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British Journal of Nutrition British Journal of Nutrition

Article contents

Current issues surrounding the definition of trans-fatty acids: implications for health, industry and food labels

Published online by Cambridge University Press:  18 April 2013

Ye Wang  and
Spencer D. Proctor
Ye Wang
Affiliation:
Metabolic and Cardiovascular Diseases Laboratory, Molecular Cell Biology of Lipids Group, Alberta Diabetes and Mazankowski Alberta Heart Institutes, 4-002J Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB, CanadaT6G 2E1
Spencer D. Proctor*
Affiliation:
Metabolic and Cardiovascular Diseases Laboratory, Molecular Cell Biology of Lipids Group, Alberta Diabetes and Mazankowski Alberta Heart Institutes, 4-002J Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB, CanadaT6G 2E1
*
*Corresponding author: Dr S. D. Proctor, fax +1 780 492 9270, email spencer.proctor@ualberta.ca
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Abstract

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The definition of trans-fatty acids (TFA) was established by the Codex Alimentarius to guide nutritional and legislative regulations to reduce TFA consumption. Currently, conjugated linoleic acid (CLA) is excluded from the TFA definition based on evidence (primarily preclinical studies) implying health benefits on weight management and cancer prevention. While the efficacy of CLA supplements remains inconsistent in randomised clinical trials, evidence has emerged to associate supplemental CLA with negative health outcomes, including increased subclinical inflammation and oxidative stress (particularly at high doses). This has resulted in concerns regarding the correctness of excluding CLA from the TFA definition. Here we review recent clinical and preclinical literature on health implications of CLA and ruminant TFA, and highlight several issues surrounding the current Codex definition of TFA and how it may influence interpretation for public health. We find that CLA derived from ruminant foods differ from commercial CLA supplements in their isomer composition/distribution, consumption level and bioactivity. We conclude that health concerns associated with the use of supplemental CLA do not repudiate the exclusion of all forms of CLA from the Codex TFA definition, particularly when using the definition for food-related purposes. Given the emerging differential bioactivity of TFA from industrial v. ruminant sources, we advocate that regional nutrition guidelines/policies should focus on eliminating industrial forms of trans-fat from processed foods as opposed to all TFA per se.

Keywords

Trans-fatty acidsRuminant trans-fatConjugated linoleic acidVaccenic acid
Type
Review Article
Information
British Journal of Nutrition , Volume 110 , Issue 8 , 28 October 2013 , pp. 1369 - 1383
Copyright
Copyright © The Authors 2013 

References

1Mozaffarian, D, Aro, A & Willett, WC (2009) Health effects of trans-fatty acids: experimental and observational evidence. Eur J Clin Nutr 63, Suppl. 2, S5–S21.CrossRefGoogle ScholarPubMed
2Brouwer, IA, Wanders, AJ & Katan, MB (2010) Effect of animal and industrial trans fatty acids on HDL and LDL cholesterol levels in humans – a quantitative review. PloS one 5, e9434.CrossRefGoogle ScholarPubMed
3Voorrips, LE, Brants, HA, Kardinaal, AF, et al. (2002) Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands Cohort Study on Diet and Cancer. Am J Clin Nutr 76, 873–882.CrossRefGoogle ScholarPubMed
4Chavarro, JE, Stampfer, MJ, Campos, H, et al. (2008) A prospective study of trans-fatty acid levels in blood and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 17, 95–101.CrossRefGoogle ScholarPubMed
5Vinikoor, LC, Millikan, RC, Satia, JA, et al. (2010) Trans-fatty acid consumption and its association with distal colorectal cancer in the North Carolina Colon Cancer Study II. Cancer Causes Control 21, 171–180.CrossRefGoogle ScholarPubMed
6Stachowska, E (2008) Conjugated dienes of linoleic acid and tumorigenesis. Ann Acad Med Stetin 54, 122–125.Google ScholarPubMed
7Kennedy, A, Martinez, K, Schmidt, S, et al. (2010) Antiobesity mechanisms of action of conjugated linoleic acid. J Nutr Biochem 21, 171–179.CrossRefGoogle ScholarPubMed
8Reynolds, CM & Roche, HM (2010) Conjugated linoleic acid and inflammatory cell signalling. Prostaglandins Leukot Essent Fatty Acids 82, 199–204.CrossRefGoogle ScholarPubMed
9Gebauer, SK, Chardigny, JM, Jakobsen, MU, et al. (2011) Effects of ruminant trans fatty acids on cardiovascular disease and cancer: a comprehensive review of epidemiological, clinical, and mechanistic studies. Adv Nutr 2, 332–354.CrossRefGoogle ScholarPubMed
10Bendsen, NT, Christensen, R, Bartels, EM, et al. (2011) Consumption of industrial and ruminant trans fatty acids and risk of coronary heart disease: a systematic review and meta-analysis of cohort studies. Eur J Clin Nutr 65, 773–783.CrossRefGoogle ScholarPubMed
11Brouwer, IA, Wanders, AJ & Katan, MB (2013) Trans fatty acids and cardiovascular health-research completed? Eur J Clin Nutr (epublication ahead of print version 27 March 2013).CrossRefGoogle ScholarPubMed
12EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2012) Statement on the safety of the “conjugated linoleic acid (CLA)-rich oils” Clarinol and Tonalin TG80 as Novel Food ingredients. EFSA J 10, 2700.CrossRefGoogle Scholar
13United States Food and Drug Administration (2007) GRAS notice inventory-GRN No.232 – conjugated linoleic acid isomers. http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt = grasListing&id = 232.Google Scholar
14EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2010) Scientific opinion on the substantiation of health claims related to conjugated linoleic acid (CLA) isomers. EFSA J 8, 1794.Google Scholar
15Riserus, U, Arner, P, Brismar, K, et al. (2002) Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care 25, 1516–1521.CrossRefGoogle ScholarPubMed
16Riserus, U, Basu, S, Jovinge, S, et al. (2002) Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance. Circulation 106, 1925–1929.CrossRefGoogle ScholarPubMed
17Riserus, U, Vessby, B, Arner, P, et al. (2004) Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. Diabetologia 47, 1016–1019.CrossRefGoogle ScholarPubMed
18Food Standards Australia New Zealand (FSANZ) (2009) Intake of trans fatty acids in New Zealand and Australia review report-2009 assessment. http://www.foodstandards.gov.au/_srcfiles/TFAs_Aus_NZ_Food%20_Supply.pdf.Google Scholar
19Palmquist, DL, Lock, AL, Shingfield, KJ, et al. (2005) Biosynthesis of conjugated linoleic acid in ruminants and humans. Adv Food Nutr Res 50, 179–217.CrossRefGoogle ScholarPubMed
20McCrorie, TA, Keaveney, EM, Wallace, JM, et al. (2011) Human health effects of conjugated linoleic acid from milk and supplements. Nutr Res Rev 24, 206–227.CrossRefGoogle ScholarPubMed
21Health Canada (2010) Conjugated Linoleic Acid. http://www.hc-sc.gc.ca/dhp-mps/prodnatur/applications/licen-prod/monograph/mono_cla-alc-eng.php.Google Scholar
22Tetens, I (2010) Scientific Opinion on the safety of “conjugated linoleic acid (CLA)-rich oil” (Tonalin® TG 80) as a Novel Food ingredient. EFSA J 8, 1600.Google Scholar
23Lock, AL & Bauman, DE (2004) Modifying milk fat composition of dairy cows to enhance fatty acids beneficial to human health. Lipids 39, 1197–1206.CrossRefGoogle ScholarPubMed
24Parodi, PW (1999) Conjugated linoleic acid: an anticarcinogenic fatty acid present in milk fat. J Dairy Sci 82, 1339–1349.CrossRefGoogle ScholarPubMed
25Fritsche, J & Steinhart, H (1998) Amounts of conjugated linoleic acid (CLA) in German foods and evaluation of daily intake. Z Lebensm Unters Forsch 2065, 77–82.CrossRefGoogle Scholar
26Maurelli, S, Blasi, F, Cossignani, L, et al. (2009) Enzymatic synthesis of structured triacylglycerols containing CLA isomers starting from sn-1,3-diacylglycerols. J Am Oil Chem Soc 86, 127–133.CrossRefGoogle Scholar
27Chardigny, JM, Masson, E, Sergiel, JP, et al. (2003) The position of rumenic acid on triacylglycerols alters its bioavailability in rats. J Nutr 133, 4212–4214.CrossRefGoogle ScholarPubMed
28Valeille, K & Martin, JC (2004) Complete stereospecific determination of conjugated linoleic acids in triacylglycerol of milk-fat. Reprod Nutr Dev 44, 459–464.CrossRefGoogle ScholarPubMed
29Paterson, LJ, Weselake, RJ, Mir, PS, et al. (2002) Positional distribution of CLA in TAG of lamb tissues. Lipids 37, 605–611.CrossRefGoogle ScholarPubMed
30Yurawecz, MP, Hood, JK, Mossoba, MM, et al. (1995) Furan fatty acids determined as oxidation products of conjugated octadecadienoic acid. Lipids 30, 595–598.CrossRefGoogle ScholarPubMed
31Sugano, M, Tsujita, A, Yamasaki, M, et al. (1997) Lymphatic recovery, tissue distribution, and metabolic effects of conjugated linoleic acid in rats. J Nutr Biochem 8, 38–43.CrossRefGoogle Scholar
32Martin, JC, Sebedio, JL, Caselli, C, et al. (2000) Lymphatic delivery and in vitro pancreatic lipase hydrolysis of glycerol esters of conjugated linoleic acids in rats. J Nutr 130, 1108–1114.CrossRefGoogle ScholarPubMed
33Bracco, U (1994) Effect of triglyceride structure on fat absorption. Am J Clin Nutr 60, 1002S–1009S.CrossRefGoogle ScholarPubMed
34Gervais, R, Gagnon, F, Kheadr, EE, et al. (2009) Bioaccessibility of fatty acids from conjugated linoleic acid-enriched milk and milk emulsions studied in a dynamic in vitro gastrointestinal model. Int Dairy J 19, 574–581.CrossRefGoogle Scholar
35Engberink, MF, Geleijnse, JM, Wanders, AJ, et al. (2012) The effect of conjugated linoleic acid, a natural trans fat from milk and meat, on human blood pressure: results from a randomized crossover feeding study. J Hum Hypertens 26, 127–132.CrossRefGoogle ScholarPubMed
36de Roos, B, Wanders, AJ, Wood, S, et al. (2011) A high intake of industrial or ruminant trans fatty acids does not affect the plasma proteome in healthy men. Proteomics 11, 3928–3934.CrossRefGoogle Scholar
37Smit, LA, Katan, MB, Wanders, AJ, et al. (2011) A high intake of trans fatty acids has little effect on markers of inflammation and oxidative stress in humans. J Nutr 141, 1673–1678.CrossRefGoogle ScholarPubMed
38Wanders, AJ, Brouwer, IA, Siebelink, E, et al. (2010) Effect of a high intake of conjugated linoleic acid on lipoprotein levels in healthy human subjects. PloS one 5, e9000.CrossRefGoogle ScholarPubMed
39Sluijs, I, Plantinga, Y, de Roos, B, et al. (2010) Dietary supplementation with cis-9, trans-11 conjugated linoleic acid and aortic stiffness in overweight and obese adults. Am J Clin Nutr 91, 175–183.CrossRefGoogle ScholarPubMed
40Asp, ML, Collene, AL, Norris, LE, et al. (2011) Time-dependent effects of safflower oil to improve glycemia, inflammation and blood lipids in obese, post-menopausal women with type 2 diabetes: a randomized, double-masked, crossover study. Clin Nutr 30, 443–449.CrossRefGoogle ScholarPubMed
41Joseph, SV, Jacques, H, Plourde, M, et al. (2011) Conjugated linoleic acid supplementation for 8 weeks does not affect body composition, lipid profile, or safety biomarkers in overweight, hyperlipidemic men. J Nutr 141, 1286–1291.CrossRefGoogle ScholarPubMed
42Pfeuffer, M, Fielitz, K, Laue, C, et al. (2011) CLA does not impair endothelial function and decreases body weight as compared with safflower oil in overweight and obese male subjects. J Am Coll Nutr 30, 19–28.CrossRefGoogle Scholar
43Smit, LA, Baylin, A & Campos, H (2010) Conjugated linoleic acid in adipose tissue and risk of myocardial infarction. Am J Clin Nutr 92, 34–40.CrossRefGoogle ScholarPubMed
44Castro-Webb, N, Ruiz-Narvaez, EA & Campos, H (2012) Cross-sectional study of conjugated linoleic acid in adipose tissue and risk of diabetes. Am J Clin Nutr 96, 175–181.CrossRefGoogle ScholarPubMed
45Venkatramanan, S, Joseph, SV, Chouinard, PY, et al. (2010) Milk enriched with conjugated linoleic acid fails to alter blood lipids or body composition in moderately overweight, borderline hyperlipidemic individuals. J Am Coll Nutr 29, 152–159.CrossRefGoogle ScholarPubMed
46Brown, AW, Trenkle, AH & Beitz, DC (2011) Diets high in conjugated linoleic acid from pasture-fed cattle did not alter markers of health in young women. Nutr Res 31, 33–41.CrossRefGoogle Scholar
47Lacroix, E, Charest, A, Cyr, A, et al. (2012) Randomized controlled study of the effect of a butter naturally enriched in trans fatty acids on blood lipids in healthy women. Am J Clin Nutr 95, 318–325.CrossRefGoogle ScholarPubMed
48Zlatanos, SN, Laskaridis, K & Sagredos, A (2008) Conjugated linoleic acid content of human plasma. Lipids Health Dis 7, 34.CrossRefGoogle ScholarPubMed
49Sato, K, Shinohara, N, Honma, T, et al. (2011) The change in conjugated linoleic acid concentration in blood of Japanese fed a conjugated linoleic acid diet. J Nutr Sci Vitaminol (Tokyo) 57, 364–371.CrossRefGoogle ScholarPubMed
50Declercq, V, Taylor, CG & Zahradka, P (2011) Isomer-specific effects of conjugated linoleic acid on blood pressure, adipocyte size and function. Br J Nutr 107, 1413–1421.CrossRefGoogle ScholarPubMed
51Park, Y, Terk, M & Park, Y (2011) Interaction between dietary conjugated linoleic acid and calcium supplementation affecting bone and fat mass. J Bone Miner Metab 29, 268–278.CrossRefGoogle ScholarPubMed
52Lasa, A, Simon, E, Churruca, I, et al. (2011) Effects of trans-10, cis-12 CLA on liver size and fatty acid oxidation under energy restriction conditions in hamsters. Nutrition 27, 116–121.CrossRefGoogle ScholarPubMed
53Obsen, T, Faergeman, NJ, Chung, S, et al. (2012) Trans-10, cis-12 conjugated linoleic acid decreases de novo lipid synthesis in human adipocytes. J Nutr Biochem 23, 580–590.CrossRefGoogle ScholarPubMed
54Lasa, A, Miranda, J, Churruca, I, et al. (2011) The combination of resveratrol and CLA does not increase the delipidating effect of each molecule in 3T3-L1 adipocytes. Nutr Hosp 26, 997–1003.Google Scholar
55Ashwell, MS, Ceddia, RP, House, RL, et al. (2010) Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis. J Nutr Biochem 21, 848–855.CrossRefGoogle Scholar
56Yu, J, Yu, B, Jiang, H, et al. (2012) Conjugated linoleic acid induces hepatic expression of fibroblast growth factor 21 through PPAR-alpha. Br J Nutr 107, 461–465.CrossRefGoogle ScholarPubMed
57Hommelberg, PP, Plat, J, Remels, AH, et al. (2010) Trans-10, cis-12 conjugated linoleic acid inhibits skeletal muscle differentiation and GLUT4 expression independently from NF-kappaB activation. Mol Nutr Food Res 54, 1763–1772.CrossRefGoogle ScholarPubMed
58Jiang, S, Chen, H, Wang, Z, et al. (2011) Activated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes. J Nutr Biochem 22, 656–664.CrossRefGoogle ScholarPubMed
59Martinez, K, Kennedy, A & McIntosh, MK (2011) JNK inhibition by SP600125 attenuates trans-10, cis-12 conjugated linoleic acid-mediated regulation of inflammatory and lipogenic gene expression. Lipids 46, 885–892.CrossRefGoogle ScholarPubMed
60Zhai, JJ, Liu, ZL, Li, JM, et al. (2010) Different mechanisms of cis-9, trans-11- and trans-10, cis-12- conjugated linoleic acid affecting lipid metabolism in 3T3-L1 cells. J Nutr Biochem 21, 1099–1105.CrossRefGoogle ScholarPubMed
61Stringer, DM, Zahradka, P, Declercq, VC, et al. (2010) Modulation of lipid droplet size and lipid droplet proteins by trans-10, cis-12 conjugated linoleic acid parallels improvements in hepatic steatosis in obese, insulin-resistant rats. Biochim Biophys Acta 1801, 1375–1385.CrossRefGoogle ScholarPubMed
62DeClercq, V, Zahradka, P & Taylor, CG (2010) Dietary t10, c12-CLA but not c9, t11 CLA reduces adipocyte size in the absence of changes in the adipose renin–angiotensin system in fa/fa Zucker rats. Lipids 45, 1025–1033.CrossRefGoogle Scholar
63Stachowska, E, Siennicka, A, Baskiewcz-Halasa, M, et al. (2012) Conjugated linoleic acid isomers may diminish human macrophages adhesion to endothelial surface. Int J Food Sci Nutr 63, 30–35.CrossRefGoogle ScholarPubMed
64Rungapamestry, V, McMonagle, J, Reynolds, C, et al. (2012) Inter-organ proteomic analysis reveals insights into the molecular mechanisms underlying the anti-diabetic effects of cis-9, trans-11-conjugated linoleic acid in ob/ob mice. Proteomics 12, 461–476.CrossRefGoogle ScholarPubMed
65Hsu, YC, Meng, X, Ou, L, et al. (2010) Activation of the AMP-activated protein kinase-p38 MAP kinase pathway mediates apoptosis induced by conjugated linoleic acid in p53-mutant mouse mammary tumor cells. Cell Signal 22, 590–599.CrossRefGoogle ScholarPubMed
66Stachowska, E, Kijowski, J, Dziedziejko, V, et al. (2011) Conjugated linoleic acid regulates phosphorylation of PPARgamma by modulation of ERK 1/2 and p38 signaling in human macrophages/fatty acid-laden macrophages. J Agric Food Chem 59, 11846–11852.CrossRefGoogle ScholarPubMed
67Declercq, V, Taylor, CG, Wigle, J, et al. (2012) Conjugated linoleic acid improves blood pressure by increasing adiponectin and endothelial nitric oxide synthase activity. J Nutr Biochem 23, 487–493.CrossRefGoogle ScholarPubMed
68Kim, DI, Kim, KH, Kang, JH, et al. (2011) Trans-10, cis-12-conjugated linoleic acid modulates NF-kappaB activation and TNF-alpha production in porcine peripheral blood mononuclear cells via a PPARgamma-dependent pathway. Br J Nutr 105, 1329–1336.CrossRefGoogle Scholar
69Kim, KH, Kim, DI, Kim, SH, et al. (2011) Trans-10, cis-12-conjugated linoleic acid attenuates tumor necrosis factor-alpha production by lipopolysaccharide-stimulated porcine peripheral blood mononuclear cells through induction of interleukin-10. Cytokine 56, 224–230.CrossRefGoogle ScholarPubMed
70Perdomo, MC, Santos, JE & Badinga, L (2011) Trans-10, cis-12 conjugated linoleic acid and the PPAR-gamma agonist rosiglitazone attenuate lipopolysaccharide-induced TNF-alpha production by bovine immune cells. Domest Anim Endocrinol 41, 118–125.CrossRefGoogle ScholarPubMed
71Paek, J, Kang, JH, Kim, SS, et al. (2010) Trans-10, cis-12 conjugated linoleic acid directly enhances the chemotactic activity of porcine peripheral blood polymorphonuclear neutrophilic leukocytes by activating F-actin polymerization in vitro. Res Vet Sci 89, 191–195.CrossRefGoogle Scholar
72Kelley, NS, Hubbard, NE & Erickson, KL (2007) Conjugated linoleic acid isomers and cancer. J Nutr 137, 2599–2607.CrossRefGoogle ScholarPubMed
73Bialek, A, Tokarz, A, Dudek, A, et al. (2010) Influence of diet enriched with conjugated linoleic acids on their distribution in tissues of rats with DMBA induced tumors. Lipids Health Dis 9, 126.CrossRefGoogle ScholarPubMed
74Bougnoux, P, Hajjaji, N, Maheo, K, et al. (2010) Fatty acids and breast cancer: sensitization to treatments and prevention of metastatic re-growth. Prog Lipid Res 49, 76–86.CrossRefGoogle ScholarPubMed
75Heinze, VM & Actis, AB (2012) Dietary conjugated linoleic acid and long-chain n-3 fatty acids in mammary and prostate cancer protection: a review. Int J Food Sci Nutr 63, 66–78.CrossRefGoogle ScholarPubMed
76Hsu, YC & Ip, MM (2011) Conjugated linoleic acid-induced apoptosis in mouse mammary tumor cells is mediated by both G protein coupled receptor-dependent activation of the AMP-activated protein kinase pathway and by oxidative stress. Cell Signal 23, 2013–2020.CrossRefGoogle Scholar
77Rakib, MA, Kim, YS, Jang, WJ, et al. (2010) Attenuation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced gap junctional intercellular communication (GJIC) inhibition in MCF-10A cells by c9, t11-conjugated linoleic acid. J Agric Food Chem 58, 12022–12030.CrossRefGoogle ScholarPubMed
78Palmieri, G, Bergamo, P, Luini, A, et al. (2011) Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation. PloS one 6, e25888.CrossRefGoogle ScholarPubMed
79Degen, C, Lochner, A, Keller, S, et al. (2011) Influence of in vitro supplementation with lipids from conventional and Alpine milk on fatty acid distribution and cell growth of HT-29 cells. Lipids Health Dis 10, 131.CrossRefGoogle ScholarPubMed
80Bassaganya-Riera, J & Hontecillas, R (2010) Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease. Curr Opin Clin Nutr Metab Care 13, 569–573.CrossRefGoogle ScholarPubMed
81Gorissen, L, Raes, K, Weckx, S, et al. (2010) Production of conjugated linoleic acid and conjugated linolenic acid isomers by Bifidobacterium species. Appl Microbiol Biotechnol 87, 2257–2266.CrossRefGoogle ScholarPubMed
82Martin, CA, Milinsk, MC, Visentainer, JV, et al. (2007) Trans fatty acid-forming processes in foods: a review. An Acad Bras Cienc 79, 343–350.CrossRefGoogle ScholarPubMed
83Kemeny, Z, Recseg, K, Henon, G, et al. (2001) Deodorization of vegetable oils: prediction of trans polyunsaturated fatty acid content. J Am Oil Chem Soc 78, 973–979.CrossRefGoogle Scholar
84Mozaffarian, D (2008) Commentary: ruminant trans fatty acids and coronary heart disease – cause for concern? Int J Epidemiol 37, 182–184.CrossRefGoogle ScholarPubMed
85Santora, JE, Palmquist, DL & Roehrig, KL (2000) Trans-vaccenic acid is desaturated to conjugated linoleic acid in mice. J Nutr 130, 208–215.Google ScholarPubMed
86Turpeinen, AM, Mutanen, M, Aro, A, et al. (2002) Bioconversion of vaccenic acid to conjugated linoleic acid in humans. Am J Clin Nutr 76, 504–510.Google ScholarPubMed
87Bhattacharya, A, Banu, J, Rahman, M, et al. (2006) Biological effects of conjugated linoleic acids in health and disease. J Nutr Biochem 17, 789–810.CrossRefGoogle ScholarPubMed
88Wolff, RL, Combe, NA, Destaillats, F, et al. (2000) Follow-up of the delta4 to delta16 trans-18 : 1 isomer profile and content in French processed foods containing partially hydrogenated vegetable oils during the period 1995–1999. Analytical and nutritional implications. Lipids 35, 815–825.CrossRefGoogle ScholarPubMed
89Micha, R, King, IB, Lemaitre, RN, et al. (2010) Food sources of individual plasma phospholipid trans fatty acid isomers: the Cardiovascular Health Study. Am J Clin Nutr 91, 883–893.CrossRefGoogle ScholarPubMed
90Sartika, RA (2011) Effect of trans fatty acids intake on blood lipid profile of workers in East Kalimantan, Indonesia. Malays J Nutr 17, 119–127.Google ScholarPubMed
91Varraso, R, Kabrhel, C, Goldhaber, SZ, et al. (2012) Prospective study of diet and venous thromboembolism in US women and men. Am J Epidemiol 175, 114–126.CrossRefGoogle ScholarPubMed
92Vesper, HW, Kuiper, HC, Mirel, LB, et al. (2012) Levels of plasma trans-fatty acids in non-Hispanic white adults in the United States in 2000 and 2009. JAMA 307, 562–563.CrossRefGoogle ScholarPubMed
93Laake, I, Pedersen, JI, Selmer, R, et al. (2011) A prospective study of intake of trans-fatty acids from ruminant fat, partially hydrogenated vegetable oils, and marine oils and mortality from CVD. Br J Nutr 108, 743–754.CrossRefGoogle ScholarPubMed
94Hansen, CP, Berentzen, TL, Halkjaer, J, et al. (2012) Intake of ruminant trans fatty acids and changes in body weight and waist circumference. Eur J Clin Nutr 66, 1104–1109.CrossRefGoogle ScholarPubMed
95Baylin, A, Kabagambe, EK, Ascherio, A, et al. (2003) High 18 : 2 trans-fatty acids in adipose tissue are associated with increased risk of nonfatal acute myocardial infarction in Costa Rican adults. J Nutr 133, 1186–1191.CrossRefGoogle ScholarPubMed
96Lemaitre, RN, King, IB, Mozaffarian, D, et al. (2006) Plasma phospholipid trans fatty acids, fatal ischemic heart disease, and sudden cardiac death in older adults: The Cardiovascular Health Study. Circulation 114, 209–215.CrossRefGoogle ScholarPubMed
97Kraft, J, Spiltoir, JI, Salter, AM, et al. (2011) Differential effects of the trans-18 : 1 isomer profile of partially hydrogenated vegetable oils on cholesterol and lipoprotein metabolism in male F1B hamsters. J Nutr 141, 1819–1826.CrossRefGoogle ScholarPubMed
98Teixeira, AM, Dias, VT, Pase, CS, et al. (2012) Could dietary trans fatty acids induce movement disorders? Effects of exercise and its influence on NaK-ATPase and catalase activity in rat striatum. Behav Brain Res 226, 504–510.CrossRefGoogle ScholarPubMed
99Collison, KS, Zaidi, MZ, Saleh, SM, et al. (2012) Nutrigenomics of hepatic steatosis in a feline model: effect of monosodium glutamate, fructose, and trans-fat feeding. Genes Nutr 7, 265–280.CrossRefGoogle Scholar
100Dhibi, M, Brahmi, F, Mnari, A, et al. (2011) The intake of high fat diet with different trans fatty acid levels differentially induces oxidative stress and non alcoholic fatty liver disease (NAFLD) in rats. Nutr Metab 8, 65.CrossRefGoogle ScholarPubMed
101Pimentel, GD, Lira, FS, Rosa, JC, et al. (2012) Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NFkappaBp65 signaling in adult offspring. J Nutr Biochem 23, 265–271.CrossRefGoogle ScholarPubMed
102Bowman, GL, Silbert, LC, Howieson, D, et al. (2012) Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging. Neurology 78, 241–249.CrossRefGoogle ScholarPubMed
103Harvey, KA, Arnold, T, Rasool, T, et al. (2008) Trans-fatty acids induce pro-inflammatory responses and endothelial cell dysfunction. Br J Nutr 99, 723–731.CrossRefGoogle ScholarPubMed
104Kummerow, FA, Zhou, Q & Mahfouz, MM (1999) Effect of trans fatty acids on calcium influx into human arterial endothelial cells. Am J Clin Nutr 70, 832–838.CrossRefGoogle ScholarPubMed
105Iwata, NG, Pham, M, Rizzo, NO, et al. (2011) Trans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cells. PloS one 6, e29600.CrossRefGoogle ScholarPubMed
106Mozaffarian, D (2006) Trans fatty acids – effects on systemic inflammation and endothelial function. Atheroscler Suppl 7, 29–32.CrossRefGoogle ScholarPubMed
107Fournier, N, Attia, N, Rousseau-Ralliard, D, et al. (2012) Deleterious impact of elaidic fatty acid on ABCA1-mediated cholesterol efflux from mouse and human macrophages. Biochim Biophys Acta 1821, 303–312.CrossRefGoogle ScholarPubMed
108Enke, U, Jaudszus, A, Schleussner, E, et al. (2011) Fatty acid distribution of cord and maternal blood in human pregnancy: special focus on individual trans fatty acids and conjugated linoleic acids. Lipids Health Dis 10, 247.CrossRefGoogle ScholarPubMed
109Rosenthal, MD & Doloresco, MA (1984) The effects of trans fatty acids on fatty acyl delta 5 desaturation by human skin fibroblasts. Lipids 19, 869–874.CrossRefGoogle ScholarPubMed
110Tyburczy, C, Major, C, Lock, AL, et al. (2009) Individual trans octadecenoic acids and partially hydrogenated vegetable oil differentially affect hepatic lipid and lipoprotein metabolism in golden Syrian hamsters. J Nutr 139, 257–263.CrossRefGoogle ScholarPubMed
111Wang, Y, Jacome-Sosa, MM, Ruth, MR, et al. (2009) Trans-11 vaccenic acid reduces hepatic lipogenesis and chylomicron secretion in JCR:LA-cp rats. J Nutr 139, 2049–2054.CrossRefGoogle ScholarPubMed
112Bassett, CM, Edel, AL, Patenaude, AF, et al. (2010) Dietary vaccenic acid has antiatherogenic effects in LDLr − / −  mice. J Nutr 140, 18–24.CrossRefGoogle Scholar
113Jacome-Sosa, MM, Lu, J, Wang, Y, et al. (2010) Increased hypolipidemic benefits of cis-9, trans-11 conjugated linoleic acid in combination with trans-11 vaccenic acid in a rodent model of the metabolic syndrome, the JCR:LA-cp rat. Nutr Metab 7, 60.CrossRefGoogle Scholar
114Anadon, A, Martinez-Larranaga, MR, Martinez, MA, et al. (2011) A 4-week repeated oral dose toxicity study of dairy fat naturally enriched in vaccenic, rumenic and alpha-linolenic acids in rats. J Agric Food Chem 59, 8036–8046.CrossRefGoogle Scholar
115Sun, X, Zhang, J, Macgibbon, AK, et al. (2011) Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic dermatitis in mice. Clin Exp Allergy 41, 729–738.CrossRefGoogle ScholarPubMed
116Van Nieuwenhove, CP, Cano, PG, Perez-Chaia, AB, et al. (2011) Effect of functional buffalo cheese on fatty acid profile and oxidative status of liver and intestine of mice. J Med Food 14, 420–427.CrossRefGoogle Scholar
117Wang, Y, Jacome-Sosa, MM, Ruth, MR, et al. (2012) The intestinal bioavailability of vaccenic acid and activation of peroxisome proliferator-activated receptor-α and -γ in a rodent model of dyslipidemia and the metabolic syndrome. Mol Nutr Food Res 56, 1234–1246.CrossRefGoogle Scholar
118Chardigny, JM, Destaillats, F, Malpuech-Brugere, C, et al. (2008) Do trans fatty acids from industrially produced sources and from natural sources have the same effect on cardiovascular disease risk factors in healthy subjects? Results of the trans Fatty Acids Collaboration (TRANSFACT) study. Am J Clin Nutr 87, 558–566.CrossRefGoogle ScholarPubMed
119Motard-Belanger, A, Charest, A, Grenier, G, et al. (2008) Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factors for cardiovascular disease. Am J Clin Nutr 87, 593–599.CrossRefGoogle ScholarPubMed
120Tardy, AL, Lambert-Porcheron, S, Malpuech-Brugere, C, et al. (2009) Dairy and industrial sources of trans fat do not impair peripheral insulin sensitivity in overweight women. Am J Clin Nutr 90, 88–94.CrossRefGoogle Scholar
121Onakpoya, IJ, Posadzki, PP, Watson, LK, et al. (2012) The efficacy of long-term conjugated linoleic acid (CLA) supplementation on body composition in overweight and obese individuals: a systematic review and meta-analysis of randomized clinical trials. Eur J Nutr 51, 127–134.CrossRefGoogle ScholarPubMed
122Schoeller, DA, Watras, AC & Whigham, LD (2009) A meta-analysis of the effects of conjugated linoleic acid on fat-free mass in humans. Appl Physiol Nutr Metab 34, 975–978.CrossRefGoogle ScholarPubMed
123Whigham, LD, Watras, AC & Schoeller, DA (2007) Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am J Clin Nutr 85, 1203–1211.CrossRefGoogle ScholarPubMed
124Lenz, TL & Hamilton, WR (2004) Supplemental products used for weight loss. J Am Pharm Assoc 44, 59–67, quiz 67–58.CrossRefGoogle ScholarPubMed
125Salas-Salvadó, J, Marquez-Sandoval, F & Bullo, M (2006) Conjugated linoleic acid intake in humans: a systematic review focusing on its effect on body composition, glucose, and lipid metabolism. Crit Rev Food Sci Nutr 46, 479–488.CrossRefGoogle Scholar
126Tricon, S & Yaqoob, P (2006) Conjugated linoleic acid and human health: a critical evaluation of the evidence. Curr Opin Clin Nutr Metab Care 9, 105–110.CrossRefGoogle Scholar
127Bachmair, EM, Bots, ML, Mennen, LI, et al. (2012) Effect of supplementation with an 80:20 cis9, trans11 conjugated linoleic acid blend on the human platelet proteome. Mol Nutr Food Res 56, 1148–1159.CrossRefGoogle ScholarPubMed
128Labonte, ME, Couture, P, Paquin, P, et al. (2011) Comparison of the impact of trans fatty acids from ruminant and industrial sources on surrogate markers of cholesterol homeostasis in healthy men. Mol Nutr Food Res 55, Suppl. 2, S241–S247.CrossRefGoogle ScholarPubMed
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