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Comparative effects of dried plum and dried apple on bone in postmenopausal women

  • Shirin Hooshmand (a1), Sheau C. Chai (a1), Raz L. Saadat (a1), Mark E. Payton (a2), Kenneth Brummel-Smith (a3) and Bahram H. Arjmandi (a1)...

Aside from existing drug therapies, certain lifestyle and nutritional factors are known to reduce the risk of osteoporosis. Among the nutritional factors, dried plum or prunes (Prunus domestica L.) is the most effective fruit in both preventing and reversing bone loss. The objective of the present study was to examine the extent to which dried plum reverses bone loss in osteopenic postmenopausal women. We recruited 236 women, 1–10 years postmenopausal, not on hormone replacement therapy or any other prescribed medication known to influence bone metabolism. Qualified participants (n 160) were randomly assigned to one of the two treatment groups: dried plum (100 g/d) or dried apple (comparative control). Participants received 500 mg Ca plus 400 IU (10 μg) vitamin D daily. Bone mineral density (BMD) of lumbar spine, forearm, hip and whole body was assessed at baseline and at the end of the study using dual-energy X-ray absorptiometry. Blood samples were collected at baseline, 3, 6 and 12 months to assess bone biomarkers. Physical activity recall and 1-week FFQ were obtained at baseline, 3, 6 and 12 months to examine physical activity and dietary confounders as potential covariates. Dried plum significantly increased BMD of ulna and spine in comparison with dried apple. In comparison with corresponding baseline values, only dried plum significantly decreased serum levels of bone turnover markers including bone-specific alkaline phosphatase and tartrate-resistant acid phosphatase-5b. The findings of the present study confirmed the ability of dried plum in improving BMD in postmenopausal women in part due to suppressing the rate of bone turnover.

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Corresponding author
*Corresponding author: Dr B. H. Arjmandi, fax +1 850 645 5000, email
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1 National Osteoporosis Foundation (2010) National Osteoporosis Foundation.
2 Barnes, PM, Powell-Griner, E, McFann, K, et al. (2004) Complementary and alternative medicine use among adults: United States, 2002. Adv Data 343, 119.
3 Macdonald, HM, New, SA, Golden, MH, et al. (2004) Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids. Am J Clin Nutr 79, 155165.
4 Prynne, CJ, Mishra, GD, O'Connell, MA, et al. (2006) Fruit and vegetable intakes and bone mineral status: a cross sectional study in 5 age and sex cohorts. Am J Clin Nutr 83, 14201428.
5 Tucker, KL, Hannan, MT, Chen, H, et al. (1999) Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 69, 727736.
6 Tucker, KL, Hannan, MT & Kiel, DP (2001) The acid-base hypothesis: diet and bone in the Framingham Osteoporosis Study. Eur J Nutr 40, 231237.
7 Tucker, KL, Chen, H, Hannan, MT, et al. (2002) Bone mineral density and dietary patterns in older adults: the Framingham Osteoporosis Study. Am J Clin Nutr 76, 245252.
8 Muhlbauer, RC, Lozano, A, Reinli, A, et al. (2003) Various selected vegetables, fruits, mushrooms and red wine residue inhibit bone resorption in rats. J Nutr 133, 35923597.
9 Franklin, M, Bu, SY, Lerner, MR, et al. (2006) Dried plum prevents bone loss in a male osteoporosis model via IGF-I and the RANK pathway. Bone 39, 13311342.
10 Deyhim, F, Stoecker, BJ, Brusewitz, GH, et al. (2005) Dried plum reverses bone loss in an osteopenic rat model of osteoporosis. Menopause 12, 755762.
11 Smith, BJ, Ethriedge, A, Lucas, EA, et al. (2003) Dried plum promotes bone recovery comparable to parathyroid hormone in osteopenic rats following hind limb unloading. J Bone Min Res 18, S277.
12 Bu, SY, Lucas, EA, Franklin, M, et al. (2007) Comparison of dried plum supplementation and intermittent PTH in restoring bone in osteopenic orchidectomized rats. Osteoporos Int 18, 931942.
13 Arjmandi, BH, Lucas, EA, Juma, S, et al. (2001) Dried plum prevent ovariectomy-induced bone loss in rats. JANA 4, 5056.
14 Arjmandi, BH, Birnbaum, R, Goyal, NV, et al. (1998) Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content. Am J Clin Nutr 68, 1364S1368S.
15 Arjmandi, BH (2001) The role of phytoestrogens in the prevention and treatment of osteoporosis in ovarian hormone deficiency. J Am Coll Nutr 20, 398S402S.
16 Lucas, EA, Wild, RD, Hammond, LJ, et al. (2002) Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. J Clin Endocrinol Metab 87, 15271532.
17 Arjmandi, BH, Khalil, DA, Lucas, EA, et al. (2002) Dried plums improve indices of bone formation in postmenopausal women. J Womens Health Gend Based Med 11, 6168.
18 Lane, NE, Haupt, D, Kimmel, DB, et al. (1999) Early estrogen replacement therapy reverses the rapid loss of trabecular bone volume and prevents further deterioration of connectivity in the rat. J Bone Miner Res 14, 206214.
19 Kalu, DN, Arjmandi, BH, Liu, CC, et al. (1994) Effects of ovariectomy and estrogen on the serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3. Bone Miner 25, 135148.
20 Sallis, JF, Fortmann, SP, Solomon, DS, et al. (1984) Increasing returns of physician surveys. Am J Public Health 74, 1043.
21 Hooshmand, S & Arjmandi, BH (2009) Viewpoint: dried plum, an emerging functional food that may effectively improve bone health. Ageing Res Rev 8, 122127.
22 Finkelstein, JS, Brockwell, SE, Mehta, V, et al. (2008) Bone mineral density changes during the menopause transition in a multiethnic cohort of women. J Clin Endocrinol Metab 93, 861868.
23 Gustafsson, IB, Vessby, B, Ohrvall, M, et al. (1994) A diet rich in monounsaturated rapeseed oil reduces the lipoprotein cholesterol concentration and increases the relative content of n-3 fatty acids in serum in hyperlipidemic subjects. Am J Clin Nutr 59, 667674.
24 Patade, A, Devareddy, L, Lucas, EA, et al. (2008) Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women. J Womens Health (Larchmt) 17, 355366.
25 Vahouny, GV, Satchithanandam, S, Chen, I, et al. (1988) Dietary fiber and intestinal adaptation: effects on lipid absorption and lymphatic transport in the rat. Am J Clin Nutr 47, 201206.
26 Kayano, S, Kikuzaki, H, Fukutsuka, N, et al. (2002) Antioxidant activity of prune (Prunus domestica L.) constituents and a new synergist. J Agric Food Chem 50, 37083712.
27 Nakatani, N, Kayano, S, Kikuzaki, H, et al. (2000) Identification, quantitative determination, and antioxidative activities of chlorogenic acid isomers in prune (Prunus domestica L.). J Agric Food Chem 48, 55125516.
28 Basu, S, Michaelsson, K, Olofsson, H, et al. (2001) Association between oxidative stress and bone mineral density. Biochem Biophys Res Commun 288, 275279.
29 Garrett, IR, Boyce, BF, Oreffo, RO, et al. (1990) Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 85, 632639.
30 Nielsen, FH, Hunt, CD, Mullen, LM, et al. (1987) Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J 1, 394397.
31 Nielsen, FH (1994) Biochemical and physiologic consequences of boron deprivation in humans. Environ Health Perspect 102, Suppl. 7, 5963.
32 Dismore, ML, Haytowitz, DB, Gebhardt, SE, et al. (2003) Vitamin K content of nuts and fruits in the US diet. J Am Diet Assoc 103, 16501652.
33 Iwamoto, J, Takeda, T & Sato, Y (2004) Effects of vitamin K2 on osteoporosis. Curr Pharm Des 10, 25572576.
34 Azinge, EC & Bolarin, DM (2006) Osteocalcin and bone-specific alkaline phosphatase in sickle cell haemoglobinopathies. Niger J Physiol Sci 21, 2125.
35 Gundberg, CM, Looker, AC, Nieman, SD, et al. (2002) Patterns of osteocalcin and bone specific alkaline phosphatase by age, gender, and race or ethnicity. Bone 31, 703708.
36 Lenora, J, Norrgren, K, Thorsson, O, et al. (2009) Bone turnover markers are correlated with total skeletal uptake of 99mTc-methylene diphosphonate (99mTc-MDP). BMC Med Phys 9, 3.
37 Wang, J, Pei, F, Tu, C, et al. (2007) Serum bone turnover markers in patients with primary bone tumors. Oncology 72, 338342.
38 Ding, C, Parameswaran, V, Udayan, R, et al. (2008) Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study. J Clin Endocrinol Metab 93, 19521958.
39 Lund, HL, Nafstad, P, Olsen, I, et al. (2009) C-reactive protein variations for different chronic somatic disorders. Scand J Public Health 37, 640646.
40 Maugeri, D, Russo, MS, Franze, C, et al. (1998) Correlations between C-reactive protein, interleukin-6, tumor necrosis factor-alpha and body mass index during senile osteoporosis. Arch Gerontol Geriatr 27, 159163.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
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