Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 53
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Allerton, Dean Campbell, Matthew Gonzalez, Javier Rumbold, Penny West, Daniel and Stevenson, Emma 2016. Co-Ingestion of Whey Protein with a Carbohydrate-Rich Breakfast Does Not Affect Glycemia, Insulinemia or Subjective Appetite Following a Subsequent Meal in Healthy Males. Nutrients, Vol. 8, Issue. 3, p. 116.


    Crujeiras, A B Zulet, M A Abete, I Amil, M Carreira, M C Martínez, J A and Casanueva, F F 2016. Interplay of atherogenic factors, protein intake and betatrophin levels in obese–metabolic syndrome patients treated with hypocaloric diets. International Journal of Obesity, Vol. 40, Issue. 3, p. 403.


    Dhillon, Jaapna Running, Cordelia A. Tucker, Robin M. and Mattes, Richard D. 2016. Effects of food form on appetite and energy balance. Food Quality and Preference, Vol. 48, p. 368.


    Dhillon, Jaapna Craig, Bruce A. Leidy, Heather J. Amankwaah, Akua F. Osei-Boadi Anguah, Katherene Jacobs, Ashley Jones, Blake L. Jones, Joshua B. Keeler, Chelsey L. Keller, Christine E.M. McCrory, Megan A. Rivera, Rebecca L. Slebodnik, Maribeth Mattes, Richard D. and Tucker, Robin M. 2016. The Effects of Increased Protein Intake on Fullness: A Meta-Analysis and Its Limitations. Journal of the Academy of Nutrition and Dietetics, Vol. 116, Issue. 6, p. 968.


    Gibson, A. A. Seimon, R. V. Franklin, J. Markovic, T. P. Byrne, N. M. Manson, E. Caterson, I. D. and Sainsbury, A. 2016. Fast versus slow weight loss: development process and rationale behind the dietary interventions for the TEMPO Diet Trial. Obesity Science & Practice, Vol. 2, Issue. 2, p. 162.


    Hansen, Camilla P Heitmann, Berit L Sørensen, Thorkild IA Overvad, Kim and Jakobsen, Marianne U 2016. Intake of ruminant trans-fatty acids, assessed by diet history interview, and changes in measured body size, shape and composition. Public Health Nutrition, Vol. 19, Issue. 03, p. 494.


    Heggen, Eli Svendsen, Mette Klemsdal, Tor Ole and Tonstad, Serena 2016. Low Carbohydrate and Moderately Fat-Reduced Diets Similarly Affected Early Weight Gain in Varenicline-Treated Overweight or Obese Smokers. Nicotine & Tobacco Research, Vol. 18, Issue. 6, p. 1440.


    Li, Jia Armstrong, Cheryl and Campbell, Wayne 2016. Effects of Dietary Protein Source and Quantity during Weight Loss on Appetite, Energy Expenditure, and Cardio-Metabolic Responses. Nutrients, Vol. 8, Issue. 2, p. 63.


    Liisberg, Ulrike Myrmel, Lene Secher Fjære, Even Rønnevik, Alexander K. Bjelland, Susanne Fauske, Kristin Røen Holm, Jacob Bak Basse, Astrid Linde Hansen, Jacob B. Liaset, Bjørn Kristiansen, Karsten and Madsen, Lise 2016. The protein source determines the potential of high protein diets to attenuate obesity development in C57BL/6J mice. Adipocyte, Vol. 5, Issue. 2, p. 196.


    Mateo-Gallego, Rocío Marco-Benedí, Victoria Perez-Calahorra, Sofía Bea, Ana M. Baila-Rueda, Lucía Lamiquiz-Moneo, Itziar de Castro-Orós, Isabel Cenarro, Ana and Civeira, Fernando 2016. Energy-restricted, high-protein diets more effectively impact cardiometabolic profile in overweight and obese women than lower-protein diets. Clinical Nutrition,


    Morell, P. and Fiszman, S. 2016. Revisiting the role of protein-induced satiation and satiety. Food Hydrocolloids,


    Pratt, Nathan S. Ellison, Brenna D. Benjamin, Aaron S. and Nakamura, Manabu T. 2016. Improvements in recall and food choices using a graphical method to deliver information of select nutrients. Nutrition Research, Vol. 36, Issue. 1, p. 44.


    Rao, Theertham Pradyumna 2016. Role of guar fiber in appetite control. Physiology & Behavior, Vol. 164, p. 277.


    Raynor, Hollie A. and Champagne, Catherine M. 2016. Position of the Academy of Nutrition and Dietetics: Interventions for the Treatment of Overweight and Obesity in Adults. Journal of the Academy of Nutrition and Dietetics, Vol. 116, Issue. 1, p. 129.


    Ruiz-Tovar, Jaime Zubiaga, Lorea Diez, Maria Murcia, Ana Boix, Evangelina Muñoz, José Luis and Llavero, Carolina 2016. Preoperative Regular Diet of 900 kcal/day vs Balanced Energy High-Protein Formula vs Immunonutrition Formula: Effect on Preoperative Weight Loss and Postoperative Pain, Complications and Analytical Acute Phase Reactants After Laparoscopic Sleeve Gastrectomy. Obesity Surgery, Vol. 26, Issue. 6, p. 1221.


    Russell, Wendy R. Baka, Athanasia Björck, Inger Delzenne, Nathalie Gao, Dan Griffiths, Helen R. Hadjilucas, Ellie Juvonen, Kristiina Lahtinen, Sampo Lansink, Mirian Loon, Luc Van Mykkänen, Hannu östman, Elin Riccardi, Gabriele Vinoy, Sophie and Weickert, Martin O. 2016. Impact of Diet Composition on Blood Glucose Regulation. Critical Reviews in Food Science and Nutrition, Vol. 56, Issue. 4, p. 541.


    Vanselow, Jens Kucia, Marzena Langhammer, Martina Koczan, Dirk and Metges, Cornelia C. 2016. Maternal high-protein diet during pregnancy, but not during suckling, induced altered expression of an increasing number of hepatic genes in adult mouse offspring. European Journal of Nutrition, Vol. 55, Issue. 3, p. 917.


    Voortman, T Braun, K V E Kiefte-de Jong, J C Jaddoe, V W V Franco, O H and van den Hooven, E H 2016. Protein intake in early childhood and body composition at the age of 6 years: The Generation R Study. International Journal of Obesity, Vol. 40, Issue. 6, p. 1018.


    Wojcik, Jennifer L Aukema, Harold M Zahradka, Peter and Taylor, Carla G 2016. Effects of high protein diets on metabolic syndrome parameters. Current Opinion in Food Science, Vol. 8, p. 43.


    Alencar, Michelle K. Beam, Jason R. McCormick, James J. White, Ailish C. Salgado, Roy M. Kravitz, Len R. Mermier, Christine M. Gibson, Ann L. Conn, Carole A. Kolkmeyer, Deborah Ferraro, Robert T. and Kerksick, Chad M. 2015. Increased meal frequency attenuates fat-free mass losses and some markers of health status with a portion-controlled weight loss diet. Nutrition Research, Vol. 35, Issue. 5, p. 375.


    ×

Dietary protein – its role in satiety, energetics, weight loss and health

  • Margriet S. Westerterp-Plantenga (a1), Sofie G. Lemmens (a1) and Klaas R. Westerterp (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114512002589
  • Published online: 01 August 2012
Abstract

Obesity is a serious health problem because of its co-morbidities. The solution, implying weight loss and long-term weight maintenance, is conditional on: (i) sustained satiety despite negative energy balance, (ii) sustained basal energy expenditure despite BW loss due to (iii) a sparing of fat-free mass (FFM), being the main determinant of basal energy expenditure. Dietary protein has been shown to assist with meeting these conditions, since amino acids act on the relevant metabolic targets. This review deals with the effects of different protein diets during BW loss and BW maintenance thereafter. Potential risks of a high protein diet are dealt with. The required daily intake is 0·8–1·2 g/kg BW, implying sustaining the original absolute protein intake and carbohydrate and fat restriction during an energy-restricted diet. The intake of 1·2 g/kg BW is beneficial to body composition and improves blood pressure. A too low absolute protein content of the diet contributes to the risk of BW regain. The success of the so-called ‘low carb’ diet that is usually high in protein can be attributed to the relatively high-protein content per se and not to the relatively lower carbohydrate content. Metabolic syndrome parameters restore, mainly due to BW loss. With the indicated dosage, no kidney problems have been shown in healthy individuals. In conclusion, dietary protein contributes to the treatment of obesity and the metabolic syndrome, by acting on the relevant metabolic targets of satiety and energy expenditure in negative energy balance, thereby preventing a weight cycling effect.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Dietary protein – its role in satiety, energetics, weight loss and health
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Dietary protein – its role in satiety, energetics, weight loss and health
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Dietary protein – its role in satiety, energetics, weight loss and health
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Prof. Dr M. S. Westerterp-Plantenga, fax +31433670976, email m.westerterp@maastrichtuniversity.nl
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1FX Pi-Sunyer (1993) Medical hazards of obesity. Ann Intern Med 119, 655660.

2JC Seidell (1995) Obesity in Europe. Obes Res 3, 8993S.

3MS Westerterp-Plantenga , N Natalie Luscombe-Marsh , MPGM Lejeune , et al. (2006) Dietary protein, metabolism, and body-weight regulation: dose-response effects. Int J Obes Relat Metab Disord 30, S16S23.

4MS Westerterp-Plantenga , A Nieuwenhuizen , D Tome , et al. (2009) Dietary protein, weight loss, and weight maintenance. Annu Rev Nutr 29, 2141.

6MJ Stock (1999) Gluttony and thermogenesis revisited. Int J Obes Relat Metab Disord 23, 11051117.

7AR Skov , S Toubro , B Ronn , et al. (1999) Randomized trial on protein vs carbohydrate in ad libitum fat reduced diet for the treatment of obesity. Int J Obes Relat Metab Disord 23, 528536.

8MS Westerterp-Plantenga , MP Lejeune , I Nijs , et al. (2004) High protein intake sustains weight maintenance after body weight loss in humans. Int J Obes Relat Metab Disord 28, 5764.

9TL Halton & FB Hu (2005) The effects of high protein diets on thermogenesis, satiety and weight loss: a critical review. J Am Coll Nutr 23, 373385.

13FM Sacks , GA Bray , VJ Carey , et al. (2009) Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 360, 859873.

14TM Larsen , SM Dalskov , M van Baak , et al. (2010) Diet, Obesity, and Genes (Diogenes) Project. Diets with high or low protein content and glycemic index for weight-loss maintenance. N Engl J Med 363, 21022113.

15P Deibert , D Konig , A Schmidt-Trucksaess , et al. (2004) Weight loss without losing muscle mass in pre-obese and obese subjects induced by a high-soy-protein diet. Int J Obes Relat Metab Disord 28, 13491352.

18ND Luscombe , PM Clifton , M Noakes , et al. (2002) Effects of Energy-Restricted Diets Containing Increased Protein on Weight Loss, Resting Energy Expenditure, and the Thermic Effect of Feeding in Type 2 Diabetes. Diabetes Care 25, 652657.

19ND Luscombe , PM Clifton , M Noakes , et al. (2003) Effect of a high-protein, energy-restricted diet on weight loss and energy expenditure after weight stabilization in hyperinsulinemic subjects. Int J Obes Relat Metab Disord 27, 582590.

20GD Brinkworth , M Noakes , JB Keogh , et al. (2004) Long-term effects of a high-protein, low-carbohydrate diet on weight control and cardiovascular risk markers in obese hyperinsulinemic subjects. Int J Obes Relat Metab Disord 28, 661670.

21S Soenen & MS Westerterp-Plantenga (2010) Changes in body fat percentage during body weight stable conditions of increased daily protein intake vs. control. Physiol Behav 101, 635638.

24A Hochstenbach-Waelen , KR Westerterp , S Soenen , et al. (2010) No long-term weight maintenance effects of gelatin in a supra-sustained protein diet. Physiol Behav 101, 237244.

25S Soenen , A Hochstenbach-Waelen & MS Westerterp-Plantenga (2011) Efficacy of α-lactalbumin and milk protein on weight loss and body composition during energy restriction. Obesity 19, 370379.

28E Scharrer (1999) Control of food intake by fatty acid oxidation and ketogenesis. Nutrition 15, 704714.

29MA Veldhorst , MS Westerterp-Plantenga & KR Westerterp (2009) Gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet. Am J Clin Nutr 90, 519526.

31KR Westerterp , SAJ Wilson & A Rolland (1999) Diet-induced thermogenesis measured over 24 h in a respiration chamber: effect of diet composition. Int J Obes Relat Metab Disord 23, 287292.

32MS Westerterp-Plantenga , V Rolland , SA Wilson , et al. (1999) Satiety related to 24 h diet-induced thermogenesis during high protein/carbohydrate vs high fat diets measured in a respiration chamber. Eur J Clin Nutr 53, 495502.

33A Hochstenbach-Waelen , MA Veldhorst , AG Nieuwenhuizen , et al. (2009) Comparison of 2 diets with either 25 % or 10 % of energy as casein on energy expenditure, substrate balance, and appetite profile. Am J Clin Nutr 89, 831838.

34A Hochstenbach-Waelen , MS Westerterp-Plantenga , MA Veldhorst , et al. (2009) Single-protein casein and gelatin diets affect energy expenditure similarly but substrate balance and appetite differently in adults. J Nutr 139, 22852292.

39MA Veldhorst , AG Nieuwenhuizen , A Hochstenbach-Waelen , et al. (2009) A breakfast with alpha-lactalbumin, gelatin, or gelatin + TRP lowers energy intake at lunch compared with a breakfast with casein, soy, whey, or whey-GMP. Clin Nutr 28, 147155.

40MA Veldhorst , AG Nieuwenhuizen , A Hochstenbach-Waelen , et al. (2009) Dose-dependent satiating effect of whey relative to casein or soy. Physiol Behav 96, 675682.

41MA Veldhorst , AG Nieuwenhuizen , A Hochstenbach-Waelen , et al. (2009) Effects of complete whey-protein breakfasts versus whey without GMP-breakfasts on energy intake and satiety. Appetite 52, 388395.

43DW Gietzen , S Hao & TG Anthony (2007) Mechanisms of food intake repression in indispensable amino acid deficiency. Annu Rev Nutr 27, 6378.

46Y Boirie , M Dangin , P Gachon , et al. (1997) Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci USA 94, 1493014935.

49L Stryer (1988) Biochemistry. New York: Freeman.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: