 135148.

20JF Sallis , SP Fortmann , DS Solomon , (1984) Increasing returns of physician surveys. Am J Public Health 74, 1043.

21S Hooshmand & BH Arjmandi (2009) Viewpoint: dried plum, an emerging functional food that may effectively improve bone health. Ageing Res Rev 8, 122127.

22JS Finkelstein , SE Brockwell , V Mehta , (2008) Bone mineral density changes during the menopause transition in a multiethnic cohort of women. J Clin Endocrinol Metab 93, 861868.

24A Patade , L Devareddy , EA Lucas , (2008) Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women. J Womens Health (Larchmt) 17, 355366.

26S Kayano , H Kikuzaki , N Fukutsuka , (2002) Antioxidant activity of prune (Prunus domestica L.) constituents and a new synergist. J Agric Food Chem 50, 37083712.

27N Nakatani , S Kayano , H Kikuzaki , (2000) Identification, quantitative determination, and antioxidative activities of chlorogenic acid isomers in prune (Prunus domestica L.). J Agric Food Chem 48, 55125516.

28S Basu , K Michaelsson , H Olofsson , (2001) Association between oxidative stress and bone mineral density. Biochem Biophys Res Commun 288, 275279.

29IR Garrett , BF Boyce , RO Oreffo , (1990) Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 85, 632639.

31FH Nielsen (1994) Biochemical and physiologic consequences of boron deprivation in humans. Environ Health Perspect 102, Suppl. 7, 5963.

32ML Dismore , DB Haytowitz , SE Gebhardt , (2003) Vitamin K content of nuts and fruits in the US diet. J Am Diet Assoc 103, 16501652.

33J Iwamoto , T Takeda & Y Sato (2004) Effects of vitamin K2 on osteoporosis. Curr Pharm Des 10, 25572576.

35CM Gundberg , AC Looker , SD Nieman , (2002) Patterns of osteocalcin and bone specific alkaline phosphatase by age, gender, and race or ethnicity. Bone 31, 703708.

36J Lenora , K Norrgren , O Thorsson , (2009) Bone turnover markers are correlated with total skeletal uptake of 99mTc-methylene diphosphonate (99mTc-MDP). BMC Med Phys 9, 3.

37J Wang , F Pei , C Tu , (2007) Serum bone turnover markers in patients with primary bone tumors. Oncology 72, 338342.

38C Ding , V Parameswaran , R Udayan , (2008) Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study. J Clin Endocrinol Metab 93, 19521958.

39HL Lund , P Nafstad , I Olsen , (2009) C-reactive protein variations for different chronic somatic disorders. Scand J Public Health 37, 640646.

40D Maugeri , MS Russo , C Franze , (1998) Correlations between C-reactive protein, interleukin-6, tumor necrosis factor-alpha and body mass index during senile osteoporosis. Arch Gerontol Geriatr 27, 159163.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *