Skip to main content Accessibility help
×
Home
Hostname: page-component-5cfd469876-wkcxx Total loading time: 0.187 Render date: 2021-06-24T06:49:53.787Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true }

Dietary acetic acid reduces serum cholesterol and triacylglycerols in rats fed a cholesterol-rich diet

Published online by Cambridge University Press:  08 March 2007

Takashi Fushimi
Affiliation:
Central Research Institute, Mizkan Group Corporation, 2–6 Nakamura-cho, Handa Aichi 475–8585, Japan
Kazuhito Suruga
Affiliation:
Laboratory of Nutritional Physiology and COE Program in the 21st Century, School of Food and Nutritional Sciences, The University of Shizuoka, Shizuoka 422–8526, Japan
Yoshifumi Oshima
Affiliation:
Central Research Institute, Mizkan Group Corporation, 2–6 Nakamura-cho, Handa Aichi 475–8585, Japan
Momoko Fukiharu
Affiliation:
Central Research Institute, Mizkan Group Corporation, 2–6 Nakamura-cho, Handa Aichi 475–8585, Japan
Yoshinori Tsukamoto
Affiliation:
Central Research Institute, Mizkan Group Corporation, 2–6 Nakamura-cho, Handa Aichi 475–8585, Japan
Toshinao Goda
Affiliation:
Laboratory of Nutritional Physiology and COE Program in the 21st Century, School of Food and Nutritional Sciences, The University of Shizuoka, Shizuoka 422–8526, Japan
Corresponding
E-mail address:
Rights & Permissions[Opens in a new window]

Abstract

To investigate the efficacy of the intake of vinegar for prevention of hyperlipidaemia, we examined the effect of dietary acetic acid, the main component of vinegar, on serum lipid values in rats fed a diet containing 1% (w/w) cholesterol. Animals were allowed free access to a diet containing no cholesterol, a diet containing 1% cholesterol without acetic acid, or a diet containing 1% cholesterol with 0·3% (w/w) acetic acid for 19 d. Then, they were killed after food deprivation for 7 h. Cholesterol feeding increased serum total cholesterol and triacylglycerol levels. Compared with the cholesterol-fed group, the cholesterol and acetic acid-fed group had significantly lower values for serum total cholesterol and triacylglycerols, liver ATP citrate lyase (ATP-CL) activity, and liver 3-hydroxy-3-methylglutaryl-CoA content as well as liver mRNA levels of sterol regulatory element binding protein-1, ATP-CL and fatty acid synthase (P<,0·05). Further, the serum secretin level, liver acyl-CoA oxidase expression, and faecal bile acid content were significantly higher in the cholesterol and acetic acid-fed group than in the cholesterol-fed group (P<0·05). However, acetic acid feeding affected neither the mRNA level nor activity of cholesterol 7a-hydroxylase. In conclusion, dietary acetic acid reduced serum total cholesterol and triacylglycerol: first due to the inhibition of lipogenesis in liver; second due to the increment in faecal bile acid excretion in rats fed a diet containing cholesterol.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2006

References

Apfel, R, Benbrook, D, Lernhardt, E, Ortiz, MA, Salbert, G & Pfahl, M (1994) A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol Cell Biol. 14 70257035CrossRefGoogle ScholarPubMed
Aritsuka, T, Tanaka, K & Kiriyama, S (1989) Effect of beet fiber on lipid metabolism in rats fed a cholesterol-free diet in comparison with pectin and cellulose. J Jpn Soc Nutr Food Sci 42 295304CrossRefGoogle Scholar
Ballard, FJ (1972) Supply and utilization of acetate in mammals. Am J Clin Nutr. 25 773779CrossRefGoogle ScholarPubMed
Bennett, MK, Lopez, JM, Sanchez, HB & Osborne, TF (1995) Sterol regulation of fatty acid synthase promotor. J Biol Chem. 270 2557825583CrossRefGoogle Scholar
Chang, C, Ohshima, T & Koizumi, C (1994) Changes in the composition of free amino acids, organic acids and lipids during processing and ripening of ‘Hatahata-zushi’, a fermented fish product of sandfish (Arctoscopus japonicus). J Sci Food Agric. 66 7582CrossRefGoogle Scholar
Crabtree, B, Gordon, M & Christie, SL (1990) Measurement of the rates of acetyl-CoA hydrolysis and synthesis from acetate in rat hepatocytes and the role of these fluxes in substrate cycling. Biochem J. 270 219225CrossRefGoogle ScholarPubMed
DeBuysere, MS & Olson, MS (1983) The analysis of acetyl-coenzyme A derivatives by reverse-phase high-performance liquid chromatography. Anal Biochem. 133 373379CrossRefGoogle Scholar
Folch, J, Lees, M & Stanley, GHS (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 226 497509Google ScholarPubMed
Foufelle, F & Ferré, P (2002) New perspective in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J. 366 377391CrossRefGoogle Scholar
Fujii, T, Sasaki, T & Okuzumi, M (1992) Chemical composition and microbial flora of saba-narezushi (fermented mackerel with rice) (in Japanese). Bull Jap Soc Fish Sci. 58 891894CrossRefGoogle Scholar
Fungwe, TV, Cagen, LM, Cook, GA, Wilcox, HG & Heimberg, M (1993) Dietary cholesterol stimulates hepatic biosynthesis of triglyceride and reduces oxidation of fatty acids in the rat. J Lipid Res. 34 933941Google ScholarPubMed
Fungwe, TV, Fox, JE, Cagen, LM, Wilcox, HG & Heimberg, M (1994) Stimulation of fatty acid biosynthesis by dietary cholesterol and of cholesterol synthesis by dietary fatty acid. J Lipid Res. 35 311318Google ScholarPubMed
Fushimi, T & Sato, Y (2005) Effect of acetic acid feeding on the circadian changes in glycogen and metabolites of glucose and lipid in liver and skeletal muscle of rats. Br J Nutr. 94 714719CrossRefGoogle ScholarPubMed
Fushimi, T, Tayama, K, Fukaya, M, Kitakoshi, K, Nakai, N, Tsukamoto, Y & Sato, Y (2001) Acetic acid feeding enhances glycogen repletion in liver and skeletal muscle of rats. J Nutr 131 19731977CrossRefGoogle ScholarPubMed
Fushimi, T, Tayama, K, Fukaya, M, Kitakoshi, K, Nakai, N, Tsukamoto, Y & Sato, Y (2002) The efficacy of acetic acid for glycogen repletion in rat skeletal muscle after exercise. Int J Sports Med. 23 218222CrossRefGoogle ScholarPubMed
Goda, T, Yasutake, H & Takase, S (1994) Dietary fat regulates cellular retinol-binding protein II gene expression in rat jejunum. Biochim Biophys Acta. 1200 3440CrossRefGoogle ScholarPubMed
Hara, H, Haga, S, Aoyama, Y & Kiriyama, S (1999) Short-chain fatty acids suppress cholesterol synthesis in rat liver and intestine. J Nutr. 129 942948CrossRefGoogle ScholarPubMed
Hardie, DG (2003) The AMP-activated protein kinase cascade: the key sensors of cellular energy status. Endocrinology. 144 51795183CrossRefGoogle Scholar
Hardie, DG, Carling, D & Carlson, M (1998) The AMP-activated/SNF 1 protein kinase subfamily: metabolic sensors of the eukaryotic cell Ann Rev Biochem. 67 821855CrossRefGoogle Scholar
Horton, JD, Bashimakov, Y, Shimomura, I & Shimano, H (1998) Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci U S A. 95 59875992CrossRefGoogle ScholarPubMed
Kawaguchi, T, Osatomi, K, Yamashita, H, Kabashima, T & Uyeda, K (2002) Mechanism for fatty acid 'sparing' effect on glucose-induced transcription. J Biol Chem. 277 38293835CrossRefGoogle ScholarPubMed
Kishi, M, Fukaya, M, Tsukamoto, Y, Nagasawa, T, Kakehana, K & Nishizawa, N (1999) Enhancing effect of dietary vinegar on the intestinal absorption of calcium in ovariectomized rats. Biosci Biotechnol Biochem. 63 905910CrossRefGoogle ScholarPubMed
Kondo, S, Tayama, K, Tsukamoto, Y, Ikeda, K & Yamori, Y (2001) Antihypertensive effects of acetic acid and vinegar on spontaneously hypertensive rats. Biosci Biotechnol Biochem. 65 26902694CrossRefGoogle ScholarPubMed
Liljeberg, H & Björck, I (1998) Delayed gastric emptying rate may explain improved glycaemia in healthy subjects to a starchy meal with added vinegar. Eur J Clin Nutr 52 368371CrossRefGoogle ScholarPubMed
Lopez, JM, Bennett, MK, Sanchez, HB, Rosenfeld, JM & Osborne, TF (1996) Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid. Proc Natl Acad Sci U S A. 93 10491053CrossRefGoogle ScholarPubMed
Mine, H, Yamagami, Y & Ohno, N (1982) Studies in food seasoning (part 3) 'Takikomi-zushi' (in Japanese). Rep Res Matsuyama Shinonome Jr Coll. 13 8188Google Scholar
Mochizuki, K, Suruga, K, Kitagawa, M, Takase, S & Goda, T (2001) Modulation of the expression of peroxisome proliferator-activated receptor-dependent genes through disproportional expression of two subtypes in the small intestine. Arch Biochem Biophys. 389 4148CrossRefGoogle ScholarPubMed
Mochizuki, K, Suruga, K, Sakaguchi, N, Takase, S & Goda, T (2002) Major intestinal coactivator p300 strongly activates peroxisome proliferator-activated receptor in intestinal cell line. Caco-2. Gene. 291 271277CrossRefGoogle ScholarPubMed
Moundras, C, Behr, SR, Remesy, C & Demigne, C (1997) Fecal losses of sterols and bile acids induced by feeding rats guar gum are due to greater pool size and liver bile acid secretion. J Nutr 127 10681076CrossRefGoogle ScholarPubMed
Nakazawa, I & Muraoka, H (1989) Healthy foods (in Japanese). New Food Indust. 31 3540Google Scholar
Noshiro, M, Nishimoto, M, Morohashi, K & Okuda, K (1989) Molecular cloning of cDNA for cholesterol 7 alpha-hydroxylase from rat liver microsomes. Nucleotide sequence and expression. FEBS Lett 257 97100CrossRefGoogle ScholarPubMed
Pearce, NJ, Yates, JW & Berkhout, TA (1998) The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Biochem J. 334 113119CrossRefGoogle ScholarPubMed
Reeves, PG, Nielsen, FH & Fahey, GC (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123 19391951CrossRefGoogle ScholarPubMed
Ren, H, Endo, tH, Watanabe, E & Hayashi, T (1997) Chemical and sensory characteristics of Chinese, Korean and Japanese vinegars. J Tokyo Univ Fish 84 111Google Scholar
Ross, CM & Poluhowich, JJ (1984) The effect of apple cider vinegar on adjuvant arthritic rats. Nutr Res 4 737741CrossRefGoogle Scholar
Saha, AK & Ruderman, NB (2003) Malonyl-CoA and AMP-activated proteinkinase: an expanding partnership. Mol Cell Biochem. 253 6570CrossRefGoogle Scholar
Sanchez-Vincente, C, Rondriguez-Nodal, F, Minguela, A, Garcia, LJ, San Roman, JI, Calvo, JJ & Lopez, MA (1995) Cholinergic pathways are involved in secretin and VIP release and the exocrine pancreatic response after intraduodenally perfused acetic and lactic acids in the rat. Pancreas. 10. 9399CrossRefGoogle Scholar
Sato, R, Okamoto, A, Inoue, J, Miyamoto, W, Sakai, Y, Emoto, N, Shimano, H & Maeda, M (2000) Transcriptional regulation of the ATP citrate-lyase gene by sterol regulatory element-binding proteins. J Biol Chem. 275 1249712502CrossRefGoogle ScholarPubMed
Shimizu, I, Hirota, M, Matsumura, M & Shima, K (1987) Effects of gut hormones on bile acid uptake and release in cultured rat hepatocytes. Gastroenterol Jpn. 22 174178Google ScholarPubMed
Spydevold, O, Davis, EJ & Bremer, J (1976) Replenishment and depletion of citric acid cycle intermediates in skeletal muscle. Eur J Biochem 71 155165CrossRefGoogle ScholarPubMed
Takeda, Y, Suzuki, F & Inoue, H (1969) ATP-citrate lyase (citrate-cleavege enzyme) Methods Enzymol 13 153160CrossRefGoogle Scholar
Winder, WW & Hardie, DG (1999) AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol. 277 E1E10Google ScholarPubMed
Yokogoshi, H, Mochizuki, H, Nanami, K, Hida, Y, Miyachi, F & Oda, H (1999) Dietary taurine enhances cholesterol degradation and reduces serum and liver cholesterol concentrations in rats fed a high-cholesterol diet. J Nutr 129 17051712CrossRefGoogle ScholarPubMed
Zhou, G, Myers, R & Li, Y (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 108 11671174CrossRefGoogle ScholarPubMed
You have Access
122
Cited by

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Dietary acetic acid reduces serum cholesterol and triacylglycerols in rats fed a cholesterol-rich diet
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Dietary acetic acid reduces serum cholesterol and triacylglycerols in rats fed a cholesterol-rich diet
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Dietary acetic acid reduces serum cholesterol and triacylglycerols in rats fed a cholesterol-rich diet
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *