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Dietary phosphorus restriction to half the minimum required amount slightly reduces weight gain and length of tibia, but sustains femur mineralization and prevents nephrocalcinosis in female kittens

Published online by Cambridge University Press:  09 March 2007

F. J. H. Pastoor ,
R. Otitz ,
A. TH. Van Tklooster  and
A. C. Beynen
F. J. H. Pastoor
Affiliation:
Department of Laboratory Animal Science, Utrecht University, Utrecht, The Netherlands
R. Otitz
Affiliation:
Department of Laboratory Animal Science, Utrecht University, Utrecht, The Netherlands
A. TH. Van Tklooster
Affiliation:
Department of Large Animal Medicine and Nutrition, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
A. C. Beynen
Affiliation:
Department of Laboratory Animal Science, Utrecht University, Utrecht, The Netherlands Department of Large Animal Medicine and Nutrition, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
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Abstract

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The effects of dietary P restriction to half the recommended minimum level on growth, bone and renal mineralization and urinary composition were studied in female kittens. In two separate experiments, 8-week-old weanling kittens were fed on purified diets containing either 4·6 or 9·2 mmol P/MJ (2·8 or 5·6 g P/kg diet). In the second experiment there was an additional low-P diet in which the Ca concentration was reduced from 9·5 to 4·8 mmol/MJ (7·5 v. 3.8 g Ca/kg diet). P restriction slightly but systematically reduced weight gain (to a maximum of 16%) and growth of the tibia (by 1–4%); the former effect was statistically significant (P < 0·05) between the ages of 15 and 20 weeks in Expt 1 only, and the latter did not reach statistical significance at any time point (P g 0·13). No adverse effect of P restriction was found on mineralization of femur at the age of 39 weeks. Kidney Ca concentrations were significantly lowered (Expt 1, 6 v. 20/μmol/g dry weight, P < 0-001; Expt 2, 7 v. 16/μmol/g dry weight, P < 0-01) in cats fed on the low-P diets, this effect not being affected by the dietary Ca:P ratio. Urinary P concentration was significantly depressed (by 50–96%) after feeding the low-P diets (P < 0-001). P intake did not influence P, Ca and Mg retention during the period of 15 to 39 weeks of age.

Keywords

PhosphorusMineral excretionBoneNephrocalcinosisCat
Type
Mineral metabolism in companion animals
Information
British Journal of Nutrition , Volume 74 , Issue 1 , July 1995 , pp. 85 - 100
Copyright
Copyright © The Nutrition Society 1995

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