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Dietary protein – its role in satiety, energetics, weight loss and health

  • Margriet S. Westerterp-Plantenga (a1), Sofie G. Lemmens (a1) and Klaas R. Westerterp (a1)
Abstract

Obesity is a serious health problem because of its co-morbidities. The solution, implying weight loss and long-term weight maintenance, is conditional on: (i) sustained satiety despite negative energy balance, (ii) sustained basal energy expenditure despite BW loss due to (iii) a sparing of fat-free mass (FFM), being the main determinant of basal energy expenditure. Dietary protein has been shown to assist with meeting these conditions, since amino acids act on the relevant metabolic targets. This review deals with the effects of different protein diets during BW loss and BW maintenance thereafter. Potential risks of a high protein diet are dealt with. The required daily intake is 0·8–1·2 g/kg BW, implying sustaining the original absolute protein intake and carbohydrate and fat restriction during an energy-restricted diet. The intake of 1·2 g/kg BW is beneficial to body composition and improves blood pressure. A too low absolute protein content of the diet contributes to the risk of BW regain. The success of the so-called ‘low carb’ diet that is usually high in protein can be attributed to the relatively high-protein content per se and not to the relatively lower carbohydrate content. Metabolic syndrome parameters restore, mainly due to BW loss. With the indicated dosage, no kidney problems have been shown in healthy individuals. In conclusion, dietary protein contributes to the treatment of obesity and the metabolic syndrome, by acting on the relevant metabolic targets of satiety and energy expenditure in negative energy balance, thereby preventing a weight cycling effect.

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Corresponding author
*Corresponding author: Prof. Dr M. S. Westerterp-Plantenga, fax +31433670976, email m.westerterp@maastrichtuniversity.nl
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1 FX Pi-Sunyer (1993) Medical hazards of obesity. Ann Intern Med 119, 655660.

2 JC Seidell (1995) Obesity in Europe. Obes Res 3, 8993S.

3 MS Westerterp-Plantenga , N Natalie Luscombe-Marsh , MPGM Lejeune , et al. (2006) Dietary protein, metabolism, and body-weight regulation: dose-response effects. Int J Obes Relat Metab Disord 30, S16S23.

4 MS Westerterp-Plantenga , A Nieuwenhuizen , D Tome , et al. (2009) Dietary protein, weight loss, and weight maintenance. Annu Rev Nutr 29, 2141.

6 MJ Stock (1999) Gluttony and thermogenesis revisited. Int J Obes Relat Metab Disord 23, 11051117.

7 AR Skov , S Toubro , B Ronn , et al. (1999) Randomized trial on protein vs carbohydrate in ad libitum fat reduced diet for the treatment of obesity. Int J Obes Relat Metab Disord 23, 528536.

8 MS Westerterp-Plantenga , MP Lejeune , I Nijs , et al. (2004) High protein intake sustains weight maintenance after body weight loss in humans. Int J Obes Relat Metab Disord 28, 5764.

9 TL Halton & FB Hu (2005) The effects of high protein diets on thermogenesis, satiety and weight loss: a critical review. J Am Coll Nutr 23, 373385.

13 FM Sacks , GA Bray , VJ Carey , et al. (2009) Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 360, 859873.

14 TM Larsen , SM Dalskov , M van Baak , et al. (2010) Diet, Obesity, and Genes (Diogenes) Project. Diets with high or low protein content and glycemic index for weight-loss maintenance. N Engl J Med 363, 21022113.

15 P Deibert , D Konig , A Schmidt-Trucksaess , et al. (2004) Weight loss without losing muscle mass in pre-obese and obese subjects induced by a high-soy-protein diet. Int J Obes Relat Metab Disord 28, 13491352.

18 ND Luscombe , PM Clifton , M Noakes , et al. (2002) Effects of Energy-Restricted Diets Containing Increased Protein on Weight Loss, Resting Energy Expenditure, and the Thermic Effect of Feeding in Type 2 Diabetes. Diabetes Care 25, 652657.

19 ND Luscombe , PM Clifton , M Noakes , et al. (2003) Effect of a high-protein, energy-restricted diet on weight loss and energy expenditure after weight stabilization in hyperinsulinemic subjects. Int J Obes Relat Metab Disord 27, 582590.

20 GD Brinkworth , M Noakes , JB Keogh , et al. (2004) Long-term effects of a high-protein, low-carbohydrate diet on weight control and cardiovascular risk markers in obese hyperinsulinemic subjects. Int J Obes Relat Metab Disord 28, 661670.

21 S Soenen & MS Westerterp-Plantenga (2010) Changes in body fat percentage during body weight stable conditions of increased daily protein intake vs. control. Physiol Behav 101, 635638.

24 A Hochstenbach-Waelen , KR Westerterp , S Soenen , et al. (2010) No long-term weight maintenance effects of gelatin in a supra-sustained protein diet. Physiol Behav 101, 237244.

25 S Soenen , A Hochstenbach-Waelen & MS Westerterp-Plantenga (2011) Efficacy of α-lactalbumin and milk protein on weight loss and body composition during energy restriction. Obesity 19, 370379.

28 E Scharrer (1999) Control of food intake by fatty acid oxidation and ketogenesis. Nutrition 15, 704714.

29 MA Veldhorst , MS Westerterp-Plantenga & KR Westerterp (2009) Gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet. Am J Clin Nutr 90, 519526.

31 KR Westerterp , SAJ Wilson & A Rolland (1999) Diet-induced thermogenesis measured over 24 h in a respiration chamber: effect of diet composition. Int J Obes Relat Metab Disord 23, 287292.

32 MS Westerterp-Plantenga , V Rolland , SA Wilson , et al. (1999) Satiety related to 24 h diet-induced thermogenesis during high protein/carbohydrate vs high fat diets measured in a respiration chamber. Eur J Clin Nutr 53, 495502.

33 A Hochstenbach-Waelen , MA Veldhorst , AG Nieuwenhuizen , et al. (2009) Comparison of 2 diets with either 25 % or 10 % of energy as casein on energy expenditure, substrate balance, and appetite profile. Am J Clin Nutr 89, 831838.

34 A Hochstenbach-Waelen , MS Westerterp-Plantenga , MA Veldhorst , et al. (2009) Single-protein casein and gelatin diets affect energy expenditure similarly but substrate balance and appetite differently in adults. J Nutr 139, 22852292.

39 MA Veldhorst , AG Nieuwenhuizen , A Hochstenbach-Waelen , et al. (2009) A breakfast with alpha-lactalbumin, gelatin, or gelatin + TRP lowers energy intake at lunch compared with a breakfast with casein, soy, whey, or whey-GMP. Clin Nutr 28, 147155.

40 MA Veldhorst , AG Nieuwenhuizen , A Hochstenbach-Waelen , et al. (2009) Dose-dependent satiating effect of whey relative to casein or soy. Physiol Behav 96, 675682.

41 MA Veldhorst , AG Nieuwenhuizen , A Hochstenbach-Waelen , et al. (2009) Effects of complete whey-protein breakfasts versus whey without GMP-breakfasts on energy intake and satiety. Appetite 52, 388395.

43 DW Gietzen , S Hao & TG Anthony (2007) Mechanisms of food intake repression in indispensable amino acid deficiency. Annu Rev Nutr 27, 6378.

46 Y Boirie , M Dangin , P Gachon , et al. (1997) Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci USA 94, 1493014935.

49 L Stryer (1988) Biochemistry. New York: Freeman.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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