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Dairy products, calcium and phosphorus intake, and the risk of prostate cancer: results of the French prospective SU.VI.MAX (Supplémentation en Vitamines et Minéraux Antioxydants) study

  • E. Kesse (a1), S. Bertrais (a1), P. Astorg (a1), A. Jaouen (a1), A. Arnault (a1), P. Galan (a1) and S. Hercberg (a1)...
Abstract

Although dairy products have been found to be associated with an elevated risk of prostate cancer, studies investigating the potential effect of Ca are limited, and findings are inconsistent. The objective of the present study was to test the relationship between the risk of prostate cancer and consumption of dairy products and Ca. The analysis included 2776 men from the French SU.VI.MAX (Supplementation en Vitamines et Minéraux Antioxydants) prospective study, among whom sixty-nine developed prostate cancer during the follow-up period (median: 7·7 years). Food consumption was assessed at inclusion from repeated 24h records and nutrient intake was calculated using a food composition table. A higher risk of prostate cancer was observed among subjects with higher dairy product (relative risk (RR; 95% CI), 4th quartile V. 1st: 1·35 (1·02, 1·78), P=0·04) and Ca intake (RR (95% CI), 4th quartile P. 1st: 2·43 (1·05, 5·62), P=0·04). Nevertheless, we identified a harmful effect of yoghurt consumption upon the risk of prostate cancer (RR (95% CI), increment 125g/d: 1·61 (1·07, 2·43), P=0·02) independently of the Ca content. Our data support the hypothesis that dairy products have a harmful effect with respect to the risk of prostate cancer, largely related to Ca content. The higher risk of prostate cancer with linear increasing yoghurt consumption seems to be independent of Ca and may be related to some other component.

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      Dairy products, calcium and phosphorus intake, and the risk of prostate cancer: results of the French prospective SU.VI.MAX (Supplémentation en Vitamines et Minéraux Antioxydants) study
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      Dairy products, calcium and phosphorus intake, and the risk of prostate cancer: results of the French prospective SU.VI.MAX (Supplémentation en Vitamines et Minéraux Antioxydants) study
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*Corresponding author: fax +33 153 018070, emmanuelle.kesse@cnam.fr
References
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Baron JA, Beach M, Wallace K, Grau MV, Sandler RS, Mandel JS, Heber D & Greenberg ER 2005 Risk of prostate cancer in a randomized clinical trial of calcium supplementation. Cancer Epidemiol Biomarkers Prev 14, 586589.
Bostwick DG, Burke HB, Djakiew D et al. (2004) Human prostate cancer risk factors. Cancer 101, 23712490.
Chan JM & Giovannucci EL 2001 Dairy products, calcium, and vitamin D and risk of prostate cancer. Epidemiol Rev 23, 8792.
Chan JM, Pietinen P, Virtanen M, Malila N, Tangrea J, Albanes D & Virtamo J 2000 Diet and prostate cancer risk in a cohort of smokers, with a specific focus on calcium and phosphorus (Finland). Cancer Causes Control 11, 859867.
Chan JM, Stampfer MJ, Ma J, Gann PH, Gaziano JM & Giovannucci EL 2001 Dairy products, calcium, and prostate cancer risk in the Physicians' Health Study. Am J Clin Nutr 74, 549554.
Chen TC & Holick MF 2003 Vitamin D and prostate cancer prevention and treatment. Trends Endocrinol Metab 14, 423430.
Dagnelie PC, Schuurman AG, Goldbohm RA & van den Brandt PA 2004 Diet, anthropometric measures and prostate cancer risk: a review of prospective cohort and intervention studies. BJU Int 93, 11391150.
Giovannucci E, Rimm EB, Wolk A, Ascherio A, Stampfer MJ, Colditz GA & Willett WC 1998 Calcium and fructose intake in relation to risk of prostate cancer. Cancer Res 58, 442447.
Hercberg S(coordinator) Table de composition SU.VI.MAX des aliments Paris: Les éditions INSERM/Economica. 2005
Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, Malvy D, Roussel AMFavier A & Briancon S 2004 The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 164, 23352342.
Korn EL, Graubard BI & Midthune D 1997 Time-to-event analysis of longitudinal follow-up of a survey: choice of the time-scale. Am J Epidemiol 145, 7280.
Kristal AR, Cohen JH, Qu P & Stanford JL 2002 Associations of energy, fat, calcium, and vitamin D with prostate cancer risk. Cancer Epidemiol Biomarkers Prev 11, 719725.
Mennen LI, Bertrais S, Galan P, Arnault N, Potier de Couray G & Hercberg S 2002 The use of computerised 24 h dietary recalls in the French SU.VI.MAX Study: number of recalls required. Eur J Clin Nutr 56, 659665.
Michaud DS, Augustsson K, Rimm EB, Stampfer MJ, Willet WC & Giovannucci E 2001 A prospective study on intake of animal products and risk of prostate cancer. Cancer Causes Control 12, 557567.
Remontet L, Esteve J, Bouvier AM et al. , 2003 Cancer incidence and mortality in France over the period 1978–2000. Rev Epidemiol Sante Publique 51, 330.
Rodriguez C, McCullough ML, Mondul AM, Jacobs EJ, FakhrabadiShokoohi D, Giovannucci EL, Thun MJ & Calle EE 2003 Calcium, dairy products, and risk of prostate cancer in a prospective cohort of United States men. Cancer Epidemiol Biomarkers Prev 12, 597603.
Schuurman AG, van den Brandt PA, Dorant E & Goldbohm RA 1999 Animal products, calcium and protein and prostate cancer risk in The Netherlands Cohort Study. Br J Cancer 80, 11071113.
Tavani A, Gallus S, Franceschi S & La Vecchia C 2001 Calcium, dairy products, and the risk of prostate cancer. Prostate 48, 118121.
Tavani A, Bertuccio P, Bosetti C, Talamini R, Negri E, Franceschi S, Montella M & La Vecchia C 2005 Dietary intake of calcium, vitamin D, phosphorus and the risk of prostate cancer. Eur Urol 48, 2733.
Tseng M, Breslow RA, Graubard BI & Ziegler RG 2005 Dairy, calcium, and vitamin D intakes and prostate cancer risk in the National Health and Nutrition Examination Epidemiologic Follow-up Study cohort. Am J Clin Nutr 81, 11471154.
Willett W & Stampfer MJ 1986 Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 124, 1727.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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