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Dietary flavonoid intake and colorectal cancer: a case–control study

  • Janet A. M. Kyle (a1) (a2), Linda Sharp (a3) (a4), Julian Little (a3) (a5), Garry G. Duthie (a1) and Geraldine McNeill (a2)...
Abstract

Diets rich in flavonoids may reduce the risk of developing colorectal cancer. Flavonoids are widely distributed in foods of plant origin, though in the UK tea is the main dietary source. Our objective was to evaluate any independent associations of total dietary and non-tea intake of four flavonoid subclasses and the risk of developing colorectal cancer in a tea-drinking population with a high colorectal cancer incidence. A population-based case–control study (264 cases with histologically confirmed incident colorectal cancer and 408 controls) was carried out. Dietary data gathered by FFQ were used to calculate flavonoid intake. Adjusted OR and 95 % CI were estimated by logistic regression. No linear association between risk of developing colorectal cancer and total dietary flavonol, procyanidin, flavon-3-ol or flavanone intakes was found, but non-tea flavonol intake was inversely associated with colorectal cancer risk (OR 0·6; 95 % CI 0·4, 1·0). Stratification by site of cancer and assessment of individual flavonols showed a reduced risk of developing colon but not rectal cancer with increasing non-tea quercetin intake (OR 0·5; 95 % CI 0·3, 0·8; Ptrend < 0·01). We concluded that flavonols, specifically quercetin, obtained from non-tea components of the diet may be linked with reduced risk of developing colon cancer.

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Corresponding author
*Corresponding author: Dr Janet A. M. Kyle, fax +44 1224 559348, email j.kyle@abdn.ac.uk
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4 FJB Duijnhoven , HB De Mesquita , P Ferrari , (2009) Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 89, 14411452.

9 SJ Duthie , W Johnson & VL Dobson (1997) The effect of dietary flavonoids on DNA damage (strand breaks and oxidized pyrimidines) and growth in human cells. Mutat Res 390, 141151.

11 HP Kim , I Mani , L Iversen , (1998) Effects of naturally occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea-pigs. Prostaglandins Leukot Essent Fatty Acids 58, 1724.

13 G Peng , DA Dixon , SJ Muga , (2006) Green tea polyphenol ( − )-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis. Mol Carcinog 45, 309319.

14 JB Daskiewicz , F Depeint , L Viornery , (2005) Effects of flavonoids on cell proliferation and caspase activation in a colonic cell line HT 29, SAR study. J Med Chem 48, 27902804.

15 AA Franke , LJ Custer , RV Cooney , (2002) Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidin. Adv Exp Med Biol 505, 123133.

16 F Gosse , S Guyot , S Roussi , (2005) Chemopreventive properties of apple procyanidins on human colon cancer derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Carcingogenesis 26, 12911295.

20 J Lin , SM Zhang , K Wu , (2006) Flavonoid intake and colorectal cancer risk in men and women. Am J Epidemiol 164, 644651.

21 T Hirvonen , J Virtamo , P Korhonen , (2001) Flavonol and flavone intake and the risk of cancer in male smokers (Finland). Cancer Causes Control 12, 789796.

22 P Knekt , R Jarvinen , R Seppanen , (1997) Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol 146, 223230.

24 ICW Arts , PCH Hollman , HBB de Mesquita , (2001) Dietary catechins and epithelial cancer incidence: the Zutphen elderly study. Int J Cancer 92, 298302.

25 ICW Arts , DR Jacobs Jr, M Gross , (2002) Dietary catechins and cancer incidence among postmenopausal women: the Iowa Women's Health Study (United States). Cancer Causes Control 13, 373382.

27 MGL Hertog , PCH Hollman & MB Katan (1992) Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in The Netherlands. J Agric Food Chem 40, 23792783.

28 M Rossi , E Negri , R Talamini , (2006) Flavonoids and colorectal cancer in Italy. Cancer Epidemiol Biomarkers Prev 15, 15551558.

29 E Theodoratou , J Kyle , R Cetnarskyj , (2007) Dietary flavonoids and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 16, 684693.

31 L McKie , A MacInnes , J Hendry , (2000) The food consumption patterns and perceptions of dietary advice of older people. J Hum Nutr Diet 13, 173183.

33 J Little , L Sharp , LF Masson , (2006) Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case–control study in the Grampian region of Scotland. Int J Cancer 119, 21552164.

38 TV Macfarlane , RJM Gray , J Kincey , (2007) Factors associated with the temporomandibular disorder, pain dysfunction syndrome (PDS): Manchester case–control study. Oral Dis 7, 321330.

41 MGL Hertog , PCH Hollman & B van de Putte (1993) Content of potentially anticarcinogenic flavonoids of tea infusions, wines and fruit juices. J Agric Food Chem 41, 12421246.

43 IC Arts , B van De Putte & PC Hollman (2000) Catechin contents of foods commonly consumed in The Netherlands. 2. Tea, wine, fruit juices, and chocolate milk. J Agric Food Chem 48, 17521757.

45 PCH Hollman & ICW Arts (2000) Flavonols, flavones and flavanols – nature, occurrence and dietary burden. J Sci Food Agric 80, 10811093.

49 WK Kim , MH Bang , ES Kim , (2005) Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. J Nutr Biochem 16, 155162.

50 CH Park , JY Chang , ER Hahm , (2005) Quercetin, a potent inhibitor against β-catenin/Tcf signalling in SW480 colon cancer cells. Biochem Biophys Res Commun 328, 227234.

54 JR Vane & RM Botting (1998) Anti-inflammatory drugs and their mechanism of action. Inflamm Res 47, S78S87.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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