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Development and cross-validation of prediction equations for estimating resting energy expenditure in severely obese Caucasian children and adolescents

Published online by Cambridge University Press:  08 March 2007

Stefano Lazzer ,
Fiorenza Agosti ,
Alessandra De Col  and
Alessandro Sartorio
Stefano Lazzer
Affiliation:
Experimental Laboratory for Endocrinological Research, Italian Institute for Auxology, IRCCS, Milan and Piancavallo (VB), Italy Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
Fiorenza Agosti
Affiliation:
Experimental Laboratory for Endocrinological Research, Italian Institute for Auxology, IRCCS, Milan and Piancavallo (VB), Italy
Alessandra De Col
Affiliation:
Experimental Laboratory for Endocrinological Research, Italian Institute for Auxology, IRCCS, Milan and Piancavallo (VB), Italy
Alessandro Sartorio*
Affiliation:
Experimental Laboratory for Endocrinological Research, Italian Institute for Auxology, IRCCS, Milan and Piancavallo (VB), Italy Division of Auxology, Italian Institute for Auxology, IRCCS, Milan and Piancavallo (VB), Italy
*
*Corresponding author: Dr Alessandro Sartorio, fax +39 02 619112435, email sartorio@auxologico.it
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Abstract

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The objectives of the present study were to develop and cross-validate new equations for predicting resting energy expenditure (REE) in severely obese children and adolescents, and to determine the accuracy of new equations using the Bland–Altman method. The subjects of the study were 574 obese Caucasian children and adolescents (mean BMI z-score 3·3). REE was determined by indirect calorimetry and body composition by bioelectrical impedance analysis. Equations were derived by stepwise multiple regression analysis using a calibration cohort of 287 subjects and the equations were cross-validated in the remaining 287 subjects. Two new specific equations based on anthropometric parameters were generated as follows: (1) REE=(Sex×892·68)−(Age×115·93)+(Weight×54·96)+(Stature×1816·23)+1484·50 (R2 0·66; se 1028·97 kJ); (2) REE=(Sex×909·12)−(Age×107·48)+(fat-free mass×68·39)+(fat mass×55·19)+3631·23 (R2 0·66; se 1034·28 kJ). In the cross-validation group, mean predicted REE values were not significantly different from the mean measured REE for all children and adolescents, as well as for boys and for girls (difference <2 %) and the limits of agreement (±2 sd) were +2·06 and −1·77 MJ/d (NS). The new prediction equations allow an accurate estimation of REE in groups of severely obese children and adolescents. These equations might be useful for health care professionals and researchers when estimating REE in severely obese children and adolescents.

Keywords

Prediction equationEnergy expenditureChildrenAdolescentsBody compositionObesity
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 5 , November 2006 , pp. 973 - 979
Copyright
Copyright © The Nutrition Society 2006

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